Clinical trials: Affective Disorder
Depression, Major Depressive Disorder
The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression
Many people with depression are treated with a serotonin-specific reuptake inhibitor anti-depressant (SSRI) and feel 'better'. Although many people feel 'better', they do not feel completely 'well'.
- Conditions
- Depression, Major Depressive Disorder, Unipolar Depression
- Trial name
- NCT00125957
- Testing
- Wellbutrin
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mclean Hospital
Schizophrenia, Bipolar Disorder
CSP #572 - Genetics of Functional Disability in Schizophrenia and Bipolar Illness
The purpose of this study is to detect genetic associations for the development of schizophrenia (SZ) and bipolar illness (BP) by comparing Veterans with these diseases to "psychiatrically healthy" Veterans from Veterans Health…
- Trial name
- NCT01149551
- Where
- 25 sites in United States
- Volunteers
- 9,356 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Major Depressive Disorder
Intradermal Acupuncture as an Adjunct to SSRI Tapering in Major Depressive Disorder
This randomized controlled trial aims to evaluate the clinical efficacy of intradermal acupuncture as an adjunctive intervention to assist selective serotonin reuptake inhibitor (SSRI) dose reduction or discontinuation in adult…
- Trial name
- NCT07390981
- Testing
- Selective Serotonin Reuptake Inhibitors (SSRIs), Intradermal Acupuncture
- Volunteers
- 114 people
- Sponsor
- First People's Hospital of Hangzhou
Major Depressive Disorder
Pharmacogenomic Testing in Major Depressive Disorder
This is a two-arm double-blind prospective randomized controlled trial (RCT) to evaluate clinical impact of pharmacogenomic testing on the treatment of major depressive disorder.
- Trial name
- NCT03228953
- Testing
- Pharmacogenomic testing
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Columbia University
Major Depressive Disorder, Depression
A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder
The purpose of this study is to determine if TC-5214 or placebo (a tablet that looks like medicine tablet or capsule, but contains no active medicine) is safe and effective when taken together with another antidepressant.
- Trial name
- NCT01180400
- Testing
- TC-5214
- Where
- 66 sites in Czechia, Estonia and 8 more
- Volunteers
- 295 people
- Sponsor
- AstraZeneca
Postpartum Depression
A Study To Assess The Safe-Use Conditions For Administration of ZULRESSO® in a Home Setting
The primary purpose of this study was to evaluate whether the safe-use conditions for administration of brexanolone (ZULRESSO®) can be implemented in a home setting.
- Trial name
- NCT05059600
- Testing
- ZULRESSO®
- Where
- 6 sites in United States
- Volunteers
- 52 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Anxiety Disorders, Mood Disorders
Mental Health Related to School Dropout in Luxembourg
This study aims to investigate psychosocial risk- and protective factors such as psychiatric disorder, socio-economic background and family functioning among school dropouts and to compare the findings with those by a matched…
- Conditions
- Anxiety Disorders, Mood Disorders, Eating Disorders, Substance-related Disorders
- Trial name
- NCT01354236
- Where
- Luxembourg
- Volunteers
- 200 people
- Sponsor
- Public Research Centre Health, Luxembourg
Bipolar Disorder
AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium
Lithium (Li) is the leading treatment for BD, protecting against both maniac and depressive relapse, and reducing the risk of suicide and mortality.
- Trial name
- AMIND (NCT05044611)
- Testing
- Anhydrous Amiloride Hydrochloride
- Where
- 2 sites in France
- Volunteers
- 148 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bipolar Disorder, Depressed
Interpersonal and Social Rhythm Therapy Enter the Brief Title for Protocol IRB 09-003781>
In patients with bipolar disorder referred for psychotherapy, is interpersonal and social rhythm therapy delivered in a group psychotherapy format over 2-3 weeks feasible? This project will help determine if interpersonal social…
- Trial name
- IPSRT (NCT01037283)
- Testing
- Interpersonal and Social Rhythm Therapy
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Schizophrenia Disorders, Bipolar Disorder
Visual Perception in Schizophrenia
This study aims to identify novel markers of psychosis using electroencephalography (EEG).
- Conditions
- Schizophrenia Disorders, Bipolar Disorder, Schizo Affective Disorder
- Trial name
- NCT06911931
- Testing
- EEG measure of visual processing
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Major Depressive Disorder, Sleep Disturbance
A Transdiagnostic Sleep and Circadian Treatment for Major Depressive Disorder
This study will examine the use of a transdiagnostic Sleep and Circadian Treatment (TranS-C) in treating Major Depressive Disorder (MDD) in Chinese adults.
- Trial name
- NCT03786731
- Testing
- Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C)
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Major Depressive Disorder
Individual MBCT vs. CBT in Major Depression: A Pilot Study.
Background: Depression is a highly recurrent disorder, which often requires lifelong treatment. Psychotherapy has an important role in the treatment of depression, both in the treatment of the acute phase and in prevention of…
- Trial name
- NCT05108701
- Testing
- Individual Psychotherapy
- Volunteers
- 27 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Severe Postpartum Depression
A Study of BRII-296 in Adults With Severe Postpartum Depression (PPD)
The primary purpose of this study is to evaluate the safety and tolerability of BRII-296 administered by 2 intramuscular injections, administered with Depo Medrol as assessed by the incidence of adverse events, changes from…
- Trial name
- NCT06057012
- Testing
- BRII-296, Depo Medrol
- Where
- 11 sites in United States
- Volunteers
- 11 people
- Sponsor
- Brii Biosciences Limited
Major Depressive Disorder
Exercise-priming of CBT for Depression: the CBT+ Trial
This study investigates the effects of intentionally sequencing aerobic exercise immediately prior to cognitive behavioral therapy (CBT) to determine its effects on mechanisms of CBT (i.e., working alliance, behavioral…
- Trial name
- NCT07221929
- Testing
- Rest, Aerobic Activity
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Wisconsin, Madison
Emotional Disorder, Anxiety Disorders
The Unified Protocol for the Treatment of Emotional Disorders in Spanish Public Mental Health System
The present randomized, controlled trial will compare the cost-efficacy and acceptability of the Unified Protocol in group format against traditional individual Cognitive Behavioral Treatment in a sample of patients with…
- Conditions
- Emotional Disorder, Anxiety Disorders, Depressive Disorder
- Trial name
- NCT03064477
- Testing
- Unified Protocol, Cognitive Behavioral Therapy (TAU)
- Where
- 3 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Universitat Jaume I
Bipolar Disorder, Manic
Study of Lumateperone in the Treatment of Patients With Bipolar Mania
This is a multicenter, randomized, double-blind, placebo-controlled, study in the acute treatment of patients with a diagnosis of bipolar I disorder with manic episodes or manic episodes with mixed features (bipolar mania), with…
- Trial name
- NCT06462612
- Testing
- Lumateperone
- Where
- 35 sites in United States, Bulgaria and 2 more
- Volunteers
- 351 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Schizophrenia, Bipolar Disorder
Development of a Mobile Heath Augmented Brief Suicide Prevention Intervention for People With SMI
Schizophrenia and bipolar disorder are associated with high risk for suicide, yet there are few brief interventions that directly target suicide prevention in this large population.
- Conditions
- Schizophrenia, Bipolar Disorder, Suicide and Self-harm
- Trial name
- NCT03198364
- Testing
- Safety and Recovery Therapy, Mobile Augmentation
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of California, San Diego
Major Depressive Disorder
Major Depressive Disorder With Mixed Features - Extension
Lurasidone HCl is a compound that is a candidate for the treatment of major depressive with mixed features.This clinical study is designed to test how well Lurasidone works to treat major depressive disorder with mixed features…
- Trial name
- RESOLVE3 (NCT01423253)
- Testing
- Lurasidone
- Where
- 17 sites in United States
- Volunteers
- 48 people
- Sponsor
- Sumitomo Pharma America, Inc.
Major Depressive Disorder, Breast Cancer
Feasibility Trial of Tele-IPT and Tele-Pharmacotherapy for Patients With Depression and Non-Metastatic Breast Cancer
Cancer and depression commonly occur together, and each worsens the other. We conducted a large psychotherapy study treating depression in breast cancer patients, showing that psychotherapy lowers symptoms.
- Conditions
- Major Depressive Disorder, Breast Cancer, Venlafaxine
- Trial name
- IPT (NCT04973930)
- Testing
- Interpersonal Psychotherapy, Venlafaxine HCl ER
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New York State Psychiatric Institute
Fibromyalgia (FM), Chronic Fatigue Syndrome (CFS)
Functional and Affective Effects of a Brief tDCS Intervention in Fibromyalgia and Chronic Fatigue Syndrome
Functional and Affective Effects of a brief tDCS Intervention in Fibromyalgia and Chronic Fatigue Syndrome Fibromyalgia (FM) and chronic fatigue syndrome (CFS) are characterized by persistent, multidimensional symptoms arising…
- Trial name
- FibFatDCS (NCT07573709)
- Testing
- Transcraneal Direct Current Electric Stimulation (tDCS), Transcranial Direct Current Electric Stimulation (tDCS)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Donostia
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