Clinical trials: Agitation, Psychomotor
Acute Agitation
Safety and Tolerability of INP105 (Olanzapine by I231 POD® Device) Nasal Spray in Healthy Volunteers - SNAP 101
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of INP105, which is an investigational drug-device combination product comprised of the drug component OLZ administered by a…
- Trial name
- SNAP101 (NCT03624322)
- Testing
- Zyprexa IM, Zydis, INP105
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Impel Pharmaceuticals
Bipolar I Disorder
Staccato Loxapine in Agitated Patients With Bipolar Disorder
Phase 3 safety and efficacy study of Staccato Loxapine in the treatment of acute agitation in bipolar 1 disorder patients.
- Trial name
- NCT00721955
- Testing
- Inhaled loxapine 5 mg, Inhaled loxapine 10 mg
- Where
- 6 sites in United States
- Volunteers
- 314 people
- Sponsor
- Alexza Pharmaceuticals, Inc.
Alzheimer's Disease
An Evaluation of the Safety and Efficacy of Memantine in Agitated Patients With Moderate to Severe Alzheimer's Disease
About 65% of patients with severe Alzheimer's Disease (AD) will have symptoms of agitation. There are drawbacks associated with the currently available therapeutic interventions for agitation associated with Alzheimer's Disease.
- Trial name
- NCT00097916
- Testing
- memantine HCl
- Where
- 9 sites in United States
- Volunteers
- 34 people
- Sponsor
- Forest Laboratories
Dementia
Decoding Death and Dying in People With Dementia by Digital Thanotyping
How can healthcare professionals recognize that a person with dementia is at the end of life? When people are dying, their physical, mental, and social abilities are gradually declining.
- Trial name
- 5-D (NCT06437132)
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 270 people
- Sponsor
- University of Bergen
Agitation, Craniotomy
Agitation in Post Operative Neurosurgical Patients
Agitation is a significant clinical issue in anesthesiology and critical care medicine. Several studies have carried out to survey the epidemics of agitation in post-anesthesia care unit and intensive care unit, and results…
- Trial name
- NCT00590499
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Capital Medical University
Agitation, Excited Delirium
Stress Biomarkers Among Patients Undergoing Treatment for Excited Delirium and Severe Pain in the Emergency Department
The purpose of this project is to determine the levels of stress biomarkers associated with severe pain, agitation from intoxication or psychosis, and excited delirium at various levels of the disease in order to compare them to…
- Conditions
- Agitation, Excited Delirium, Pain
- Trial name
- Agitation (NCT01747824)
- Where
- United States
- Volunteers
- 1,322 people
- Sponsor
- Hennepin Healthcare Research Institute
Psychomotor Agitation
Haloperidol vs. Valproate in Agitation
The aim of this study is to compare the efficacy of haloperidol and valproate in management of people with agitation in emergency department
- Trial name
- NCT01750541
- Testing
- Haloperidol, Valproate
- Where
- Iran
- Volunteers
- 56 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Schizophrenia
Staccato Loxapine in Agitation (Proof of Concept)
The purpose of this study is to assess efficacy and safety of Staccato Loxapine in the treatment of acute agitation in schizophrenic patients.
- Trial name
- NCT00369577
- Testing
- Inhaled Loxapine 5 mg, Inhaled Loxapine 10 mg
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Alexza Pharmaceuticals, Inc.
Psychomotor Agitation
The Effect of Dexmedetomidine on Emergence Agitation in Children Undergoing a Surgery Under Desflurane Anesthesia
After genernal anesthesia using sevoflurane or desflurane, the investigators can observe many cases of agiation (over 80%) and despite of no report of long-term complication, agitation is a big issue in PACU for doctors and…
- Trial name
- NCT01578161
- Testing
- Dexmedetomidine, 0.9% Normal Saline
- Where
- South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Agitation, Anesthesia
Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Children
Emergence delirium (ED) from general anesthesia posts risk and harm to pediatric population undergo general anesthesia. The purpose of the study is to compare the use of dexmedetomidine versus placebo in reducing the incidence…
- Conditions
- Agitation, Anesthesia, Pediatrics
- Trial name
- DexPeds (NCT00857727)
- Testing
- Dexmedetomidine, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Agitation,Psychomotor
Observational Study Evaluating the Safety of ADASUVE® in Agitation Associated With Schizophrenia or Bipolar I Disorder
This postmarketing observational study will evaluate the safety of ADASUVE® in treating patients with agitation associated with schizophrenia or bipolar I disorder.
- Trial name
- NCT03513549
- Testing
- Loxapine 10 MG
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Alexza Pharmaceuticals, Inc.
Dementia, Aggression
Study of Electroconvulsive Therapy (ECT) Treatment for Agitation and Aggression in Dementia
Agitation/aggression is one of the most common and serious behavioral complications of dementia. If the behavior is refractory to standard care (behavior approaches and off label use of psychotropic medications), other evidence…
- Conditions
- Dementia, Aggression, Agitation
- Trial name
- NCT01856010
- Testing
- ECT treatment, Standard Care (Non-ECT group)
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Pine Rest Christian Mental Health Services
Alzheimer's Disease, Psychosis
Treatment of Behavioral Symptoms in Alzheimer's Disease
The optimal strategy for the treatment of behavioral complications in patients with probable Alzheimer's disease (AD) remains unclear.
- Conditions
- Alzheimer's Disease, Psychosis, Agitation
- Trial name
- NCT00009217
- Testing
- Haloperidol-Haloperidol
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- New York State Psychiatric Institute
Agitation, Schizophrenia
Sub-Lingual Dexmedetomidine in Agitation Associated With Schizophrenia
This is a two-stage adaptive Phase Ib trial design, that will identify two doses (lowest dose with clinical benefit and highest safe dose) in a first stage and better evaluate safety, tolerability and variability of effect in the…
- Trial name
- NCT04010305
- Testing
- Sublingual film containing BXCL501 (Dexmedetomidine)
- Where
- 12 sites in United States
- Volunteers
- 135 people
- Sponsor
- BioXcel Therapeutics Inc
Sepsis, Agitation
Safety Study of Dexmedetomidine in Septic Patients
Septic patients in Intensive Care Unit always need mechanical ventilation and conscious-sedation. But the recommended dose 0.2-0.7μg/kg/h could not run well because of wide range.
- Trial name
- NCT01976754
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Anxiety, Agitation
Family Videos and Virtual Reality in Intensive Care Patients
This randomized controlled trial was conducted to evaluate the effects of family videos and virtual reality-based nature videos on anxiety, agitation, pain, and vital signs in adult intensive care unit patients.
- Conditions
- Anxiety, Agitation, Pain, Physiological Parameters
- Trial name
- NCT07794696
- Testing
- Family Video.Participants watched a five-minute video prepared by their family members twice daily on the second and third days of intensive care.
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Sennur Kula Şahin
Agitation, Dementia
Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY III)
A study to determine the safety and efficacy of BXCL501 dosing for episodes of agitation associated with dementia when they occur (given as needed [PRN]), for a maximum of 168 doses within a 12-week treatment period.
- Trial name
- NCT05665088
- Testing
- BXCL501
- Where
- 7 sites in United States
- Volunteers
- 13 people
- Sponsor
- BioXcel Therapeutics Inc
Psychomotor Agitation, Behavioral Disorder
Clinical Trial of Peer Support in the ED (PCORI)
The purpose of this study is to conduct a clinical trial that tests the acceptability, fidelity, and feasibility of a peer support modified intervention for agitation management within the emergency department.
- Trial name
- NCT06556069
- Testing
- Peer-Support Enhanced Agitation Code Team (PACT)
- Where
- United States
- Volunteers
- 57,870 people, healthy volunteers welcome
- Sponsor
- Yale University
Agitation
Quality Improving Program on Agitation in the Surgical Intensive Care Unit
Agitation in the intensive care unit can have multiple consequences. The investigators hypothesize that agitation and its consequences can be reduced by the introduction of a reminder aiming at guiding the management of…
- Trial name
- NCT02199262
- Testing
- music intervention, reflexology, reminder
- Where
- Switzerland
- Volunteers
- 1,107 people
- Sponsor
- University Hospital, Geneva
Brain Injuries, Craniocerebral Trauma
DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury
The investigators intend to determine the effect of adrenergic blockade on 1) short-term physiology, behavior, and cognition and 2) long-term neuropsychological outcomes after severe Traumatic Brain Injury (TBI).
- Conditions
- Brain Injuries, Craniocerebral Trauma, Trauma, Nervous System, Traumatic Brain Injury
- Trial name
- NCT01322048
- Testing
- IV Propranolol and Per Tube Clonidine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University