Clinical trials: Affective Disorders, Psychotic
Schizophrenia, Bipolar Disorder
Using Motivational Techniques to Increase Levels of Physical Activity in Long Term Psychiatric Inpatient Wards
The current research project aims at investigating whether it is possible to obtain an increase in physical activity among inpatients with schizophrenia spectrum disorders by the use of motivational interviewing and environmental…
- Conditions
- Schizophrenia, Bipolar Disorder, Inpatient Facility Diagnoses, Cardiovascular Risk Factor
- Trial name
- FYSAKT (NCT03528278)
- Testing
- Motivational interviewing and environmental interventions
- Where
- 2 sites in Norway
- Volunteers
- 83 people
- Sponsor
- Oslo University Hospital
Schizophrenia, Schizo Affective Disorder
REACH Study (Recovery Environments: Assessing Cognitive & Brain Health in Community Mental Health)
The purpose of this study is to understand how different types of community-based mental health care affect thinking abilities, daily functioning, and brain activity in adults with schizophrenia and related conditions.
- Conditions
- Schizophrenia, Schizo Affective Disorder, Schizophreniform Disorders
- Trial name
- NCT07006935
- Testing
- Clubhouse Model of Psychosocial Rehabilitation for Serious Mental Illness, Usual Community-Based Mental Health Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Western Reserve University
Postpartum Depression, Major Depressive Disorder
Neuropsychobiological Correlates of Sex-steroid Hormone Manipulation in Healthy Women: a Risk Model for Depression
The project aimed at identifying neuropsychobiological signatures of pharmacological sex-steroid hormone manipulations in healthy women as a risk model for depression.
- Conditions
- Postpartum Depression, Major Depressive Disorder, Postpartum Psychosis, Menopause
- Trial name
- GnRHa (NCT02661789)
- Testing
- Goserelin 3.6 mg implant
- Where
- Denmark
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Gitte Moos Knudsen
Schizophrenia, Major Depressive Disorder
Effectiveness of Traditional Chinese Metacognitive Training (MCT) in Patients With Schizophrenia, Depression, or Bipolar Disorder Attending a Psychiatric Day Hospital in Taiwan
Schizophrenia is characterized by positive symptoms such as delusions and hallucinations, which significantly impact daily functioning.
- Conditions
- Schizophrenia, Major Depressive Disorder, Bipolar Disorder
- Trial name
- NCT07051746
- Testing
- Metacognitive Training (MCT), Traditional Chinese version
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- ZI-YU LIN
Schizophrenia, Mood Disorders
Alcohol Use Disorders in Schizophrenia
The purpose of the study is to evaluate a new treatment to help patients who have problems because of their use of alcohol. The treatment is called Behavioral Treatment for Alcohol Abuse in Schizophrenia (BTAAS).We are interested…
- Conditions
- Schizophrenia, Mood Disorders, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT00280813
- Testing
- Supportive Treatment in Addiction Recovery (STAR)
- Where
- 4 sites in United States
- Volunteers
- 54 people
- Sponsor
- University of Maryland, Baltimore
Schizophrenia, Schizoaffective Disorder
Adherence in Patients Admitted to a Psychiatric Unit for Acute Psychosis: an Analysis of Serum Levels of Antipsychotics.
This is a screening study aimed at estimating the frequency of antipsychotic non-compliance in patients with a history of schizophrenia or other psychotic disorder admitted to an inpatient psychiatric unit.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT01786369
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Northwell Health
MDD, Bipolar Disorder
Evaluation of Generalization Paradigm Patterns Among Different Psychiatric Disorders
Learning includes the ability to generalize to new situations and respond to similar, yet not identical stimuli. In previous work, focused on stimulus generalization in healthy volunteers, tones that were negatively reinforced…
- Conditions
- MDD, Bipolar Disorder, Schizophrenia Disorder, Anxiety Disorder (Panic Disorder or GAD)
- Trial name
- NCT01501812
- Testing
- Generalization pattern
- Where
- Israel
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shalvata Mental Health Center
Schizophrenia, Schizo-Affective Disorder
Correlation Between Clinical Deterioration in Schizophrenic Patients and Hair Cortisol Levels
The importance of stress as a possible deteriorating factor for schizophrenic patients is well documented. However, this notion is based on subjective experience and retrospective psychological analysis.
- Trial name
- NCT01754532
- Testing
- Hair Sample
- Where
- Israel
- Volunteers
- 34 people
- Sponsor
- Shalvata Mental Health Center
Schizophrenia
Pharmacodynamic/Pharmacokinetic Study of AQW051 in Schizophrenia
Part 1 of the study will assess the enhancement of task-related brain activation (BOLD response) in key brain areas in schizophrenia during the performance of working memory, episodic memory and visual activation tasks as…
- Trial name
- NCT00825539
- Testing
- AQW051
- Where
- 7 sites in United States
- Volunteers
- 68 people
- Sponsor
- Novartis Pharmaceuticals
Psychotic Disorders, Mood Disorders
A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences
This is a randomized controlled trial testing the efficacy of Resilience Training in college students with elevated transdiagnostic risk for developing a serious mental illness.
- Conditions
- Psychotic Disorders, Mood Disorders, Anxiety Disorders
- Trial name
- NCT06929442
- Testing
- Resilience Training (RT), Life Skills Training (LST)
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Massachusetts General Hospital
Schizophrenia Disorders, Schizo Affective Disorder
SEEG-Guided DBS for Schizophrenia
This is a prospective, randomized, interventional study designed to evaluate the efficacy and safety of SEEG-guided deep brain stimulation (DBS) for symptom improvement in patients with treatment-resistant schizophrenia.
- Trial name
- NCT07671261
- Testing
- SEEG implantation, Deep brain stimulation
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Ruijin Hospital
Schizophrenia, Schizoaffective Disorder
As Study of the Pharmacokinetics of Paliperidone Extended-release and Risperidone Immediate-release Formulations
The purpose of this study is to compare the steady-state pharmacokinetics of paliperidone after oral administration of 15 mg extended-release (ER) OROS paliperidone once daily with the steady-state pharmacokinetics of…
- Trial name
- NCT00796185
- Testing
- Paliperidone ER
- Volunteers
- 62 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Major Depression Moderate, Major Depression Severe
EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT
This study aims to investigate the neurophysiological and inflammatory changes associated with electroconvulsive therapy (ECT) in patients diagnosed with Major Depressive Disorder who are resistant to at least two antidepressant…
- Conditions
- Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression With Panic Attacks
- Trial name
- NCT07748091
- Testing
- Electroconvulsive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Bipolar Disorder, Schizophrenia
Clinical Risk State for Bipolar Disorder in Adolescents
Aim: The purpose of the study is to characterize the at-risk phases preceding a first episode of bipolar disorder and of schizophrenia, and to identify clinical and biological predictors of the disease development.
- Trial name
- NCT01383915
- Where
- United States
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Severe Mental Illness, Depression / Major Depressive Disorder
Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN)
This randomized, rater-blind, multicenter clinical trial will evaluate whether a personalized pharmaco-lifestyle intervention improves mental functioning in adults with severe mental illness, including schizophrenia, bipolar…
- Conditions
- Severe Mental Illness, Depression / Major Depressive Disorder, Bipolar Disorder (BD), Schizophrenia
- Trial name
- LIFETRAIN (NCT07586150)
- Testing
- Semaglutide (SEMA), Exercise module, Anti-inflammatory diet module
- Where
- 5 sites in Austria, Germany and 1 more
- Volunteers
- 140 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Major Depressive Disorder, Bi-Polar Disorder
DELPhI Evaluation of Psychiatric Conditions
DELPhI acquisition and analysis software, a QuantalX Neuroscience development, which is designed to measure, analyze, and display brain electrical activity of human electroencephalogram (EEG), to transcranial magnetic stimulation…
- Conditions
- Major Depressive Disorder, Bi-Polar Disorder, ADHD, Schizophrenia
- Trial name
- NCT03842345
- Sponsor
- QuantalX Neuroscience
Schizophrenia, Schizoaffective Disorder
Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI)
The overall goal of this project is to improve the treatment of alcohol dependence in patients with serious mental illness (SMI).
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Alcohol Dependence
- Trial name
- vivitrol (NCT00453609)
- Testing
- long-lasting injectable naltrexone
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- State University of New York - Upstate Medical University
Schizophrenia, Bipolar Affective Disorder
Quality of Life, Safety and Compliance of Patients Using Monotherapy or Combinatorial Therapy With Quetiapine for Treatment of Schizophrenia or Bipolar Affective Disorder
The goal of this observational study is to evaluate the quality of life, drug safety and therapy compliance of schizophrenia or bipolar affective disorder patients during the treatment with quetiapine monotherapy or in…
- Trial name
- NCT07858565
- Testing
- Quetiapine (drug), quetiapine + aripiprazole, quetiapine + haloperidol
- Where
- Bosnia and Herzegovina
- Volunteers
- 500 people
- Sponsor
- Bosnalijek D.D
Schizophrenia, Bipolar Disorder
IBIS: Italian Burden of Illness on Schizophrenia & Bipolar Disorder
Multicentre, retrospective observational cohort study based on LHU administrative databases aimed to described the pharmacoutilization of antipsychotics in patients affected by schizophrenia and bipolar disorder, the resource…
- Trial name
- IBIS (NCT01392482)
- Where
- 16 sites in Italy
- Volunteers
- 751,725 people
- Sponsor
- AstraZeneca
Psychotic Disorders
A Study Based on the French National Health Insurance Database in Participants With Psychotic Disorders
The primary purpose of the study is to compare therapy with antipsychotic medication (antipsychotic monotherapy or antipsychotic combination) versus no antipsychotic medication, and antipsychotic monotherapy versus antipsychotic…
- Trial name
- NCT05633108
- Testing
- No Intervention
- Where
- United Kingdom
- Volunteers
- 579,728 people
- Sponsor
- Eisai Co., Ltd.