Clinical trials: Agitation, Emergence
Post Operative Delerium, Post Operative Cognitive Dysfunction
Eye Movements to Predict Post-Operative Delirium
Postoperative delirium (POD) is a common complication in older adults undergoing surgery, lacking objective and noninvasive diagnostic methods.
- Trial name
- EYE-POD (NCT07806487)
- Where
- Chile
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chile
Delirium in Old Age, Frailty
Association of Frailty and Delirium in Elderly Hip Fracture Patients
Several studies have shown that frailty can be used as a marker for risk of adverse outcomes in elderly patients such as falls, disability, hospitalization, mortality, and can be used to predict patient clinical outcomes.
- Trial name
- NCT05246254
- Testing
- Frailty index scale
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Cancer Surgery, Intraoperative Hypothermia
Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival
Intraoperative hypothermia is common in patients having major surgery and the compliance with intraoperative temperature monitoring and management remains poor.
- Conditions
- Cancer Surgery, Intraoperative Hypothermia, Targeted Temperature Management, Postoperative Delirium
- Trial name
- NCT06256354
- Testing
- Routine thermal management, Target temperature management
- Where
- 36 sites in China
- Volunteers
- 3,992 people
- Sponsor
- Peking University First Hospital
Eye Abnormalities, Arrythmia
Relation Between Oculocardiac Reflex and Laryngospasm
The aim of this study is to evaluate whether there is a significant relation between various arrhythmias during the surgeon's stretching the eye muscles and laryngospasm and emergence agitation in strabismus surgeries
- Trial name
- NCT05339880
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- TC Erciyes University
Delirium, Cognitive Impairment
Incidence and Characteristics of Postoperative Cognitive Dysfunction in Elderly Quebec Francophone Patients
The purpose of this study is to determine what percentage of patients have cognitive problems (for example, memory or concentration difficulties) after surgery and anesthesia, what the characteristics of these problems are, and…
- Conditions
- Delirium, Cognitive Impairment, Cognitive Decline, Cognitive Change
- Trial name
- NCT03337282
- Testing
- Protocolized general anesthesia
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Postoperative Delirium
Baden Prevention and Reduction of Incidence of Postoperative Delirium Trial
The purpose of this study is to find out whether postoperative delirium can be more properly prevented by the combination of determined preventive agents in past studies.
- Trial name
- PRIDe (NCT02433041)
- Testing
- Haloperidol, Ketamine, Haloperidol + Ketamine
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Critical Illness, Mechanical Ventilation
Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill Patients
The goal of this prospective multicenter observational study is to characterize early trajectories of consciousness recovery following the first valid structured awakening trial in mechanically ventilated critically ill adults, a…
- Conditions
- Critical Illness, Mechanical Ventilation, Weaning Invasive Mechanical Ventilation, Sedation and Analgesia
- Trial name
- AWAKE-ICU (NCT07710066)
- Testing
- Structured Awakening Evaluation (SAE)
- Volunteers
- 500 people
- Sponsor
- Patricia Rodriguez Villamizar
POCD - Postoperative Cognitive Dysfunction, Recovery Time
The Effects of Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy
In this study, the investigators want to examine the effects of intravenous anesthetic drugs and gases on cognitive functions in the postoperative period in individuals who will undergo surgery for obesity.
- Conditions
- POCD - Postoperative Cognitive Dysfunction, Recovery Time, Postoperative Neurocognitive Disorder, Postoperative Delirium
- Trial name
- NCT07637357
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Osteoarthritis, Femoral Head Necrosis
Donepezil Attenuate Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved.
- Conditions
- Osteoarthritis, Femoral Head Necrosis, Rheumatoid Arthritis
- Trial name
- DAPOCD (NCT02927522)
- Testing
- Donepezil
- Where
- China
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Postoperative Delirium, Sedation
The Effect of Reversal of Remimazolam Sedation With Flumazenil on Cognitive Function in Patients Undergoing Hip Arthroplasty Under Spinal Anesthesia
This clinical trial aims to establish whether reversing remimazolam sedation with flumazenil can prevent postoperative neurocognitive disorders in patients undergoing total hip replacement surgery.
- Conditions
- Postoperative Delirium, Sedation, Remimazolam, Hip Arthroplasty, Total
- Trial name
- NCT07277881
- Testing
- remimazolam sedation reversal with flumazenil
- Volunteers
- 150 people
- Sponsor
- Medical University of Gdansk
Emergence Delirium
Incidence of Emergence Delirium in the PACU
Emergence delirium (ED) is serious complication in the postoperative period in paediatric anaesthesia, reported incidence is 20-60%.
- Trial name
- PACUDEL (NCT04531020)
- Testing
- PAED measurement
- Where
- Czechia
- Volunteers
- 1,421 people
- Sponsor
- Brno University Hospital
Postoperative Agitation, Emergence Delirium, Anesthesia
Impact of Neuromonitoring on Postoperative Agitation in Pediatric General Anesthesia
Postoperative agitation is frequently observed in the pediatric patient group following general anesthesia. The exact cause of this agitation has not been clearly determined; however, it may be associated with various factors…
- Trial name
- NCT07243990
- Testing
- dsa intervention group, Traditional Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sakarya University
MRI Sedation, Pediatric Sedation
Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging
The most common imaging procedure requiring sedation/anesthesia for the pediatric population is magnetic resonance imaging (MRI). However, the optimal anesthetic/sedation plan has not been determined for these procedures.
- Conditions
- MRI Sedation, Pediatric Sedation, Propofol Dosage, Emergence Delirium, Anesthesia
- Trial name
- NCT07369128
- Testing
- Dexmedetomidine (IV) 0.5 mcg/kg, Propofol (IV) 2-4 mg/kg, Dexmedetomidine (IV) 1 mcg/kg
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Boston Children's Hospital
Thyroid Diseases
Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery
Thyroid surgery requires smooth emergence from anesthesia to minimize coughing, hemodynamic fluctuations, and agitation during extubation, which may contribute to postoperative complications such as bleeding or cervical hematoma.
- Trial name
- DEX-THYROID (NCT07462195)
- Testing
- Dexmedetomidine, Standard General Anesthesia
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- Bach Mai Hospital
Strabismus
Anesthetic Depth and the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery
This study evaluates the association between the depth of general anesthesia and the occurrence of emergence agitation (EA). The investigators hypothesized that optimal level of anesthetic depth could decrease the incidence of EA…
- Trial name
- NCT02521259
- Testing
- BIS
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Seoul National University Bundang Hospital
Procedural Sedation and Analgesia During Bone Marrow Aspiration and Biopsy
Dexmedetomidine Versus Midazolam Added to Ketamine in Pediatric Patients Undergoing Bone Marrow Aspiration and Biopsy
Group I :The patients will receive midazolam intravenously (i.v.) in a dose of 0.05 mg/kg diluted by 50ml saline over 10 minutes using syringe pump plus 1 mg/kg ketamine (iv).
- Trial name
- NCT03647579
- Testing
- midazolam intravenous infusion of 0.05 mg/kg plus 1 mg/kg ketamine, Dexmedetomidine intravenous infusion of 2mic/kg plus 1 mg/kg ketamine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Postoperative Delirium
Association of Haptoglobin 2-2 With Postoperative Delirium
Patients with major orthopedic surgery will be recruited. Participants will be monitored for delirium after surgery. Participants' blood will be harvested for the determination of haptoglobin types, levels of oxidative stress and…
- Trial name
- NCT03392480
- Where
- 8 sites in China
- Sponsor
- Sun Yat-sen University
Delirium - Postoperative
Effectiveness of Electroencephalography Guided Anesthesia
This study will use brain wave information, known as electroencephalography (EEG), to help guide anesthesia delivery during surgery.
- Trial name
- EEG Anesthesia (NCT07567729)
- Testing
- EEG-guided anesthesia training program for anesthesia providers, EEG-Guided Intervention
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Stanford University
Delirium, Post-operative Delirium
Nitric Oxide Levels Were Associated With Postoperative Delirium Following Cardiac Surgery
This study is a single-center prospective observational study conducted at the operating room, post-anesthesia care unit, and ICU of Tongji Hospital, from April 2023 to September 2024.
- Trial name
- NCT06748391
- Where
- China
- Volunteers
- 1,939 people
- Sponsor
- Tongji Hospital
Desflurane Anesthesia
Desflurane in Children With Laryngeal Mask Airway
The purpose of this study is to characterize the airway responses to desflurane during maintenance of and emergence from anesthesia in children whose airways were supported with laryngeal mask airways (LMAs).
- Trial name
- NCT02470442
- Testing
- Sevoflurane/Desflurane, Sevoflurane
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital