Clinical trials: Ageing
Mild Cognitive Impairment
Improve New Learning and Memory in Individuals With Mild Cognitive Impairment
The current study is a double-blind, placebo-control randomized clinical trial examining the efficacy of memory retraining in individuals with Mild Cognitive Impairment (MCI).
- Trial name
- NCT05396248
- Testing
- Memory Retraining Exercises
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Kessler Foundation
Aging, Inflammation
Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation
This study focuses on whether high cardiorespiratory fitness in older adults has a protective effect on the vascular response to acute inflammation in comparison to low-fit older and young adults.
- Trial name
- NCT03889158
- Testing
- Typhoid Vaccine, Ascorbic Acid
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Disuse Atrophy, Aging
Immobilization and Protein Supplementation (IM-PRO)
In the present study, the effects of 5 days of lower limb immobilization with or without twice-daily protein supplementation on muscle mass and muscle fiber characteristics will be determined.
- Trial name
- IM-PRO (NCT01588808)
- Testing
- Immobilization
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Mitochondrial Function, Physical Function
Resveratrol to Enhance Vitality and Vigor in Elders
Resveratrol, a compound found in red wine and dark-skinned grapes, will improve the function of mitochondria (energy producing components) within the leg muscles of moderate functioning older adults.
- Trial name
- REVIVE (NCT02123121)
- Testing
- Resveratrol 1000 mg/day, Resveratrol 1500 mg/day, Vegetable cellulose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Florida
Volunteers
Effects of Mode of Contraction on Neuromuscular Fatigue
Aging is associated with multiple deteriorations of the neuromuscular system. Given the increase in life expectancy, the investigators can now distinguish old adults (>60 years old) who conserve their neuromuscular capacities…
- Trial name
- DYN-AGING (NCT04516538)
- Testing
- Mini Mental State Examination, 6 Minutes Walk Test, Timed up and go
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Fall, Gait, Unsteady
The Brain Stimulation and Physical Therapy Study
This pilot work will determine the feasibility of tDCS intervention as an effective adjunct intervention to PT aimed at improving gait, balance, and mobility in older adults at risk of falling.
- Conditions
- Fall, Gait, Unsteady, Aging, Accidental Fall
- Trial name
- NCT04181658
- Testing
- Real tDCS and Physical Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Hebrew SeniorLife
Bipolar Disorder (BD), Depression - Major Depressive Disorder
Epigenetic Enhancement of Cognitive Training in Aging Mood and Schizophrenia Spectrum Disorder Populations
The aim of this clinical trial is to investigate the effects of a three-week virtual reality-based cognitive remediation training (VR-CRT) programme in combination with daily intake of a histone deacetylase inhibitor (HDACi)…
- Conditions
- Bipolar Disorder (BD), Depression - Major Depressive Disorder, Cognitive Impairment, Schizophrenia Disorders
- Trial name
- EPIC (NCT07404085)
- Testing
- Virtual Reality-based cognitive remediation therapy (VR-CRT), Virtual Reality-based control treatment (VR-CT), HDACi butyrate
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Rehabilitation, Aging Problems
Plantar Fasciitis Management on Postural Control
Foot pain is common in the general population. Plantar fasciopathy may affect 7% of the population at some time in their lives, but the incidence increases with age.
- Conditions
- Rehabilitation, Aging Problems, Foot Diseases, Mobility Limitation
- Trial name
- NCT06172517
- Testing
- Orthosis intervention
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Université du Québec à Chicoutimi
Aging, Face; Atrophy
Fractional Laser Drug Delivery of a Local Anesthetic
The purpose of this study is to assess the clinical efficacy of fractional CO2 laser-assisted delivery of a topically applied anesthetic to the perceived pain during filler injection.
- Trial name
- NCT05734248
- Testing
- Facial filler injection
- Where
- 2 sites in Greece
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ioannina
Hyperparathyroidism, Parathyroid
Parathyroidectomy and Mobility Study
This study evaluates whether surgical removal of the parathyroid gland (parathyroidectomy) improves physical function and mobility in older adults with primary hyperparathyroidism (PHPT).
- Conditions
- Hyperparathyroidism, Parathyroid, Mobility
- Trial name
- NCT07103876
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Florida
Aging, Aphasia
Exercise Effects on Word Learning
The aging Veteran population will substantially increase over the next 10 years, as the 24.9% of Veterans who are currently between 55-64 years of age join the 38.5% who are already over age 65.
- Trial name
- NCT03370471
- Testing
- Retrieval Practice + Moderate Intensity Exercise, Retrieval Practice + Gentle Stretching, Study Only + Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Parkinson's Disease (PD), Alzheimer's Disease (AD)
Quantification of Hsp90 in the Human Brain
This study tests the radiolabeled molecule ("tracer"), [¹¹C]HSP990, using positron emission tomography (PET) imaging to assess whether it can be used to measure levels of Heat Shock Protein 90 (Hsp90).
- Conditions
- Parkinson's Disease (PD), Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS)
- Trial name
- NCT07380204
- Testing
- [11C]HSP990 PET dosimetry, [11C]HSP990 PET test-retest, [11C]HSP990 simplified scan protocol
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cognitive Disorders, Muscular Disorders, Atrophic
Dietary Strategy to Tackle Cognitive and Locomotor Abilities in Early Elderly Subjects
Polyphenols, precisely resveratrol, with red wine as the most substantial source, was associated with improvements in cognitive function.
- Trial name
- WinAging (NCT06871384)
- Testing
- Nonalcoholic red wine group (Intervention group), Drinking water group (Control group)
- Where
- 3 sites in Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Aging
A Person-centred and Thriving Promoting Care Model for Residential Aged Care
The overall aim of this study is to evaluate the effects, meaning and significance of a person-centred and thriving promoting model for residential aged care in Australia, Norway and Sweden.
- Trial name
- NCT02714452
- Testing
- Person-centred care
- Where
- Sweden
- Volunteers
- 865 people, healthy volunteers welcome
- Sponsor
- Umeå University
Healthy, Aging
Adipose Tissue Blood Flow in Aging Humans
The goal of this basic science clinical trial is to understand whether adipose tissue blood flow changes between younger and older healthy adults.
- Trial name
- NCT06096532
- Testing
- 75 gm oral glucose load
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Memory Disorders, Alzheimer's Disease
Amyloid Plaque and Tangle Imaging in Aging and Dementia
Amyloid senile plaques (SPs) and neurofibrillary tangles (NFTs) are neuropathological hallmarks of Alzheimer's disease (AD) that also accumulate in key brain regions in association with normal aging.
- Trial name
- NCT00355498
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Acquired Brain Injury, Subarachnoid Hemorrhage
Cohort Study on the Effects of Aging in Acquired Brain Injury Patients
A prospective cohort study (questionnaires), with an embedded case control study (neuropsychological assessments) in which the data is gathered within a timeframe of 3 years.
- Conditions
- Acquired Brain Injury, Subarachnoid Hemorrhage, Traumatic Brain Injury, Cerebrovascular Accident
- Trial name
- BRAINReADAPT (NCT05499806)
- Where
- 2 sites in Netherlands
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Aging
Mind-body Interventions for Healthy Aging
The goal of this study is to examine the impact of mind-body interventions in enhancing behavioral and neural correlates of attentional control in older adults.
- Trial name
- HealthyAgers (NCT03626532)
- Testing
- Mindfulness-Based Stress Reduction (MBSR), Lifestyle Education (LifeEd)
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Hormone Deficiency, Aging
Three Month Treatment of Growth Hormone Releasing Hormone (GHRH) in the Elderly
The purpose of the study is to evaluate the effect of a naturally occurring hormone, called Growth Hormone Releasing Hormone (GHRH) on the muscle, bone, and fat tissues of the body.
- Trial name
- NCT01410799
- Testing
- Growth Hormone Releasing Hormone (GHRH )
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Frailty, Sarcopenia
Effect of a Multicomponent Therapeutic Exercise Program in Primary Care on Frailty and Sarcopenia in Older Adults
Background: Frailty and sarcopenia are common conditions in older adults that increase the risk of disability, dependence, and hospitalizations.
- Conditions
- Frailty, Sarcopenia, Aging, Exercises Therapy
- Trial name
- FRACTEP-65 (NCT07132632)
- Testing
- 12-week multicomponent therapeutic exercise program including supervised and home-based sessions focused on strength, balance, mobility, and aerobic capacity
- Volunteers
- 60 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina