Clinical trials: Affective Disorder
Major Depressive Disorder
The Safety and Efficacy of Psilocybin in Cancer Patients With Major Depressive Disorder
This is a Phase II, single-center, fixed dose, open label trial to explore the safety, tolerability and efficacy of a 25mg dose of psilocybin in cancer patients with MDD.
- Trial name
- NCT04593563
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Maryland Oncology Hematology, PA
Perinatal Depression, Affective Disorder
Validation of the French Version of the Perinatal Assessment of Paternal Affectivity (PAPA)
The transition to parenthood is a critical period for both the woman and her partner, and this can affect the mental health of the parents.
- Conditions
- Perinatal Depression, Affective Disorder, Fathers
- Trial name
- French-Papa (NCT06594263)
- Where
- France
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Depressive Disorder
An Eight-week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Depression
The purpose of the study is to evaluate the efficacy and safety of saredutant (or SR48968C) in patients with depression. The primary objective is to evaluate the efficacy of a 100 mg dose of saredutant compared to placebo in…
- Trial name
- NCT00250614
- Testing
- Saredutant succinate (SR48968C)
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- Sanofi
Major Depressive Disorder
Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD)
The investigators are testing the efficacy of Smartphone-delivered cognitive behavioral therapy (CBT) treatment for major depressive disorder (MDD).
- Trial name
- NCT04594616
- Testing
- Smartphone-delivered CBT for MDD
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Bipolar Depression
Memantine Augmentation of Lamotrigine Incomplete-Response in Bipolar Depression
The purpose of this study is to investigate whether addition of memantine to bipolar depression patients who have had an incomplete response to lamotrigine (Lamictal) which is frequently used to treat bipolar depression in the…
- Trial name
- NCT00305578
- Testing
- Memantine
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Indiana University
Schizophrenia, Bipolar Disorder
The Role of Dysmyelination in Cognitive Impairment of Psychotic Spectrum Disorders
This is a single center study that uses both between-group comparisons and correlational analyses to establish biomarkers of dysmyelination and cognitive impairment in Psychotic Spectrum Disorders using imaging and…
- Trial name
- NCT03166098
- Testing
- Cognitive Function Assessments
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- NYU Langone Health
Major Depressive Disorder
A Study in the Treatment of Children and Adolescents With Major Depressive Disorder
The purpose of this study is to assess whether duloxetine is superior to placebo in the treatment of children and adolescents with major depressive disorder (MDD)
- Trial name
- NCT00849693
- Testing
- fluoxetine, duloxetine
- Where
- 56 sites in United States, Argentina and 2 more
- Volunteers
- 463 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder, Recurrent
Mechanisms of Mindfulness-Based Cognitive Therapy in the Treatment of Recurrent Major Depressive Disorder
The primary purpose of this study is to investigate neural mechanisms and predictors of treatment outcome in Mindfulness-Based Cognitive Therapy (MBCT) for recurrent Major Depressive Disorder.
- Trial name
- NCT03353493
- Testing
- MBCT, TAU
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Schizophrenia, Bipolar Disorder
Spanish Validation of Tool Questionnaire to Assess Patients´Perception About Antipsychotic Treatment
Non-interventional, prospective study to validate Spanish version of TOOL questionnaire in patients with schizophrenia and bipolar disorder under antipsychotic treatment
- Trial name
- TOOL (NCT00692133)
- Where
- 32 sites in Spain
- Volunteers
- 250 people
- Sponsor
- AstraZeneca
Post Partum Depression
Adaptation and Pilot Testing of Web and Mobile Interface for the VID-KIDS Intervention
COVID-19 has placed unprecedented strains on parents impacted by toxic stress (depression, addiction, intimate partner violence, and poverty) and reluctant to see mental health-service providers in home/clinic due to fears of…
- Trial name
- VID-KIDS (NCT04818047)
- Testing
- VID-KIDS Intervention Program
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Major Depressive Disorder, Repetitive Transcranial Magnetic Stimulation
Individualized dlPFC-NAcc Modulation for Anhedonia in adMDD
This study evaluates a schedule of precise repetitive transcranial magnetic stimulation for depressive adolescent with anhedonia.
- Trial name
- NCT05544071
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Xijing Hospital
Major Depressive Disorder
Ketamine in the Treatment of Depression
Depressed patients will be offered experimental treatment with a new, potentially fast-acting antidepressant called ketamine while being scanned by magnetic resonance imaging (MRI) to measure the chemical effect of the drug.
- Trial name
- NCT01558063
- Testing
- Ketamine, Saline, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Columbia University
Smoking Cessation, Bipolar Disorder
Varenicline Treatment for Smoking Cessation in Patients With Bipolar Disorder
The investigators' hypothesis is that add-on varenicline will be effective (versus placebo) in initiating abstinence from smoking in subjects with stable, euthymic bipolar disorder who are motivated to quit smoking within four…
- Trial name
- BEST (NCT01010204)
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- K.N. Roy Chengappa
Bipolar Disorder, Substance Use Disorder
Study of Icariin for Bipolar Disorder and Co-Occurring Substance Use Disorders
This study is being done to see if icariin will help with depression in patients with bipolar disorder and alcohol or cocaine use disorders. The pills used in this study contain 20% icariin.
- Trial name
- NCT01979133
- Testing
- Icariin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Texas Southwestern Medical Center
Treatment Resistant Depression
Ketamine Frequency Treatment for Major Depressive Disorder
Depression is a wide spread illness. Depression contributes most significantly to national health care costs. While the number and types of treatments used for depression have expanded over the years, even with an increased range…
- Trial name
- NCT00646087
- Testing
- Ketamine, Ketamine/Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Essentia Health
Postpartum Depression
Interaction Between Genetic Factors and Maternal Stressors During Pregnancy in the Risk of Postpartum Depression
"The prevalence of postpartum depression (PPD) is approximately 13%. PPD is associated with a higher maternal morbidity and mortality, and also with pervasive effects on the emotional, cognitive and behavioral development of the…
- Trial name
- IGEDEPP (NCT01648816)
- Where
- France
- Volunteers
- 3,338 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancers, Gynecologic Cancer
The Effect Of Meditation On Quality Of Life In Women With Breast Cancer And Other Gynecological Cancers
Women with breast cancer and other gynecologic cancers often suffer significant distress and disability from their disease. A practice of meditation-based stress reduction and cognitive-affective-behavioral learning may help…
- Trial name
- NCT00248911
- Testing
- Mindfulness based meditation program
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Weill Medical College of Cornell University
Major Depressive Disorder
Dose-finding Study With Lu AA24530 in Major Depressive Disorder
The primary purpose of this study is to assess the efficacy in treating patients with Major Depressive Disorder of one or more doses of Lu AA24530 relative to placebo
- Trial name
- NCT00599911
- Testing
- Lu AA24530, Duloxetine
- Where
- 72 sites in Australia, Austria and 15 more
- Volunteers
- 652 people
- Sponsor
- H. Lundbeck A/S
Bipolar Disorder
A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder
The purpose of this pilot study is to determine the safety and potential efficacy of sustained-release bupropion (Zyban®) for the treatment of nicotine dependence in patients with bipolar affective illness.
- Trial name
- NCT00593099
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Mental Health Issue, Anxiety Disorder
Unified Protocol: Community Connections
The purpose of this study is to administer the Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children (UP-C) and Adolescents (UP-A) to youth and participants' parents and to examine the efficacy and…
- Conditions
- Mental Health Issue, Anxiety Disorder, Depressive Disorder, Parenting
- Trial name
- NCT06038721
- Testing
- The Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Children, The Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Adolescents
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- University of Miami
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