Clinical trials: Aids
HIV/AIDS, ANTIRETROVIRAL TREATMENT
Immediate ART in Subjects With Opportunistic Diseases
The aim of this study is to compare the clinical response and mortality rate due to opportunistic disease in HIV-infected individuals who start immediate versus conventional antiretroviral therapy (ART).
- Trial name
- TARi (NCT03825523)
- Testing
- Antiretroviral Therapy (ART)
- Where
- Mexico
- Volunteers
- 114 people
- Sponsor
- Gustavo Reyes-Teran
HIV/AIDS
ADAPT for Adolescents Adolescents
Adolescents and young adults (AYA) with HIV face unique challenges to engagement in care and their ability to achieve optimal health outcomes.
- Trial name
- A4A (NCT04432571)
- Testing
- SOC-REC/SOC-OIC, SOC-REC/CCT, SOC-REC/IP-NAV
- Where
- Kenya
- Volunteers
- 880 people
- Sponsor
- Washington University School of Medicine
HIV/AIDS
MyPEEPS Mobile Plus: A Multi-Level HIV Prevention Intervention for Young MSM
MyPEEPS Mobile Plus, a multi-level intervention for improving HIV prevention outcomes in YMSM, is a novel and evidence-driven approach using mobile technology to deliver HIV prevention information specifically developed for YMSM.
- Trial name
- NCT06741618
- Testing
- MyPEEPS Mobile, Electronic PrEP peer navigation
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV/AIDS, Mobile Health
Evaluation of a Multi-Component Intervention to Support HIV Testing and Linkage to Services Among MSM in Peru
This study is testing a new program designed to improve access to HIV testing and help connect people with available treatment or prevention services, based on their test result.
- Conditions
- HIV/AIDS, Mobile Health, Feasibility Studies, Qualitative Research
- Trial name
- MERCURY (NCT07074899)
- Testing
- Multi-component HIV testing and linkage-to-services intervention
- Where
- 2 sites in Peru
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
HIV/AIDS
Social Media HIV Prevention Intervention for High Risk Rural Women
The overall aim of this R34 application is to adapt and feasibility test an evidence-based HIV prevention education for high-risk, underserved rural women in Appalachia.
- Trial name
- NCT03456453
- Testing
- NIDA Standard for HIV Prevention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Michele Staton
Adult Women Living With HIV/AIDS, Intimate Partner Violence
Clinic-Community Bridge to Improve Health Outcomes for Abused Women Living With HIV/AIDS
Women living with HIV/AIDS (WLWHA) in Baltimore experience disproportionately high rates of intimate partner violence (IPV), housing instability, and food insecurity, which adversely affect health outcomes.
- Trial name
- Bridges (NCT07553312)
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV/AIDS
Adolescents Living With HIV (ALWH): Social Networks, Adherence and Retention
human immunodeficiency virus / acquired immunodeficiency syndrome (HIV/AIDS) is the second leading cause of death in Africa. Adolescents living with HIV (ALWH) are at increased risk for HIV-related morbidity and mortality due to…
- Trial name
- NCT04077047
- Testing
- iEngage
- Where
- 2 sites in United States, South Africa
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
HIV-1-infection, AIDS
Protect and Improve Cluster of Differentiation 4 (CD4) Cells and B Cells Lymphocytes
This is a plant-based medication used to increase the amount, protect, and reduce HIV's impact on T and B lymphocytes.
- Trial name
- NCT04770701
- Testing
- Ahah Drug
- Where
- Vietnam
- Sponsor
- Trieu, Nguyen Thi, M.D.
Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis
Screening and Follow-up in Patients With HIV Infection Combined With Metabolic Associated Fatty Liver Disease
Acquired immunodeficiency syndrome (AIDS) remains a severe global infectious disease, with over 38 million people living with HIV and around 35 million cumulative deaths worldwide by 2023; approximately 1.24 million HIV-positive…
- Conditions
- Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, Fibrosis, HIV/AIDS
- Trial name
- NCT05330923
- Testing
- Liver Quantitative Ultrasound
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Peking Union Medical College Hospital
HIV/AIDS
Bridges2Scale: Testing Implementation Strategies
The goal of this clinical trial is to compare two multifaceted strategies (standard vs enhanced) for scaling Bridges in a two-arm Hybrid III effectiveness-implementation cluster randomized controlled trial (RCT) in adolescent and…
- Trial name
- NCT06347146
- Testing
- Financial Literacy Training (FLT) workshops, Mentorship, Income Generation Activity (IGA)
- Where
- Uganda
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
HIV, AIDS
Effectiveness of a Smoking Cessation Algorithm Integrated Into HIV Primary Care
To determine the efficacy of an algorithm designed to recommend smoking cessation-related pharmacotherapy options to the primary care providers of smokers living with HIV/AIDS.
- Conditions
- HIV, AIDS, Smoking Cessation
- Trial name
- NCT03670316
- Testing
- Algorithm Treatment, Quitline only
- Where
- United States
- Volunteers
- 371 people
- Sponsor
- University of Alabama at Birmingham
HIV/AIDS, HPV Infection
ORCHID: An Online Intervention for Persons With HIV (Miami)
The purpose of this research is to test ORCHID (Optimizing Resilience \& Coping with HIV through Internet Delivery), a skills-building intervention that improves mental health status for persons with HIV, who are at-risk for…
- Trial name
- ORCHID-Miami (NCT05935644)
- Testing
- ORCHID
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
AIDS (Acquired Immunodeficiency Syndrome), Cardiovascular and Cerebrovascular Diseases
BRAZILIAN REGISTRY OF CHRONIC NON-COMMUNICABLE DISEASES IN PEOPLE LIVING WITH HIV/AIDS
BRAVO proposes the establishment of a comprehensive registry of chronic noncommunicable diseases (NCDs), providing crucial data for the formulation of effective health policies for people living with HIV/AIDS (PLWHA).
- Conditions
- AIDS (Acquired Immunodeficiency Syndrome), Cardiovascular and Cerebrovascular Diseases, Respiratory Comorbidities, Chronic Kidney Disease
- Trial name
- BRAVO (NCT07118683)
- Where
- 9 sites in Brazil
- Volunteers
- 743 people
- Sponsor
- Hospital Alemão Oswaldo Cruz
Neuropathic Pain, HIV Neuropathy
Symptom Management Efficacy Study to Reduce Distal Neuropathic Pain
Distal sensory peripheral neuropathy (DSP) is a chronic, debilitating painful condition affecting quality of life in persons living with HIV.
- Conditions
- Neuropathic Pain, HIV Neuropathy, HIV/AIDS, Pain
- Trial name
- NCT03855111
- Testing
- Standard Acupuncture / Moxibustion, Individualized (Tailored) Active Acupuncture / Moxibustion
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- New York University
HIV, Substance Use Disorders
The Collaborative Care PrTNER Study
A randomized controlled trial to assess the ability of a Collaborative Care Prevention, Treatment, Navigation, Engagement, Resource (PrTNER) intervention to increase initiation of preexposure prophylaxis (PrEP) (for those at-risk…
- Conditions
- HIV, Substance Use Disorders, Substance Use, AIDS
- Trial name
- PrTNER (NCT06585631)
- Testing
- CC PrTNER
- Where
- 2 sites in United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
HIV/AIDS, Alcohol Abuse
An Economic and Relationship-strengthening Intervention to Reduce Alcohol Use in Malawi
With a full-scale randomized control trial, the investigators will evaluate the efficacy and cost effectiveness of Mlambe, an economic and relationship-strengthening intervention that provides incentivized saving accounts…
- Trial name
- NCT06367348
- Testing
- Mlambe
- Where
- Malawi
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Opportunistic Infections, HIV Related, Disseminated Mycobacterium Avium Complex Infection
Enhanced Treatment Strategy for Disseminated MAC Infection in HIV Patients: A Randomized Controlled Trial
Background: Disseminated Mycobacterium avium complex (MAC) infection remains a serious opportunistic infection in patients with advanced HIV infection, particularly among those with severe immunosuppression.
- Trial name
- NCT07585461
- Testing
- Standard Triple Therapy, Experimental: Standard Triple Therapy Plus Fluoroquinolone
- Volunteers
- 124 people
- Sponsor
- Shanghai Public Health Clinical Center
HIV/AIDS, Young Adult
Intervention for Virologic Suppression in Youth
The goal of this randomized clinical trial is to test the effect of a technology-based intervention with an Adaptive Treatment Strategy (ATS) among youth living with HIV (YLWH) (18-29 years old).
- Conditions
- HIV/AIDS, Young Adult, Mobile Health, Mental Health Issue
- Trial name
- iVY (NCT05877729)
- Testing
- Standard of Care, Video-counseling+app
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Francisco
HIV, AIDS
Efficacy and Safety of Immune Checkpoint Inhibitors for Refractory Opportunistic Infections in AIDS
This prospective, single-arm, open-label study aims to evaluate the efficacy and safety of a PD-1 inhibitor (Sintilimab) combined with standard anti-infective therapy in patients with advanced HIV disease (AHD) who are suffering…
- Conditions
- HIV, AIDS, Immune Checkpoint Inhibitors, Refractory Opportunistic Infection
- Trial name
- NCT07579247
- Testing
- Sintilimab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Public Health Clinical Center
TB - Tuberculosis, HIV/AIDS
Pre- and Post-treatment Lung Microbiota, Metabolome and Immune Signatures at the Site of Disease in Patients With Active Pulmonary Tuberculosis
The diverse microbial communities in different parts of the human body (microbiome) are important for health but understudied in pulmonary tuberculosis (TB), which is the single biggest infectious cause of death in the world.
- Trial name
- TB-LUNG (NCT04700579)
- Where
- 3 sites in South Africa
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Stellenbosch