Clinical trials: Aids
Distress, Depression
Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors
The purpose of this study is to determine whether psilocybin-assisted group psychotherapy is a safe and feasible treatment for demoralization in long-term AIDS survivors (LTAS).
- Conditions
- Distress, Depression, Grief
- Trial name
- NCT02950467
- Testing
- Psilocybin, Modified brief Supportive Expressive Group Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Joshua Woolley
Vaccine Adverse Reaction, Seroconversion
Safety and Immunogenicity of Oxford AstraZeneca Vaccine Against COVID-19 Infection
After SARS-COV-2 inactivated vaccine authorization for use in different countries including Egypt, investigating its immunogenicity, safety, and efficacy in preventing COVID-19 infection is highly needed.
- Trial name
- NCT04756271
- Testing
- SARS-Cov-2 neutralizing antibody titer
- Where
- Egypt
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- Zagazig University
PrEP, PrEP Adherence Monitoring
Prevention ICONA Dedicated Ensemble
Despite significant advances in HIV treatment, transmission remains a public health concern. In 2022, there were 1.3 million new HIV infections worldwide and 1,888 new diagnoses in Italy, with sexual transmission being the…
- Conditions
- PrEP, PrEP Adherence Monitoring, HIV, HIV -1 Infection
- Trial name
- PrIDE (NCT07186244)
- Where
- 53 sites in Italy
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Fondazione ICONA
Effects of Photographic Aids (Photos of Faces) on Patient Recall of Their Clinical Care Team, Effects of Photographic Aids (Photos of Faces) on Clinician-patient Communication
Put a Face to a Name (Part A): The Effects of Photographic Aids on Patient Satisfaction, Clinician Communication, and Quality of Care
Communication is critical within healthcare, and is the root cause of most errors. With increased adoption and use of new information technologies and mediated communication systems, such as Electronic Health Records (EHR), that…
- Conditions
- Effects of Photographic Aids (Photos of Faces) on Patient Recall of Their Clinical Care Team, Effects of Photographic Aids (Photos of Faces) on Clinician-patient Communication, Effects of Photographic Aids (Photos of Faces) on Overall Patient Satisfaction
- Trial name
- Face2Name (NCT01658644)
- Testing
- Provision of Clinical Care Handout
- Where
- Canada
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Menopause
A Menopause Interactive Decision Aid System
The purpose of this study is to develop and test a web-based system intended to help women going through menopause make more informed choices regarding menopause treatments.
- Trial name
- NCT00345072
- Testing
- Web-based decision aid system
- Where
- 2 sites in United States
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Chronic Pain, HIV Infections
Mindfulness Intervention for Individuals With HIV and Chronic Pain
This project is a single-site, two-arm, randomized controlled pilot study examining the impact of a 2-hour version of Mindfulness-Oriented Recovery Enhancement (ONE MORE) training for individuals with HIV and chronic pain.
- Trial name
- NCT06481501
- Testing
- ONE Mindfulness-Oriented Recovery Enhancement
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Florida State University
Human Immunodeficiency Virus, Sexually Transmitted Diseases
A Non-inferiority Randomized Controlled Trial to Evaluate Promoting Condom Use Among MSM and Transgender Individuals in China
This is a pragmatic, non-inferiority, randomized controlled trial comparing the effectiveness of two methods (crowdsourcing versus social marketing) for creating one-minute videos promoting condom use among MSM and TG in China.
- Trial name
- NCT02516930
- Testing
- crowdsourced video, social marketing video
- Where
- China
- Volunteers
- 1,173 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Human Immunodeficiency Virus (HIV)
Repeat Doses of SB-728mR-T After Cyclophosphamide Conditioning in HIV-Infected Subjects on HAART
The purpose of this study is to evaluate the safety and tolerability of repeat doses of T-cell immunotherapy (SB-728mR-T) following cyclophosphamide conditioning. CCR5 is a major co-receptor for HIV entry into T-cells.
- Trial name
- NCT02225665
- Testing
- SB-728mR-T, Cyclophosphamide
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- Sangamo Therapeutics
HIV Infections
A Phase I/II Dose Escalation Study of Intradermal gp160 to Evaluate Safety, Delayed Type Hypersensitivity (Skin Test) Responses and Immunogenicity in Asymptomatic HIV Seropositive Patients With More Than 400 CD4+ Cells
To determine the safety of intradermal gp160 in HIV seropositive individuals who are asymptomatic and have a relatively intact immune system.
- Trial name
- NCT00000667
- Testing
- gp160 Vaccine (MicroGeneSys)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Covid19
COVID-19 and HIV Patients
As of May 26, 2020, 5,508,904 confirmed cases (145,279 in France) of COVID-19 and 346,508 deaths (28,457 in France) have been reported since December 8, 2019 worldwide.
- Trial name
- COCOVIH (NCT04523012)
- Testing
- Seroprevalence of SARS-CoV-2 infection in patients with HIV infection
- Where
- France
- Volunteers
- 2,200 people
- Sponsor
- Centre de Recherches et d'Etude sur la Pathologie Tropicale et le Sida
Tuberculosis
Safety and Immune Responses After Vaccination With Two Investigational RNA-based Vaccines Against Tuberculosis in BCG Vaccinated Volunteers
This is a two-part randomized, placebo-controlled, observer-blind, safety and dose-finding Phase Ib/IIa study. This study will evaluate up to four dose levels of the BNT164 investigational vaccines (BNT164a1 and BNT164b1) to…
- Trial name
- NCT05547464
- Testing
- BNT164a1, BNT164b1
- Where
- 8 sites in Mozambique, South Africa
- Volunteers
- 497 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
HIV Infections, Anus Neoplasms
Chemoprevention of Anal Neoplasia Arising Secondary to Anogenital Human Papillomavirus Infection in Persons With HIV Infection.
PRIMARY: In Phase I, to define a broadly tolerable dose of isotretinoin that can be used in combination with interferon alfa-2a (IFN alfa-2a).
- Trial name
- NCT00000764
- Testing
- Isotretinoin, Interferon alfa-2a
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infection
Immune Activation and Drug Absorption in HIV-Infected Patients
The investigators' objective is to describe the variability of rifampicin absorption, markers of inflammation and gut damage, intestinal absorptive capacity, and intestinal permeability among HIV-infected volunteers.
- Trial name
- NCT01845298
- Testing
- Rifampicin 600 mg
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Drexel University
Osteoporosis, HIV
Bone Health in Aging HIV Infected Women
Design: Open-label randomised multicenter international strategic trial of older women on combination antiretroviral therapy (cART) containing tenofovir-emtricitabine (TDF/FTC) with HIV RNA suppression for > 6 months to : 1.
- Conditions
- Osteoporosis, HIV, Menopause
- Trial name
- BEING (NCT02815566)
- Testing
- tenofovir-alafenamide-emtricitabine, tenofovir-emtricitabine
- Where
- 7 sites in Canada, Italy
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
HIV (Human Immunodeficiency Virus)
Rudi Kundini, Pamoja Kundini
This protocol describes an individually randomized trial that will include adult people living with HIV (PLHIV) currently receiving HIV care at one of two participating health facilities and identified as high risk for…
- Trial name
- RKPK: Phase II (NCT05373095)
- Testing
- PKC (adapted adherence counseling) and Conditional Cash Transfers
- Where
- 4 sites in Tanzania
- Volunteers
- 692 people
- Sponsor
- University of California, Berkeley
HIV, Smoking
Immunosuppressive Effects of Smoking and HIV-1 on the Development of Lung Disease
This study plans to learn more about pulmonary complications of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS).
- Conditions
- HIV, Smoking, COPD
- Trial name
- NCT02058719
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Gastric Cancer, Head and Neck Cancer
Phenylbutyrate and Valganciclovir in Treating Patients With Relapsed or Refractory Epstein-Barr Virus-Positive Cancer
RATIONALE: The Epstein-Barr virus can cause cancer and lymphoproliferative disorders. Valganciclovir is an antiviral drug that acts against the Epstein-Barr virus.
- Conditions
- Gastric Cancer, Head and Neck Cancer, Lymphoma, Lymphoproliferative Disorder
- Trial name
- NCT00387530
- Testing
- oral sodium phenylbutyrate, valganciclovir, polymerase chain reaction
- Where
- United States
- Sponsor
- University of California, San Diego
Malaria, Hiv
OPTImizing Malaria And HIV Treatment in a Shifting Landscape in Africa
A longitudinal study with four parallel cohorts with each participant followed for 2 years: two cohorts in Busia (high malaria transmission site) and two cohorts in Kampala (low malaria transmission).
- Trial name
- OPTIMAH (NCT06967519)
- Testing
- Artemether-lumefantrine (AL), artesunate-amodiaquine (AS-AQ)
- Where
- 2 sites in Uganda
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Yale University
HIV, STDs
Culturally Congruent HIV Risk Reduction App for Young Women, an Acceptability & Pilot Evaluation
Smartphone applications and mobile technologies offer users the potential to access critical information (e.g., proper condom use, directions to testing sites, and other sexual and reproductive health services) when it is needed…
- Trial name
- NCT02733692
- Testing
- Understanding Reproductive Health for Ladeez (GURHL) Code
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- City University of New York, School of Public Health
HIV Infections
Intermittent Therapy in HIV-1 Infected Patients With Successful Viral Suppression Under Highly Active Antiretroviral Therapy (HAART)
Although lifelong continuous therapy with HAART remains the standard of care of HIV infection, allowing to achieve undetectable plasma viral RNA, restore CD4 cell count and provide substantial decline in HIV-related morbidity and…
- Trial name
- NCT00122551
- Testing
- Intermittent antiretroviral therapy
- Where
- 2 sites in France
- Volunteers
- 400 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis