Clinical trials: Affect
Solid Tumors
A Study to Assess the Pharmacokinetics of Ramucirumab (IMC-1121B) in Combination With FOLFIRI
The purpose of this study is to assess the effect of concomitant ramucirumab (IMC-1121B) on the pharmacokinetics of irinotecan and its metabolite SN-38 when coadministered with folinic acid and 5-fluorouracil, in participants…
- Trial name
- NCT01634555
- Testing
- Ramucirumab (IMC-1121B), Irinotecan, Folinic acid
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Eli Lilly and Company
Sepsis
Kidney Response to Sepsis Affects Angiogenic Balance and Likelihood of CCI and PICS
This study investigates the mechanism by which kidney dysfunction perpetuates inflammation, immunosuppression, and catabolism (PICS) in chronic critical illness.
- Trial name
- NCT02276066
- Testing
- GFR by Iohexol, Urine Collection, Blood samples
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of Florida
Healthy
This Study in Healthy Men Tests How Different Doses of BI 705564 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How BI 705564 Affects the Way the Body Breaks Down Midazolam
The primary objective of this trial is to investigate safety and tolerability of BI 705564 in healthy male subjects, following oral administration of multiple rising doses.
- Trial name
- NCT03325712
- Testing
- BI 705564, Midazolam
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Aging, Chronic Low-back Pain
Adaptability and Resilience in Aging Adults-2
Chronic low back pain is a major health concern among older adults and is associated with increased economic, functional, and psychological burden.
- Trial name
- ARIAA-2 (NCT04068922)
- Testing
- Resilience Intervention
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Florida
Alcohol Drinking
Do Treatments for Smoking Cessation Affect Alcohol Drinking?
The purpose of this study is to examine the effect of smoking cessation medications on alcohol drinking. Effect of 2mg/day, 1mg/day, placebo varenicline was evaluated.
- Trial name
- NCT00580645
- Testing
- varenicline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Chronic Kidney Disease
Safe Kidney Care Cohort Study
Chronic kidney disease (CKD) is common, but it is often over-looked in patients with this disease when they are getting medical treatment. Patients with CKD have special needs for their medical treatment.
- Trial name
- NCT01407367
- Where
- 2 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Maryland, Baltimore
Anxiety Disorders, Public Speaking Fear
Reward Processes and Rehearsal in Exposure Therapy
The purpose of this study is to 1) examine the importance of self-reported relief following exposure and 2) test whether positive-focused rehearsal following exposure can improve treatment outcomes for participants who endorse…
- Trial name
- NCT06132425
- Testing
- Exposure, Rehearsal
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of California, Los Angeles
Diabetic Retinopathy
Evaluating How the Treatments in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Affect Diabetic Retinopathy (The ACCORD Eye Study)
Diabetic retinopathy (DR) is an eye disease that can occur in people with diabetes and can cause poor vision or blindness. The Action to Control Cardiovascular Risk in Diabetes (ACCORD) study is examining the effect of various…
- Trial name
- NCT00542178
- Testing
- Hypoglycemic Agents, Standard glycemia control, Intensive BP treatment
- Where
- 7 sites in United States, Canada
- Volunteers
- 3,472 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stress, Psychological Stress
Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity
The aim of the Everyday Moments of Mindfulness (EMMI) study is to test whether brief mindfulness-based practices will improve daily psychological stress responses in women (age 30-60) who report a history of early life adversity.
- Conditions
- Stress, Psychological Stress, Child Maltreatment, Depressive Symptoms
- Trial name
- EMMI (NCT04606199)
- Testing
- Mindfulness-based intervention, up to 5 minutes 0-3 times/day
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Placebo, Expectations
Effects of Expectations on Negative Affect, Perceived Cognitive Effort, and Pain
The investigators administer a functional neuroimaging task to investigate the effect of cue expectancy on participants' self-reported ratings across a variety of affective and cognitive domains.
- Trial name
- NCT05425563
- Testing
- Pain Expectancy Cues, Vicarious Pain Expectancy Cues, Cognitive Effort Expectancy Cues
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Solid Tumors
A Study of Necitumumab Monotherapy and the QT/QTc Interval in Patient With Advanced Solid Tumors
The purpose of this study is to determine whether treatment with necitumumab monotherapy affects the QT/QTc interval among participants with advanced solid tumors refractory to standard treatment or for which no standard…
- Trial name
- NCT01624467
- Testing
- Necitumumab
- Where
- 8 sites in United States
- Volunteers
- 75 people
- Sponsor
- Eli Lilly and Company
Gliosis, Obesity
Does What You Eat Affect Your Brain
The purpose of this study is to use magnetic resonance imaging (MRI) to evaluate the human hypothalamus for signs of inflammation in response to specific diets.
- Conditions
- Gliosis, Obesity, Eating
- Trial name
- WYE (NCT05626907)
- Testing
- Diet modification #1, Diet modification #2, Diet modification #3
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Washington
Non-cystic Fibrosis Bronchiectasis
A Study in Patients With Non-cystic Fibrosis Bronchiectasis to Test How Well Different Doses of BI 1323495 Are Tolerated and How BI 1323495 Affects Biomarkers of Inflammation
This study is open to adults with non-cystic fibrosis bronchiectasis. The main purpose of this study is to find out how a medicine called BI 1323495 is tolerated by people with non-cystic bronchiectasis.
- Trial name
- NCT04656275
- Testing
- BI 1323495
- Where
- 3 sites in Germany
- Volunteers
- 7 people
- Sponsor
- Boehringer Ingelheim
Healthy
A Study in Healthy Men to Test Whether Zongertinib Affects How 3 Other Medicines (Midazolam, Omeprazole, and Repaglinide) Are Taken up and Processed by the Body
The main objective of this trial is to assess the effect of multiple oral doses of zongertinib on the pharmacokinetics of midazolam, omeprazole and repaglinide.
- Trial name
- NCT06494761
- Testing
- zongertinib, midazolam, omeprazole
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Obesity, Physical Activity
Positive Psychology for Physical Activity Promotion
This study is for physically inactive adults. Participants will be enrolled in the Positive Psychology and Physical Activity intervention designed to help them overcome barriers to physical activity, based on the principals of…
- Trial name
- PPPA (NCT03826173)
- Testing
- PPPA, PA
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Brown University
Healthy
A Study to Learn About How Itraconazole Affects the Blood Level of Study Medicine (PF-07817883) in Healthy Adults.
The purpose of this study is to learn how Itraconazole affects the blood level of PF-07817883 in Healthy Adults. This study is seeking participants who are: male and female aged 18 to 65 years old, overtly healthy.
- Trial name
- NCT05822440
- Testing
- PF-07817883, Itraconazole
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Rheumatoid Arthritis
RHYTHM (Formerly Escape II Myocardium)
For aim 1, the proposed studies will be performed in 150 patients with RA and 25 subjects without RA (healthy volunteers) who will function as controls.
- Trial name
- RHYTHM (NCT01548768)
- Testing
- TNF inhibitors, DMARDs
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Columbia University
Stress Disorders, Post-Traumatic, Affect
Examining Effects of a Therapeutic Focus on Positive Memories on Post-Trauma Health
Posttraumatic stress disorder (PTSD) has devastating health consequences. Evidence-based PTSD interventions address the substantial burden of PTSD on the health of individuals and societies; however, several individuals receiving…
- Conditions
- Stress Disorders, Post-Traumatic, Affect, Memory
- Trial name
- NCT05523453
- Testing
- Processing of Positive Memories Technique (PPMT), Supportive Counseling (SC)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of North Texas, Denton, TX
Healthy
Activating and Identifying Neural Responses to Social Rejection: a Combined tDCS and fMRI Study
This research study identifies neural pathways regulating negative moods during rejection by combining transcranial direct current stimulation (tDCS) and fMRI in a sample of healthy controls.
- Trial name
- NCT02739789
- Testing
- tDCS
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Bipolar Disorder
Examining the Effect of EEG-guided Theta Burst Stimulation in Bipolar Disorder
Bipolar Disorder (BD) is a common and highly debilitating psychiatric disorder, however, the predisposing brain mechanisms are poorly understood.
- Trial name
- NCT05179785
- Testing
- Continuous Theta Burst Stimulation (cTBS), Intermittent Theta Burst Stimulation (iTBS)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mary Phillips, MD MD (Cantab)