Clinical trials: Aggressive Behaviour
Conduct Disorder, Aggression
Long-Term Lithium Treatment for Aggressive Conduct Disorder
This study will examine the long-term effects of lithium used to treat children and adolescents with aggressive conduct disorder (severe aggression).
- Trial name
- NCT00000385
- Testing
- Lithium
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Drexel University
Impulsive Aggression Comorbid With ADHD
Phase I Study to Assess the Absorption, Metabolism, and Excretion of [14C] Labeled SPN-810M
An Open-Label, Single-Dose, Mass-Balance Study to Assess the Absorption, Metabolism, and Excretion of Radio Labeled SPN-810M in Healthy Adult Male Volunteers
- Trial name
- NCT02023606
- Testing
- SPN-810M
- Where
- United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Supernus Pharmaceuticals, Inc.
Aggressive Periodontitis
Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis
clinical parameters and IL-17 and Il-18 GCF levels were measured in 25 aggressive periodontitis patients compared to 25 periodontally healthy individuals.
- Trial name
- NCT05297084
- Testing
- non surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Emotional Regulation, Alcohol Drinking in College
Just-in-Time Coping Prompts for Reactive Digital Behavior in College Students
This study looks at the moments when college students feel a strong emotional swing, and how those moments relate to reacting online when upset, drinking alcohol, and eating in response to emotions.
- Conditions
- Emotional Regulation, Alcohol Drinking in College, Emotional Eating, Aggression
- Trial name
- REACT (NCT07789314)
- Testing
- Momentary coping prompt, Active control message
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Florida
Breast Cancer
Detection of Aggressive Breast Tumors Using Tc-99m-NC100692
The purpose of this study is to compare two types of radioactive drugs to see if they provide the same or different information about any disease that may be present in the participants breast.
- Trial name
- NCT00888589
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Michael O'Connor
Aggression, Anger
Group CBT for Aggression in Veterans
Posttraumatic stress disorder (PTSD) robustly predicts anger and aggression, and U.S. Iraq/Afghanistan-era combat Veterans report that treatment for anger and aggression is among their top priorities.
- Conditions
- Aggression, Anger, Posttraumatic Stress Disorder
- Trial name
- CBT-A (NCT02233517)
- Testing
- Cognitive Behavioral Therapy, Present Centered Therapy
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- VA Office of Research and Development
Malaria, Seizures
Aggressive Antipyretics for Fever Reduction in CNS Malaria
The study will examine whether prophylactic and scheduled treatment with acetaminophen and ibuprofen can decrease the maximum temperature experienced during the acute illness in children with CNS malaria.
- Conditions
- Malaria, Seizures, Coma, Parasitemia
- Trial name
- NCT03399318
- Testing
- Acetaminophen, Ibuprofen
- Where
- 3 sites in Malawi, Zambia
- Volunteers
- 256 people
- Sponsor
- University of Rochester
Pituitary Adenomas, Prolactinomas
Targeted Therapy With Lapatinib in Patients With Recurrent Pituitary Tumors Resistant to Standard Therapy
This study focuses on new therapies for a challenging disease in pituitary medicine, that of aggressive pituitary tumors which have limited therapeutic options beyond standard surgical, radiotherapy, and select medical therapies…
- Trial name
- NCT00939523
- Testing
- Lapatinib
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Cedars-Sinai Medical Center
Workplace Stress
Violence in ICU: Outcomes, Lessons, and Experiences of ICU Team (The VIOLENT-Study)
This study aims to investigate the perceptions, experiences, and responses of healthcare professionals working in intensive care units in Switzerland concerning patient violence.
- Trial name
- NCT06921083
- Where
- Switzerland
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Lymphoma, Large B-Cell, Diffuse, Follicular Lymphoma Grade 3B
Relmacabtagene Autoleucel As Second-Line Therapy in Adult Patients with Aggressive B-cell NHL
The primary objective of this study is to asess the efficacy of Relmacabtagene autoleucel as second-line therapy in adult patients with aggressive B-cell Non-Hodgkins Lymphoma who are ineligible for haematopoietic stem cell…
- Conditions
- Lymphoma, Large B-Cell, Diffuse, Follicular Lymphoma Grade 3B, High-grade B-cell Lymphoma, Mediastinal B-Cell Diffuse Large Cell Lymphoma
- Trial name
- NCT06093841
- Testing
- Relmacabtagene Autoleucel, Fludarabine, Cyclophosphamide
- Where
- 13 sites in China
- Volunteers
- 46 people
- Sponsor
- Shanghai Ming Ju Biotechnology Co., Ltd.
Non-Hodgkin Lymphoma, DLBCL
A Safety Study of SGN-CD19B in Patients With B-cell Non-Hodgkin Lymphoma
The study will examine the safety profile of SGN-CD19B administered as a single agent. The main purpose of the study is to estimate the highest dose that does not cause unacceptable side effects of SGN-CD19B in patients with…
- Conditions
- Non-Hodgkin Lymphoma, DLBCL, Diffuse Large B-cell Lymphoma, Grade 3 Follicular Lymphoma
- Trial name
- NCT02702141
- Testing
- SGN-CD19B
- Where
- 16 sites in United States
- Volunteers
- 44 people
- Sponsor
- Seagen Inc.
Intrabony Periodontal Defect
Perforated Collagen Membrane With Nanohydroxyapatite for Intrabony Defects
The ultimate goal of periodontal therapy is the regeneration of periodontal tissues which have been destroyed due to periodontal disease.
- Trial name
- NCT03399279
- Testing
- Open flap debridment, Perforated collagen membrane, Occlusive membrane
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hepatocellular Carcinoma
Pathological Results of Aggressive Hepatocellular Carcinomas Treated Using SIRT
The aim of our study is to analyze pathological analysis of surgically treated aggressive hepatocellular carcinomas after radio-embolization.
- Trial name
- PAHCHS (NCT05045573)
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Montpellier
Lymphoma, B-Cell
Improving the Outcome of High-risk Aggressive B-cell Lymphoma Patients With Nivolumab Maintenance Therapy
This trial is designed as a unicenter, single arm phase II trial. The aim of the trial is to test whether prognosis of high-risk Aggressive B cell Lymphoma (ABCL) patients who are in complete remission (CR) post…
- Trial name
- NivoM (NCT03569696)
- Testing
- nivolumab
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Meirav Kedmi MD
High Grade B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements
Study of Zanubrutinib, Rituximab and Combination Chemotherapy in Newly-diagnosed Aggressive B-cell Non-Hodgkin Lymphoma
Non-Hodgkin lymphoma (NHL), with high aggressiveness and mortality, is one of the top ten high-incidence tumors in the world and is among the ten most prevalent cancers worldwide with the fastest growing incidence.
- Conditions
- High Grade B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements, Diffuse Large B Cell Lymphoma, B-cell Non Hodgkin Lymphoma
- Trial name
- NCT05164770
- Testing
- Zanubrutinib+R-CHOP; Zanubrutinib+R-DA-EPOCH; Zanubrutinib+R-HD MTX, R-CHOP; R-DA-EPOCH; R-HD MTX
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shandong Provincial Hospital
Generalized Aggressive Periodontitis
Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families.
Generalized aggressive periodontitis (GAP) is an inflammatory disease that causes the severe and rapid destruction of periodontal tissue.
- Trial name
- NCT03642353
- Testing
- Triclosan
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Child Behavior Problem, Disruptive Behavior
Pilot Study of Cognitive Behavior Therapy With Role-plays in Virtual Reality for Children With Behavior Problems
The main aim of this small pilot trial is to evaluate preliminary effects and feasibility of the child intervention YourSkills for child disruptive behavior (e.g., enhanced anger or aggressive behavior) when evaluated in Sweden…
- Conditions
- Child Behavior Problem, Disruptive Behavior, Oppositional Defiant Disorder, Conduct Problems
- Trial name
- NCT06559800
- Testing
- YourSkills: Cognitive behavioral therapy for children/youth with role-plays in virtual reality
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Karolinska Institutet
Lymphoma
Combination Chemotherapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. It is not yet known which regimen of combination chemotherapy is most effective for non-Hodgkin's lymphoma.
- Trial name
- NCT00005867
- Testing
- bleomycin sulfate, CHOP regimen, cyclophosphamide
- Where
- 46 sites in United Kingdom
- Volunteers
- 310 people
- Sponsor
- Lymphoma Trials Office
Mental Disorders
Effects of a Psychiatric Intensive Care Unit
The purpose of the study is to compare the effects of using or not using a Psychiatric Intensive Care Unit (PICU) in an acute psychiatric department.
- Trial name
- NCT00184119
- Testing
- Psychiatric Intensive Care Unit, Care in whole acute unit
- Where
- Norway
- Volunteers
- 118 people
- Sponsor
- Norwegian University of Science and Technology
B-Cell Non-Hodgkin Lymphoma
Pembrolizumab and Tazemetostat to Overcome Immune Tolerance Following ASCT or CAR T-cell Therapy in Patients With Aggressive B-Cell Non-Hodgkin's Lymphoma
This phase II trial tests how well pembrolizumab and tazemetostat work to treat patients who have received autologous stem cell transplantation (ASCT) or chimeric antigen receptor (CAR) T cell therapy for aggressive non hodgkins…
- Trial name
- NCT06242834
- Testing
- Biospecimen Collection, Computed Tomography, Echocardiography
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Northwestern University