Clinical trials: Aerosol Disease
Peritoneal Carcinomatosis
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) and Electrostatic PIPAC (ePIPAC) With Paclitaxel In Patients With Peritoneal Carcinomatosis
Peritoneal carcinomatosis (PC) is a miserable disease with poor treatment outcome. Intraperitoneal administration of anticancer drugs enables an extremely high concentration of drugs to directly contact the target cancer lesions…
- Trial name
- NCT05395910
- Testing
- Paclitaxel
- Where
- Singapore
- Volunteers
- 36 people
- Sponsor
- National University Hospital, Singapore
Esophageal Cancer, Lung Cancer
4-Dimensional CT Derived Ventilation Versus SPECT Aerosol Ventilation in Patients With Thoracic Malignancies
Objectives: Primary Objective: 1. To determine the correlation between 4-dimensional computed tomography (4D CT) derived ventilation and single photon emission tomography (SPECT) aerosol Tc-99m determined ventilation.
- Trial name
- NCT00531180
- Testing
- 4D CT scans, Lung Function Imaging
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- M.D. Anderson Cancer Center
COVID-19 Pneumonia
A Different Use of The Aerosol Box in COVID-19 Patients; Internal Jugular Vein Cannulation
During the COVID-19 pandemic, health employees are at high risk of infection. This study aimed to determine experiences with an aerosol box (AB), used with the aim of preventing contamination by droplets during internal jugular…
- Trial name
- NCT04954118
- Testing
- Internal jugular vein cannulation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Parkinson Disease
Staccato Apomorphine Single and Multi Dose PK
This study will be conducted in 3 parts. A) compare the pharmacokinetics (PK) of a single dose of AZ-009 with that of a therapeutically-relevant dose of a commercially available apomorphine injector in healthy volunteers; B)…
- Trial name
- NCT03822364
- Testing
- 009-1, active comparator, 009-0
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Pneumonia, Pneumocystis Carinii, HIV Infections
An Open Label Study to Evaluate the Long-Term Safety and Effectiveness of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients
To evaluate the safety, tolerability, and efficacy of long term, bi-weekly administration of aerosol pentamidine when used as a prophylactic agent in patients who have had at least two or more episodes of AIDS-associated…
- Trial name
- NCT00002030
- Testing
- Pentamidine isethionate
- Where
- United States
- Sponsor
- Fisons
Bronchial Asthma
Pharmacodynamic Bioequivalence Study of Albuterol Sulfate Inhalation Aerosol, 0.09 mg Albuterol Base/ Inhalation
Pharmacodynamic bioequivalence study of Albuterol Sulfate Inhalation Aerosol 0.09 mg
- Trial name
- NCT05292976
- Testing
- Methacholine Chloride, Albuterol Sulfate HFA 0.09 mg (Reference), Albuterol Sulfate HFA 0.18 mg (Reference)
- Where
- United States
- Sponsor
- Aurobindo Pharma Ltd
COVID-19
Baldachin: Ceiling HEPA-filtration to Prevent Nosocomial Transmission of COVID-19
In this study, a patient space occupied by a patient with confirmed COVID-19 in an open-space multiple bed area in the Intermediate Care Unit will be equipped with a mobile, optimally placed high efficiency particulate air…
- Trial name
- NCT05648097
- Testing
- Baldachin
- Where
- Switzerland
- Volunteers
- 104 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Bronchial Asthma
To Study Generic Fluticasone Propionate Inhalation Aerosol for the Treatment of Bronchial Asthma
This is a randomized, assessor-blind, placebo controlled, multicenter, clinical endpoint bioequivalence study to compare the efficacy and safety of generic fluticasone propionate inhalation aerosol USP 44 mcg (Glenmark…
- Trial name
- NCT05363202
- Testing
- Fluticasone propionate Inhalation Aerosol 44 mcg, FLOVENT HFA 44 mcg
- Where
- 11 sites in India
- Volunteers
- 790 people
- Sponsor
- Glenmark Pharmaceuticals Ltd. India
Nasal Polyps
A Comparison of Beclomethasone Aqueous Spray and Aerosol Delivery Systems in Nasal Polyps
The purpose of this study is to determine if intranasal Beclomethasone delivered by aerosol or spray is more effective in treatment of nasal polyps.
- Trial name
- NCT00788463
- Testing
- Intranasal Beclomethasone aerosol, Intranasal Beclomethasone spray
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Nicotine Vaping, Nicotine Dependence
Assess the Influence of Nicotine Flux and Nicotine Form on Subjective Effects Related to Dependency
Electronic nicotine delivery systems (ENDS) heat and vaporize a nicotine-containing liquid to produce an aerosol that can deliver nicotine to the blood and the brain.
- Conditions
- Nicotine Vaping, Nicotine Dependence, Nicotine Addiction
- Trial name
- NCT05430334
- Testing
- e-liquid 1, e-liquid 2, e-liquid 3
- Where
- Lebanon
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Obese, Asthma
Aerosol Deposition in Asthmatic Obese Women Using Heliox
BACKGROUND: The aim of this study was to assess pulmonary deposition and distribution of radio-aerosol in obese and normal women, using 2-D planar scintigraphy.
- Trial name
- NCT02620956
- Testing
- nebulizing with heliox and oxygen
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jacqueline de Melo Barcelar
Asthma
Pharmacokinetics (PK) Study of Epinephrine Inhalation Aerosol in Healthy Volunteers
This study examines the pharmacokinetic profile of Armstrong's proposed Epinephrine Inhalation Aerosol USP, an HFA-MDI (E004), in healthy male and female adult volunteers.
- Trial name
- NCT01143051
- Testing
- epinephrine inhalation aerosol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Amphastar Pharmaceuticals, Inc.
Cystic Fibrosis
Self-dispersing Liquids as Aerosol Drug Carriers
Inhaled medications are often used to treat lung diseases such as cystic fibrosis. We are performing this study to determine whether inhaled medications dissolved in surfactant-based solutions will distribute more evenly…
- Trial name
- NCT00628134
- Testing
- calfactant, isotonic saline
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Coronavirus
A Pilot Clinical Study on Inhalation of Mesenchymal Stem Cells Exosomes Treating Severe Novel Coronavirus Pneumonia
In December 2019, a novel coronavirus infectious disease characterized by acute respiratory impairment due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan city of Hubei province in China.
- Trial name
- NCT04276987
- Testing
- MSCs-derived exosomes
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Ruijin Hospital
Hypoxemic Respiratory Failure, Airway Obstruction
In Line Aerosol Nebulization With High Flow
The objective of ILAN is to assess the safety, feasibility and bronchodilator efficacy of in-line bronchodilator nebulizer delivery with VMN via HFNC system in hypoxemic respiratory failure patients treated with bronchodilators…
- Trial name
- ILAN (NCT05880836)
- Testing
- nebulizer via in-line drug delivery maintaining high-flow nasal cannula oxygen, standard jet nebulization (SJN) with face mask
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Contamination by COVID 19 During Oral Care
Risk of Contamination by COVID-19 During Oral Care With Aerosolization
The sudden Covid-19 pandemic has led all healthcare workers to adapt to an unprecedented situation by continuing to provide care while protecting themselves and their patients.
- Trial name
- Bu-Covid (NCT04817319)
- Testing
- Oral care with/without aerosolization
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Disease, Chronic Obstructive
Trial Comparing Treatment With Tiotropium Inhalation Capsules to Combivent® Inhalation Aerosol in COPD Patients.
The objective of this study is to evaluate the efficacy and safety of 12 weeks treatment with tiotro pium HandiHaler® 18 mcg daily compared to Combivent® MDI CFC Inhalation Aerosol 2 actuations qid in COPD patients currently…
- Trial name
- NCT00388882
- Testing
- tiotropium, ipratropium bromide / albuterol
- Where
- 40 sites in United States, Argentina and 3 more
- Volunteers
- 327 people
- Sponsor
- Boehringer Ingelheim
Pulmonary Disease, Chronic Obstructive
Ipratropium Bromide/Salbutamol Delivered by the Respimat® Inhaler Compared to Ipratropium Bromide Respimat®, COMBIVENT® Inhalation Aerosol and Placebo in Adults With Chronic Obstructive Pulmonary Disease
The primary objective of this study was to compare the long-term (12-week) bronchodilator efficacy and safety of ipratropium bromide / salbutamol combination administered by the Respimat® 40 mcg / 200 mcg (one inhalation q.i.d.)…
- Trial name
- NCT02177253
- Testing
- Ipratropium bromide / Salbutamol, Ipratropium bromide, COMBIVENT Inhalation Aerosol
- Volunteers
- 1,118 people
- Sponsor
- Boehringer Ingelheim
Rhinitis, Allergic, Perennial
Study in Adult and Adolescent Subjects With PAR (Perennial Allergic Rhinitis)
The purpose of the study is to assess the efficacy and safety of an investigational nasal aerosol compared with placebo nasal aerosol in the treatment of perennial allergic rhinitis.
- Trial name
- NCT01134705
- Testing
- Beclomethasone dipropionate hydrofluoroalkane HFA Nasal Aerosol
- Where
- 35 sites in United States
- Volunteers
- 474 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
COVID-19
Comparison of Viral Particle Dispersion Following Administration of an MDI or Nebulizer in Subjects With COVID-19
A randomized, 2-period crossover, single-center, open-label study for viral sample collection. After initiation of inhaled therapy with nebulizer or MDI, cascade impactors and surface samplers will be used to assess viral loads…
- Trial name
- NCT04681079
- Testing
- albuterol sulfate (MDI), albuterol sulfate (nebulizer)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Theravance Biopharma