Clinical trials: Affective Disorder
Borderline Personality Disorder, Major Depression
Dorsomedial rTMS For Depression In Borderline Personality Disorder
This randomized trial with a crossover design will examine the efficacy of rTMS targeting the dorsomedial prefrontal cortex as a treatment for medication-resistant major depression in patients meeting diagnostic criteria for…
- Trial name
- rTMS (NCT03472638)
- Testing
- Dorsomedial prefrontal rTMS
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Sedentary Behavior, Affect
Effects of Multi-day Interruptions in Sitting on Type 2 Diabetes-relevant Outcomes in Children
The overall objective of this in-lab randomized controlled trial is to test the efficacy of multi-day interruptions in sedentary behavior vs.
- Conditions
- Sedentary Behavior, Affect, Metabolic Disturbance, Anxiety
- Trial name
- NCT04469790
- Testing
- SIT+WALK, EX
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Major Depressive Disorder, Healthy Controls
Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets
The study is investigating dysfunctions in neurocircuitry in regards to irritability with healthy controls (HC) and individuals with Major Depressive Disorder (MDD) by performing MRIs.
- Trial name
- UNIKET (NCT05046184)
- Testing
- Ketamine Hydrochloride, Midazolam injection
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Depression, Depression, Postpartum
Effectiveness of Supplemental Calcium in Preventing Postpartum Depression
This study will evaluate the effectiveness of taking supplemental calcium while pregnant in reducing the risk of postpartum depression.
- Trial name
- NCT00228033
- Testing
- Elemental calcium (as carbonate)
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Depressive Disorders
Acute, Affective, Organic Disorders.
The purpose of the study is to investigate whether patients with brief depressive periods together with other fluctuating psychiatric symptoms, have this condition due to epilepsy or an other organic brain disorder.
- Trial name
- NCT00201474
- Where
- Norway
- Volunteers
- 32 people
- Sponsor
- Norwegian University of Science and Technology
Postpartum Anxiety, Postpartum Depression (PPD)
Narrative Nursing for Cesarean Mothers' Anxiety and Breastfeeding Confidence
This study tests whether a nurse-led "4-step narrative nursing" program can reduce anxiety and improve breastfeeding confidence in mothers who are having a planned or non-emergency cesarean section.
- Conditions
- Postpartum Anxiety, Postpartum Depression (PPD), Breastfeeding Self-Efficacy, Cesarean Section Wound
- Trial name
- NARRCARE (NCT07272252)
- Testing
- 4-step narrative nursing program
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Xi Huang
Major Depressive Disorder (MDD), Hypovitaminosis D
Effect of Vitamin D Supplementation on Brain Waves in Female Major Depressive Disorder Patients With Hypovitaminosis D
Major Depressive Disorder (MDD) is a common mood disorder characterized by persistent sadness, loss of interest and cognitive impairment.
- Trial name
- NCT07579078
- Testing
- Dietary vitamin D
- Where
- Bangladesh
- Volunteers
- 34 people
- Sponsor
- Bangladesh Medical University
Major Depressive Disorder (MDD)
Evaluation of the Concordance Between Measures Obtained by a Medical Device for Emotional Monitoring (EMOCARE) and the Patient Health Questionnaire (PHQ-9) Score in Patients With Mild to Severe Depressive Episode
The aim of this clinical investigation is to find out whether the EMOCARE emotional monitoring software provides consistent results compared with the tools available for assessing the emotional state of patients suffering from…
- Trial name
- EMC1 (NCT06601140)
- Testing
- EMOCARE software
- Where
- 11 sites in France
- Volunteers
- 104 people
- Sponsor
- Emobot
Bipolar Disorder
Effectiveness RCT of Customized Adherence Enhancement
Approximately one in two individuals with bipolar disorder (BD) are non-adherent with medication, often leading to severe and negative consequences.
- Trial name
- CAE-E (NCT04622150)
- Testing
- Customized Adherence Enhancement (CAE), Enhanced Treatment as Usual (eTAU)
- Where
- 3 sites in United States
- Volunteers
- 190 people
- Sponsor
- Case Western Reserve University
Postpartum, Postpartum Depression (PPD)
Postpartum Care in the NICU Multi-Site
Parents of infants admitted to the neonatal intensive care unit (NICU) face unique challenges in caring for their own health after giving birth.
- Conditions
- Postpartum, Postpartum Depression (PPD), Hypertension Disorders in Pregnancy, Postpartum Anxiety
- Trial name
- PeliCaN (NCT07873190)
- Testing
- Postpartum Doula Support in the NICU
- Where
- 14 sites in United States
- Volunteers
- 756 people
- Sponsor
- Children's Hospital of Philadelphia
Bipolar Disorder
Open-Label Study of N-Acetylcysteine in Children and Adolescents 5-17 With Bipolar Spectrum Disorders
Children between the ages of 5-17 years old who have or display symptoms of emotional dysregulation (explosiveness, mood swings, irritability, and/or violent behavior) are invited to participate in a 12-week research study to…
- Trial name
- NCT02357290
- Testing
- Open-label Treatment with N-Acetylcysteine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Depression, Dysthymia
Cognitive Behavioral Therapy (REBT/CBT) Evaluation for Dysthymia in the Practice of Clinical Social Work at Primary Care
Introduction: Minor psychiatric disorders are important in primary care, because of its high prevalence and consumption of healthcare resources generated.
- Conditions
- Depression, Dysthymia, Ambulatory Health Services
- Trial name
- NCT02112708
- Testing
- Rational-Emotive-Behavioral Therapy, Control Group usual care
- Where
- Spain
- Volunteers
- 129 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Depressive Disorder
Multi-Dimensional Diagnosis,Individualized Therapy,and Management Technique for Major Depressive Disorder:Based on Clinical and Pathological Characteristics
Major Depressive Disorder is one of the most common mental diseases,which increases health-care costs and the financial burden to families and societies.
- Trial name
- STEP-MDD (NCT03219008)
- Testing
- Fluoxetine, fluoxetine + cognitive-behavioral treatment（CBT）, fluoxetine + Amfebutamone
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Shanghai Mental Health Center
Major Depressive Episode, Major Depressive Disorder
Depression-Reduction by Accelerated Personalized NeuroModulation and Its Effects on Sleep
Advances in repetitive transcranial magnetic stimulation (rTMS) protocols with intermittent theta-burst stimulation (iTBS) have significantly decreased the duration for one single session and thereby enabled accelerated treatment…
- Conditions
- Major Depressive Episode, Major Depressive Disorder, Borderline Personality Disorder
- Trial name
- DREAMS (NCT04832750)
- Where
- Germany
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Oldenburg
Healthy Volunteer
Endophenotype Characterization of a Family Psychiatric Disorder
Bipolar disorder is a chronic and frequent mood pathology, that impacts on emotional and socio-professional life of sick subjects, and also increase mortality by suicide. Suicide is considered as a bipolar disorder result.
- Trial name
- EnBiGen (NCT02843997)
- Testing
- Endophenotype and sequencing
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Major Depressive Disorder
Study of Intravenous NRX-1074 in Patients With Major Depressive Disorder
The purpose of this study is to evaluate the efficacy and safety of NRX-1074 following a single intravenous dose in subjects with major depressive disorder.
- Trial name
- NCT02067793
- Testing
- NRX-1074 1 mg, NRX-1074 5 mg, NRX-1074 10 mg
- Where
- 12 sites in United States
- Volunteers
- 151 people
- Sponsor
- Naurex, Inc, an affiliate of Allergan plc
Major Depression, Sleep Architecture
Combining Light Therapy and CPAP in Depression
In a double-blind, parallel-group controlled trial, we aim to measure the effect of two weeks of light therapy combined with the CPAP on compliance CPAP in patients with major depressive disorder.
- Conditions
- Major Depression, Sleep Architecture, Obstructive Sleep Apnea, Compliance
- Trial name
- LUCIOPRESS (NCT06781593)
- Testing
- Light therapy
- Where
- 2 sites in France
- Volunteers
- 130 people
- Sponsor
- Hôpital le Vinatier
Depressive Symptoms, Remited Major Depressive Disorder
Cognitive Control Emotion Training to Prevent Major Depression in Youth At-Risk
The goal of this clinical trial is to learn if intervention of positive emotion working memory (PEWM), or negative emotion working memory (NEWM), or positive attention bias training (PABT) can prevent major depressive disorder…
- Trial name
- CTE 2019 (NCT04346784)
- Testing
- positive emotion working memory(PEWM) training, negative emtion working memory(NEWM) training, PABT
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Hunan Normal University
Anxiety, Anxiety Acute
Anxiety Skills Study
The purposes of this study are: (1) to identify baseline predictors of relative success in cognitive, behavioral, and mindfulness-based treatments for anxiety, (2) explore who benefits from a brief, video-based skill training…
- Conditions
- Anxiety, Anxiety Acute, Anxiety Chronic, Anxiety and Mood Disorders
- Trial name
- NCT07774481
- Testing
- Cognitive therapy, Behavioral therapy, Mindfulness-based therapy
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Ohio State University
Bipolar Disorder, Schizophrenia
Post-Authorization Safety Surveillance Study of Asenapine in Participants With Bipolar Disorder (P08307)
This study will assess asenapine (Sycrest®) use in participants with bipolar disorder; comparison will be made to the use of risperidone (RISPERDAL®CONSTA®) and olanzapine (Zyprexa®).
- Trial name
- NCT01495741
- Volunteers
- 42 people
- Sponsor
- Organon and Co
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