Clinical trials: Age, open to volunteers
Polyarticular Course Juvenile Idiopathic Arthritis
Safety, Tolerability, Pharmacokinetics, and Efficacy of Filgotinib for the Treatment of Polyarticular-course Juvenile Idiopathic Arthritis in Children and Adolescents
This is a multicenter Phase 3, open-label, single-arm study to evaluate the safety, tolerability, PK, and efficacy of orally administered filgotinib for up to 18 weeks.
- Trial name
- GALAHOPPER (NCT07554495)
- Testing
- Filgotinib
- Where
- 14 sites in Belgium, Czechia and 7 more
- Volunteers
- 65 people
- Sponsor
- Alfasigma S.p.A.
Pneumonia, Pneumonia in Children
Assessing Role of Probiotics in Children Aged 6-36 Months Treated for Pneumonia
The main questions this study aims to answer are: Does using probiotic nasal spray (LiveSpo Navax containing Bacillus subtilis and Bacillus clausii, 1x10^9 CFU/mL), with or without oral probiotics (LiveSpo Pregmom containing…
- Trial name
- NCT07399717
- Testing
- Navax, Navax-PregMom
- Where
- Vietnam
- Volunteers
- 330 people
- Sponsor
- Anabio R&D
Muscle Architecture, Ultrasonic Diagnosis
Feasibility and Preliminary Effects of a Structured Resistance Training Program in Children Aged 10-14 Years
This study is a randomised controlled pilot trial designed to evaluate the feasibility, safety, and preliminary efficacy of a 12-week resistance training intervention in children aged 10-14 years.
- Trial name
- NCT07512570
- Testing
- Progressive Resistance Training Program
- Where
- Czechia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Aging, Foot Muscle Dysfunction
Effects of Rehabilitative Exergame Training on Foot Muscle Activity, Balance, and Mobility in Older Adults
This study is designed as a randomized controlled trial. A total of 40 healthy older adults residing in private and public nursing homes and rehabilitation centers in Mersin will be enrolled.
- Conditions
- Aging, Foot Muscle Dysfunction, Sarcopenia, Age-Related Muscle Weakness
- Trial name
- EXG-FOOT (NCT07357662)
- Testing
- Exergame-based Balance and Foot Muscle Training, Conventional Functional Balance Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Tarsus University
Retinal Disease, Age-Related Macular Degeneration
Stem Cell Ophthalmology Treatment Study II
This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.
- Conditions
- Retinal Disease, Age-Related Macular Degeneration, Retinitis Pigmentosa, Stargardt Disease
- Trial name
- SCOTS2 (NCT03011541)
- Testing
- Arm 1
- Where
- 4 sites in United States, Austria and 1 more
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Aging, Adverse Drug Interaction
MinMed: Do Older Adults do Better With Less Medication
Many health care providers believe "less-is-more" for older adults, and evidence suggests minimizing certain medications might improve health outcomes.
- Conditions
- Aging, Adverse Drug Interaction, Frailty
- Trial name
- NCT05307666
- Testing
- Medication minimization
- Where
- Canada
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Esophageal Cancer
Chemoradiation Plus Iparomlimab Consolidation in Older With ESCC
This study was conducted in elderly (≥70 years old) patients with locally advanced esophageal squamous cell carcinoma (ESCC). Aim to evaluate the efficacy and safety of Iparomlimab consolidation therapy following concurrent…
- Trial name
- NCT07038629
- Testing
- S1, Iparomlimab, Radiation
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Seizures, Seizures, Focal
Study of the Pharmacokinetics, Safety, and Tolerability of ZONISADE in Children 1 Month to 17 Years of Age With Partial-onset Seizures
The purpose of this research is to determine the optimal dose, safety and tolerability of zonisamide oral suspension in children ages 1 month to 17 years of age who have partial-onset (focal) seizures.
- Conditions
- Seizures, Seizures, Focal, Seizure, Partial Onset, Seizure Disorder, Partial
- Trial name
- NCT06534502
- Testing
- Zonisamide Oral Product
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Azurity Pharmaceuticals
AML, Adult
Assessment of Geriatric Evaluations Impact on New AML Guidance
The goal of the study is to measure physiologic age (there is no current formal definition but is meant to imply that patients should be evaluated holistically rather than on age alone) at baseline in newly diagnosed AML patients…
- Trial name
- AGE-ING (NCT05909501)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Sleep Quality
Magnesium Supplement for Sleep Quality in Women With Poor Sleep
This study will test whether a magnesium supplement (Magnesium Breakthrough) improves sleep quality and mood in women ages 35 to 60 who have poor sleep but no diagnosed sleep disorder.
- Trial name
- NCT07708857
- Testing
- Magnesium Breakthrough
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jacksonville University
Intermediate AMD
A Clinical Trial Evaluating the Safety and Efficacy of a New Light Combination Therapy Addressing Intermediate AMD
The proposed clinical investigation wants primary to validate the safety of the innovative light therapy approach and in second priority provide insight and confirmations on therapeutic effect.
- Trial name
- retinaSEES-PoC (NCT06557369)
- Testing
- reSEES
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Oculox Technologies SA
Assisted Hatching, Advanced Age
The Impact of Assisted Hatching on Pregnancy Outcomes After Vitrified-Warmed Embryo Transfer in Advanced-age Patients
The goal of this clinical trial is to evaluate the effect of laser assisted hatching (LAH) on pregnancy outcomes, with live birth rate as the primary outcome, in advanced age infertile women aged ≥35 years who are undergoing…
- Trial name
- NCT07490561
- Testing
- Laser assisted hatching
- Volunteers
- 916 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Fertility
INtensity of OVarian Stimualtion and Euploid Embryos
This randomized trial was designed as a no-inferiority trial aiming to evaluate if the intensity of stimulation (a milder vs a more intense approach) may have an impact on the number of euploid embryos and the morpho kinetic…
- Trial name
- INOVEE (NCT06154083)
- Testing
- Follitropin-delta (Rekovelle) 20 mcg/day from D1, Follitropin-delta (Rekovelle) 15 mcg/day from D1
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundación Santiago Dexeus Font
Polypoidal Choroidal Vasculopathy (PCV), Age Related Macular Degeneration
Efficacy and Durability of a Personalized Treat-and-extend Regimen of Faricimab for Treatment-naive Polypoidal Choroidal Vasculopathy
To evaluate the Efficacy of a personalized treat-and-extend regimen of faricimab for treatment-naive polypoidal choroidal vasculopathy
- Trial name
- HANGANG (NCT07461441)
- Testing
- Faricimab Injection [Vabysmo]
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yeungnam University College of Medicine
Procedural Pain, Pain-related Fear
Distraction Cards Versus Emotion-Regulation Toy Squeezing During Intramuscular Vaccination in Preschool Children
This single-center, parallel-group, randomized experimental study will compare the effects of two active non-pharmacological interventions - distraction-card use and emotion-regulation toy squeezing - on procedural pain and…
- Trial name
- NCT07669961
- Testing
- Distraction-Card Group, Emotion-Regulation Toy-Squeezing Group
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Mersin University
Pain, Abuse, Drug
Age-dependent Effects of Smoked and Oral Delta-9-THC
This study will assess the age-dependent effects of smoked and oral THC on abuse liability, intoxication, analgesia and impairment as a function of age.
- Conditions
- Pain, Abuse, Drug, Intoxication; Cannabinoids
- Trial name
- SAGE (NCT05865470)
- Testing
- Cannabis, Dronabinol
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Dry Age-related Macular Degeneration, Macular Degeneration, Dry
Observation of the Natural Course of Age-related Macular Degeneration
This research will study natural course of dry AMD in Chinese population, screen fundus imaging indicators for patients with Chinese dry AMD, describe the clinical features of Chinese patients with dry AMD, and obtain a…
- Trial name
- NCT05418231
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Severe Aplastic Anemia, Aplastic Anaemia
A Novel Conditioning Regimen for Haplo-HSCT in Older Patients With SAA
The goal of this prospective, multicenter, single arm observational study is to evaluate the efficacy and safety of the BFCA regimen in ≥ 40 years old SAA patients undergoing haplo-HSCT.
- Conditions
- Severe Aplastic Anemia, Aplastic Anaemia, Hematopoietic Cell Transplant
- Trial name
- NCT07586735
- Testing
- BFCA conditiong regimen
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Peking University People's Hospital
Facail Skin Aging
Facial Exercise and Daily Habit Modification Program for Skin Quality and Wrinkle Severity in Middle-Aged Women
This randomized controlled trial will evaluate the effectiveness of a 12-week program combining facial muscle exercises and daily habit modification for improving skin quality and reducing wrinkle severity in middle-aged women.
- Trial name
- NCT07792460
- Testing
- Facial Exercise and Daily Habit Modification Program
- Where
- Iraq
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- University of Zakho
Acute Otitis Media, AOM - Acute Otitis Media
Amoxicillin-clavulanate Versus Amoxicillin Versus Placebo in Acute Otitis Media in Children
The goal of this trial is to compare amoxicillin to amoxicillin-clavulanate and to placebo in the treatment of acute middle ear infections in small children.
- Trial name
- SAVOtitis (NCT07878910)
- Testing
- Amoxicillin, Amoxicillin + Clavulanate
- Where
- 3 sites in Finland
- Volunteers
- 219 people
- Sponsor
- Kuopio University Hospital
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