Clinical trials: Age 65 and Older
Acute Myeloid Leukemia
ALFA-0703 Study in Older Patients With Acute Myeloblastic Leukemia (AML)
A Randomized Multicenter Phase III Study to Evaluate the Role of All-trans Retinoic Acid (ATRA) in Combination with Induction Chemotherapy, or Azacitidine and Idarubicin as salvage therapy and Idarubicin with Cytarabine or…
- Trial name
- ALFA-0703 (NCT01067274)
- Testing
- Vesanoid (ATRA), AZACITIDINE (VIDAZA), CYTARABINE
- Where
- 26 sites in France
- Sponsor
- Acute Leukemia French Association
Dehydration
Hydration and Outcome in Older Patients
Dehydration is recognised as a major issue in healthcare. Recovery after illness, extended length of stay, pressure sores and slow tissue recovery can all be impacted by dehydration.
- Trial name
- HOOP (NCT01703715)
- Testing
- The Hydrant
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Nottingham
Accidental Falls, Aged
Whole-Body Point-of-Care Ultrasound in Older Adults Presenting to the Emergency Department After a Fall
Falls are one of the most common reasons older adults visit the emergency department. In many older patients, a fall that looks "mechanical" is actually caused by an underlying medical problem such as syncope, heart disease…
- Conditions
- Accidental Falls, Aged, Syncope
- Trial name
- NCT07886164
- Testing
- Whole-body point-of-care ultrasound (POCUS)
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Kocaeli City Hospital
Health Literacy, Middle Aged
Health Literacy-Based Multifactorial Program for Adults With Sarcopenia
Sarcopenia is a common age-related condition characterized by the progressive loss of muscle mass and function, which may lead to reduced physical performance, disability, and poorer quality of life.
- Conditions
- Health Literacy, Middle Aged, Elderly (People Aged 65 or More), Exercise Therapy
- Trial name
- NCT07654478
- Testing
- Multicomponent Intervention
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Hospital
Vaccination Refusal
A RCT Evaluating an Online Intervention in Increasing Pneumococcal Vaccination Among Older Adults
To evaluate the relative efficacy of an online intervention based on the Trans-theoretical Model delivered by a fully-automated Chatbot with natural language processing functions versus a control in promoting pneumococcal…
- Trial name
- NCT05772117
- Testing
- Chatbot-delivered interventions tailored to stage of changes, Chatbot-delivered standard interventions
- Where
- Hong Kong
- Volunteers
- 374 people
- Sponsor
- Chinese University of Hong Kong
Lymphoma
S1106 Rituximab With Combination Chemotherapy or Bendamustine Hydrochloride Followed by Consolidation Chemotherapy and Stem Cell Transplantation in Older Patients With Previously Untreated Mantle Cell Lymphoma
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some find cancer cells and help kill them or carry cancer-killing substances to them.
- Trial name
- NCT01412879
- Testing
- rituximab, bendamustine hydrochloride, cyclophosphamide
- Where
- 204 sites in United States
- Volunteers
- 53 people
- Sponsor
- SWOG Cancer Research Network
Frailty, Sarcopenia
Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery
The goal of this observational study is to learn if simple tests for frailty and muscle strength can help predict which older adults (age 65 and older) are at higher risk for problems after major abdominal surgery.
- Conditions
- Frailty, Sarcopenia, Sarcopenia in Elderly, Muscle Strength
- Trial name
- NCT06988176
- Testing
- Frailty assessment, nutrition assessment, cognition assessment, muscle strength testing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Elderly (People Aged 65 or More), Well Being
The Effects of Virtual Tours on Elderly People Living Alone
This experimental study aimed to determine the effect of virtual museum tours on the psychological well-being and loneliness levels of individuals aged 65 years and older living alone.
- Conditions
- Elderly (People Aged 65 or More), Well Being, Loneliness, Nursing
- Trial name
- NCT07874997
- Testing
- VIRTUAL TOUR
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Merve OZKAN
Nocturia
Comparison Between Desmopressin and Fesoterodine for Treatment of Night Time Voiding in Women Aged 65 and Older
Nocturia, or voiding at night, is an extremely troublesome symptom which is highly prevalent in the elderly. Desmopressin is a treatment for nocturia but it can result in hyponatremia (low blood sodium), particularly in those…
- Trial name
- DEFEND (NCT02262936)
- Testing
- Desmopressin, Fesoterodine
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Mount Sinai Hospital, Canada
PARKINSON DISEASE (Disorder), Aged 65 Years or Older
Multidimensional Assessment of Fatigability in Older Adults Living in Southern Switzerland and Elderly With Parkinson's Disease
With our study, the investigators aim to assess the impact of the fatigue experienced during daily life activities (tiredness) and whether there is a relationship with muscle fatigue during an exercise task.
- Trial name
- LifeLike (NCT07485218)
- Where
- 5 sites in Italy, Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Covid19
A Phase 2 Study of RTB101 as COVID-19 Post-Exposure Prophylaxis in Older Adults
The proposed trial will obtain preliminary data on the feasibility of studying RTB101 as compared to placebo for COVID-19 post-exposure prophylaxis in adults age ≥ 65 years to inform the design of a subsequent pivotal trial.
- Trial name
- NCT04584710
- Testing
- RTB101
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Restorbio Inc.
Cognitive Decline, Aging
Zinde Zihin Program to Reduce Alzheimer's Disease Risk in Adults Aged 65 and Older
This study aims to evaluate the feasibility and implementation of the Zinde Zihin ("Fit Mind") multidomain lifestyle program for older adults aged 65 years and older living in public nursing homes.
- Conditions
- Cognitive Decline, Aging, Alzheimer Disease
- Trial name
- ZZ-MIND (NCT07244848)
- Testing
- Zinde Zihin (Fit Mind) Multidomain Lifestyle Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Burdur Mehmet Akif Ersoy University
Pneumococcal Vaccines, Pneumococcal Conjugate Vaccine
A Phase 3 Trial Evaluating the Safety, Tolerability, and Immunogenicity of a 13-valent Pneumococcal Conjugate Vaccine in Japanese Elderly Adults Aged 65 Years Old and Older
The purpose of this study is to evaluate the safety, tolerability and immunogenicity of a single dose of 13-valent pneumococcal conjugate vaccine compared to a single dose of 23-valent pneumococcal polysaccharide vaccine in…
- Trial name
- NCT01646398
- Testing
- 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine
- Where
- 8 sites in Japan
- Volunteers
- 764 people, healthy volunteers welcome
- Sponsor
- Pfizer
Breast Cancer, Aging
Impact of Physical Activity on Biomarker of Aging and Body Composition Among Breast Cancer Survivors Age 65 and Older
To determine if exercise will affect the increase in p16 expression that is associated with both chemotherapy administration and advancing age.
- Conditions
- Breast Cancer, Aging, Physical Activity
- Trial name
- NCT02328313
- Testing
- Walk with Ease Program
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Frailty Syndrome
The Effectiveness of Training Using Exergaming on Selected Physical and Psychological Parameters in a Population of Patients Over the Age of 65 Belonging to Specific Subgroups of the Frailty Syndrome
This study aims to evaluate the effects of a six-week exergaming-based training program on physical and psychological parameters in individuals aged 65 and older diagnosed with frailty or pre-frailty.
- Trial name
- FREX (NCT07036224)
- Testing
- Exergaming Training using Kinect sensor device
- Where
- Poland
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Influenza
Safety and Immunogenicity of High-Dose Quadrivalent Influenza Vaccine in Participants ≥65 Years in the US
This randomized, modified double-blind, active-controlled, multi-center trial assessed the safety and immunogenicity of the high-dose quadrivalent influenza vaccine (QIV-HD) compared to either the licensed or investigational…
- Trial name
- NCT03282240
- Testing
- QIV-HD, Licensed TIV-HD1, Investigational TIV-HD2
- Where
- 36 sites in United States
- Volunteers
- 2,670 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Physical Activity
Social Goals and Individual Incentives to Promote Walking in Older Adults
The goal of this randomized and controlled trial is to test whether a financial incentive of a donation to achieve a social goal is more effective to motivate and sustain a daily walking habit than the same dollar value given to…
- Trial name
- NCT01643538
- Testing
- Financial incentive, Social Goal, Personal financial incentives & social goals
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Pennsylvania
Psychological Well Being, Psychological Flexibility
Finding With Nature: A Study Testing Nature-Based Support for Family Caregivers Aged 65 and Over
This research project investigates the effects of a nature-based programme (Finding with Nature, FWN), on psychological well-being, functioning, and nature connectedness among older adults (65 and older) who provide care for…
- Conditions
- Psychological Well Being, Psychological Flexibility, Physical Functioning, Burden, Caregiver
- Trial name
- FWN (NCT07821970)
- Testing
- Finding with Nature Programme
- Volunteers
- 350 people
- Sponsor
- JAMK University Of Applied Sciences
Acute Myeloid Leukemia
Treatment of Older Adult Acute Myeloid Leukemia Patients Aged 55 to 65 Years
The purpose of this study is to determine whether the escalation dosage of Daunorubicin and cytarabine is effective and safety in the treatment of older adult Chinese acute myeloid leukemia（AML） patients aged 55 to 65 years.
- Trial name
- NCT02432872
- Testing
- Daunorubicin, Cytarabine
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Jianxiang Wang
Pneumonia, Postoperative Complications
Postoperative Pulmonary Complications in Elderly Patients Undergoing Major Abdominal Surgery
This study aims to identify the risk factors associated with postoperative pulmonary complications (PPCs) in patients aged 65 years and older who undergo major abdominal surgery.
- Trial name
- PPC65MAS (NCT07306897)
- Where
- Turkey (Türkiye)
- Volunteers
- 239 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital