Clinical trials: Affective Disorder
Perinatal Depression, Post Partum Depression
Accelerated TMS for Perinatal Depression
We are studying a treatment for depression called accelerated Transcranial Magnetic Stimulation (TMS) among pregnant and postpartum individuals.
- Conditions
- Perinatal Depression, Post Partum Depression, Major Depressive Disorder
- Trial name
- PAiNT (NCT06968390)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brigham and Women's Hospital
Bipolar Disorder, Schizophrenia
COMpassion for Psychiatric Disorders And Self-Stigma
People with mental disorders face frequent stigmatizing attitudes and behaviors from others . In response to this, they tend to isolate themselves, with the risk of impeding care and the process of recovery and integration into…
- Conditions
- Bipolar Disorder, Schizophrenia, Depression, Borderline Personality Disorder
- Trial name
- COMPASS (NCT05698589)
- Testing
- Compassion Focused Therapy, Ending Self Stigma
- Where
- 7 sites in France
- Volunteers
- 336 people
- Sponsor
- University Hospital, Strasbourg, France
Depression, Depressive Disorder
Microbiotherapy in Characterized Depressive Disorder
The study aims to evaluate the contribution of a multi-targeted microbiotherapy at 12 weeks in depressed-patients in a situation of failure of a 1st line of antidepressant treatment and treated in add-on with a 2nd…
- Conditions
- Depression, Depressive Disorder, Depressive Disorder, Major
- Trial name
- PROMOOD (NCT05280015)
- Testing
- microbiotherapy (GynMDD)
- Where
- 4 sites in France
- Volunteers
- 92 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Major Depression
Adapting Cognitive Behavioral Therapy (CBT) for Chinese Americans
The goals of this study were to a) test whether cognitive behavioral therapy (CBT) is effective in treating depressed Chinese Americans, b) to develop and test the effectiveness of culturally adapt CBT, and c) to test the…
- Trial name
- NCT01786746
- Testing
- cognitive behavioral therapy, culturally adapted cognitive behavioral therapy
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Claremont McKenna College
Treatment Resistant Depression
IV Ketamine vs. IN Esketamine for MDD TRD
The goal of this observational study is to learn about the comparative acute effects of ketamine vs esketamine in participants over the age of 18 for the treatment of their severe depression and suicidal ideations.
- Trial name
- NCT06488586
- Testing
- Low dose IV Ketamine vs. IN Esketamine
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Gustavo Vazquez
Perimenopause, PMDD
Transcutaneous Auricular Neurostimulation (tAN) for Premenstrual Dysphoric Disorder (PMDD) and Perimenopause
Transcutaneous Auricular Neurostimulation (tAN) will be administered to women with premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and perimenopause.
- Trial name
- NCT07688720
- Testing
- transcutaneous auricular neurostimulation (tAN)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Texas Christian University
Major Depressive Disorder, Major Depressive Episode
Mobile Observation Of Depression
The primary aim of this project is to test if OCOsense glasses can function as a digital phenotyping tool derived from behavioural and physiological signals related to facial expression and motion recorded using the glasses.
- Conditions
- Major Depressive Disorder, Major Depressive Episode, Bipolar Disorder
- Trial name
- MOOD (NCT05815459)
- Testing
- OCOsense
- Where
- United Kingdom
- Volunteers
- 84 people
- Sponsor
- Emteq Ltd
Depression
Effectiveness of a Technology Assisted Behavioral Intervention in Assisting People With Major Depressive Disorder
This study will develop and evaluate the effectiveness of a technology-assisted behavioral intervention, consisting of Internet-based cognitive behavioral therapy combined with telephone and email support, in reducing depressive…
- Trial name
- NCT00719979
- Testing
- Behavioral intervention (iCBT + TeleCoach), Internet-based cognitive behavioral therapy (I-CBT), Treatment as usual / Wait-list control
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Northwestern University
Schizophrenia, Mood Disorders
Alcohol Use Disorders in Schizophrenia
The purpose of the study is to evaluate a new treatment to help patients who have problems because of their use of alcohol. The treatment is called Behavioral Treatment for Alcohol Abuse in Schizophrenia (BTAAS).We are interested…
- Conditions
- Schizophrenia, Mood Disorders, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT00280813
- Testing
- Supportive Treatment in Addiction Recovery (STAR)
- Where
- 4 sites in United States
- Volunteers
- 54 people
- Sponsor
- University of Maryland, Baltimore
Bipolar Disorder
BIMET Study: Evolution of Metabolic and Cardiovascular Risks Factors in Patients With Bipolar Disorder
To assess the prevalence of Metabolic Syndrome in Spanish population with Bipolar I or II Disorder. To analyse the clinical progress disease in patients with Bipolar I or II Disorder for 12 months using the assessment of the…
- Trial name
- BIMET (NCT00584961)
- Testing
- non-interventional
- Volunteers
- 553 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Major Depressive Disorder
The Efficacy and Safety of Task-state-based Temporal Interference Stimulation (TI) in the Treatment of Patients With Depression
This study intends to investigate the intervention efficacy of temporal interference stimulation (TI) on mood symptoms in depressed patients, as well as to explore the neuroimaging mechanisms of TI improvement in depressed…
- Trial name
- NCT06826469
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 43 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Major Depressive Disorder
Closed-Loop Deep Brain Stimulation for Major Depression
Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry.
- Trial name
- PReSiDio (NCT04004169)
- Testing
- Stimulation-ON, Stimulation-OFF, Stimulation-ON Active Control
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Andrew Krystal
Major Depressive Disorder
Mindfulness-Based Cognitive Therapy for Depressed IAPT Non-Responders
If not treated sufficiently, Major Depression tends to take a recurrent or chronic lifetime course that is associated with a significantly increased risk for physical and neurodegenerative disorders.
- Trial name
- NCT05236959
- Testing
- Mindfulness-Based Cognitive Therapy, Treatment as Usual
- Where
- 4 sites in United Kingdom
- Volunteers
- 234 people
- Sponsor
- Sussex Partnership NHS Foundation Trust
First Episode Psychosis, Schizophrenia, Childhood
Early Psychosis Intervention - Spreading Evidence-based Treatment
Implementation of 'NAVIGATE' in Ontario aims to help youth and emerging adults suffering from a first episode of psychosis. Although Ontario already has early psychosis intervention programs, the team's recent work has identified…
- Conditions
- First Episode Psychosis, Schizophrenia, Childhood, Psychosis, Schizophrenia
- Trial name
- EPI-SET (NCT03919760)
- Testing
- NAVIGATE, Treatment as Usual
- Where
- 6 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Centre for Addiction and Mental Health
Treatment-Resistant Depression
Functional and Neurochemical Correlates of Treatment Response in Major Depressive Disorder
This is an ancillary study to a clinical trial that is being conducted at Massachusetts General Hospital. Investigators at MGH are conducting a clinical trial to test the efficacy of ziprasidone together with escitalopram for…
- Trial name
- NCT01598324
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mclean Hospital
Major Depressive Disorder (MDD)
Theta-Burst Stimulation to Treat Depression
The goal of this clinical trial is to explore the effects of non-invasive brain stimulation protocols using intermittent theta-burst stimulation (iTBS) on brain plasticity and depression severity in depressed individuals aged 18…
- Trial name
- INSPiRE-D (NCT07033780)
- Testing
- Spaced iTBS, Compressed iTBS
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Centre for Addiction and Mental Health
Postpartum Depression
Effect of Exercise and Wellness Interventions on Preventing Postpartum Depression
The purpose of this study is to examine the efficacy of the active interventions (exercise or wellness/support intervention) compared to usual care on the prevention of postpartum depression among women at risk for depression.
- Trial name
- HM2 (NCT01883479)
- Testing
- Exercise, Wellness/Support
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Schizophrenia, Schizophreniform Disorder
Integrated Care in Psychotic Disorders With Severe Mental Illness
The study examine the effectiveness of an integrated care program including therapeutic assertive community treatment (ACT) for people with psychotic disorders fulfilling severe and persistent mental illness (SPMI, ACCESS-II…
- Conditions
- Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder, Delusional Disorder
- Trial name
- ACCESS-II (NCT01888627)
- Testing
- Integrated care
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Depression, Major Depressive Disorder
Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive Symptoms
Ketamine has been shown to have an antidepressant effect when given intravenously in doses of 2mg/kg. Ketamine is used as a standard induction drug during general anesthesia.
- Trial name
- NCT02422303
- Testing
- ketamine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Major Depressive Disorder
An Open Prospective Trial of IV Ketamine in Suicidal Adolescents
1. Investigate the safety and effectiveness of a single dose of IV Ketamine for adolescents with suicidal ideation and depression.
- Trial name
- NCT02048423
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nationwide Children's Hospital
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