Clinical trials: Ageing
Aging, Wrinkle
Restylane Refyne for Correction of Horizontal Neck Rhytides
Subjects with grades ranging from 1---3 on the Transverse Neck Line Scale, will be randomized to receive up to 1cc of Restylane Refyne on one side of their neck utilizing a cannula and up to 1cc of Restylane Refyne on the other…
- Conditions
- Aging, Wrinkle, Rhytides
- Trial name
- NCT04162496
- Testing
- Restylane Refyne
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Siperstein Dermatology
Aging, Cognitive Aging
Impact of Music Improvisation Training on Cognitive Function in Older Adults
This project will develop and test the effects and mechanisms of a music improvisation training intervention on self-regulation of older adults with and without MCI.
- Conditions
- Aging, Cognitive Aging, Cognitive Impairment, Cognitive Training
- Trial name
- NCT05980286
- Testing
- Piano Improvisation, Music Listening
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Aging, Hyperthermia
Aging and Gastrointestinal Barrier Function
The purpose of this study is to assess the gastrointestinal responses of the elderly and younger populations during hyperthermia.
- Trial name
- NCT05816551
- Testing
- Hyperthermia Trial, Control Trial
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
PreDiabetes, Aging
A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes
The goal of this pilot and feasibility study is to investigate the effects of a short course of metformin therapy on a surrogate marker of cellular senescence and autophagy among adult patients with prediabetes.
- Trial name
- NCT03309007
- Testing
- Metformin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of New Mexico
Aging, Osteoporosis
Determinants of Vitamin K Metabolism
The purpose of this study is to learn how the body responds to different amounts of vitamin K in the diet in order to understand the roles that vitamin K may have in the body.
- Trial name
- NCT00336232
- Testing
- Vitamin K
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Tufts University
Aging
Nutraceutical Effects on Long-Term Memory
Interventions to improve the cognitive health of older adults are of critical importance. In the current protocol, ithe investigators conducted a short-term (two months) randomized clinical trial to examine the influence of the…
- Trial name
- NCT01963767
- Testing
- NT-020
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Physical Disability, Cognitive Impairment
Improving Aging in Place in Subsidized Housing
This pilot study will evaluate the feasibility and preliminary effectiveness of an adapted version of the Function Focused Care intervention, delivered by telephone, for improving aging in place for older adults living in…
- Conditions
- Physical Disability, Cognitive Impairment, Physical Activity
- Trial name
- NCT04212442
- Testing
- Independent Living Program for Affordable Housing.
- Where
- 13 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Aging
Subjects' Satisfaction on Pan Facial Aesthetic Enhancement After Treatment With Azzalure® and the Restylane® Range
The aim of this study is to assess subjects' satisfaction linked to the pan facial management of rejuvenation with injections of Azzalure® and Restylane® fillers. This will be an open, multi-centre study.
- Trial name
- FIRST (NCT01529203)
- Testing
- Botulinum Toxin Type A (Azzalure), Restylane ranges
- Where
- 5 sites in France, Spain and 1 more
- Volunteers
- 60 people
- Sponsor
- Galderma R&D
Fatigue, Aging
Mechanisms to Reduce Mental and Physical Fatigue Following Exercise Training in Older Adults
Fatigue is a strong predictor of negative health outcomes in older adults. The research in this study will compared the effects of 8-weeks of branched chain amino acids (BCAAs: dietary supplements commonly taken to improve muscle…
- Trial name
- BCAA (NCT05484661)
- Testing
- BCAA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Symptomatic Menopause, Cognitive Impairments
Attention & Memory Impairments in Menopausal Women
The purpose of this study is to determine whether a medication called Vyvanse® (lisdexamfetamine; LDX) has an impact on cognitive functioning, specifically measures of sustained attention, verbal encoding and recall and working…
- Trial name
- NCT01324024
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Anemia, Unexplained Anemia (UAE)
Trial To Evaluate the Efficacy of Intravenous Iron in Older Adults With Unexplained Anemia
The purpose of this study is to determine whether treatment of unexplained anemia in older adults with a short course of weekly intravenous iron infusions can improve physical activity and therefore quality of life.
- Trial name
- NCT01309659
- Testing
- iron sucrose
- Where
- 5 sites in United States
- Volunteers
- 19 people
- Sponsor
- Duke University
Alzheimer Disease, Dementia
Brain Safe: Consumer Intervention to Reduce Exposure to Drugs Linked to Alzheimer's Disease
This study is an RCT to evaluate the effectiveness of Brain Safe on reducing anticholinergic exposure. Over 42 months, the trial will enroll 700 community-dwelling older adults who were prescribed one or more strong…
- Trial name
- NCT04121858
- Testing
- Brain Safe App, Attention Control App
- Where
- 2 sites in United States
- Volunteers
- 706 people
- Sponsor
- Indiana University
Depression
Aging Brain Changes, Executive Dysfunction and Depression
The purpose of this study is to look at the relationship between age related structural brain changes and changes in depressive symptoms,disability and several aspects of cognitive functioning following treatment with…
- Trial name
- FA (NCT00918684)
- Testing
- Escitalopram
- Volunteers
- 116 people
- Sponsor
- Weill Medical College of Cornell University
Mild Cognitive Impairment (MCI), Depression
Brain Aging and Treatment Response in Geriatric Depression
The proposed project will evaluate the role of neuroimaging biomarkers of brain aging (i.e., neurodegenerative and vascular brain changes) and mild cognitive impairment in the patterns of treatment response to memantine combined…
- Trial name
- NCT01902004
- Testing
- Escitalopram, Memantine
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of California, Los Angeles
Healthy Aging, Alzheimer Disease
Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease
The overall goal is to characterize the acute exercise response as it relates to brain glucose metabolism in aging and Alzheimer's Disease (AD).
- Trial name
- AEROBIC (NCT04299308)
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Aging, Physical Activity
Smart Television and Exercise Promotion for Independent Living Facilities
Physical activity (PA) has physical, emotional, and cognitive benefits for seniors (e.g., increased strength and balance, reduced frailty, fewer falls, improved brain function, lower mortality risk), yet many seniors have limited…
- Trial name
- STEP4Life (NCT03001778)
- Testing
- Usability Testing
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Klein Buendel, Inc.
Depression
Using Peer Mentors to Deliver Depression Care
Can peer mentors be integrated into depression care to older adults with mental health professional supervision? We will assess whether peer mentors who are lay persons who are in recovery from depression can provide depression…
- Trial name
- NCT02261818
- Testing
- Meetings with peer mentors
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Smoking Cessation
Motivating Change in Aging Smokers
The purpose of this research is to evaluate messages that motivate older smokers to make quit attempts using evidence based smoking treatments (EBSTs).
- Trial name
- NCT05194917
- Testing
- Older Smoker Motivational Intervention, Control Motivational Message
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Low Back Pain
EMPOWER: Empowering the Management of Pain-Obesity-Weight Through Enhanced Reward
The central objective of research is to examine the feasibility and acceptability of an 8-month single-arm behavioral intervention (i.e., EMPOWER) among overweight/obese middle-aged and older adults with moderate-to-high impact…
- Trial name
- NCT04851587
- Testing
- In-Person (or Remote) Intervention
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Florida
Poor Quality Sleep
Efficacy & Safety of Eszopiclone (Lunesta) in Nursing Home Patients
The purpose of this study is to examine the effects of the sleep aid Lunesta (Eszopiclone), on older adults who reside in a nursing home and have poor sleep as determined by wrist actigraphy.
- Trial name
- NCT00460993
- Testing
- Lunesta
- Volunteers
- 71 people
- Sponsor
- Emory University