Clinical trials: Aging Problems
HIV, Frailty
Improving Physical Ability and Cellular Senescence Elimination in HIV
This clinical trial is a Phase II study designed to test the safety and effectiveness of a combination of dasatinib and quercetin (D+Q) in improving physical function for people with HIV who are frail or prefrail.
- Conditions
- HIV, Frailty, Prefrail, Aging Problems
- Trial name
- IPACE-HIV (NCT07144293)
- Testing
- Dasatinib, Quercetin
- Where
- 24 sites in United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS, Cognitive Impairment
A Randomized Pilot Trial Evaluating the Impact of a Yoga Intervention on Cognition in Older Adults Infected With HIV
Approximately 50% of people living with HIV (and as many as 80% over the age of 50) have difficulties with cognitive functions such as memory and thinking that can have a profound negative impact on activities of daily living and…
- Conditions
- HIV/AIDS, Cognitive Impairment, Aging, Mobility Limitation
- Trial name
- NCT03071562
- Testing
- Yoga-mindfulness
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Adria Quigley
Fall, Age Problem
A Specific Dance Intervention in Older Adults in Hong Kong
This study is a fully-powered randomised controlled trial and an essential follow-up study of our pilot work. The 21-style specific dance intervention to improve the balance and reduce the risks of falls (SDIIBRF) was suggested…
- Trial name
- NCT06563661
- Testing
- The 21-style specific dance exercises
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Aging Problems
Dose-response of Anteroposterior Mobilizations in Weight Bearing Talus Dorsiflexion
Ankle mobility limitations are common in older adults. A possible treatment to restore joint mobility is manual therapy based on mobilization techniques, in this case, applied on the ankle joint.
- Trial name
- ANKLE_WBROM (NCT04563663)
- Testing
- Posteriorization of the talus.
- Where
- Spain
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Aging Problems
Relationship of de Ankle ROM With Balance and Falls in Older Adults
The ankle is an important joint to maintain a good balance within the population of the older adult. As people get older, problems appear in this joint. Many of these problems affect the correct joint range of the ankle.
- Trial name
- ANKLE_JOINT (NCT03898999)
- Testing
- Overall status
- Where
- Spain
- Volunteers
- 87 people
- Sponsor
- University of Valencia
Stroke, Problem of Aging
Modulation of Cerebral Blood Flow Using Quercetin, a Nutritional Supplement
The purpose of this study is to find out if quercetin can increase blood levels of hypoxia-inducible transcription factor 1 (HIF-1 protein) and to see if there is a corresponding increase in blood flow to the brain.
- Trial name
- Quercetin (NCT01376011)
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Delirium, Surgery--Complications
Predictive Factors and Complications of Delirium
The objective of this research was to determine the incidence, predisposing and triggering factors of delirium following cardiac surgery and its consequences within 30 days of surgery and during a 12-18-month follow-up in older…
- Conditions
- Delirium, Surgery--Complications, Age Problem
- Trial name
- NCT03246165
- Testing
- Cardiac surgery
- Volunteers
- 173 people
- Sponsor
- University of Sao Paulo
Ageing
The OMAGE (Optimization of Medication in AGEd) Transitional Care-Pathway: Impact on Readmissions
Background : The transitional care OMAGE-P combines three best practices recommendations from the French National Authority for Health (HAS) (i) a comprehensive review of diagnosis and treatments (ii) a standardized medical…
- Trial name
- OMAGE-P (NCT02657642)
- Volunteers
- 484 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aging Problems
Effects of Feet and Ankle Mobilization on Balance of Older Adults
This study aims to assess whether mobilization of the ankle and foot produces significant improvements in the balance of the elderly.
- Trial name
- FEET_BALANCE (NCT03092869)
- Testing
- Feet and Ankle Mobilization, Proprioceptive Training
- Where
- 2 sites in Spain
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Social Isolation, Loneliness
The CONNECT Program: Testing a Telephone-Based Mental Health Intervention for Older Adults
This study will test a telephone-based group intervention called "The CONNECT Program" which is designed for adults aged 65+ who are currently experiencing social isolation or loneliness, and symptoms of anxiety or depression.
- Conditions
- Social Isolation, Loneliness, Depression, Anxiety
- Trial name
- CONNECT (NCT05120765)
- Testing
- The CONNECT Program
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Manitoba
Age Problems, Cognitive Impairment
Feasibility Aquatic Physical Exercise to Reduce Falls in Institutionalized Elderly
This is a pilot randomized control trial with single blinding of the assessor that will be conducted in two nursing homes residence to evaluate the applicability of a physical exercise program performed in an aquatic environment…
- Conditions
- Age Problems, Cognitive Impairment, Elderly, Postural Balance
- Trial name
- PrePhysFalls (NCT03019211)
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Ramon Llull
Aging Problems, Frailty
Impact of Skills Acquired Through Judo Training on Risk Factors for Falling in Elderly Men and Women
Falls and injuries from falls are one of the greatest threats to public health. One of the risk factors for accidental falls is a low self-efficacy regarding the perceived capability to perform activities without the risk of…
- Conditions
- Aging Problems, Frailty, Fall Injury, Accidental Fall
- Trial name
- J4BE (NCT04061785)
- Testing
- Judo4Balance - 12 week judo inspired exercise program
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dalarna University
Age Problem
Home Accidents Among Turkish Older Men and Women
Background: Home accidents are a significant public health issue in developed and developing countries. The present study aims to identify the factors associated with home accidents among older individuals in Türkiye.
- Trial name
- NCT06514872
- Testing
- prevalance and determinants of home accidents
- Where
- Turkey (Türkiye)
- Volunteers
- 8,225 people
- Sponsor
- Ataturk University
Colorectal Cancer, Age Problem
A Cross-sectional Survey of Colorectal Cancer Patients in Different Age Groups
This study will help to determine the main clinical symptom differences between patients of different ages, discover the family genetic predisposition of patients of different ages, and obtain the differences in pathological…
- Trial name
- NCT06145230
- Where
- China
- Volunteers
- 430 people
- Sponsor
- Wang Guiyu
Aging Problems
Effects and Dose-response of Manual Therapy in the ROM of the Ankle in Older People
Limitations of the joint range of the ankle in elderly people is usually common. One of the ways to treat this limitation is through manual therapy, although the effects it produces in dose-response terms are still not well…
- Trial name
- ANKLE_ROM (NCT03600402)
- Testing
- Experimental, Control
- Where
- Spain
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Age Problem, Fall
Fall Risk Assessment Using Hybrid Machine Learning and Deep Learning Approaches and a Novel Posturography
The purpose of this project is to combine a novel posturogrpahy based on HTC VIVE trackers and hybrid machine learning and deep learning algorithms to establish a set of simple, convenient and valid fall risk assessment tool.
- Trial name
- NCT05308563
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Age Problem, Old Age; Debility
Swedish Palliative Care Guide (S-PCG) at Nursing Homes
Palliative care aims to improve the quality of life for patients and families who are affected life-threatening, incurable disease. The care should be person-centred, but it is not entirely clear how this is best achieved.
- Conditions
- Age Problem, Old Age; Debility, Dementia
- Trial name
- NCT06431659
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Region Skane
Cardiovascular Diseases, Cardiovascular Risk Factor
Chinese Multi-provincial Cohort Study-Beijing Project
The Chinese Multi-provincial Cohort Study (CMCS)-Beijing project is a sub-study in CMCS participants from Beijing, which intended to investigate the progression and determinants of atherosclerosis and aging related health…
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Aging Problems, Smell Disorder
- Trial name
- CMCS-Beijing (NCT04253054)
- Testing
- Cardiovascular risk factors, Aging related health problems
- Where
- 3 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Obesity, Aging
Metabolic Control of Aging and Disease - the MetAGE Deep Phenotyping Cohort
The goal of this prospective observational study is to identify and validate blood based aging biomarkers in relation to cardiometabolic phenotypes of young and old, female and male subjects with or without obesity.
- Conditions
- Obesity, Aging, Aging Problems, Metabolic Syndrome
- Trial name
- Pro-Metage (NCT06511297)
- Testing
- comprehensive metabolic phenotyping
- Where
- 2 sites in Austria
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Thomas Scherer
Age Problem
Pathology of Helicases and Premature Aging: Study by Derivation of hiPS
Topic of this work is the involvement of replicative helicases in human premature ageing syndrome. Replicative helicases are ubiquitous and essential during numerous reactions of the DNA metabolism.
- Trial name
- HeliPS (NCT03898817)
- Testing
- taking of cutaneous cells
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Montpellier