Clinical trials: Affect
Depression
Adolescent Attention to Emotion Study
Rates of depression increase rapidly during adolescence, especially for girls, and, thus, research is needed to spur the development of novel interventions to prevent adolescent depression.
- Trial name
- NCT04105868
- Testing
- Neurofeedback
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Melanoma
Does the Aid of MelaFind Affect Clinical Management Decisions
The objective of this study is to determine and compare the performance of dermatologists (in Germany) on the excision decision against the performance of MelaFind, a non-invasive and objective multi-spectral computer vision…
- Trial name
- NCT01387581
- Where
- United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- MELA Sciences, Inc.
Postmenopausal Osteoporosis, Osteoporosis
Parathyroid Hormone (PTH) for Osteoporosis in Postmenopausal Women
Parathyroid hormone (PTH) increases bone formation and thereby improves bone density and bone strength in postmenopausal women with osteoporosis. However, prolonged PTH treatment increases bone formation less and less over time.
- Trial name
- NCT00086619
- Testing
- synthetic hPTH 1-34
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Chronic Low Back Pain, Negative Affectivity
Treating Negative Affect in Low Back Pain Patients
This study will examine how the use of antidepressant, physical therapy, and combination of both affects pain, function, and depression outcomes in chronic low back pain patients.
- Trial name
- TNA-LBP (NCT04747314)
- Testing
- Antidepressant, Enhanced Fear Avoidance Rehabilitation
- Where
- 3 sites in United States
- Volunteers
- 308 people
- Sponsor
- Ajay Wasan, MD, Msc
Vaccination; Infection
Mood and Influenza Vaccine Response: A Feasibility Trial
This study is a 2-arm, parallel, randomised controlled feasibility trial of a brief video intervention designed to induce positive affect (mood) in older adults in primary care settings prior to the receipt of influenza…
- Trial name
- NCT03144518
- Testing
- Positive Affect Intervention, Neutral Control Intervention, Northern Hemisphere Influenza Vaccine 2017/18 (Delivered as part of Standard Care)
- Where
- United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Diabetic Peripheral Neuropathy
Use of Topical Lidocaine to Reduce Pain in Patients With Diabetic Neuropathy
The purpose of this study is to see if an investigational drug known as the lidocaine 5% patch is safe and effective in reducing the symptoms of diabetic neuropathy, to examine how topical lidocaine affects the nerve endings, and…
- Trial name
- NCT01086150
- Testing
- Skin biopsy, Lidocaine 5% patches
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Asthma
How Different Beta-2 Receptor Genotypes Affect an Asthmatic's Response to Regular Salmeterol Treatment
The purpose of the study is to find out how well a long-acting beta agonist like salmeterol works in people with different forms of the same gene.
- Trial name
- SECS (NCT00595361)
- Testing
- salmeterol
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Obesity, Physical Activity
Positive Psychology for Physical Activity Promotion
This study is for physically inactive adults. Participants will be enrolled in the Positive Psychology and Physical Activity intervention designed to help them overcome barriers to physical activity, based on the principals of…
- Trial name
- PPPA (NCT03826173)
- Testing
- PPPA, PA
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Brown University
Depression, Anxiety
Treatment for Affect Dimensions
The purpose of this study is to evaluate the efficacy and targets of Positive Affect Treatment, a psychotherapy specifically aimed at enhancing reward sensitivity in individuals with low positive affect (a core feature of…
- Trial name
- TAD (NCT03439748)
- Testing
- Positive Affect Treatment, Negative Affect Treatment
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- University of California, Los Angeles
Alcohol Drinking
Do Treatments for Smoking Cessation Affect Alcohol Drinking?
The purpose of this study is to examine the effect of smoking cessation medications on alcohol drinking. Effect of 2mg/day, 1mg/day, placebo varenicline was evaluated.
- Trial name
- NCT00580645
- Testing
- varenicline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Affect, Bereavement
Neural Mechanisms of Enhancing Emotion Regulation in Bereaved Spouses
This study investigates the underlying mechanisms of a novel emotion regulation intervention among recently bereaved spouses. More specifically, this study examines how thinking about an emotional stimulus in a more adaptive way…
- Conditions
- Affect, Bereavement, Emotions, Depressive Symptoms
- Trial name
- NCT04822194
- Testing
- Cognitive Emotion Regulation Training
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Bryan Denny
Neonatal Sepsis, Low Birth Weight
Safety of Skin Cleansing With Chlorhexidine in Preterm Low Birth Weight Infants
The purpose of this study is to examine if single skin cleansing with 0.25% chlorhexidine affects skin condition, temperature, and bacterial colonization in stable preterm (28-36 weeks gestational age) low birth weight (1001-2000…
- Trial name
- NCT00947518
- Testing
- Chlorhexidine, Normal saline
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Multiple Sclerosis
A Positive Psychology Intervention for Patients With Multiple Sclerosis
Positive psychology (PP) uses targeted activities to increase the frequency and intensity of positive emotional experiences such as positive affect.
- Trial name
- NCT03637699
- Testing
- Positive Psychology
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Low Positive Affect
Effects of a Wellbeing Intervention on Inflammation Through Reward and Threat Processes
This study aims to evaluate how savoring influences reward and threat processes and downstream inflammation. Savoring is designed to enhance positive affect, which may blunt stress responses and reduce downstream inflammation.
- Trial name
- SAVOR (NCT06294145)
- Testing
- Savoring Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Placebo, Expectations
Effects of Expectations on Negative Affect, Perceived Cognitive Effort, and Pain
The investigators administer a functional neuroimaging task to investigate the effect of cue expectancy on participants' self-reported ratings across a variety of affective and cognitive domains.
- Trial name
- NCT05425563
- Testing
- Pain Expectancy Cues, Vicarious Pain Expectancy Cues, Cognitive Effort Expectancy Cues
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
The Skeletal Effects of SSRIs
Do Serotonin Reuptake Inhibitors (SSRIs) Affect Bone Mass in Adolescents
Building on findings from animal studies, pediatric clinical trials, epidemiologic research in adults, and on preliminary findings from the investigators' laboratory in children and adolescents, this project aims to investigate…
- Trial name
- SSRI_BMD (NCT02147184)
- Where
- United States
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- Chadi A. Calarge
Dialysis; Complications, Life Quality
Recovery Time and Affecting Factors in Hemodialysis Patients
Patients undergoing hemodialysis (HD) can experience symptoms such as lassitude, pain, muscle cramps, nausea, vomiting, constipation, diarrhea, rash, skin dryness, sleep disorders, and emotional and sexual problems after the…
- Trial name
- NCT04274556
- Testing
- Post-dialysis recovery group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Istanbul Demiroglu Bilim University
Cerebral Palsy, Children
Does Increasing Auditory Cueing Affect Gait Parameters in Children With Cerebral Palsy During a Functional Task?
To determine the clinical efficacy of auditory cueing using a cross over design to investigate whether increasing auditory cueing frequency by 20% above self paced cadence affects gait parameters in children with Cerebral Palsy…
- Trial name
- NCT02666560
- Testing
- Auditory Cueing
- Volunteers
- 19 people
- Sponsor
- Institute of Child Health
Stress, Psychological
The Impact of 8 Weeks of Digital Meditation Application and Healthy Eating Program on Work Stress and Health Outcomes
The aim of the present study is to test the effects of a digital meditation intervention and/or a healthy eating intervention in a sample of UCSF employees with overweight and obesity (BMI>=25kg/m2) who report mild to moderate…
- Conditions
- Stress, Psychological, Behavioral Symptoms, Sleep
- Trial name
- SFUC+Health (NCT03945214)
- Testing
- Meditation, Healthy Eating, Meditation + healthy eating
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Idiopathic Pulmonary Fibrosis
A Study to Test How Taking BI 1015550 for 12 Weeks Affects Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF)
This study is open to adults with idiopathic pulmonary fibrosis (IPF) who are at least 40 years old. People taking standard medicines for IPF, including antifibrotic medicines, can continue taking them throughout the study.
- Trial name
- NCT04419506
- Testing
- BI 1015550
- Where
- 75 sites in United States, Argentina and 20 more
- Volunteers
- 147 people
- Sponsor
- Boehringer Ingelheim