Clinical trials: Aged Skin
Age-related Skin Changes
Evaluation of Age-related Skin Changes and Instrument Reliability Using Clinical Probe Measurements and Imaging Modalities
To evaluate the reliability of different non-invasive skin probe measurements.
- Trial name
- NCT04552249
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Allergan
Breast Cancer, Elderly
Caelyx Adjuvant in Elderly Breast Cancer
This is an open label Phase II study in elderly patients (65y or older) with early breast cancer who are candidate for adjuvant chemotherapy.
- Trial name
- NCT00284336
- Testing
- Caelyx, endoxan
- Where
- 2 sites in Belgium
- Volunteers
- 16 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Postherpetic Neuralgia, Healthy Age/Gender Matched Volunteers
Evaluation of Five Selected Markers in Skin Biopsies of Patients With Postherpetic Neuralgia and Healthy Controls
Postherpetic Neuralgia is a painful nerve condition that can occur when nerve fibers are damaged following an outbreak of shingles.
- Trial name
- STTR (NCT01379716)
- Testing
- skin biopsy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Photoaging
Investigating Age Dependence of Fibroblast and Extracellular Matrix Responses to Cross-linked Hyaluronic Acid Filler in Human Skin
The purpose of the study is to investigate the impact of the injection of dermal filler on the quality of the skin dermal extracellular matrix in persons between the ages of 30-50 years.
- Trial name
- NCT06195605
- Testing
- Restylane-L, Vehicle
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Chlorhexidine Allergy, Infection
Pilot Study: Safety of Chlorhexidine (CHG) Baths in Patients Less Than 2 Months of Age
Literature provides overwhelming evidence supporting the use of chlorhexidine gluconate (CHG) a rapid onset, broad spectrum, topical antiseptic for reducing healthcare-associated infections (HAIs).
- Conditions
- Chlorhexidine Allergy, Infection, Rash
- Trial name
- NCT02326467
- Testing
- Chlorhexidine gluconate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Celeste Chandonnet
Skin Aging on Face, Skin Care Dermocosmetics
Efficacy of Topical Niacinamide Riboside on the Signs of Facial Skin Aging
Niacinamide riboside (topical NR, also known as nicotinamide riboside) is an endogenous compound and a precursor (building block) to the essential cellular co-enzyme, nicotinamide adenine dinucleotide (NAD+).
- Conditions
- Skin Aging on Face, Skin Care Dermocosmetics, Skin Care, Fine Lines and Wrinkles
- Trial name
- NR-RADIANCE (NCT07774000)
- Testing
- Topical niacinamide riboside
- Where
- South Africa
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- ChromaDex, Inc.
Skin Infections, Bacterial
Pharmacokinetics of Retapamulin in Pediatric Subjects With Uncomplicated Skin Infections.
A study to evaluate the pharmacokinetics of Retapamulin Ointment, 1%, in pediatric subjects (2-24 months) with secondarily-infected traumatic lesions, secondarily-infected dermatoses, or impetigo (bullous and non-bullous).
- Trial name
- NCT00555061
- Testing
- Retapamulin Ointment, 1%
- Where
- 25 sites in United States, Argentina and 7 more
- Volunteers
- 60 people
- Sponsor
- GlaxoSmithKline
Skin Aging of Face and Hands, Facial Wrinkles - Rough Texture - Hyperpigmentation
DMAE Oleate for Facial Skin Firmness and Fine Lines in Healthy Adults
This single-arm, cosmetic study will evaluate the efficacy of topical DMAE Oleate on facial skin firmness and lines/wrinkles in healthy adults.
- Conditions
- Skin Aging of Face and Hands, Facial Wrinkles - Rough Texture - Hyperpigmentation, Skin Laxity
- Trial name
- NCT07255560
- Testing
- Topical DMAE Oleate
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bionos Biotech S.L.
Skin Ageing
Skin Mitochondrial Protection by R0090948A Active
The study intends to evaluate the skin longevity through mitochondria protection efficacy of cosmetic products after 3 months of product application, under UV exposures or not, followed by skin biopsies.
- Trial name
- NCT07853027
- Testing
- Skin biopsy
- Volunteers
- 13 people
- Sponsor
- L'Oreal
Ovarian Cancer, Breast Cancer
Comprehensive Outcomes for After Cancer Health
This study intends to explore feasibility, acceptability, and outcomes related to the use of a digital health coaching intervention for individuals who have completed primary therapy for cancer.
- Conditions
- Ovarian Cancer, Breast Cancer, Lung Cancer, Gastric Cancer
- Trial name
- COACH (NCT05349227)
- Testing
- Digital Health Coaching Program, Fitbit
- Where
- 7 sites in United States
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- Pack Health
Moderate to Severe Chronic Plaque-type Psoriasis
Study to Assess the Long-term Safety, Tolerability, Efficacy of Secukinumab in Pediatric Patients of Age 6 to <18 Years, With Moderate to Severe Plaque Psoriasis
This was an open-label, parallel-group, two-arm, multicenter study in pediatric subjects aged 6 years to less than 18 years, at randomization, with moderate to severe chronic plaque psoriasis.
- Trial name
- NCT03668613
- Testing
- secukinumab low dose, secukinumab high dose
- Where
- 23 sites in United States, Belgium and 7 more
- Volunteers
- 84 people
- Sponsor
- Novartis Pharmaceuticals
Primary Immune Thrombocytopenia
Efficacy and Safety of TPO Receptor Agonists in the Treatment of Elderly ITP Patients
Elderly ITP patients have many underlying diseases, hormone contraindications and many adverse reactions during the use of hormones. TPO-RAs are oral small-molecule non-peptide drugs.
- Trial name
- NCT05311930
- Testing
- 2.5mg/d Hetrombopag
- Volunteers
- 69 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Healthy, Wound Healing
Effects of Topical SLPI on Skin Wounds
This study will evaluate the effects of a protein called secretory leukocyte protease inhibitor (SLPI), on skin wound healing. Produced naturally by the body, SLPI modifies levels of elastase, a substance that breaks down the…
- Trial name
- NCT00005569
- Testing
- SLPI (Secretory Leukocyte Protease Inhibitor)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Condylomata Acuminata
Immunogenicity Study of the Recombinant Human Papillomavirus Virus Type 6/11 Bivalent Vaccine
This phase Ⅱ clinical study was designed to evaluate the immunogenicity and safety of the novel recombinant HPV type 6/11 bivalent vaccine, manufactured by Xiamen Innovax Biotech CO., LTD., in healthy volunteers aged 18-55 years…
- Trial name
- NCT02710851
- Testing
- low dosage HPV Vaccine(1:1), low dosage HPV Vaccine(1:2), high dosage HPV Vaccine(1:1)
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Jun Zhang
SARS CoV-2, Kawasaki Disease
Genome Analysis of Human Endogenous Retroviruses (HERVs)(COVID19)
Human Endogenous Retroviruses (HERVs) are ancient sequences that became integrated into our DNA during evolutionary processes. The significance of their presence in DNA is still being studied, but HERVs appear to be involved in…
- Conditions
- SARS CoV-2, Kawasaki Disease, Retrovirus Infection
- Trial name
- HERV_COVID (NCT06775457)
- Testing
- sample collection
- Where
- 5 sites in Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Radiation Tolerance, Skin Aging
Skin Safety Profile of Different Exposure to the Light Emitting Diode (LED) in Healthy Subjects
Photomodulation is a process which manipulates or regulates cell activity using light sources without thermal effect. Different studies have investigated the use of non-thermal low dose light emitting diode (LED) array for…
- Conditions
- Radiation Tolerance, Skin Aging, Rhytids
- Trial name
- NCT00818311
- Testing
- LED GentleWaves®
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- L'Oreal
Breast Cancer Female
Prospective Research for Elderly (≥65 Years Old) Early Breast Cancer Patients
The elderly patients over 65 years old with breast cancer have concomitant diseases, poor tolerance to conventional treatment, and the specific prognosis of breast cancer is relatively good.
- Trial name
- EEBC (NCT05680194)
- Testing
- operation, Bisphosphonate
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking Union Medical College Hospital
Hair Care, Hair Loss
Olistic_2025 for Hair Loss, Hair Growth, and Skin Improvement
The goal of this randomized, double-blind, placebo-controlled clinical trial is to find out whether daily oral intake of the nutraceutical Olistic Next Women can reduce hair loss, improve hair growth and quality, and improve…
- Conditions
- Hair Care, Hair Loss, Female Pattern Hair Loss
- Trial name
- NCT07300813
- Testing
- Olistic Next Women
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bionos Biotech S.L.
Lichen Simplex Chronicus
A Study to Investigate Improvement in Pruritus of Lichen Simplex Chronicus With Dupilumab Injections Compared With Placebo in Male and Female Participants Aged at Least 18 Years (STYLE 2)
This is a parallel, Phase 3, 2-arm study for treatment. The purpose of this study is to measure improvement in pruritus with dupilumab subcutaneous injections compared with placebo injections in male and female participants aged…
- Trial name
- NCT06687980
- Testing
- Dupilumab
- Where
- 63 sites in United States, Argentina and 15 more
- Volunteers
- 138 people
- Sponsor
- Sanofi
Skin Aging, Purpura
Topical Vitamin A Versus Vehicle Cream in the Treatment of Aged Skin
The objectives of this study are to evaluate the safety and efficacy of 0.5% retinol (Vitamin A) versus it's vehicle cream in the treatment and prevention of skin aging and Bateman's Purpura (bruising).
- Trial name
- NCT00272610
- Testing
- 0.4% Retinol Cream
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan