Clinical trials: Affective Disorder
Ischemia, Stress, Mental
Neurocardiac Interactions Evaluated by Anatomic and Physiologic MRI Assessment
The purpose of project is to answer fundamental questions about the mechanisms underlying mental stress ischemia in patients with coronary artery disease, mood disorders, or both, and to identify potential biomarkers and…
- Trial name
- NIRVANA (NCT02962154)
- Testing
- Coronary CT Angiography, Mood Symptom Scale, Anxiety Symptom Scale
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Major Depression
Psychotherapeutic Text Messaging for Depression Pilot Study
Major depression is the leading cause of disability in the United States and is a major contributor to suicide, a leading cause of premature death.
- Trial name
- TEXT4U (NCT02872454)
- Testing
- Text Messaging
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- University of Michigan
Schizophrenia, Psychotic Disorders
Role Functioning Changes NOS
During this study the investigators will 1) collect measures of social cognition and social functioning in adolescents and young adults who are experiencing early symptoms of a major mental disorder; and 2) evaluate the…
- Conditions
- Schizophrenia, Psychotic Disorders, Bipolar Disorder
- Trial name
- NCT02505022
- Testing
- Pharmacotherapy, Behavioral treatment
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Northwestern University
Bipolar Disorder
Toward Exercise as Medicine for Adolescents With Bipolar Disorder
This study seeks to bridge the knowledge-to-action gap regarding "exercise as medicine" for adolescents with bipolar disorder (BD).
- Trial name
- TEAM-BD (NCT03562520)
- Testing
- Behavior change counseling
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Caesarean Section, Mother-Child Relations
Effect of Mother's Push at Cesarean Delivery Mother's PUSHING AT CS A RANDOMIZED CONTROLLED TRIAL
The purpose of this study is to assess the safety and efficacy of the mother's active pushing during cesarean delivery.
- Conditions
- Caesarean Section, Mother-Child Relations, Post Operative Pain, Postpartum Depression
- Trial name
- NCT05520580
- Testing
- Mother's push during CS
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Post Partum Depression
Maternal Mental Health in the Hospital Setting
Perinatal (around the time of birth) mental health disorders are common difficulties of pregnancy. Perinatal depression is made up of major and minor depressive events during pregnancy and the first 12 months after delivery.
- Trial name
- MMH (NCT03777046)
- Testing
- Standard of Care (SOC), SOC with Psychology Therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 545 people, healthy volunteers welcome
- Sponsor
- Michelle Lopez
Molecular Mechanisms of Pharmacological Action, Depression
Effects of Acute Prucalopride Administration in Healthy Volunteers
This study will investigate whether administration of a single dose of the serotonin receptor subtype 4 (5-HT4) partial agonist prucalopride has effects on emotional processing and non-emotional cognition in healthy volunteers…
- Conditions
- Molecular Mechanisms of Pharmacological Action, Depression, Depressive Disorder, Mood Disorders
- Trial name
- NCT03863366
- Testing
- Prucalopride
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Affective Disorders, Psychotic Disorder
The Effects of Progressive Muscle Relaxation Therapy in Patients With Schizophrenia
This study applied a randomized parallel case-controlled design. The study purpose was to evaluate the effects of progressive muscle relaxation on anxiety, psychiatric symptoms and quality of life among patients with chronic…
- Trial name
- NCT03667729
- Testing
- progressive muscle relaxation
- Volunteers
- 75 people
- Sponsor
- Taipei Medical University
Bipolar Disorder
Transcranial Photobiomodulation for Executive Function in Bipolar Disorder
Transcranial light therapy, or transcranial photobiomodulation (tPBM), is a treatment that stimulates the brain by applying near-infrared light to the forehead.
- Trial name
- TPEB (NCT05408637)
- Testing
- Transcranial Phoobiomodulation (tPBM)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Paolo Cassano
Major Depressive Disorder, Obsessive-Compulsive Disorder
Bioequivalence Study of Paroxetine Tablets and Paxil® Under Fasting and Fed Conditions in Chinese Healthy Volunteers
The objective of this study is to compare the rate and extent of absorption of paroxetine hydrochloride 20 mg tablets (test) and Paxil® (reference) administered as 20 mg tablet under fed conditions.
- Conditions
- Major Depressive Disorder, Obsessive-Compulsive Disorder, Panic Disorder, Social Anxiety Disorder
- Trial name
- NCT03504475
- Testing
- Paroxetine Hydrochloride Tablet 20 mg, Paxil® 20 mg
- Where
- 2 sites in China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Major Depressive Disorder, Bipolar Disorder
Mindfulness-Based Cognitive Therapy for Perinatal Women With Mood Disorders
This study will investigate the effectiveness of mindfulness-based cognitive therapy (MBCT) for mood stabilization in perinatal women (preconception, pregnant, and postpartum) with a history of mood disorders.
- Trial name
- MBCT (NCT02150681)
- Testing
- Mindfulness-based cognitive therapy
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- University of California, Los Angeles
Major Depressive Disorder
Randomised Placebo-controlled Duloxetine-referenced Efficacy and Safety Study of 2.5, 5 and 10 mg of Vortioxetine (Lu AA21004) in Acute Treatment of Major Depressive Disorder
The purpose of the study is to evaluate the efficacy and the tolerability of three fixed doses of Vortioxetine in order to establish the appropriate clinical effective dose range in the treatment of Major Depressive Disorder…
- Trial name
- NCT00635219
- Testing
- Vortioxetine (Lu AA21004), Duloxetine
- Volunteers
- 766 people
- Sponsor
- H. Lundbeck A/S
Anxiety State
Music Listening to Lower Anxiety During ECT Treatment.
The purpose of this study is to assess whether music listening is helpful in lowering anxiety in patients about to start their ECT treatment.
- Trial name
- MIECT (NCT04706728)
- Testing
- Listening to playlists with music prior to-, during and after the ECT procedure, Listening to playlists with sound from nature (rain, waves) prior to-, during and after the ECT procedure
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Aalborg University
Bipolar Depression
Treatment Clinical Practice in Bipolar Depression in Spain
Cross-sectional observational, non interventional, multicenter study of retrospective review of clinical records of ambulatory followed up bipolar patients in order to record epidemiological aspects of the course of the disorder…
- Trial name
- EPIDEP (NCT00757328)
- Where
- 23 sites in Spain
- Volunteers
- 378 people
- Sponsor
- AstraZeneca
Major Depression, Post-Traumatic Stress Disorder
Expanding and Testing VA Collaborative Care Models for Depression
Based on the published evidence, collaborative care for depression is both necessary and sufficient for improving care and outcomes for depressed patients in primary care settings.
- Trial name
- ReTIDES (NCT00119028)
- Testing
- Depression Care Quality Improvement Implementation
- Where
- 6 sites in United States
- Sponsor
- US Department of Veterans Affairs
Bipolar Disorder
Galantamine-CR and Cognitive Dysfunction in Bipolar Disorder
The purpose of the study is to determine whether the investigational drug galantamine-CR (Reminyl- Controlled Release capsule) is useful in improving problems with memory in bipolar patients with stable mood.
- Trial name
- NCT00181636
- Testing
- Galantamine-CR
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder, Depression
The Effect of Psilocybin on MDD Symptom Severity and Synaptic Density
PROTOCOL SYNOPSIS Title The effect of psilocybin on Major depressive disorder (MDD) symptom severity and synaptic density - a single dose randomized, double blind, placebo-controlled phase 2b positron emission tomography study…
- Trial name
- PSIPET (NCT04630964)
- Testing
- Psilocybin, Niacin
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Section for Affective Disorders; Northern Stockholm Psychiatry
Alcohol Abuse, Cannabis Abuse
Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse
The purpose of this study is to determine whether Integrated Cognitive Behavioral Therapy or Twelve Step Facilitation Therapy is most effective for treatment of dually diagnosed veterans with depressive and substance use…
- Conditions
- Alcohol Abuse, Cannabis Abuse, Major Depressive Disorder, Substance-Related Disorders
- Trial name
- NCT00108407
- Testing
- Integrated Cognitive Behavioral Therapy, Twelve Step Facilitation Therapy
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Major Depressive Disorder
Zuranolone Pharmacokinetics (PK) and Safety Study Adolescent Participants With Major Depressive Disorder (MDD)
The primary purpose of this study is to evaluate the pharmacokinetics and safety of Zuranolone in adolescents (ages 12 to 17 years) with MDD.
- Trial name
- NCT05655507
- Testing
- Zuranolone
- Where
- 4 sites in United States
- Volunteers
- 19 people
- Sponsor
- Biogen
Vascular Depression
Efficacy and Safety Study of Desvenlafaxine in the Treatment of Vascular Depression
To examine the efficacy and safety of treatment with desvenlafaxine for vascular depression. Primary efficacy, as it pertains to depressive symptoms, will be assessed by overall change in symptom severity score from baseline to…
- Trial name
- NCT01974934
- Testing
- Desvenlafaxine Succinate
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Hotel-Dieu Grace Healthcare
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