Clinical trials: Age Related Cognitive Decline
Age-related Cognitive Decline
A Group Study on the Effects of a Short Multi-Domain Cognitive Training in Healthy Elderly Italian People
Alongside physiological cognitive ageing, nowadays there is an alarming increase in the incidence of dementia that requires communities to invest in its prevention.
- Trial name
- NCT03771131
- Testing
- Multi-domain cognitive training
- Where
- Italy
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Memory, Cognitive Function
Effect of Daily Mixed Spice Consumption on Memory Function
The aging process entails a multitude of structural and functional alterations within the brain, culminating in a gradual and progressive decline in cognitive function.
- Trial name
- NCT06889961
- Testing
- Mixed spices
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cognitive Decline
Study of Postoperative Cognitive Decline in Aged Patients
postoperative cognitive decline is a common and deleterious complication in aged patients.The link between inflammation and postoperative cognitive decline has also been reported.However,the link between SOD1，SOD2，Osteopontin，…
- Trial name
- NCT03765840
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Jia-feng Wang
Age-Related Cognitive Decline, Age-Related Memory Disorders
Memory Improvement With Docosahexaenoic Acid Study (MIDAS)
The purpose of this study is to investigate the effect of docosahexaenoic acid (DHA, 22:6n-3) in improving cognitive functions in subjects with age-related cognitive decline.
- Trial name
- MIDAS (NCT00278135)
- Where
- 14 sites in United States
- Volunteers
- 485 people
- Sponsor
- dsm-firmenich Switzerland AG
Mild Cognitive Impairment (MCI), Memory Disorders, Age Related
Music for the Mind Study
The goal of this pilot clinical trial is to learn if older adults with mild cognitive impairment (MCI) find two music programs equally acceptable.
- Conditions
- Mild Cognitive Impairment (MCI), Memory Disorders, Age Related, Memory Decline
- Trial name
- M4M (NCT06866327)
- Testing
- Piano lessons, Music Lessons
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Rochester
Cognitive Decline, Age-Related Memory Disorders
Prehabilitation Exercise Plus Perioperative Optimization of Senior Health
The purpose of this study is the examine the feasibility of and estimate the efficacy of a preoperative exercise (i.e. prehabilitation) program in 40 up to sedentary older adults (i.e.
- Conditions
- Cognitive Decline, Age-Related Memory Disorders, Postoperative Complications, Age-Related Atrophy
- Trial name
- NCT03291795
- Testing
- Exercise Intervention
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Duke University
Frail Elderly Subjects
Omega-3 Fatty Acids and/or Multi-domain Intervention in the Prevention of Age-related Cognitive Decline
Epidemiological and fundamental research carried out in recent years has highlighted the role played by omega-3 fatty acids in the process of cognitive decline that accompanies advancing age and Alzheimer's disease.
- Trial name
- MAPT (NCT00672685)
- Testing
- omega-3, multi-domain intervention
- Where
- 13 sites in France, Monaco
- Volunteers
- 1,680 people
- Sponsor
- University Hospital, Toulouse
LONGEVITY 1, Frailty
Longevity in Russia
This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia.
- Conditions
- LONGEVITY 1, Frailty, Aging, Age-related Cognitive Decline
- Trial name
- NCT06268132
- Where
- Russia
- Volunteers
- 4,000 people
- Sponsor
- Center for Strategic Planning, of the Federal Medical and Biological Agency
Age-Related Cognitive Decline
EMBRACE - From Vulnerable to Empowered: Implementation and Evaluation of a Multicomponent Program to Tackling Age-related Decline
EMBRACE is a randomized, controlled, multi-domain, blinded clinical trial involving 120 community-dwelling older adults at risk of cognitive decline, lasting 12 months.
- Trial name
- EMBRACE (NCT07628686)
- Testing
- EMBRACE Intervention
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Fernando Pessoa
Age-related Cognitive Decline
Train the Brain With Music: Brain Plasticity and Cognitive Benefits Induced by Musical Practice in Elderly People
This longitudinal study aims to countervail age-related cognitive and cerebral decline in healthy retired people through intensive piano / keyboard music practice in Switzerland and Germany.
- Trial name
- TBM (NCT03674931)
- Testing
- musical practice, music education
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Complications of Prematurity
Prematurity Related Risks of Cognitive Impairment at School Age
The main purpose of this study is to better evaluate prematurely born children cognitive development at school age, with regards to birth conditions but also to social situation, intra family relationships, and modalities of…
- Trial name
- NEORIS (NCT02054507)
- Testing
- Cognitive evaluation (Wechsler IV tests)
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jean Michel Hascoet
Age-related Cognitive Decline
Effect of Transcranial NIR Light Upon Memory
A double-blind placebo-controlled study evaluating the effect of 1068nm NIR trans-cranial phototherapy upon the cognitive function of healthy individuals between the age of 45 years and 80 years.
- Trial name
- NCT04568057
- Testing
- NIR Transcranial phototherapy device
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Maculume Ltd.
Dementia of the Alzheimer Type, Age-related Cognitive Decline
Dosage and Efficacy of Probucol-induced apoE to Negate Cognitive Deterioration
DEPEND is an open-label but dosage-masked trial of the retired cholesterol-lowering drug probucol as an agent to increase availability of apolipoprotein E (apoE) in the cerebrospinal fluid (CSF) of cognitively intact older…
- Conditions
- Dementia of the Alzheimer Type, Age-related Cognitive Decline, Mild Cognitive Impairment Due to Alzheimer Disease
- Trial name
- DEPEND (NCT02707458)
- Testing
- Probucol
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Age-Related Memory Disorders
A Safety and Efficacy Study of Ispronicline (TC-1734-112) in Subjects With Age Associated Memory Impairment (AAMI)
The purpose of this Phase II study is to evaluate the efficacy and safety of ispronicline (TC-1734-112) compared to placebo (inactive substance pill) in patients with age associated memory impairment (AAMI).
- Trial name
- NCT00109564
- Testing
- ispronicline (nicotinic acetylcholine receptor agonist)
- Where
- 15 sites in United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Targacept Inc.
Cognitive Impairment, Mild Cognitive Impairment
ArtontheBrain: An Inclusive Evidence-based Cognitive Health App for Older Adults to Promote Aging at Home
The research proposed here will evaluate whether a web-based recreation intervention, called ArtontheBrain, has positive health benefits to older adult users.
- Conditions
- Cognitive Impairment, Mild Cognitive Impairment, Dementia, Age-related Cognitive Decline
- Trial name
- NCT03551483
- Testing
- ArtontheBrain, Seniors Online Victoria
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Baycrest
Aging, Age-related Cognitive Decline
Acute Raspberry Intake on Metabolic Control and Cognitive Function
The purpose of this project is to determine whether restoring the post-prandial metabolic/inflammatory balance via supplementation with raspberries results in improved cognitive performance, and if these enhancements are mediated…
- Conditions
- Aging, Age-related Cognitive Decline, Obesity
- Trial name
- NCT03743792
- Testing
- Active breakfast, Control breakfast
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- USDA Human Nutrition Research Center on Aging
Memory Impairment, Age-related Cognitive Decline
Development of an Innovative Health Ingredient From Marine By-products for the Healthy Aging
This interventional, randomised, placebo-controlled and double-blind study aims to evaluate the effect of a dietary supplementation with a blue fish hydrolysate derived from marine by-products, containing peptides and n-3…
- Trial name
- BRAINBOOSTER (NCT04910399)
- Testing
- Blue fish hydrolysate
- Where
- 2 sites in France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Abyss Ingredients
Atherosclerosis, Vascular Disease
The Effect of Folic Acid on Atherosclerosis, Cognitive Performance and Hearing
The purpose of this study is to determine if folic acid supplementation can slow down atherosclerotic progression, age-related cognitive decline and age-related hearing loss.
- Conditions
- Atherosclerosis, Vascular Disease, Cognitive Decline, Hearing Loss
- Trial name
- NCT00110604
- Testing
- folic acid (0.8 mg)
- Where
- Netherlands
- Volunteers
- 835 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Age-related Hearing Loss
Prediction of Age-Related Hearing Loss Based on Comprehensive Risk Factors
This study aims to develop a predictive model for age-related hearing loss (ARHL) based on multi-source risk factors and artificial intelligence techniques.
- Trial name
- NCT07612618
- Testing
- Not applicable- observational study
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Cardiovascular Risk Factors, Age-Related Cognitive Decline
Effects of Tart Cherry Juice on the Body
Tart cherries are a rich source of antioxidants. Studies have shown that tart cherries exert anti-oxidative and anti-inflammatory properties.
- Trial name
- NCT02922920
- Testing
- Tart cherry juice
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Delaware