Clinical trials: Affective Disorder
Mood Disorders, Psychotic Disorders
Family-Focused Therapy for Youth With Early-Onset Bipolar or Psychotic Disorders
The present study aims to : 1. compare different approaches (high intensity vs. low intensity) to training community providers (those who routinely treat young patients with bipolar disorder, psychosis, or sub-threshold high-risk…
- Trial name
- FFT (NCT02097563)
- Testing
- High Intensity Training, Low Intensity Training
- Where
- 3 sites in United States
- Volunteers
- 133 people
- Sponsor
- University of California, Los Angeles
Schizophrenia and Related Disorders, Bipolar Disorder
A Register Study of Effects Following Local Variation in Rates of Involuntary Care
Involuntary mental health care is permitted because it is believed to make people with severe mental disorders (SMD) better and prevent them from getting worse or even dying In this study we will investigate whether low levels of…
- Trial name
- NCT04655287
- Volunteers
- 21,759 people
- Sponsor
- University Hospital, Akershus
Bipolar Depression, Bipolar Disorder
Safety, Tolerability and Pharmacokinetics of Repeat Doses of GSK1014802.
GSK1014802 is a use-dependent sodium channel blocker and an effective anticonvulsant in animal models. This study is being conducted to obtain information regarding the safety, tolerability and pharmacokinetics of repeated doses…
- Trial name
- NCT00908154
- Testing
- GSK1014802
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Biogen
Treatment-resistant Depression
The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression
In this project, the investigators evaluate an accelerated schedule of repetitive transcranial magnetic stimulation for treatment-resistant depression.
- Trial name
- NCT05607654
- Testing
- active iTBS
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Depression, Unipolar
Intermittent Theta-burst Stimulation for Major Depression: an Intensity-response Study
The United States Food and Drug Administration (FDA) approved intermittent theta-burst stimulation (iTBS) in 2018 as a form of repetitive transcranial magnetic stimulation (rTMS).
- Trial name
- NCT06392867
- Testing
- intermittent theta-burst stimulation (iTBS)
- Where
- Hong Kong
- Volunteers
- 246 people
- Sponsor
- The Hong Kong Polytechnic University
Bipolar Disorder
Pragmatic Patient-oriented Extension Study of Dialectical Behavior Therapy Booster Sessions for Youth With and/or at Familial Risk for Bipolar Disorder
The study intervention is DBT adapted for youth with and/or at familial risk for bipolar disorder. Participants will have completed one full year of DBT in a previous study. This study is examining use of booster sessions.
- Trial name
- DB2 (NCT05627492)
- Testing
- Dialectical behavioral therapy
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre for Addiction and Mental Health
Bipolar Disorder
Clinical Trial of a Nutritional Supplement in Adults With Bipolar Disorder
The purpose of the trial was to determine whether a 36-ingredient micronutrient supplement (primarily vitamins and minerals) is beneficial for the treatment of bipolar disorder, when studied under randomized and fully blinded…
- Trial name
- NCT00109577
- Testing
- MCN36 (nutritional supplement)
- Where
- 2 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Social Avoidant Behavior, Major Depressive Disorder
Using TMS to Understand Neural Processes of Social Motivation
The purpose of this study is to use transcranial magnetic stimulation (TMS) to better understand the neural circuits associated with social motivation.
- Conditions
- Social Avoidant Behavior, Major Depressive Disorder, Social Anxiety Disorder
- Trial name
- NCT06274112
- Testing
- TMS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Auburn University
Major Depressive Disorder
Brexpiprazole as Adjunctive Treatment in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment
To evaluate the long-term efficacy and safety of brexpiprazole as an adjunctive treatment to an antidepressant treatment (ADT) for adult patients with Major Depressive Disorder (MDD).
- Trial name
- NCT01838681
- Testing
- Brexpiprazole, ADT
- Where
- 107 sites in United States, Bulgaria and 14 more
- Volunteers
- 1,986 people
- Sponsor
- H. Lundbeck A/S
Depressive Disorder, Major
Study of Adjunctive or Monotherapy Rapastinel Treatment in Patients With Major Depressive Disorder (MDD)
Multicenter, open-label, long-term extended access treatment protocol in adult patients with a primary diagnosis of MDD.
- Trial name
- NCT03668600
- Testing
- Rapastinel
- Where
- 74 sites in United States
- Volunteers
- 230 people
- Sponsor
- Naurex, Inc, an affiliate of Allergan plc
Right Hemispheric Stroke
Functional Connectivity and Predictors of Affective Aprosodia Intervention in Subacute Right Hemisphere Stroke
This study is an investigation of a behavioral speech and language treatment for emotional prosody recognition and production deficits in subacute right hemisphere stroke.
- Trial name
- NCT04575909
- Testing
- Aprosodia Intervention, No-Intervention
- Where
- United States
- Sponsor
- Johns Hopkins University
Major Depressive Disorder (MDD)
Efficacy, Safety and Tolerability of Agomelatine in the Treatment of Major Depressive Disorder
This study will assess efficacy, safety and tolerability of agomelatine (AGO178) 25 mg and 50 mg in patients with Major Depressive Disorder (MDD). This study includes an 8-week double-blind phase and a 52-week open-label phase.
- Trial name
- NCT00411242
- Testing
- agomelatine
- Where
- 51 sites in United States
- Volunteers
- 503 people
- Sponsor
- Novartis
Depression, Major Depressive Disorder
Novel Neural Circuit Biomarkers of Major Depression Response to CCBT
The purpose of the study is to learn more about computer-assisted cognitive behavioral therapy or "CCBT" and to examine connections in the brains of patients with depression.
- Conditions
- Depression, Major Depressive Disorder, Depressive Disorder, Depression, Unipolar
- Trial name
- NCT03096886
- Testing
- Computer-Augmented Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Depressive Disorder, Major
OnabotulinumtoxinA as Treatment for Major Depressive Disorder in Adult Females
This study will evaluate the safety and efficacy of onabotulinumtoxinA (BOTOX®) compared with placebo as treatment for major depressive disorder (MDD) in adult females.
- Trial name
- NCT02116361
- Testing
- onabotulinumtoxinA, Normal Saline
- Where
- 35 sites in United States
- Volunteers
- 258 people
- Sponsor
- Allergan
Depression, Depressive Disorder
Improving Retention of Hispanics Receiving Antidepressant Therapy
This study will develop an intervention that will increase the retention of Hispanics with major depression in antidepressant therapy.
- Trial name
- NCT00057642
- Testing
- Sertraline, Venlafaxine Extended Release
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- New York State Psychiatric Institute
Major Depression in Remission
Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Study 1.2 (Stress Manipulation)
This study investigates how remitted individuals with past major depressive disorder (MDD) make approach-avoidance decisions and which brain regions are implicated in such decisions.
- Trial name
- NCT04325529
- Testing
- Aversive stimuli
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Inflammatory Bowel Diseases, Mild Cognitive Impairment
Cognitive Impairment and Affective Mood Disorders in Patients With IBD
The aim is to evaluate the presence of mild cognitive impairment (MCI) in patients with inflammatory bowel disease (IBD). This will be done by cognitive tests.
- Conditions
- Inflammatory Bowel Diseases, Mild Cognitive Impairment, Depression, Anxiety
- Trial name
- COGN-IBD-1 (NCT05760729)
- Testing
- Cognitive testing
- Where
- 3 sites in Romania
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Bipolar Disorder, Mood Disorder
Mindfulness in Mood Dysregulated Youth
Mindfulness group therapy can help children with mood irregularities and family history of bipolar disorder.
- Conditions
- Bipolar Disorder, Mood Disorder, Emotional Disturbance
- Trial name
- NCT02120937
- Testing
- MBCT-C Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Major Depression
Thyroid Medication and Antidepressants for Treating Major Depression
This study will evaluate the effectiveness of treatment with supplemental triiodothyronine (T3, Cytomel) and sertraline (Zoloft), a selective serotonin reuptake inhibitor (SSRI), in improving symptoms of major depressive disorder…
- Trial name
- NCT00208702
- Testing
- Triiodothyronine, Sertraline
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Emory University
Postpartum Depression (PPD), Postpartum Anxiety
AI-Enabled Wearable Monitoring for Detection of Postpartum Depression and Anxiety
The goal of this observational study is to examine whether passively collected wearable data can be used to predict onset and severity of postpartum depression and anxiety symptoms. The main questions it aims to answer are: 1.
- Trial name
- NCT07866053
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
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