Clinical trials: Affective Disorder
Depression; Bipolar Disorder
Comparing Different Patterns of rTMS in Major Depression
This trial will compare the trajectories of improvement for three different patterns of twice-daily rTMS in major depression: two daily sessions of dorsomedial prefrontal rTMS delivered at 0 min vs. 30 min vs. 60 min intervals.
- Trial name
- NCT02778035
- Testing
- Dorsomedial prefrontal rTMS
- Where
- 2 sites in Canada
- Volunteers
- 180 people
- Sponsor
- University Health Network, Toronto
Traditional Chinese Medicine, Major Depressive Disorder
Establishing TCM Daycare Model and Teaching Mechanism of Depression Patients
The teaching platform of the TCM daycare clinics for depression patients will provide a good clinical training environment for the trainees.
- Trial name
- NCT04469608
- Testing
- acupuncture
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- China Medical University Hospital
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Glutamate Probes in Adolescent Depression
The purpose of this study is to learn if measures of brain chemicals from a brain scan called Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) and brain activity (known as cortical excitability and inhibition) collected by…
- Conditions
- Major Depressive Disorder, Major Depressive Disorder, Recurrent, Major Depressive Disorder, Remitted
- Trial name
- GPII (NCT02307617)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Major Depression
Brain Abnormalities in Late-Onset Major Depression
The objective of this project is to examine the state of the brain in people over 50 years old suffering from late-onset depression by means of an extensive clinical assessment programme, including magnetic resonance imaging…
- Trial name
- NCT00260468
- Testing
- Clinical examination program
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Depression, Postpartum, Depression
Using a Preparation and Education Intervention to Reduce Postpartum Depression Among New Mothers (The MADE IT 2 Study)
This study will test an intervention that aims to prevent postpartum depression by providing new mothers with information on and resources for dealing with the disorder.
- Trial name
- NCT00951717
- Testing
- Behavioral education intervention
- Where
- United States
- Volunteers
- 590 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postpartum Depression
A Study of BRII-297 in Healthy Adult Subjects
The goal of this clinical trial is to evaluate the safety, tolerability, and pharmacokinetics of BRII-297 in healthy adult subjects.
- Trial name
- NCT05845840
- Testing
- BRII-297
- Where
- Australia
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Brii Biosciences Limited
Sleep, Mild Cognitive Impairment
Light and Sleep Fragmentation
This trial will examine scheduled exposure to bright light in the morning and afternoon as a countermeasure to sleep fragmentation in older individuals with mild cognitive impairment.
- Conditions
- Sleep, Mild Cognitive Impairment, Mood Disorders
- Trial name
- NCT06009289
- Testing
- Light therapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Stanford University
Major Depressive Disorder
Repetitive Transcranial Magnetic Stimulation in Pharmaco-naïve Patients With Major Depression
Repetitive transcranial magnetic stimulation (rTMS) has become a safe and efficacious treatment for patients with treatment-resistant depression.
- Trial name
- NAIV (NCT04000022)
- Testing
- intermittent theta burst stimulation (iTBS)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bonn
Depressive Disorder, Major, Depression
Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder
Evidence exists supporting the ability of genetic variations to influence patient drug response and side effects. Previous studies utilizing an open-label design have shown significant improvement in major depressive disorder…
- Conditions
- Depressive Disorder, Major, Depression, Depressive Disorder
- Trial name
- NCT02466477
- Testing
- GeneSight Psychotropic (GEN), Enhanced-GeneSight Psychotropic (E-GEN), Treatment as Usual (TAU)
- Where
- 14 sites in Canada
- Volunteers
- 542 people
- Sponsor
- Assurex Health Inc.
Major Depressive Disorder
Medical and Psychiatric Co-Morbidity Among Treatment Resistant Patients With Major Depression Disorder
Assessing psychiatric and physiological co-morbidity in TRD and non-TRD patients
- Trial name
- NCT00229398
- Sponsor
- Sheba Medical Center
Bipolar Disorder
Efficacy and Safety of Galantamine for Improving Dysfunction in People With Bipolar Disorder
This study will examine whether extended release galantamine, a drug approved by the Food and Drug Administration to reduce cognitive impairments in people with Alzheimer's disease, can perform the same function in stable people…
- Trial name
- NCT00741598
- Testing
- Galantamine-ER
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder
Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)
The goal of this clinical trial is to learn if intravenous (IV) ketamine with Dialectical Behavioural Therapy (DBT) reduces suicidal ideation in individuals with suicidality who have been diagnosed with Borderline Personality…
- Conditions
- Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder, Treatment-resistant Bipolar Depression, Major Depressive Disorder (MDD)
- Trial name
- KET-DBT (NCT07569198)
- Testing
- Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Joshua Rosenblat
Major Depressive Disorder(MDD)
Efficacy of Clinical Application of Transcranial Low Intensity Focused Ultrasonic Stimulation for Patients With Major Deperessive Disorder - Exploratory Clinical Trial
The non-invasive type ultrasonography system is applied to patients with major depressive disorder to evaluate their effectiveness and safety.
- Trial name
- NCT04405791
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Gangnam Severance Hospital
Major Depressive Disorder
Feasibility of a Behavioral Activation Trial
The goal of this project is to train community mental health therapists in behavioral activation (BA) treatment for major depressive disorder and then to conduct a study examining the feasibility of evaluating the effectiveness…
- Trial name
- NCT02992158
- Testing
- behavioral activation, treatment-as-usual
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Bipolar Disorder, Schizophrenia
Immuno-Genetic, Inflammation, Retro-Virus, Environment
Immunology combined to neurobiology now offer prominent tools to yield biomarkers, so far missing in psychiatry, and to design innovative treatment approaches based on the discovery of new molecular and cellular targets.
- Trial name
- I-Give (NCT02878408)
- Testing
- Blood sampling
- Where
- 6 sites in France
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Pr. Marion Leboyer
Postpartum Depressive Disorder
Quetiapine in Postpartum Depression
The purpose of the study is to evaluate the efficacy and tolerability of quetiapine in female patients with postpartum depressive disorder with psychotic symptoms
- Trial name
- NCT00681668
- Testing
- Quetiapine
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- AstraZeneca
Prenatal Anxiety, Prenatal Depression
Effectiveness of an Online Biopsychosocial Intervention to Improve Well-being and Mental Health During Pregnancy
This study aims to develop and implement a preventive intervention through a mobile application to help pregnant women feel better emotionally and cope with the changes of pregnancy in a more positive way.
- Conditions
- Prenatal Anxiety, Prenatal Depression, Wellbeing, Obstetrical Complications
- Trial name
- BienGestar (NCT06871397)
- Testing
- Biopsychosocial Cognitive Behavioral Intervention
- Where
- Spain
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Mood Disorders, Bipolar Disorder
Technology Enhanced Family Treatment
The investigators propose to enhance the scalability of family-focused therapy (FFT), a 12-session evidence-based therapy for youth at high risk for mood disorders, through augmentation with a novel mobile phone application…
- Conditions
- Mood Disorders, Bipolar Disorder, Major Depression
- Trial name
- NCT03913013
- Testing
- Family-Focused Treatment with MCC App
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, Los Angeles
Psychotic Disorders, Mood Disorders
Transcranial Direct Current Stimulation as Treatment for Auditory Hallucinations
The present study aims to examine the efficacy of transcranial direct current stimulation on the severity of auditory hallucinations.
- Conditions
- Psychotic Disorders, Mood Disorders, Personality Disorders, Stress Disorders, Post-Traumatic
- Trial name
- tDCS (NCT01977521)
- Testing
- Eldith DC Stimulator stimulation
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Iris Sommer
Treatment Resistant Depressive Disorder
Ketamine for Treatment Resistant Late-Life Depression
The purpose of this study is to examine the effectiveness of a single infusion of ketamine (KET), to determine which dose is optimal 7 days after infusion using Bayesian Adaptive Randomization, and to learn about how ketamine…
- Trial name
- NCT02556606
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
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