Clinical trials: Adverse Reaction to Drug
Blood Coagulation Disorder, Postoperative Blood Loss
Comparative Study of Tranexamic Acid Dosing in Cardiac Surgery
Tranexamic axid is routinely used as an antifibrinolytic agent in cardiac surgery to reduce the risk of blood loss and transfusion.
- Conditions
- Blood Coagulation Disorder, Postoperative Blood Loss, Adverse Drug Event, Fibrinolysis; Hemorrhage
- Trial name
- NCT07164300
- Testing
- Tranexamic acid at a dose of 10 mg/kg followed by 1 mg/kg/h, Tranexamic acid at a dose of 20 mg/kg, Tranexamic acid at a dose of 30 mg/kg
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University of Ioannina
Adverse Reaction to Other Drugs and Medicines
Norfloxacin Versus Ciprofloxacin for Spontaneous Bacterial Peritonitis (SBP) Prevention
For the prevention of spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis, norfloxacin 400mg per day is a standard regimen. Ciprofloxacin 750 mg per week is also known to be effective for prevention of SBP.
- Trial name
- NCT01542801
- Testing
- Norfloxacin, ciprofloxacin
- Where
- 7 sites in South Korea
- Volunteers
- 124 people
- Sponsor
- Korea University
Diagnostic Agent Adverse Reaction, Radiation Exposure
18F-LY3950321-01 Biodistribution and Safety Study
18F-LY3950321 (also known as 18F-MNI-1256) is a radiolabeled positron emission tomography (PET) tracer targeting granzyme B. The overall goal of this protocol is to evaluate the safety, tolerability, and radiation dosimetry of…
- Trial name
- NCT05775601
- Testing
- 18F-LY3950321, PET Scan
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Clinical Efficacy, Treatment Efficacy
Lubiprostone for Functional Constipation in the Under 18 Years Patients
The investigators will enroll subjects 8 - < 18 years of age, fulfilling Rome IV criteria for functional constipation. Participants will be randomly assigned to either Lubiprostone treatment (study group), or the control group…
- Conditions
- Clinical Efficacy, Treatment Efficacy, Drug Side Effect
- Trial name
- NCT05144295
- Testing
- Lubiprostone Pill, Lactulose Oral Liquid Product, Bisacodyl 5 MG
- Where
- 2 sites in Egypt
- Volunteers
- 274 people
- Sponsor
- Alexandria University
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Adverse Drug Reaction (ADR)
The INTEGRATE Study: Integrated Pharmacogenetics, TDM and Active Pharmacovigilance as Innovative Tools for the Optimisation and Appropriateness of Drug Therapy
The primary goal of this observational study is to evaluate the feasibility of implementing a multidisciplinary approach based on pharmacogenetics, TDM (Therapeutic Drug Monitoring) and MedReview into the clinical practice in…
- Trial name
- INTEGRATE (NCT06822959)
- Testing
- Pharmacogenetics, TDM and MedReview
- Where
- 2 sites in Italy
- Volunteers
- 450 people
- Sponsor
- Direzione centrale salute, politiche sociali e disabilità
Steven-Johnson Syndrome, Toxic Epidermal Necrolysis
Severe Cutaneous Adverse Reactions in Thailand
The multicenter registry of patients with severe cutaneous adverse reactions among tertiary medical institutes in Thailand to study clinical characteristics, etiologies, therapeutic outcomes, quality of life, and the values of in…
- Conditions
- Steven-Johnson Syndrome, Toxic Epidermal Necrolysis, Drug Reaction With Eosinophilia and Systemic Symptoms, Acute Generalized Exanthematous Pustulosis
- Trial name
- ThaiSCAR (NCT02574988)
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Chulalongkorn University
Hypersensitivity, Beta Lactam Adverse Reaction
Protocol of Reintroduction of Beta-lactams in Children at Low Risk of Anaphylaxis.
The purpose of this study is to establish the rationale for the practice of performing an oral reintroduction test without previous skin tests in children at low risk of IgE-mediated reaction or drug-induced toxidermia, and to…
- Trial name
- TRO-b-lact (NCT03553251)
- Where
- France
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Adverse Reaction to Drug, Neonatal Disorder
Exploratory Propofol Dose Finding Study In Neonates
The aim of the study is to explore the optimal propofol dose in neonates receiving a single intravenous propofol bolus for endotracheal intubation during (semi-)elective INSURE (intubation-surfactant-extubation) procedure…
- Trial name
- NEOPROP (NCT01621373)
- Testing
- propofol administration
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Adverse Cutaneous Reaction to Alternative Medical Therapy
Serum Interleukin -21 Level in Patients With Severe Adverse Cutaneous Drug Reaction.
Adverse cutaneous drug reactions are undesirable and typically unanticipated reactions independent of the intended therapeutic purpose of a medication. It may be either immunologic (eg, drug allergy) or non-immunologic.
- Trial name
- NCT03166241
- Testing
- serum interleukin 21, Complete Blood Picture, Liver function test
- Volunteers
- 30 people
- Sponsor
- Assiut University
Colorectal Adenocarcinoma, Oesogastric
Cardiovascular Events From Trifluridine/Tipiracil +/- Oxaliplatin in Colorectal/Oesogastric Adenocarcinoma Patients
The purpose of this study is to assess the incidence of cardiovascular events in patients with esophageal/stomach or colorectal cancer treated by trifluridine/tipiracil +/- oxaliplatin after an episode of cardiac angina-related…
- Trial name
- NCT04894123
- Testing
- Trifluridine/Tipiracil, Oxaliplatin
- Where
- 11 sites in France
- Volunteers
- 1 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Medication Reaction
Prevention of Drug Rash From Certain Cancer Therapies Using Tretinoin Cream
This research is being done to study whether using of topical tretinoin can help prevent the common rash that patients often get while taking epidermal growth factor inhibitor (EGFR-I) medications such ascetuximab or erlotinib.
- Trial name
- NCT01349556
- Testing
- Tretinoin
- Sponsor
- Johns Hopkins University
Drug Reaction
Motion Sickness Medications and Vestibular Time Constant
Sea sickness represents a major limitation on the performance of ships' crew. One of the challenges faced by the physician in the motion sickness clinic when prescribing anti-sea sickness medication is to select the appropriate…
- Trial name
- NCT03270839
- Testing
- Bonine 25Mg Chewable Tablet, Kwells
- Where
- Israel
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Idiopathic Parkinson's Disease, Drug Induced Dyskinesia
Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease
The study will involve an eighteen-week, double-blind, placebo-controlled parallel designed comparison between add-on topiramate and add-on placebo to stable treatment with amatadine in the treatment of Parkinson's disease (PD)…
- Trial name
- TOP-DYSK (NCT01789047)
- Testing
- Topiramate, Amantadine
- Where
- 5 sites in United States
- Volunteers
- 42 people
- Sponsor
- Rush University Medical Center
Chronic Heart Failure, Diuretics Drug Reactions
The Heart Failure Diuresis Efficacy Comparison (DEA-HF) Study
To investigate the effectiveness of three (3) IV diuretic regimens to increase natriuresis in volume-overloaded HF patients, allowing for better decongestion and potentially resulting in improved clinical and biochemical…
- Conditions
- Chronic Heart Failure, Diuretics Drug Reactions, Congestive Heart Failure
- Trial name
- DEA-HF (NCT05904808)
- Testing
- IV Furosemide, IV Furosemide and PO Metolazone, IV Furosemide and IV Acetazolamide
- Where
- Israel
- Volunteers
- 42 people
- Sponsor
- Rambam Health Care Campus
Esophagus Cancer
Impact of Dose to Cardiac Substructures on Survival in Patients With Esophageal Cancer Treated With Radiotherapy or Chemoradiotherapy (SATIATION)
Treatment of non-operable esophageal cancers is based on radiochemotherapy, or exclusive radiotherapy. The cardiac toxicity of radiotherapy in the treatment of thoracic tumor localizations is well documented, however, more and…
- Trial name
- SATIATION (NCT05996276)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Brest
Chronic Pain, Hypertension
Improving Pain Management Via Spinal Cord Stimulation and Blood Pressure Reduction
The purpose of this study (PASSION study) is to monitor symptoms of chronic pain before and after 2 weeks of a standard drug commonly used to treat elevated blood pressure compared with 2 weeks of placebo (crossover design) so…
- Conditions
- Chronic Pain, Hypertension, Diuretics Drug Reactions, SCS
- Trial name
- PASSION (NCT04676399)
- Testing
- Hydrochlorothiazide 12.5mg
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Kansas Medical Center
Adverse Drug Event, Drug Drug Interaction
Implementation of a Pharmacist-led Pharmacogenomic Clinical Service
Tabula Rasa HealthCare (TRHC), doing business as CareKinesis, is the first national pharmacy that provides science-based medication risk identification and mitigation technologies and services.
- Conditions
- Adverse Drug Event, Drug Drug Interaction, Pharmacogenomics, Elderly
- Trial name
- NCT04984538
- Testing
- Pharmacogenomic Testing
- Where
- United States
- Sponsor
- Tabula Rasa HealthCare
Influenza
Post-authorisation Safety Study (PASS) of Influenza Vaccine in United Kingdom (UK)
The purpose of this study is to conduct a pilot study to explore the potential use of routinely collected data in General Practitioner (GP) practices to conduct enhanced safety surveillance of seasonal influenza vaccines in the…
- Trial name
- NCT02567721
- Testing
- Vaccine safety surveillance
- Where
- United Kingdom
- Volunteers
- 11,530 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Oncology, Autoimmunity
Rheumatologic Adverse Events and Cancer Immunotherapy
In this study, every patient with cancer who is going to be treated by immunotherapy will fill in a form. In this form, we try to determine if he presents rheumatologic complications of his immunotherapy.
- Conditions
- Oncology, Autoimmunity, Arthritis, Adverse Drug Event
- Trial name
- NCT04791150
- Testing
- Fill in a form
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Poitiers University Hospital