Clinical trials: African Americans
Cardiovascular Diseases, Cognitive Decline
Brain Healthy Soul Food Diet Intervention Among Older African Americans
The primary goal of this project is to evaluate feasibility and acceptability of the MIND+SOUL diet and its implementation. Secondary goals of this project are to evaluate cardiovascular risk profile, nutritional health status…
- Trial name
- MIND+SOUL Diet (NCT05414682)
- Testing
- MIND+SOUL Diet
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Diabetes Mellitus, Type 2
Mechanism Underlying Beta-cell Failure in Obese African Americans With History of Hyperglycemic Crises
Obesity is common in African American (AA) patients with newly diagnosed diabetes who present with diabetic ketoacidosis (DKA). Despite the presentation with severe symptoms of insulinopenia and ketoacidosis, clinical and…
- Trial name
- NCT00753142
- Testing
- Intralipid 20%, Glucose infusion
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Emory University
Cancer
Faith-Based African American Cancer Survivorship Storytelling
The purpose of this research study is to evaluate the feasibility and acceptability of an intervention (viewing of video recordings) designed to reduce psychological distress among African Americans during treatment for cancer.
- Trial name
- NCT03082612
- Testing
- Faith-Based African American Cancer Survivorship Storytelling Intervention
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Emory University
Heart Failure (HF)
A Study of Ivabradine in African-American/ Black Subjects With Heart Failure and Left Ventricular Systolic Dysfunction.
This study is a prospective, open-label, single-arm intervention study in African-American/Black subjects with heart failure and reduced ejection fraction (HFrEF).
- Trial name
- NCT03456856
- Testing
- Ivabradine
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Amgen
Chronic Kidney Disease
Stress and CKD Among African Americans
The goal of this study is to determine whether experiencing stress from discrimination may increase chronic kidney disease (CKD) progression in African Americans.
- Trial name
- NCT03387319
- Testing
- Racialized Stressful Event Recall, Non-Racialized Stressful Event Recall
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Hepatitis C
Alisporivir (Deb025) and Boceprevir Triple Therapies in African American Participants Not Previously Treated for Chronic Hepatitis C Genotype 1
This study will assess the safety and efficacy of alisporivir (ALV) and boceprevir (BOC), each in combination with Peginterferon alfa-2a (PEG) and Ribavirin (RBV), in African American participants who have never received…
- Trial name
- NCT01446250
- Testing
- Alisporivir, Boceprevir, Peginterferon alfa-2a
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Debiopharm International SA
Smoking Cessation
Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers
The researchers are testing if counseling alone or counseling plus over-the-counter nicotine replacement therapies (NRT), like the patch,gum, or lozenge, helps African American non-daily smokers quit smoking.
- Trial name
- NCT02244918
- Testing
- Nicotine Replacement Therapy, Smoking Cessation Counseling
- Where
- 2 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Cognitive Impairment, Mild, Cognitive Decline
Efficacy of a Multimodal Brain Health Intervention for Older African Americans
This study tests the feasibility, acceptability, and efficacy of a multimodal intervention (walking, social engagement, and reminiscence), including the use of wearable digital biomarkers, for cognitively healthy and mildly…
- Trial name
- SHARP (NCT04863378)
- Testing
- Walking conversational reminiscence
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Chronic Kidney Disease, Hypertension
Five, Plus Nuts and Beans for Kidneys
This Five, Plus Nuts and Beans for Kidneys Study is a single center, randomized controlled trial with 2 parallel arms testing the hypothesis that delivery of nutritional advice to adopt a Dietary Approaches to Stop Hypertension…
- Trial name
- NCT03299816
- Testing
- Coaching DASH group (C-DASH), Self-Shopping DASH group (S-DASH)
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Johns Hopkins University
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Docetaxel or Paclitaxel in Reducing Chemotherapy-Induced Peripheral Neuropathy in African American Patients With Stage I-III Breast Cancer
This phase II trial studies how well docetaxel or paclitaxel work in reducing chemotherapy-induced peripheral neuropathy in African American patients with stages I-III breast cancer.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT04001829
- Testing
- Docetaxel, Paclitaxel, Quality-of-Life Assessment
- Where
- 482 sites in United States
- Volunteers
- 249 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
HIV/AIDS
LetSync: Pilot Test of Mobile Health (mHealth) Intervention
The Pilot Test (AKA Study B) will entail a pilot randomized, controlled trial (RCT) of an mHealth behavioral intervention, LetSync, with 80 couples (N=160) to assess its acceptability, feasibility, and preliminary impact on…
- Trial name
- NCT04951544
- Testing
- LetSync app
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Diabetes Mellitus, Type 2
Cognitive Behavioral Therapy for African Americans With Uncontrolled Type-2 Diabetes
The main purpose of the study is to assess the feasibility and acceptability of a Culturally-Tailored Cognitive Behavior intervention (CT-CB) for African American patients with uncontrolled Type 2 diabetes.
- Trial name
- NCT03562767
- Testing
- Group-based Cognitive Behavioral Intervention, Web-based Cognitive Behavioral Intervention, Usual Care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Cancer, Cardiac Disease
A Culturally-Based Palliative Care Tele-consult Program for Rural Southern Elders
Rural patients with life-limiting illness are at very high risk of not receiving appropriate care due to a lack of health professionals, long distances to treatment centers, and limited palliative care (PC) clinical expertise.
- Conditions
- Cancer, Cardiac Disease, Pulmonary Disease, Neuro-Degenerative Disease
- Trial name
- NCT03767517
- Testing
- Active Intervention, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 209 people
- Sponsor
- University of Alabama at Birmingham
Depression
African American Knowledge Optimized for Mindfully Healthy Adolescents
The purpose of this study was to better understand how African American families identify and treat emotional and behavioral concerns associated with depression in their adolescent youth.
- Trial name
- AAKOMA (NCT00578318)
- Testing
- Motivational Interviewing Active
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Georgetown University
Insulin Resistance, Endothelial Dysfunction
CD36 in Nutrient Delivery and Its Dysfunction
This proposal will test the hypothesis that chronic treatment with sildenafil with and without the use of nitric oxide substrate, L-arginine, protects against fatty acid induced impairment of endothelial function, improves…
- Trial name
- NCT03012386
- Testing
- Sildenafil Citrate in G allele carrier, Sildenafil Citrate in non G allele carrier
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Caregiver Burnout
Testing Preliminary Effectiveness of a Community Health Worker (CHW) Training Program on Caregiving
Two arm study, experimental and control, to explore the impact of an online training program to prepare community health workers (CHWs) conduct effective outreach to support African American and Latino male caregivers of older…
- Trial name
- IN-HOME (NCT06049043)
- Testing
- Intervention to Help Orient Men to Excel (IN-HOME), AARP's English "Care at Home" resource webpage
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- KDH Research & Communication
Healthy
Defining Vitamin D Insufficiency in School Age Children: A Randomized Placebo Controlled Trial of Vitamin D3
The study objective is to characterize the threshold levels of serum 25-hydroxyvitamin D for the definition of vitamin D insufficiency in 8-14 year old African American and Caucasian children.
- Trial name
- Vitamin D RCT (NCT00732758)
- Testing
- Vitamin D3 1000 IU
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pregnancy, Child Development
Improving Maternal and Child Health Through Prenatal Fatty Acid Supplementation
The purpose of the study is to test whether nutritional supplementation during pregnancy is associated with 1) improved maternal health during pregnancy; 2) improved infant birth and neurodevelopmental outcomes, and 3) whether…
- Trial name
- NAPS (NCT02647723)
- Testing
- DHA, Sugar pill
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Substance-related Disorders
Women's Treatment and Early Recovery
Approximately 25 million Americans struggle with alcohol or drug problems annually. Abuse of alcohol and drugs is costly to our nation, exacting more than $428 billion in costs related to crime, lost work productivity and health…
- Trial name
- MBRP-W (NCT02977988)
- Testing
- Mindfulness Meditation, Brain and Recovery (B&R)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Southern California
Hypertension
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study
The purpose of this study is to test the effect of oral melatonin supplementation (24 mg per night for 4 weeks) on nighttime blood pressure in African Americans with a history of elevated nighttime blood pressure.
- Trial name
- NCT01114373
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University