Clinical trials: Age 65 and Older
Acute Myeloid Leukemia
ALFA-0703 Study in Older Patients With Acute Myeloblastic Leukemia (AML)
A Randomized Multicenter Phase III Study to Evaluate the Role of All-trans Retinoic Acid (ATRA) in Combination with Induction Chemotherapy, or Azacitidine and Idarubicin as salvage therapy and Idarubicin with Cytarabine or…
- Trial name
- ALFA-0703 (NCT01067274)
- Testing
- Vesanoid (ATRA), AZACITIDINE (VIDAZA), CYTARABINE
- Where
- 26 sites in France
- Sponsor
- Acute Leukemia French Association
Prostate Cancer
Using Walk With Ease Walking Program With Men 65 and Older Being Treated for Prostate Cancer
This study is testing a walking program called Walk with Ease by the Arthritis Foundation with men undergoing treatment for prostate cancer.
- Trial name
- NCT02139774
- Testing
- Walk with Ease
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Low Back Pain
Mindfulness Meditation for Chronic Low Back Pain in Older Adults
Among mind-body therapies, there is evidence for an association between pain reduction and mindfulness meditation. Mindfulness meditation provides a potentially safe, effective, nonpharmacologic, noninvasive, simple method for…
- Trial name
- NCT00494845
- Testing
- Mindfulness, Control: Health Education Class
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Low Back Pain
Effects of Lumbar PENS and Exercise in Older Adults With Chronic Low Back Pain
The purpose of this study is to determine whether a form of electrical acupuncture, called percutaneous electrical nerve stimulation (PENS), can reduce pain and disability in older adults with chronic low back pain (LBP).
- Trial name
- NCT00101387
- Testing
- Lumbar PENS + General Conditioning and Aerobic Exercise, Lumbar PENS, Control Lumbar PENS
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Appetite, Food Intake
Effect of Sumac on Appetite and Food Intake
Sumac, is a spice that is widely used in Turkish, Iranian and Middle Eastern foods. In these regions, the fruit of sumac is used for seasoning or flavouring, as an appetizer and for souring food.
- Trial name
- NCT05534152
- Testing
- sumac
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Breast Cancer
Paclitaxel With or Without Carboplatin in Treating Women With Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if paclitaxel is more effective with or without carboplatin in treating stage IV breast…
- Trial name
- NCT00025688
- Testing
- carboplatin, paclitaxel
- Where
- 25 sites in United States
- Sponsor
- Theradex
Influenza A, Influenza B, Influenza Vaccination
Phase 2/3 Clinical Trial to Evaluate the Immunogenicity and Safety of GC3114B in Adults Aged 65 Years or Older
This is a multicenter, randomized, double-blind, active-controlled, parallel-group clinical trial in adults aged 65 years or older.
- Trial name
- GC3114B (NCT07883928)
- Testing
- vaccination of GC3114B, Vaccination of Efluelda
- Where
- South Korea
- Volunteers
- 1,806 people, healthy volunteers welcome
- Sponsor
- GC Biopharma Corp
Influenza, Influenza Vaccine
Clinical Trial of Quadrivalent Subunit Influenza Vaccine (Adjuvant) in Chinese Population Aged 65 Years and Older
The objective of this study was to evaluate the safety of quadrivalent subunit influenza vaccine (adjuvant) in people aged 65 years and older.
- Trial name
- NCT07421037
- Testing
- Quadrivalent Subunit Influenza Vaccine (Adjuvant), MF59, 0.9% sodium chloride injection (normal saline)
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ab&B Bio-tech Co., Ltd.JS
Breast Cancer, Psychosocial Effects of Cancer and Its Treatment
Chemotherapy Decisions and Outcomes in Older Women With Newly Diagnosed Breast Cancer
RATIONALE: Studying how older women make treatment decisions and how these decisions affect the outcome of treatment may help doctors plan more effective treatments and improve patient quality of life.
- Trial name
- NCT00068328
- Testing
- psychosocial assessment and care, quality-of-life assessment
- Where
- 85 sites in United States
- Volunteers
- 1,706 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Anxiety
Emotion-Focused Mindfulness Therapy: A Feasibility Study for Late Life Anxiety
Canadians 65 and older experience anxiety at a rate of 6.4%, affecting more than 300,000 people. In Ontario, 5.6% of adults 65 and older have anxiety, representing over 100,000 people.
- Trial name
- NCT04415528
- Testing
- Emotion-Focused Mindfulness Therapy
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Stacey Hatch
Influenza
Safety of Synbiotics as Adjuvant to Influenza Vaccine in Elderly
Probiotics are viable commensal microorganisms that promote the establishment of beneficial microflora. Animal and human studies demonstrate that probiotics can enhance body's immune response to stimuli.
- Trial name
- NCT01304771
- Testing
- Synbiotic AKSB
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Anticholinergic Adverse Reaction
Intervention to REduce anticholinerGic burdEN in oldER pATiEnts (REGENERATE) Aged 65 Years and Older
Medications with anticholinergic properties are frequently prescribed for several conditions in older age; for example cardiovascular drugs (e.g. digoxin, furosemide), urologicals (e.g.
- Trial name
- REGENERATE (NCT04660838)
- Testing
- ACB intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Aberdeen
Medication Adherence, Poly Pharmacy
Itaca App vs. Usual Care for Medication Adherence in Older Adults on Polypharmacy
The goal of this clinical trial is to learn if the use of a mobile app called Itaca improves medication adherence in older adults (aged ≥65) in a home care setting.
- Conditions
- Medication Adherence, Poly Pharmacy, Chronic Disease, Older Adults (65 Years and Older)
- Trial name
- NCT07631676
- Testing
- mobile app, Usual Care Group
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Roma La Sapienza
Covid19
COVID-19 Trial of the Candidate Vaccine MVA-SARS-2-S in Adults
In this multi-center phase II clinical trial, adults in stable health conditions will be vaccinated twice with either a low dose or high dose of the candidate vaccine MVA-SARS-2-S, or placebo.
- Trial name
- NCT05950776
- Testing
- MVA-SARS-2-S
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Active Aging Individuals Aged 65 and Over
Reliability and Validity Assessment of the Health-Related Quality of Life Scale Developed for Active Older Adults
INTRODUCTION You are invited to take part in this academic study because you are 65 years or older and live independently in the community.
- Trial name
- NCT07115888
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Marmara University
Visual Impairment, Hearing Loss
Survey of Sensory Impairment Indicators Among Adults Aged 65 Years and Older in Xinxing County
This cross-sectional population-based survey will be conducted among residents aged 65 years and older in Xinxing County, Yunfu, Guangdong Province, China.
- Conditions
- Visual Impairment, Hearing Loss, Dual Sensory Impairment, Cataract
- Trial name
- NCT07694505
- Where
- China
- Volunteers
- 2,854 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Frailty at Older Adults, Primary Care
Implementation of a Clinical Decision Support System in Primary Care for the Screening and Assessment of Frailty in Patients Aged 65 and Over
This observational study aims to evaluate the real-life use of a digital tool (Fragiclic) by general practitioners (GPs) and nurses to screen and assess frailty in adults aged 65 and over.
- Conditions
- Frailty at Older Adults, Primary Care, Geriatric Assessment, Implementation Research
- Trial name
- FRAGICLIC (NCT07570628)
- Where
- France
- Volunteers
- 726 people, healthy volunteers welcome
- Sponsor
- CNGE Conseil
Age 65 and Older, Polypharmacy
Effect of Longitudinal Care in Primary Health Care: An Analysis From the Patient's Perspective
Objective To explore and describe the opinions of Primary Health Care chronically ill users regarding being cared for over time by the same reference professional.
- Conditions
- Age 65 and Older, Polypharmacy, Cronic Lung Disease, Mental Disorder
- Trial name
- CUALIPRIM (NCT07320053)
- Where
- 2 sites in Spain
- Volunteers
- 26 people
- Sponsor
- IBS Granada
Veteran Aged 65 and Older
Promoting Cognitive Resilience and Reducing Frailty in Older Veterans With Bright Light Therapy
Frailty is a multifactorial syndrome characterized by vulnerability to stressors that is intricately linked to cognitive impairment and mortality risk.
- Trial name
- Brite-VET (NCT05631236)
- Testing
- Bright Light Therapy (AYO Glasses)
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Breast Cancer
Surgery With or Without Lymph Node Removal in Treating Older Women With Stage I Breast Cancer
RATIONALE: Surgery to remove axillary lymph nodes may be an effective treatment for women with breast cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of therapy with or without axillary lymph node…
- Trial name
- NCT00002720
- Testing
- tamoxifen citrate, conventional surgery
- Where
- Italy
- Volunteers
- 642 people
- Sponsor
- European Institute of Oncology