Clinical trials: Aged Skin
Skin Aging, Wrinkles in Decolletage
PIEZO-101 First-in-Human Safety and Proof-of-Concept Study
The aim of this first-in-human clinical study is to explore the safety, tolerability, pharmacodynamics, and exploratory efficacy of PIEZO-101, an investigational plasmid DNA biostimulator that aims to restore expression of key…
- Conditions
- Skin Aging, Wrinkles in Decolletage, Wrinkles in Left Knee, Left Knee Skin Laxity
- Trial name
- NCT07671027
- Testing
- PIEZO-101, Piezopen, Sterile Saline (0.9% NaCl)
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Piezo Therapeutics, Inc.
Atopic Dermatitis
Efficacy and Safety Study of MSRD-100 in Subjects With Atopic Dermatitis >=3 Months of Age and Older
This is a double-blind, randomized, vehicle-controlled, multi-center, parallel group Phase 3 study of MSRD-100 in the treatment of atopic dermatitis in subjects aged 3 months and up.
- Trial name
- MSRD-100 (NCT02677610)
- Testing
- MSRD-100, Vehicle
- Sponsor
- Merz North America, Inc.
Bladder Cancer, Breast Cancer
Exercise in Improving Mobility and Reducing Fatigue and/or Weakness in Older Cancer Survivors
RATIONALE: Exercise may help improve mobility and relieve fatigue and/or weakness in cancer survivors. It is not yet known whether exercise is more effective than standard therapy in improving mobility and reducing fatigue and/or…
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Esophageal Cancer
- Trial name
- NCT00335491
- Testing
- exercise intervention, complementary or alternative medicine procedure, fatigue assessment and management
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Utah
Photodamaged Skin
A Study to Assess the Effects of an Oral Dietary Supplement on Overall Facial Appearance Among Healthy Adult Women With Existing Skin Damage From Sun Exposure
The study hypothesis is that Imedeen will show effects on skin health, when compared to placebo over a 6 month intervention period with respect to changes in skin appearance, skin density, moisture, and in fine lines and wrinkles.
- Trial name
- NCT01787461
- Testing
- Imedeen
- Where
- 4 sites in United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Pfizer
Breast Cancer
Surgery With or Without Lymph Node Removal in Treating Older Women With Stage I Breast Cancer
RATIONALE: Surgery to remove axillary lymph nodes may be an effective treatment for women with breast cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of therapy with or without axillary lymph node…
- Trial name
- NCT00002720
- Testing
- tamoxifen citrate, conventional surgery
- Where
- Italy
- Volunteers
- 642 people
- Sponsor
- European Institute of Oncology
Pian, Fear
The Effects of Using an Interactive Game With Virtual Reality for Children During Intravenous Placement
To develop the intervention strategies of hospitalized school-age children with IV placement, using interactive virtual reality(VR)as a guiding play and emotional catharsis play, to further examine the effectiveness of reducing…
- Trial name
- NCT04558086
- Testing
- Virtual reality, Photo book
- Where
- Taiwan
- Volunteers
- 134 people
- Sponsor
- National Yang Ming Chiao Tung University
Pre-cancerous Geriatric Skin
Effect of Dermal Rejuvenation on the UVB Response of Geriatric Skin
The objective of this study is to examine the ability of dermal rejuvenation therapies to protect geriatric skin from ultraviolet light (UVB)-induced carcinogenesis.
- Trial name
- Laser Genesis (NCT02090894)
- Testing
- UV Light (Laser Genesis)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Indiana University
Acne
Safety of the Acne mRNA Vaccine in Adolescents 12 to 17 Years of Age With Moderate to Severe Acne
The purpose of this study is to assess the safety profile of intramuscular injections of the Acne mRNA vaccine at 3 dose levels compared with placebo in 12 to 17 years old participants with moderate to severe acne.
- Trial name
- NCT07756957
- Testing
- Acne mRNA (messenger ribonucleic acid) vaccine
- Volunteers
- 410 people
- Sponsor
- Sanofi
Skin Diseases, Infectious
Safety and Efficacy Study of Daptomycin in Pediatric Participants (1 to 17 Years-old) With Skin and Skin Structure Infections
This is a multi-center, evaluator-blinded, randomized, comparative study designed to assess the safety, efficacy, and pharmacokinetics (PK) of daptomycin in pediatric subjects ages 1 to 17 years, inclusive, with complicated skin…
- Trial name
- NCT00711802
- Testing
- Daptomycin, Standard of Care (SOC)
- Where
- 30 sites in United States, India and 1 more
- Volunteers
- 396 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Cancer, Breast, Age-related Cognitive Decline
Older Breast Cancer Patients: Risk for Cognitive Decline
The goal of this study is to evaluate the impact of systemic therapy on cognition in older breast cancer patients, explore change in APE, LM and Cognition domains, measure associations between cognitive decline and QOL, and…
- Conditions
- Cancer, Breast, Age-related Cognitive Decline, Cognitive Decline
- Trial name
- TLC (NCT03451383)
- Where
- United States
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Georgetown University
LMA, Pressure Injury
The Influence of Standardized Process Management of Laryngeal Mask Airway Placement Based on Pressure Monitoring on the Incidence of Adverse Reactions in Elderly Patients During the Perioperative Period
The laryngeal mask airway (LMA) is a supraglottic ventilation device designed according to human anatomy. It was developed in 1981 by Dr.
- Conditions
- LMA, Pressure Injury, Elderly, Airway Management
- Trial name
- NCT06954857
- Testing
- Cuff pressure monitor
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Xuanqi Yang
Breast Cancer
Evaluation the Diagnostic Ability of the Cancer Detection Technology (CDT) to Detect Breast Cancer Among Women Population Over Age 40
This study aimed to validate the diagnostic ability of the CDT (cancer detection technology) software to detect breast cancer among women population.
- Trial name
- NCT01043055
- Where
- Israel
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Breast Carcinoma
Partial Breast Versus Whole Breast Irradiation in Elderly Women Operated on for Early Breast Cancer
The purpose of this trial is to investigate the difference in late radiation morbidity between partial breast irradiation and whole breast irradiation given to women operated on with breast conservation surgery for early breast…
- Trial name
- NCT00892814
- Testing
- Partial breast irradiation, Whole breast irradiation
- Where
- Denmark
- Volunteers
- 882 people
- Sponsor
- Danish Breast Cancer Cooperative Group
Skin Aging, Reproductive Aging
Multidimensional Correlation Study on Skin Aging in Menopausal Women
Primary Objective: This study primarily aims to compare skin aging characteristics between women at different stages of reproductive aging in both sun-exposed and non-exposed areas, based on skin indicators collected during a…
- Conditions
- Skin Aging, Reproductive Aging, Menopause, Genetic Factors
- Trial name
- NCT07390305
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- ChinaNorm
Lung Cancer, Gastro-intestinal Cancer
The SOAR Study: a Study of Geriatric Assessment and Exercise for Older Adults and Their Support Person
Phase 2 randomized controlled study using a waitlist control group. The study also has a single arm pre-post test 12-week chair-based exercise arm for those who have received the geriatric assessment in the older adults with…
- Conditions
- Lung Cancer, Gastro-intestinal Cancer, Genito-Urinary Cancer, Breast Cancer
- Trial name
- SOAR (NCT05509751)
- Testing
- GAM, exercise, health education, online chair-based exercise combined with health education
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Martine Puts
T-Cell Dysfunction, Chemotherapy Effect
Studying the Senescent T Cell Features and Its Relationship with the Chemotherapy Efficacy in Young TNBC
The goal of this observational study is to learn about the features of senescent T lymphocytes induced by chemotherapy and its relationship with the efficacy of neoadjuvant chemotherapy in young triple-negative breast cancer…
- Conditions
- T-Cell Dysfunction, Chemotherapy Effect, Adverse Events
- Trial name
- STFREiYTNBC (NCT06684054)
- Testing
- docetaxel, anthracycline, cyclophosphamide
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Breast Cancer, Colorectal Cancer
A Study of Mental Health Care in People With Cancer
The purpose of this study is to look at mental health services for adults with depressed mood who were diagnosed with cancer at the age of 65 or older.
- Conditions
- Breast Cancer, Colorectal Cancer, Lung Cancer, Prostate Cancer
- Trial name
- NCT06037954
- Testing
- Questionnaires, Interviews, 30-minute telephone or videoconference sessions
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Growth Hormone Deficiency
Use of miRNAs in Growth Hormone Deficiency (GHD)
This study aims at improving knowledge about the diagnosis of growth hormone deficiency (GHD) and treatment with growth hormone (GH), with the goal of providing information on the presence of new biomarkers, such as miRNAs, for…
- Trial name
- GH-miRNA2 (NCT06455956)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University of Parma
SGA, Turner Syndrome
A Research Study Looking at How Safe Somapacitan is and How Well it Works in Children Who Need Help to Grow - REAL 9
The purpose of this study is to find out if somapacitan is safe and how well somapacitan works in children either born small for gestational age or with Turner syndrome, Noonan syndrome or idiopathic short stature.
- Conditions
- SGA, Turner Syndrome, Noonan Syndrome, ISS
- Trial name
- REAL 9 (NCT05723835)
- Testing
- Somapacitan
- Where
- 18 sites in United States, Malaysia and 4 more
- Volunteers
- 47 people
- Sponsor
- Novo Nordisk A/S
Incontinence
Impact on Elderly Skin Due to Wet Pad Application.
The clinical study aims to measure the changes in the stratum corneum on older healthy participants due to the application of a wet pad on the forearm.
- Trial name
- NCT06248255
- Testing
- Pads
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Essity Hygiene and Health AB