Clinical trials: Adverse Reaction to Drug
Steven-Johnson Syndrome, Toxic Epidermal Necrolysis
Severe Cutaneous Adverse Reactions in Thailand
The multicenter registry of patients with severe cutaneous adverse reactions among tertiary medical institutes in Thailand to study clinical characteristics, etiologies, therapeutic outcomes, quality of life, and the values of in…
- Conditions
- Steven-Johnson Syndrome, Toxic Epidermal Necrolysis, Drug Reaction With Eosinophilia and Systemic Symptoms, Acute Generalized Exanthematous Pustulosis
- Trial name
- ThaiSCAR (NCT02574988)
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Chulalongkorn University
Maculopathy
" En Face " OCT's Contribution in the Detection of Macular Retinal Toxicity Signs Linked to the Chronic Treatment of Synthetic Antimalarials
The maculopathy induced by the retinal toxicity of the synthetic antimalarials must be detected at the infra-clinical state, when it can still be reversible.
- Trial name
- OCTAPS (NCT02805686)
- Testing
- spectral domain optical coherence tomography, multifocal electroretinogram
- Volunteers
- 45 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Adverse Effect of Drug Therapy Metabolism Medications (Diagnosis)
Bupropion Stereoselective Disposition and CYP2D6-mediated Drug Interactions in Healthy Volunteers
Primary objectives: 1. To comprehensively characterize steady state stereoselective pharmacokinetics of bupropion and its primary and secondary metabolites in healthy volunteers 2.
- Trial name
- NCT03420469
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Indiana University
Psychiatric Disorder
Using Pharmacogenetics to Identify Patients With Polypharmacy at Risk of Medication Adverse Effects
The Researchers are trying to learn more about how individuals break down and process medications based on their genes. The Researchers want to find out whether subjects will have fewer side effects if they take different…
- Trial name
- NCT03748355
- Testing
- Pharmacogentic Analysis
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy Volunteer, Hypersensitivity Reactions
Novel Biomarkers of Non-IgE Immediate Hypersensitivity Drug Reactions
The goal of this clinical trial is to investigate biomarkers of non-IgE-mediated immediate hypersensitivity reactions during infusion of intravenous vancomycin.
- Conditions
- Healthy Volunteer, Hypersensitivity Reactions, Vancomycin
- Trial name
- NCT07605806
- Testing
- Vancomycin (IV)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Incidence of Readmissions, ADE's Due to Anticoagulants
Measuring the Incidence of Hospital Readmissions Based on Adverse Drug Events
An ADE is defined as harm caused by a drug or the inappropriate use of a drug. Retrospective record reviews in several countries have shown that anticoagulants frequently lead to hospital readmissions.
- Trial name
- NCT02074085
- Where
- Belgium
- Volunteers
- 450 people
- Sponsor
- Hasselt University
Simvastatin Adverse Reaction, Pharmacogenomics
A Pharmacogenomics Study of Simvastatin-Induced Adverse Drug Reaction
Adverse reactions of simvastatin are mostly slight and transient, however, the incidence of simvastatin-induced hepatic impairment and myopathy are obviously higher in Chinese population than other racial groups.
- Conditions
- Simvastatin Adverse Reaction, Pharmacogenomics, Accurate Medication
- Trial name
- NCT03261908
- Testing
- detection of genotype
- Where
- China
- Volunteers
- 2,200 people
- Sponsor
- Cui Yimin
Covid19, Ivermectin Poisoning
Adverse Effects of Ivermectin Used in Egypt During COVID-19
retrograde study of common and rare adverse effects of multiple doses of ivermectin used during the coivd 19 pandemic in egypt
- Conditions
- Covid19, Ivermectin Poisoning, Drug Toxicity, Drug Side Effect
- Trial name
- NCT04747678
- Testing
- Ivermectin
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Menoufia University
General Anesthetic Drug Adverse Reaction, Perioperative/Postoperative Complications
Observational of Emergence Time Between Patients Receive General Anesthesia With BIS or Spectrogram EEG Monitor
The bispectral index parameter is used to guide the titration of general anesthesia, however; conflicting results between different studies cannot prove the benefit of EEG monitor on improvement of OR efficiency.
- Trial name
- NCT05208502
- Testing
- DSA monitor
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- National Taiwan University Hospital
Chronic Liver Disease, Non-Alcoholic Fatty Liver Disease
Sonoelastography: Ultrasound Method to Measure Liver Fibrosis
HYPOTHESIS: The investigators hypothesize that sonoelastography (SE) will provide accurate quantitative measurements that can be used to stage liver fibrosis in patients with chronic liver disease. 1.
- Conditions
- Chronic Liver Disease, Non-Alcoholic Fatty Liver Disease, Hepatitis C Virus (HCV) Coinfection, Hepatitis B Virus (HBV)
- Trial name
- NCT01747772
- Testing
- Shear Wave Sonoelastography
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Massachusetts General Hospital
Bone Marrow Suppression, Brain and Central Nervous System Tumors
Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, etoposide phosphate, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Bone Marrow Suppression, Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ, Long-term Effects Secondary to Cancer Therapy in Children
- Trial name
- NCT00238173
- Testing
- filgrastim, acetylcysteine, carboplatin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- OHSU Knight Cancer Institute
Adult Hepatocellular Carcinoma, Recurrent Hepatocellular Carcinoma
Oral Thalidomide and Tegafur-uracil to Decrease Hepatocellular Carcinoma Recurrence
This single-centered phase II clinical study is to obtain preliminary information on 1-year recurrence-free survival rate, recurrence-free survival and safety profile of thalidomide in combination with tegafur-uracil in…
- Conditions
- Adult Hepatocellular Carcinoma, Recurrent Hepatocellular Carcinoma, Adverse Reaction to Drug, Vascular Endothelial Growth Factor Overexpression
- Trial name
- NCT02447679
- Testing
- thalidomine, tegafur-uracil
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital