Clinical trials: Aerosol Therapy, open to volunteers
Bronchial Asthma
Study on the Safety and Efficacy of PA9159 Inhalation Aerosol for the Treatment of Adult Bronchial Asthma
PA9159 is a highly potent novel corticosteroid. The purpose of this study is to evaluate the safety, efficacy and characteristics of population pharmacokinetics of multiple dosing of PA9159 Inhaler in patients with bronchial…
- Trial name
- NCT07324707
- Testing
- PA9159 Metered-Dose Inhaler, 120 μg per day for 28 days, Fluticasone Propionate Inhaled Aerosol 200 μg per day for 28 days
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Anhui Palo Alto Pharmaceuticals, Inc.
Respiratory Syncytial Virus (RSV)
Peginterferon α-2b Injection for Aerosol Therapy in Pediatric Respiratory Syncytial Virus Pneumonia
This is a multicenter, randomized, open-label, parallel-controlled, prospective clinical study. It aims to evaluate the efficacy and safety of aerosolized Peginterferon α-2b injection in the treatment of pediatric respiratory…
- Trial name
- NCT06881056
- Testing
- Peginterferon α-2b injection, symptomatic and supportive treatment
- Where
- 2 sites in China
- Volunteers
- 90 people
- Sponsor
- West China Second University Hospital
Peritoneal Metastasis, CRC (Colorectal Cancer)
A Prospective, Safety, and Efficacy Clinical Trial of Pressurized Intraperitoneal Aerosol Therapy for Peritoneal Metastasis of Colorectal Cancer
For colorectal cancer with peritoneal metastasis, the current first-line standard treatment offers very limited benefits and short survival.
- Trial name
- NCT07349043
- Testing
- Mitomycin-PIPAC, Raltitrexed-PIPAC
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Peritoneal Metastases from Colorectal Cancer
Systemic Antitumor Treatment with or Without Pressurized Intraperitoneal Aerosol Chemotherapy for Colon Peritoneal Metastases (PIPOX02)
The goal of this clinical trial is to learn if Pressurized intraperitoneal aerosol chemotherapy (PIPAC) significantly improve the progression-free survival (PFS) in patients with advanced peritoneal metastasis from colorectal…
- Trial name
- PIPOX02 (NCT06681038)
- Testing
- Standard Medical Therapy, PIPAC
- Where
- 15 sites in France
- Volunteers
- 114 people
- Sponsor
- Institut Cancerologie de l'Ouest
Asthma Bronchiale, COPD
Investigation of the Respiratory Profile of Patients With Obstructive Pulmonary Disease (ASTHMA, COPD)
The primary aim of the OPTIPULM study is the evaluation of recorded pulmonary function curves and, based on them, the computer modelling of lung deposition for the individually used or potentially applicable inhalation drugs.
- Trial name
- OPTIPULM (NCT06966271)
- Where
- 7 sites in Hungary
- Volunteers
- 150 people
- Sponsor
- Tradeflex Ltd
Respiratory Distress Syndrome (Neonatal), Intubation Complication
InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS
The purpose of this clinical study is to determine the effectiveness and safety of Infasurf® administered through the InfasurfAero™, a novel oral airway delivery device specifically designed to give Infasurf in a less complicated…
- Conditions
- Respiratory Distress Syndrome (Neonatal), Intubation Complication, Death; Neonatal
- Trial name
- Aero-05 (NCT05960929)
- Testing
- Infasurf Aero™
- Where
- 10 sites in United States
- Volunteers
- 220 people
- Sponsor
- ONY
ARDS (Acute Respiratory Distress Syndrome) Receiving IMV
AEROSOL THERAPY IN ARDS PATIENTS (AERO-IN-ARDS)
Aerosol therapy delivers medicines as a fine mist directly into the lungs. This allows faster action and fewer whole-body side effects. It is a key treatment for diseases such as asthma and COPD.
- Trial name
- AERO-IN-ARDS (NCT07269743)
- Testing
- Types of drugs being delivered as aerosol therapy
- Where
- India
- Volunteers
- 423 people
- Sponsor
- TS Misra Medical College
Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection
CaspoNEB: Efficacy and Safety of Caspofungin Aerosols for the Curative Treatment of Pneumocystis Pneumonia
To assess the efficacy of administrating daily caspofungin aerosols versus placebo for seven days, in adjunction of conventional systemic antifungal therapy during curative treatment of Pneumocystis pneumonia, on the clinical…
- Conditions
- Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection, Pneumocystis Infections
- Trial name
- CaspoNEB (NCT06892951)
- Testing
- Caspofungin Acetate 50 MG, Physiologic saline
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Gastric Cancer, Peritoneal Metastases
Neoadjuvant Systemic and Peritoneal Chemotherapy for Advanced Gastric Cancer
Data demonstrating the efficacy of PIPAC in patients with regionally advanced gastric cancer with positive peritoneal cytology and/or minimal peritoneal disease is limited due to the relatively recent development of this…
- Conditions
- Gastric Cancer, Peritoneal Metastases, Chemotherapy Effect
- Trial name
- SPECTRA (NCT05318794)
- Testing
- Doxorubicin and Cisplatin
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College London
COPD, Asthma Bronchiale
Pulmonary Deposition of Ultrasound Rock Salt Aerosol Inhalation Therapy
In the in vitro modeling phase, the investigators plan to use a realistic human upper respiratory tract model and an asymmetric ideal bronchial tree model.
- Conditions
- COPD, Asthma Bronchiale, Chronic Bronchitis
- Trial name
- NCT06891274
- Testing
- USN before SVN, SVN before USN
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Jingen Xia
Chronic Pulmonary Aspergillosis
Chronic Pulmonary Aspergillosis and Ambisome Aerosol with Itraconazole
This study compares the therapeutic (clinical and radiological) efficacy of a six-month treatment by itraconazole and nebulised Ambisome® (liposomal amphotericin B = LAmB) versus treatment by itraconazole alone, in non - or…
- Trial name
- NCT03656081
- Testing
- inhaled Ambisome®, Itraconazole
- Where
- France
- Volunteers
- 224 people
- Sponsor
- Poitiers University Hospital
Oligometastatic Gastric Adenocarcinoma
PIPAC in Multimodal Therapy for Patients with Oligometastatic Peritoneal Gastric Cancer
Peritoneal Carcinomatosis is the most frequent site of metastases observed in patients with gastric cancer. Current standard treatment for these patients is palliative systemic chemotherapy, but the prognosis is very poor.
- Trial name
- PIPAC_VEROne (NCT05303714)
- Testing
- FOLFOX and PIPAC
- Where
- Italy
- Volunteers
- 98 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Advanced Epithelial Ovarian Cancer, Peritoneal Carcinomatosis
Intensification Treatment of Ovarian Cancer by PIPAC
The goal of this clinical trial is to learn whether repeated cisplatin-based PIPAC added to standard TC chemotherapy can improve outcomes in women aged 18-75 years with newly diagnosed FIGO IIIB-IIIC epithelial ovarian cancer and…
- Trial name
- PrimPIPAC (NCT07514494)
- Testing
- PIPAC
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- Moscow Regional Oncological Dispensary
Bronchial Asthma
Safety and Efficacy of PA9159 Inhalation Aerosol for the Treatment of Adult Bronchial Asthma
PA9159 is a highly potent novel corticosteroid. The purpose of this study is to evaluate the safety, efficacy and characteristics of population pharmacokinetics of multiple dosing of PA9159 Inhalation Aerosol in patients with…
- Trial name
- NCT07326995
- Testing
- PA9159 Metered-Dose Inhaler, 60 μg per day for 28 days, PA9159 Metered-Dose Inhaler, 120 μg per day for 28 days, PA9159 Metered-Dose Inhaler, 240 μg per day for 28 days
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Palo Alto Pharmaceuticals, Inc.
Preserved Ratio Impaired Spirometry (PRISM)
An Exploratory Study on Triple Inhaler Therapy in Patients With Early Lung Function Impairment
Preserved Ratio Impaired Spirometry (PRISm) is characterized by a normal forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) ratio but an FEV1 below 80% of the predicted value.
- Trial name
- BGF-PRISm (NCT07595796)
- Testing
- Budesonide/glycopyrronium bromide/formoterol inhalation aerosol
- Volunteers
- 23 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University