Clinical trials: Aging, injection or injectable or infusion or IV or syringe or subcutaneous, open to volunteers
- Condition Aging
- Drug or intervention injection OR injectable OR infusion OR IV OR syringe OR subcutaneous
- Status Open to volunteers
Acute Coronary Syndromes (ACS), Iron Deficiencies
Effect of Intravenous Iron on Quality of Life in Older Patients With Acute Coronary Syndrome
The goal of this phase IV, open-label, randomized clinical trial is to evaluate whether intravenous iron improves quality of life in adults aged 65 years and older with iron deficiency after an acute coronary syndrome (ACS).
- Conditions
- Acute Coronary Syndromes (ACS), Iron Deficiencies, Elderly (People Aged 65 or More)
- Trial name
- HI-COR-65 (NCT07476859)
- Testing
- Ferric Carboxymaltose Injection [Ferinject]
- Where
- 9 sites in Spain
- Volunteers
- 538 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Psychiatric Disorders
A Dimensional Model for Personality Disorders in Later Life
Research on personality disorders (PDs) in older adults is currently limited. This is surprising, given that PDs are also common in this age group.
- Trial name
- NCT05548946
- Testing
- PID-5-BF+M and LPFS-BF 2.0 (self-report questionnaires), Secondary Questionnaires (self-report and informant questionnaires), Clinical Ratings of the dimensional model
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Cancer Survivors, Healthy Participant
A Study to Evaluate the Effects of the Combination of GI-102 With GIB-7 on Biomarkers of Aging in Healthy Adults and Cancer Survivors
This Phase 2a clinical study (GIANTS-1) aims to evaluate a novel dual-combination strategy using GI-102 and GIB-7 to address key pathological features of aging, including immunosenescence (the aging of the immune system)…
- Conditions
- Cancer Survivors, Healthy Participant, Elderly
- Trial name
- GIANTS-1 (NCT07363057)
- Testing
- GI-102 in combination with GIB-7
- Where
- 2 sites in Australia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- GI Innovation, Inc.
Longevity, Preventive Medicine
Tirzepatide and Organ-specific Biological Aging
The purpose of this study is to evaluate blood-based measures of organ-specific biological age, with a particular focus on the brain, and to investigate their relationship with established clinical indicators of health and their…
- Conditions
- Longevity, Preventive Medicine, Biological Ageing
- Trial name
- NCT07906041
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Atria Research and Global Health Institute (ARGHI)
Quality of Life, Breast Neoplasms
Improved Facial Skin Quality and Quality of Life After VYC-12L Treatment in Breast Cancer Survivors
Systemic treatments such as chemotherapy or monoclonal antibodies are an essential part of oncological treatment in breast cancer, which have demonstrated a survival benefit (1,2,3,4,5).
- Conditions
- Quality of Life, Breast Neoplasms, Skin Aging, Hyaluronic Acid
- Trial name
- ONCO AESTHETIC (NCT07917117)
- Testing
- Intradermal injection
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Healthy Aging
Uncovering the Cognitive and Neural Mechanisms Underlying Cognitive Time
Time processing, the ability to process and encode temporal information, is essential for cognitive functioning and for a large number of daily life activities.
- Trial name
- TIMES (NCT06349213)
- Testing
- FDOPA injection before PET imaging, Time perception tasks, fMRI imaging
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Dementia, Parkinsonism
DaTSCAN Imaging in Aging and Neurodegenerative Disease
The investigators propose using DaTscan in patients with REM sleep behavior disorder (RBD), mild cognitive impairment (MCI), Parkinson's disease (PD), dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and other…
- Conditions
- Dementia, Parkinsonism, Mild Cognitive Impairment, REM Sleep Behavior Disorder
- Trial name
- NCT01453127
- Testing
- I-123 Ioflupane solution injection prior to SPECT scan (DaTscan), Single photon emission computed tomography (SPECT) scan
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Aesthetic Procedures, Cosmetic Techniques
MENA Consensus on Poly-L-Lactic Acid (PLLA) Biostimulator Use in Aesthetic Dermatology
This study aims to develop expert consensus on the safe and effective use of poly-L-lactic acid (PLLA) biostimulators in aesthetic dermatology across the Middle East and North Africa (MENA) region.
- Conditions
- Aesthetic Procedures, Cosmetic Techniques, Skin Aging, Rejuvenation
- Trial name
- NCT07261748
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Venus Research Center
Wrinkle Appearance, Skin Quality
A Study to Evaluate the Efficacy of Collagen 16 Serum Alone, Against and as an Adjunct to Radiesse® Biostimulation Procedure in Female Trial Participants With Aged Skin
This study aims at assessing the efficacy of improving skin aging signs of a serum containing collagen 16 combined with a biostimulation device in healthy female subjects aged between 30 and 70 years over a period of 13 weeks.
- Trial name
- NCT07446361
- Testing
- Group 1 (Biostimulation + Test product), Group 3 (Test product Alone)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Vichy Laboratoires
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Vascular Aging, NAD
Efficacy and Safety of Coenzyme I for Injection on Vascular Aging.
Emerging evidence identifies vascular aging independently predicting cardiovascular events, yet effective clinical interventions remain lacking.
- Trial name
- NCT07328100
- Testing
- Coenzyme I for Injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai 10th People's Hospital
Peripheral Arterial Disease, Aging
SMART Exercise for PAD
Supervised exercise therapy (SET), consisting of treadmill exercise conducted three times weekly at a center while supervised by healthcare personnel, is first line therapy for people disabled by lower extremity peripheral artery…
- Conditions
- Peripheral Arterial Disease, Aging, Peripheral Vascular Diseases, Walking, Difficulty
- Trial name
- NCT06032065
- Testing
- Supervised Treadmill Exercise, Home-Based Exercise, Nitrate-rich beetroot Juice
- Where
- 3 sites in United States
- Volunteers
- 210 people
- Sponsor
- Northwestern University
Adult ALL
Virtual Reality-Infused Treadmill Training on Aging-Related Outcomes
Age-associated motor and cognitive deficits increase the risk of falls, a major cause of morbidity and mortality. Emerging evidence suggests that inflammatory mediators lead to impaired functional capacity and frailty in the…
- Trial name
- V-TARGET (NCT06727942)
- Testing
- V-TARGET intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Skin Quality
Safety and Effectiveness of NOA HYDRATION Injectable Gel for the Improvement of Skin Quality Including Attributes Such as Skin Smoothness
Facial skin quality, including attributes such as skin smoothness, can be affected by intrinsic aging and environmental factors.
- Trial name
- NCT07880756
- Testing
- NOA HYDRATION
- Where
- 4 sites in China
- Volunteers
- 150 people
- Sponsor
- AbbVie
Periorbital Hollowing, Skin Aging
Clinical Research on Deep-Plane Rejuran S Injection for Improvement in the Apperance of Periorbital Hollowing Using a Cannula Technique
The goal of this clinical study is to learn whether DOT PN (Rejuran S), a polynucleotide injectable gel, improves periorbital hollowing (a sunken look around the eyes) in adults aged 25 to 65 years when injected into the deep…
- Trial name
- NCT07912814
- Testing
- DOT PN (Rejuran S)
- Where
- 3 sites in Malaysia, Singapore and 1 more
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- PharmaResearch Co.,Ltd
Facial Wrinkles, Skin Aging
Evaluation of MD60002 Device for Facial Skin Aging
This single-center, non-controlled, single-arm clinical study is designed to evaluate the performance and safety of the Class III investigational device MD60002 (composed of highly purified polynucleotides at 3%) for aesthetic…
- Conditions
- Facial Wrinkles, Skin Aging, Skin Imperfections
- Trial name
- CIP-02-25 (NCT07881926)
- Testing
- Device: MD60002
- Where
- Italy
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Promoitalia Group Spa
Aging, Healthy
Study of Healthy Aging and Physical Function With Elamipretide
This study will utilize a daily dose of elamipetide for 4 weeks and will screen a sufficient number of subjects for 30 subjects to enroll in the study.
- Trial name
- SHAPE (NCT07275424)
- Testing
- Elamipretide will be supplied as a sterile 5.0 mL single-patient, multi-dose glass vial containing 3.75 mL of elamipretide solution (elamipretide [80 mg/mL], phosphate buffer, and benzyl alcohol)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- David Marcinek
Adults With Simple Obesity
Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With Obesity
This study is a prospective, randomized, open-label clinical trial enrolling 66 adults with simple obesity who have not used weight-loss medications for at least 3 months.
- Trial name
- NCT07293325
- Testing
- Semaglutide, Tirzepatide, Metformin
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Frailty
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for Aging Frailty
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of Aging Frailty
- Trial name
- NCT05018767
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 86 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Skin Aging
Effectiveness and Safety of Cellbooster Shape in Healthy Subjects
SUISSELLE has developed a CE marketed (2021) HA-based superficial epidermis/dermis injection filler and skinbooster product, Cellbooster® Shape (CBS). CBS is produced using patented CHAC Technology.
- Trial name
- NCT07636512
- Testing
- Skin booster injection (CBS)
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Suisselle