Clinical trials: Agitation in Dementia
Pain, Sedation
Assessment of Analgesia, Sedation, Physical Restraints and Delirium in Spanish Intensive Care Units
This study assess which Spanish intensive care units evaluate and record, in a standardized way, levels of pain, sedation / agitation, use of physical restraints and prevalence of delirium.
- Conditions
- Pain, Sedation, Agitation, Delirium
- Trial name
- ASCyD (NCT03773874)
- Testing
- Assessment
- Where
- Spain
- Volunteers
- 1,574 people
- Sponsor
- Hospital Universitario Getafe
Dementia
Reducing Agitation in People With Dementia: the Customized Activity Trial
Over 5 million Americans have Alzheimer's disease or a related dementia, a progressive and irreversible neurodegenerative condition, affecting also close to 15 million family caregivers (CG).
- Trial name
- TAP (NCT01892579)
- Testing
- Tailored Activity Program, Home Safety and Education Program
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
DEMENTIA
Memantine for Agitation in Dementia
We plan to evaluate the use of memantine in Alzheimer's disease to control agitation in the acute situation i.e under 12 weeks
- Trial name
- MAGD (NCT00371059)
- Testing
- Memantine
- Where
- 2 sites in United Kingdom
- Volunteers
- 153 people
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Dementia
Bright Light Therapy for Individuals With Dementia
Many older adults with dementia living in long-term care facilities experience depression and agitation, which cause angst and personal suffering.
- Trial name
- NCT02800850
- Testing
- Bright Light
- Volunteers
- 71 people
- Sponsor
- Radford University
Alzheimer's Disease
Effects of Light-therapy in Alzheimer's Disease
Background: Management of patients with Alzheimer's disease associated with behavioral disturbances is difficult especially in those with agitation/aggression and insomnia and nighttime behaviors.
- Trial name
- ALZ-Light (NCT02686190)
- Testing
- Luxtherapy
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Therapeutic Touch
The Effect of Therapeutic Touch on Agitation, Pain, and Cortisol Levels in Intensive Care Patients
Intensive care units (ICU) are special clinical areas where advanced monitoring and treatment of patients with life-threatening organ failure or those at risk of developing organ failure are carried out, with high technological…
- Trial name
- NCT07061340
- Testing
- Therapeutic Touch
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Firat University
Bipolar Disorder, Schizophrenia
Tachyphylaxis, Tolerance, & Withdrawal Post Treatment With Igalmi for Agitation in Schizophrenia or Bipolar Disorder
This is an in-clinic, single arm, open-label study assessing tachyphylaxis, tolerance, and withdrawal following repeated doses of Igalmi in adult males and females with agitation associated with schizophrenia or bipolar disorder.
- Conditions
- Bipolar Disorder, Schizophrenia, Agitation,Psychomotor, Schizo Affective Disorder
- Trial name
- NCT06041646
- Testing
- Sublingual film containing Igalmi
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- BioXcel Therapeutics Inc
Dementia
Study of Mirtazapine for Agitation in Dementia
This clinical trial evaluates whether Mirtazapine is more effective than placebo in treating agitation in people with dementia. The trial will assess the safety, clinical and cost effectiveness of the treatment.
- Trial name
- SYMBAD (NCT03031184)
- Testing
- Mirtazapine
- Where
- United Kingdom
- Volunteers
- 207 people
- Sponsor
- University of Sussex
Post Tonsillectomy Emergence Agitation
Melatonin for Post Tonsillectomy Emergence Agitation in Pediatric
The goal of this clinical trial is to learn if melatonin can decrease emergence agitation in pediatric post tonsillectomy. The main questions it aims to answer are: Does melatonin decrease emergence agitation in pediatric post…
- Trial name
- NCT07375342
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Benha University
Alzheimer Disease
SCI-110 for Alzheimer Disease and Agitation
As of today, there is no FDA-approved treatment for agitation in AD. Hence, it is still considered an unmet need. Sporadic observation in healthy or diagnosed individuals indicated that cannabis products, in particular, THC have…
- Trial name
- NCT05239390
- Testing
- SCI -110
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- The Israeli Medical Center for Alzheimer's
Agitation
Effects of Serotonin Inhibitors on Patient-controlled Analgesia Related Nausea and Vomiting
ED50 of dexmedetomidine for prevention of emergence agitation after tonsillectomy or adenoidectomy in children
- Trial name
- NCT01517438
- Testing
- agitation
- Volunteers
- 21 people
- Sponsor
- Seoul National University Hospital
Psychomotor Agitation
Comparison of Effects of Intravenous Midazolam and Ketamine on Emergence Agitation
Compare the effects of intravenous midazolam and ketamine on emergence agitation after sevoflurane anesthesia
- Trial name
- NCT02256358
- Testing
- Midazolam, Ketamine
- Volunteers
- 68 people
- Sponsor
- Inje University
Dementia, Agitation
Virtual Reality to Advance Dementia Care and Quality of Life
The goal of this feasibility clinical trial is to learn whether supervised virtual reality (VR) sessions can be safely and practically provided to adults aged 55 years and older with moderate-to-severe dementia who experience…
- Conditions
- Dementia, Agitation, Behavioural and Psychological Symptoms of Dementia, Major Neurocognitive Disorder
- Trial name
- VR-Care (NCT07893678)
- Testing
- Supervised Virtual Reality Sessions
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Akathisia
Akathisia in Post Operative Outpatients Surgery
The main objective of this study is to evaluate the incidence of akathisia with Droperidol, the prophylactic treatment of post operative nausea and vomiting, used at two different doses, versus control group (Ondansetron), in…
- Trial name
- NCT01942343
- Testing
- Droperidol 1,25 mg administration, Droperidol 0,625 mg administration, Odansetron 4 mg administration
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Competence
VR-Based Intervention for Caregiving Competence in Dementia
This study aims to develop and evaluate the effectiveness of a VR-based educational intervention designed to improve the dementia caregiving abilities of formal caregivers in residential care homes.
- Trial name
- VRE-ABC (NCT06797180)
- Testing
- Virtual Reality Education for Dementia Caregivers
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Mackay Medical College
Dementia, Pain
Pain in Patients With Dementia and Behavioural Disturbances
In nursing homes (NHs) 80% of the patients have dementia, between 60%-80% exhibit behavioural disturbances (BPSD), and more than 60% have pain. Both pain and BPSD is more common in those with severe dementia.
- Conditions
- Dementia, Pain, Agitation
- Trial name
- NCT01021696
- Testing
- Paracetamol, Morphine, Buprenorphine plaster
- Where
- 18 sites in Norway
- Volunteers
- 352 people
- Sponsor
- University of Bergen
Alzheimer Disease, Psychomotor Agitation
Alzheimer's in Long-Term Care--Treatment for Agitation
The purpose of this study is to see if a medication called prazosin is useful in the treatment of agitation and aggression in persons with Alzheimer's disease (AD) and other types of dementia in late life.
- Trial name
- NCT00161473
- Testing
- prazosin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Washington
Alzheimer Disease, Agitation
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
The purpose of this study is to evaluate the long-term efficacy and safety of combined formulation of xanomeline tartrate/trospium chloride in an immediate release (IR) capsule (KarXT) and xanomeline enteric capsules (KarX-EC) in…
- Trial name
- NCT06937229
- Testing
- KarXT, KarX-EC
- Where
- 252 sites in United States, Argentina and 24 more
- Volunteers
- 650 people
- Sponsor
- Bristol-Myers Squibb
Traumatic Brain Injury, Agitation,Psychomotor
Effects of Dexmedetomidine on Agitation in Critically Ill TBI Patients
Agitation is a frequent complication following traumatic braing injury in patients admitted to the intensive care unit. This agitation frequently results in the liberal use of rescue drugs such as antipsychotics, sedatives and…
- Trial name
- DEX-TBI (NCT06620393)
- Testing
- Dexmedetomidine
- Volunteers
- 72 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Music Therapy for Pain and Sedation
Music Therapy is Associated With Decreased Pain and Agitation in Intubated ICU Patients
The study is designed to analyze the use of music therapy to decrease pain and agitation in intubated ICU patients.
- Trial name
- NCT01316536
- Testing
- provide headphones with music playing, Sounds
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Francisco