Clinical trials: Age Factor
Geographic Atrophy, Age Related Macular Degeneration
Safety and Efficacy of IONIS-FB-Lrx in up to 120 Patients 55 and Older With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)
The purpose of this study is to assess the Safety and Efficacy of IONIS-FB-Lrx for up to 120 patients with Geographic Atrophy secondary to Age Related Macular Degeneration
- Trial name
- NCT03446144
- Testing
- IONIS-FB-Lrx
- Where
- 37 sites in United States, Australia and 1 more
- Sponsor
- Ionis Pharmaceuticals, Inc.
Age-related Macular Degeneration, Diabetic Macular Edema
Systemic Pharmacokinetics Following Intravitreal Injections of Anti-VEGF
Comparable data for bevacizumab and aflibercept are lacking, as are studies comparing the systemic levels of ranibizumab, bevacizumab, and aflibercept and their relative effects on circulating vascular endothelial growth factor.
- Conditions
- Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- NCT02118831
- Testing
- Blood Sample Collection, Aflibercept, Bevacizumab
- Volunteers
- 56 people
- Sponsor
- California Retina Consultants
Blast Injuries, Brain Injuries
Central Auditory Processing Deficits Associated With Blast Exposure
The current conflicts in Afghanistan and Iraq have resulted in unprecedented rates of exposure to high-intensity blasts and resulting brain injury.
- Conditions
- Blast Injuries, Brain Injuries, Age Factors
- Trial name
- NCT01567020
- Testing
- Diagnostic
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PCOS, Endometriosis
Pomegranate Juice Effect on Oxidative Stress in Infertile Women During IVF Treatment
tTe investigators estimate pomegranate supplementation effect on oxidative stress in infertile women with PCOS, endometriosis and advanced maternal age during IVF treatment.
- Conditions
- PCOS, Endometriosis, Advised Maternal Age, Male Factor Infertility
- Trial name
- NCT03978013
- Testing
- Pomegranate juice, Apple juice
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Wet Macular Degeneration, Age-related Macular Degeneration
Dorzolamide-timolol Drops With Injections to Treat AMD, RVO or DME.
This study seeks to evaluate the effect of topical aqueous suppression on the anatomic and functional response to intravitreal anti-vascular endothelial growth factor (VEGF) injections in non-responders with wet age-related…
- Conditions
- Wet Macular Degeneration, Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- NCT02571972
- Testing
- Dorzolamide-timolol
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Wills Eye
Age-Related Macular Degeneration
Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population
The aim of the study is to show a higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals.
- Trial name
- NCT00533754
- Testing
- drawing blood
- Where
- Austria
- Sponsor
- Rudolf Foundation Clinic
Breast Cancer
Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease
The purpose of this study is to determine the safety and efficacy of PF-07220060 with letrozole compared to approved treatments (ie, palbociclib, ribociclib or abemaciclib with letrozole) in people with breast cancer: HR-positive…
- Trial name
- FourLight-3 (NCT06760637)
- Testing
- PF-07220060, letrozole, abemaciclib
- Where
- 460 sites in United States, Argentina and 28 more
- Volunteers
- 1,035 people
- Sponsor
- Pfizer
Acute Cerebral Ischemia, Endovascular Thrombectomy
The Impact of Age on Short-term Post-thrombectomy Outcomes in Patients Aged 70 or Beyond With Acute Ischemic Stroke
A recent Cochrane systematic review of 18 randomized controlled trials (RCTs) comparing endovascular intervention-either mechanical thrombectomy or intra-arterial thrombolysis combined with medical treatment-to conservative…
- Conditions
- Acute Cerebral Ischemia, Endovascular Thrombectomy, Prognosis, Age Factors
- Trial name
- NCT06953427
- Where
- Taiwan
- Volunteers
- 94 people
- Sponsor
- Kuang Tien General Hospital
ART, IVF
Health in Childhood Following Assisted Reproductive Technology
The purpose of this trial is to investigate the metabolic and cardiovascular health in children aged 6-8 years born after in-vitro fertilization with frozen embryo transfer
- Conditions
- ART, IVF, Cardiovascular Risk Factor, Hypertension
- Trial name
- HiCART (NCT03719703)
- Where
- Denmark
- Volunteers
- 606 people, healthy volunteers welcome
- Sponsor
- Anja Bisgaard Pinborg
Caries,Dental, Caries Root
Coronal and Radicular Caries Prevalence and Related Risk Factor in Diabetic Patient
This study aims to investigate the prevalence and risk factors of coronal and radicular caries in middle-aged individuals with Type 2 diabetes.
- Conditions
- Caries,Dental, Caries Root, Diabetes Mellitus, Type 2
- Trial name
- NCT06701565
- Volunteers
- 265 people
- Sponsor
- Cairo University
Advanced or Metastatic Breast Cancer
A Study to Learn About the Study Medicine Called PF-07220060 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment
The purpose of this study is to learn about the safety and how effective the study medicine (PF-07220060) plus fulvestrant is compared to the study doctor's choice of treatment in people with advanced or metastatic breast cancer.
- Trial name
- NCT06105632
- Testing
- PF-07220060 CDK4 inhibitor, Fulvestrant, Everolimus
- Where
- 48 sites in United States, Argentina and 12 more
- Volunteers
- 333 people
- Sponsor
- Pfizer
Neovascular Age-elated Macular Degeneration (Wet AMD), Exudative Macular Degeneration
Safety and Efficacy of Intravitreal LFG316 in Wet Age Related Macular Degeneration (AMD)
This study will assess the safety and efficacy of LFG316 in patients with age related macular degeneration.
- Trial name
- NCT01535950
- Testing
- LFG316
- Where
- 7 sites in United States
- Volunteers
- 43 people
- Sponsor
- Novartis Pharmaceuticals
Neovascular (Wet) Age-related Macular Degeneration
A Study to Learn How Well Aflibercept Injected Into the Eye Works and How Safe it is When Given in Customized Treatment Intervals in Patients With an Eye Disease Called Neovascular Age-related Macular Degeneration After Start of Treatment
Researchers are looking for a better way to treat people who have neovascular (wet) age-related macular degeneration (nAMD or wet AMD).
- Trial name
- XPAND (NCT05473715)
- Testing
- Aflibercept(BAY86-5321, Eylea)
- Where
- 3 sites in Canada, United Kingdom
- Volunteers
- 3 people
- Sponsor
- Bayer
Macular Degeneration
VEGF-antagonism and Endothelial Function in Age-related Macular Degeneration (AMD)
The objective of this study is to evaluate the effects of 2 intravitreal injections with Ranibizumab or Avastin on endothelial function in subjects with neovascular macular degeneration compared to patients with dry AMD.
- Trial name
- NCT00727753
- Testing
- Ranibizumab, Bevacizumab, No treatment
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- University of Zurich
Wet Macular Degeneration
Connective Tissue Growth Factor in Patients With Neovascular Age Related Macular Degeneration
Age-related macular degeneration (AMD) remains a leading cause of blindness in United States and can be broadly divided into two forms: non-neovascular AMD (NNVAMD) and neovascular AMD (NVAMD) AMD.
- Trial name
- NCT05038371
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Hemophilia B
Study Evaluating rFIX; BeneFIX in Severe Hemophilia B
To characterize the safety and efficacy of rFIX in children less than 6 years of age with severe hemophilia B in the setting of acute bleeding episodes, prophylaxis, and/or surgery.
- Trial name
- NCT00037557
- Testing
- BeneFIX
- Where
- 6 sites in United States
- Volunteers
- 20 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Arterial or Venous Thrombosis
Study Regarding the Incidence of Anti-platelet Factor 4-antibodies in Patients Aged 18 to 60 Years With Spontaneous or Infection- or Vaccine-associated or Recurrent Venous and/or Arterial Thrombosis
Prospective investigation of the incidence of anti-platelet factor 4 antibodies in suspected immune-associated arterial and/or venous thrombosis
- Trial name
- NCT06650826
- Testing
- Determination of anti-platelet factor 4 antibodies in the blood
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Cardioangiologisches Centrum Bethanien
Beta-lactamase Extended Spectrum, E. Coli, Elderly, Mortality, Risk Factor
The Association Between Advancing Age and Mortality at 30 Days in Patients With Bacteremia E. Coli Beta-lactamase Phenotype Extended Spectrum RC15_0421
In the US and Europe, bacteremia are ranked the 7th leading cause of death from all causes. E. coli is one of the main microorganism involved, responsible for 30% to 45% of bacteremia. In Europe, bacteremia E.
- Trial name
- MoBaCo (NCT02847065)
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Nantes University Hospital
Age-Related Macular Degeneration
The Role of Loteprednol in Reducing Post-Intravitreal Injection Related Pain
Patients are already receiving an intravitreal injection as a standard of care, but they are consenting to receiving a loteprednol drop following the intravitreal injection.
- Trial name
- NCT05542381
- Testing
- Loteprednol Etabonate Ophthalmic Gel [Lotemax], Refresh Lubricant Eye Drops [Artificial Tears]
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Virginia Polytechnic Institute and State University
Reproductive Health, Time to Pregnancy
Reproductive Health of Couples of Childbearing Age: a Community Based Prospective Cohort Study
This community based prospective cohort study was established to investigate the fecundability of couples of childbearing age. Data are collected regarding age, body mass index, education, menstrual regularity as well as…
- Conditions
- Reproductive Health, Time to Pregnancy, Infertility, Risk Factor
- Trial name
- ReH-CP (NCT04068428)
- Where
- 4 sites in China
- Volunteers
- 2,313 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center