Clinical trials: Aging Frailty
Aging, Heart Failure With Preserved Ejection Fraction
Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure
In a randomized controlled trial, to study the utility of inspiratory muscle training (IMT) to improve functional outcomes in adults aged ≥70 years with heart failure (HF) who have been referred to palliative care for end-stage…
- Conditions
- Aging, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Frailty
- Trial name
- RETRO (NCT06576297)
- Testing
- Inspiratory Muscle Training (IMT), Standard of Care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Transitional Care, Caregivers
Connect-Home Clinical Trial
This study will test whether transitional care targeting care needs of seriously ill, skilled nursing facility (SNF) patients and their caregivers will help to improve SNF patient outcomes (preparedness for discharge, quality of…
- Conditions
- Transitional Care, Caregivers, Patient Discharge, Aging
- Trial name
- NCT03810534
- Testing
- Connect-Home
- Where
- United States
- Volunteers
- 654 people
- Sponsor
- University of North Carolina, Chapel Hill
Frailty in Aging
Ghrelin Repeated Dose Study
Frailty is a geriatric syndrome leading to physical deterioration including muscle wasting (sarcopenia) and unintentional weight loss. There are currently no approved therapies for frailty.
- Trial name
- GRD (NCT01833078)
- Testing
- ghrelin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Pain, Depressive Symptoms
Depression and Pain Perseverance Through Empowered Recovery Intervention
African American women who are 50 years of age and older with depressive symptoms, pain and difficulty with mobility will participate in the DAPPER intervention study that includes 8 nurse visits in participants' homes to help…
- Conditions
- Pain, Depressive Symptoms, Frailty, Aging
- Trial name
- DAPPER (NCT04091347)
- Testing
- DAPPER
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Johns Hopkins University
Frailty Syndrome
Ghrelin Plus Strength Training in Frail Elderly Study
Frailty is a geriatric syndrome leading to physical deterioration including muscle wasting (sarcopenia) and unintentional weight loss. There are currently no approved therapies for frailty.
- Trial name
- NCT01898611
- Testing
- Ghrelin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pennsylvania
Frailty, Frail Elderly Syndrome
Education for Prevention and Treatment of Frailty
Frailty is a condition with a high prevalence in older adults, leading to higher vulnerability and increasing the risk of adverse health outcomes and disabilities.
- Trial name
- FRAGSALUD (NCT05610605)
- Testing
- Health intervention programme: FRAGSALUD
- Where
- Spain
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Cadiz
Frailty, Sarcopenic Obesity
Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors
The continuing increase in prevalence of obesity in older adults including many older Veterans has become a major health concern.
- Conditions
- Frailty, Sarcopenic Obesity, Aging
- Trial name
- DEMFOS (NCT04221750)
- Testing
- Lifestyle therapy, Metformin Hydrochloride, Healthy Lifestyle
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Sarcopenia, Hypogonadism
TOM: Testosterone in Older Men With Sarcopenia
The purpose of this study is to determine whether testosterone replacement in older men with low testosterone levels will increase muscle strength, improve physical performance and overall sense of well being, and reduce fatigue.
- Conditions
- Sarcopenia, Hypogonadism, Muscular Diseases
- Trial name
- NCT00240981
- Testing
- Topical testosterone gel 1% (active formulation)
- Where
- 2 sites in United States
- Volunteers
- 209 people
- Sponsor
- Boston Medical Center
Frailty, Sarcopenia
FrAilty Care and wEll-funcTion in Community Dwelling Older Adults
This study is looking at whether older people could benefit from an online monitoring platform to support their individual ambitions to maintain or improve functional ability.
- Conditions
- Frailty, Sarcopenia, Aging
- Trial name
- FACET (NCT03707145)
- Testing
- Consultation, Online Support, Empowered
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Aberystwyth University
Aging, Sedentary Lifestyle
Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age
This 2-site randomized double blinded controlled trial is to confirm and more definitively clarify the impact of a 12-week course of nitrite versus placebo on mitochondrial bioenergetics in older sedentary adults.
- Conditions
- Aging, Sedentary Lifestyle, Frailty
- Trial name
- Nitrite (NCT04405180)
- Testing
- 20mg sodium nitrite tid
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Gladwin, Mark, MD
Aging, Inflammation
Effect of Metformin on Frailty in 12 Subjects
This study will test whether chronic metformin administration will improve longevity of the cell, improves its machinery by reducing aging-related biochemical parameters and thereby improving physical performance, as measured by…
- Conditions
- Aging, Inflammation, Frailty
- Trial name
- NCT03451006
- Testing
- Metformin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mayo Clinic
Aging
Cycled Testosterone Therapy to Improve Physical Function in Frail Nursing Home Residents
Frailty is a recognized cause for disability, hospitalization, and mortality in nursing home residents. Testosterone treatment is among the potentially beneficial treatments in addition to resistance exercise for improving muscle…
- Trial name
- NCT02679274
- Testing
- Testosterone
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Frailty
AllogeneiC Human Mesenchymal Stem Cells (hMSC) in Patients With Aging FRAilTy Via IntravenoUS Delivery
The purpose of this study is to look at the safety of treatment with stem cells in patients with Frailty.
- Trial name
- CRATUS (NCT02065245)
- Testing
- Allogeneic Human Mesenchymal Stem Cells (allo-hMSCs), Penicillin/Streptomycin-Free Allogeneic Human Mesenchymal Stem Cells (allo-hMSCs)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Longeveron Inc.