Clinical trials: Agitation in Dementia
Respiratory Failure, Delirium
Delirium, Agitation/Sedation, Pain and Dyspnea in Respiratory Intensive Care Unit (NIVILIUM)
Non-Invasive Mechanical Ventilation (NIV) has been increasingly used in the treatment of acute respiratory failure. Notwithstanding failure rates still remains high, ranging from 5% to 60%.
- Conditions
- Respiratory Failure, Delirium, Agitation,Psychomotor, Pain
- Trial name
- NIVILIUM (NCT03880084)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 92 people
- Sponsor
- University of Modena and Reggio Emilia
Dementia
Multidisciplinary Intervention for Challenging Behaviour (Agitation) in Patients With Dementia
The increasing prevalence of dementia is a major challenge to the health authorities in most countries. Nearly all the persons suffering from dementia experience behavioural and psychological symptoms (BPSD).
- Trial name
- TID (NCT01183351)
- Testing
- Psychosocial intervention
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Sykehuset Innlandet HF
Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease
Addressing Dementia Via Agitation-Centered Evaluation
This is a multi-center, randomized, double-blind, placebo-controlled study, to assess the efficacy and safety of AXS-05 in the treatment of agitation in patients with Alzheimer's disease.
- Conditions
- Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease, Agitation,Psychomotor
- Trial name
- ADVANCE (NCT03226522)
- Testing
- AXS-05, Bupropion
- Where
- 78 sites in United States, Australia
- Volunteers
- 366 people
- Sponsor
- Axsome Therapeutics, Inc.
Dexmedetomidine, Ketamine
Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial
This investigator-initiated, randomized, controlled, single-blind, superiority trial aims to assess the efficacy and safety of esketamine combined with dexmedetomidine for the management of agitation or delirium in intensive care…
- Conditions
- Dexmedetomidine, Ketamine, Analgesia, Respiratory Therapy
- Trial name
- SEED-NIRS (NCT07377981)
- Testing
- Esketamine combined with dexmedetomidine, Dexmedetomidine
- Where
- China
- Volunteers
- 356 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Agitation
Effect of Single-dose Dexmedetomidine on Emergence Excitement in Adults With Nasotracheal Intubation After Orthognathic Surgery
Excitement during the emergence from general anesthesia is a great post-operative problem. It may lead to serious consequences for the patient, such as injury, increased pain, hemorrhage, self-extubation, and removal of…
- Trial name
- NCT01524367
- Testing
- saline, Dexmedetomidine
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Yonsei University
Alzheimer's Disease
Memesto Wearable Repetitive Message and Music Therapy Device Music Therapy Device That Senses and Reduces Agitation in People With AD,
This is a 12-week proof-of-concept study to evaluate the efficacy of Memesto in reducing agitation in persons with Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD) currently living in a residential care…
- Trial name
- AWARD (NCT06596278)
- Testing
- Memesto
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Edgewater Safety Systems, Inc.
Agitation
Ketamine Versus Midazolam for Prehospital Agitation
This research study is being done to figure out the best approach to treatment of pre-hospital agitation. It will compare two tiered dosing treatment protocols, one ketamine-based and one midazolam-based.
- Trial name
- NCT03554915
- Testing
- Ketamine-based protocol, Midazolam-based protocol
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- Hennepin Healthcare Research Institute
Agitation, Dementia
Depakote Extended Release (ER) Versus Seroquel for Agitated Behaviors in Nursing Home Care Unit Patients With Dementia
The primary objective of the study is to assess the relative efficacy of Depakote ER and Seroquel for agitated behaviors among veterans with a dementia diagnosis residing in a Department of Veterans Affairs (VA) nursing home care…
- Trial name
- NCT00315900
- Testing
- Depakote ER, Seroquel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tuscaloosa Research & Education Advancement Corporation
Agitation Associated With Alzheimer's Disease Dementia
Safety and Efficacy of EXV-802 and EXV-801 in the Treatment of Agitation in Alzheimer's Disease Dementia
The goal of this clinical trial is to evaluate the safety and efficacy of EXV-802 and EXV-801 in treatment of agitation in participants with Alzheimer's Disease dementia.
- Trial name
- SERENADA (NCT07284472)
- Testing
- EXV-802, EXV-801
- Where
- 49 sites in United States, Canada and 7 more
- Volunteers
- 300 people
- Sponsor
- Exciva GmbH
Delayed Emergence From Anesthesia, Delirium, Cause Unknown
Inadequate Emergence After Laparoscopic Surgery in Trendelemburg Position
The purpose of this study is to determinate if the patients submitted to laparoscopic surgery in trendelemburg position develope more inadequate anaesthesic emergence than patients submitted to laparoscopic surgery in other…
- Conditions
- Delayed Emergence From Anesthesia, Delirium, Cause Unknown, Confusion, Disorientation on Emergence
- Trial name
- NCT02101671
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Corporacion Parc Tauli
Akathisia
Prophylaxis Against Metoclopramide-Induced Akathisia
ABSTRACT Study Objective: To compare the effects of midazolam and diphenhydramine for the prevention of metoclopramide induced akathisia.
- Trial name
- NCT01051271
- Testing
- midazolam
- Volunteers
- 225 people
- Sponsor
- Pamukkale University
Pain, Agitation on Recovery From Sedation
Assessment and Management of Pain, Agitation, Delirium and Sleep Deprivation (PADS) in ICU by PADS Protocol, Thailand
The investigators proposed that pain, agitation, delirium and sleep deprivation protocol (PADS) will help improve the patients' outcomes (shortening ICU length of stay, improving ventilator free days, increasing delirium free…
- Conditions
- Pain, Agitation on Recovery From Sedation, Delirium
- Trial name
- NCT04270331
- Testing
- PADS protocol
- Where
- Thailand
- Volunteers
- 509 people
- Sponsor
- Mahidol University
Agitation
Different Premedication in Pediatric Patients
The investigators studied the effects of intranasal dexmedetomidine compared with oral midazolam with different doses for premedication in children.
- Trial name
- NCT04266340
- Testing
- dexmedetomidine, midazolam, Saline
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Agitation
Effect of Deksmedetomidine and Remifentanil in Extubation Agitation
To compare the effect of two different agents deksmedetomidine, remifentanil and placebo, agitation and recovery condition, on nasal septum operation.
- Trial name
- EA (NCT02104297)
- Testing
- deksmedetomidine, Remifentanil, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Alzheimer Disease, CAREGİVER
The Progressively Lowered Stress Threshold Model
Today, with the prolongation of human life, the elderly population has increased and the frequency of diseases seen in old age has increased due to this situation. The most common of these diseases is Alzheimer's disease.
- Trial name
- NCT04305652
- Testing
- The Progressively Lowered Stress Threshold Model
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Aksaray University
Delivery of Health Care, Education, Medical
Effects of the Humanitude® Care Methodology on Health Professionals' Perception
Healthcare professionals providing care for institutionalized older patients must deal with agitated behavior daily. Such behavior alters the patient's quality of life and generates stress for the caregiver.
- Conditions
- Delivery of Health Care, Education, Medical, Caregiver
- Trial name
- Humanitude (NCT06450249)
- Testing
- Humanitude® Care Methodology (HCM) training sessions, Self-administered questionnaire
- Where
- 2 sites in France
- Volunteers
- 455 people
- Sponsor
- Lille Catholic University
Psychiatric Emergency, Aggression
TREC-Lebanon: A Trial for Rapid Tranquilisation for Agitated Patients in the Emergency Setting
This is a randomised controlled trial comparing haloperidol + promethazine versus haloperidol + promethazine + chlorpromazine for agitated patients in the emergency department.
- Conditions
- Psychiatric Emergency, Aggression, Agitation
- Trial name
- TREC (NCT03639558)
- Testing
- Haloperidol + Promethazine + Chlorpromazine, Haloperidol + Promethazine
- Where
- 2 sites in Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Joseph Dib
Agitation,Psychomotor, Haloperidol Causing Adverse Effects in Therapeutic Use
Inhaled Loxapine vs Intramuscular (IM) Haloperidol + Lorazepam for Agitation
The primary objective of this study is to determine the noninferiority of inhaled loxapine compared to intramuscular haloperidol/lorazepam on agitation reduction at 120 minutes.
- Conditions
- Agitation,Psychomotor, Haloperidol Causing Adverse Effects in Therapeutic Use, Lorazepam Causing Adverse Effects in Therapeutic Use, Loxapine Causing Adverse Effects in Therapeutic Use
- Trial name
- loxapine (NCT03110900)
- Testing
- Haloperidol + lorazepam, Loxapine
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Dementia, Parkinson Disease
Treatment of Agitation/Psychosis in Dementia/Parkinsonism (TAP/DAP)
The primary aim of this study is to determine the safety and efficacy of quetiapine (Seroquel) for the treatment of psychosis and/or agitation in patients with primary dementia complicated by coexistent parkinsonism, or patients…
- Trial name
- NCT00043849
- Testing
- Quetiapine
- Where
- 21 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute on Aging (NIA)
Dementia
Treating Behavioral Disturbances in Individuals With Dementia
This study will compare the safety and effectiveness two medications, citalopram (Celexa®) and risperidone (Risperdal®).
- Trial name
- NCT00073658
- Testing
- Citalopram, Risperidone
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- University of Pittsburgh