Clinical trials: Age Related Maculopathy
Wet Age-related Macular Degeneration
Structured Post-marketing Surveillance to Collect the Safety Data of Intravitreal Aflibercept Injection (IVT-AFL) in Patients of Wet Age-related Macular Degeneration During Real World Clinical Practice
The proposed regulatory post-marketing surveillance (PMS) study will be planned to collect the safety data of aflibercept intravitreal injection in patients with wet Age-related Macular Degeneration (AMD) in real-life treatment…
- Trial name
- NCT03290794
- Testing
- Aflibercept (Eylea, BAY86-5321)
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Bayer
Age-related Macular Degeneration, Choroidal Neovascularization
Imaging of the Angiofibrotic Switch in Neovascular AMD
The content of this research project is to identify the angiofibrotic switch, the transition from angiogenesis to fibrosis, in neovascular age-related macular degeneration (nAMD) longitudinally.
- Trial name
- NCT03838679
- Testing
- Best-corrected Visual acuity testing (BCVA), Optical coherence tomography (OCT), Color fundus photography (CFP)
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Dry Age Related Macular Degeneration.
Safety Study in Retinal Transplantation for Dry Age Related Macular Degeneration.
The long-term goal is to show that retinal transplantation can help to prevent blindness and to restore eyesight in patients with dry age related macular degeneration.
- Trial name
- NCT00346060
- Testing
- Retinal transplantation instrument, Fetal tissue.
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Radtke, Norman D., M.D.
AMD - Age-Related Macular Degeneration
The Impact of Artificial Lighting on the Visual Capacity of Patients With Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in the elderly worldwide. The dry, non-exudative form of the disease, although more common, is associated with gradual and significant…
- Trial name
- ADLs AMD (NCT07060196)
- Testing
- Distant Visual Acuity, Optical Coherence Tomography, Optical Coherence Tomography Angiography
- Where
- Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Geographic Atrophy
A Phase 1/2 Study of the Safety and Efficacy of BRX011 Oral Administration Once Daily in Subjects With Geographic Atrophy Secondary to Age-Related Macular Degeneration
This study aims to evaluate the safety and efficacy of BRX011, an oral medication, taken once daily by participants with geographic atrophy secondary to age-related macular degeneration.
- Trial name
- BELLAVISTA (NCT07029945)
- Testing
- BRX011
- Where
- 17 sites in United States, Australia
- Volunteers
- 152 people
- Sponsor
- Biojiva LLC
Pigment Epithelial Detachment
Aflibercept in Patients With Pigment Epithelial Detachments (PED)
Uncontrolled single site non randomized non interventional study to determine the safety and efficacy of intravitreal injections of Aflibercept in patients with recent vision loss due to retinal pigment epithelial detachment…
- Trial name
- NCT03370380
- Testing
- Aflibercept
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- University Hospital Muenster
Non-exudative Age-related Macular Degeneration
Non-exudative Age-related Macular Degeneration
Age-related macular degeneration (AMD) is the most prevalent cause of vision loss in developed countries and is often discussed in terms of the "dry" and the "wet" forms.
- Trial name
- NEAMD (NCT01712841)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Age-Related Macular Degeneration, Choroidal Neovascularization
20089 TA+Lucentis Combo Intravitreal Injections for Treatment of Neovascular Age-related Macular Degeneration (AMD)
The primary purpose of this study is to assess the safety \& tolerability of an investigational drug 20089 TA (6.9 mg or 13.8 mg) when used adjunctively with Lucentis 0.5 mg in subjects with sub-foveal neovascular AMD.
- Trial name
- 20089/Combo (NCT01175395)
- Testing
- IBI-20089/Lucentis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Illinois Chicago
Age-Related Macular Degeneration, Retinal Vein Occlusion
Resistance to Antibiotics in Patients Receiving Eye Injections
The administration of short courses of topical antibiotic drops before and/or after intravitreal injections is a common practice, but increasing evidence suggests this may not lower the risk of infectious endophthalmitis and…
- Conditions
- Age-Related Macular Degeneration, Retinal Vein Occlusion, Diabetic Retinopathy
- Trial name
- NCT02126423
- Testing
- Conjunctival and nasopharyngeal swabs
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Prism Vision Group
AMD - Age-Related Macular Degeneration, Anxiety
Visual Rehabilitation and Depression in Visually Impaired Patients With AMD
Purpose: The aim of this study is to evaluate the impact of visual rehabilitation in visually impaired patients with advanced AMD by the use of questionnaires on the anxiety and depression status.
- Conditions
- AMD - Age-Related Macular Degeneration, Anxiety, Depression Disorders
- Trial name
- RET 06-24 (NCT06906003)
- Testing
- visual rehabilitation program
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Age-related Macular Degeneration, Neovascular Age-related Macular Degeneration
A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD)
This research study will examine the safety and effectiveness of ONS-5010 in participants with AMD. The goal is to prevent vision loss by evaluating the effectiveness of ONS-5010 as compared with ranibizumab.
- Conditions
- Age-related Macular Degeneration, Neovascular Age-related Macular Degeneration, Wet Macular Degeneration
- Trial name
- NCT03844074
- Testing
- bevacizumab, ranibizumab
- Where
- 9 sites in Australia
- Volunteers
- 61 people
- Sponsor
- Outlook Therapeutics, Inc.
Age-Related Macular Degeneration
A Clinical Trial to Explore Safety and Efficacy of Different Doses of Pegaptanib Sodium, Compared to Sham, in Patients With Wet AMD.
The purpose of this study is to compare the ability of different doses of pegaptanib sodium to safely and effectively minimize fluid leakage within the eye, thereby stabilizing or impriving vision in patients with wet AMD when…
- Trial name
- NCT00321997
- Testing
- Pegaptanib sodium
- Volunteers
- 540 people
- Sponsor
- Eyetech Pharmaceuticals
Age-Related Macular Degeneration, Geographic Atrophy
The Natural History of Geographic Atrophy Progression (GAP) Study
The objective of the 18-month trial is to evaluate the natural history of geographic atrophy by assessing the rate of progression of the geographic atrophic lesion over time.
- Trial name
- NCT00599846
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Alcon Research
Age-Related Macular Degeneration (AMD)
Phase 1 Study of Topical Ocular PAN-90806 for Neovascular AMD
The objective of this study is to assess the safety and tolerability of topical ocular PAN-90806 in patients with active, subfoveal choroidal neovascularization associated with neovascular Age-Related Macular Degeneration (AMD).
- Trial name
- NCT02022540
- Testing
- PAN-90806 Ophthalmic Solution, Lucentis
- Where
- 22 sites in United States
- Volunteers
- 50 people
- Sponsor
- PanOptica, Inc.
Age-Related Macular Degeneration
Epidemiological Study of the Prevalence of Age-Related Macular Degeneration in Portugal
This is an epidemiological study to assess the the prevalence of Age-Related Macular (ARM) Degeneration in Portugal.
- Trial name
- NCT01298674
- Where
- 2 sites in Portugal
- Volunteers
- 6,023 people, healthy volunteers welcome
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
A Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study)
The FaReal study aims to evaluate the effectiveness, safety, clinical insights and treatment patterns in patients treated with faricimab, in neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) in…
- Trial name
- NCT06680817
- Testing
- Faricimab
- Where
- 59 sites in Austria, Bulgaria and 13 more
- Volunteers
- 875 people
- Sponsor
- Hoffmann-La Roche
Neovascular Age-related Macular Degeneration
Evaluation the Pharmacokinetics, Safety, Tolerability of TK001 in Patients With Neovascular Age-related Macular Degeneration
The purpose of this first-in-human study is to evaluate the safety, pharmacokinetics and tolerability of single ascending doses of TK001(Recombinant humanized anti-VEGF monoclonal antibody) to determine the maximum tolerated dose…
- Trial name
- NCT02613559
- Testing
- TK001
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Jiangsu T-Mab Biopharma Co.,Ltd
Reticular Pseudodrusen (RPD), Age-Related Macular Degeneration
Vitamin A Palmitate Supplementation in Patients With Reticular Pseudodrusen (RPD) and Delayed Dark Adaptation
Background: Age-related macular degeneration (AMD) is an eye disease. It is the leading cause of vision loss in people over 55 in the U.S. Changes in the eye can make it difficult for they eye to adjust to low light.
- Trial name
- NCT03478878
- Testing
- Vitamin A Palmitate
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- National Eye Institute (NEI)
Cataract, Macular Degeneration
S0000B: Vitamin E and/or Selenium in Preventing Cataract and Age-Related Macular Degeneration in Men on SELECT SWOG-S0000
RATIONALE: Aging may affect a person's vision. Vitamin E and/or selenium may help prevent cataracts or age-related macular degeneration in men receiving these drugs as part of a clinical trial for the prevention of prostate…
- Trial name
- SEE (NCT00784225)
- Testing
- selenium, vitamin E
- Where
- United States
- Volunteers
- 13,475 people, healthy volunteers welcome
- Sponsor
- SWOG Cancer Research Network
Age - Related Macular Degeneration (AMD), Diabetic Macular Edema
Wide Field OCTA in Ocular Diseases
The main retinal diseases, whether or not associated with specific mutations genetic, cause progressive degeneration of vascular retinal structures and not vascular, resulting in decreased visual function.
- Conditions
- Age - Related Macular Degeneration (AMD), Diabetic Macular Edema, Diabetic Retinopathy, Myopia
- Trial name
- WOOD-2025 (NCT07298174)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
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