Clinical trials: Airway Clearance
Cystic Fibrosis, Motor Neuron Disease
MN4000 for Treatment of CF and MND Patients in the Home Setting
The study was a non-randomized open label pilot study. It was an observational design conducted at one (1) site in the US. All enrolled subjects received treatment with the MN4000.
- Conditions
- Cystic Fibrosis, Motor Neuron Disease, Airway Clearance Impairment
- Trial name
- NCT03797677
- Testing
- MN 4000
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Hill-Rom
Cystic Fibrosis, Pulmonary
Airway Clearance System (K031876) Phase IV Device Efficacy
Phase IV interventional study of adults (18 to 55) having a diagnosis of cystic fibrosis (mild, moderate or severe). The study is completely voluntary and is designed to measure participants use and the effectiveness of the…
- Trial name
- NCT03437811
- Testing
- Electro Flo Percussor, Model 5000
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mack Biotech, Corp.
Non-cystic Fibrosis Bronchiectasis
Long-term Evaluation of the SIMEOX Device at Home in Non-cystic Fibrosis Bronchiectasis
Bronchiectasis is a chronic lung disease of multiple aetiologies characterised by permanent dilatation of the calibre of a territory of the bronchial tree with impaired mucociliary clearance.
- Trial name
- Home-BRAC (NCT06487273)
- Testing
- SIMEOX, Remote Physiotherapy
- Where
- 57 sites in France, Germany and 4 more
- Volunteers
- 622 people
- Sponsor
- Physio-Assist
Cystic Fibrosis in Children, Airway Clearance Impairment
Efficacy of Simeox Airway Clearance Therapy in Children With Cystic Fibrosis
Chest physiotherapy plays a crucial role in treatment of lung disease in cystic fibrosis (CF). New airway clearance techniques (ACTs) adapted to individual needs are still being sought to achieve the best effect of airway…
- Trial name
- NCT04084041
- Testing
- Simeox, CCPT
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Physio-Assist
Bronchiectasis, Bronchiectasis With Acute Exacerbation
A Pilot Study to Evaluate the Use of the Vest® System for Treatment of Bronchiectasis Patients in the Home Setting
This a 70 patient multi-site non blinded randomized control trial evaluating the use of the Vest® System for treatment of Non-Cystic Fibrosis Bronchiectasis (NCFBE) patients in the home setting.
- Trial name
- NCT04017312
- Testing
- High Frequency Chest Wall Oscillation, Oscillating Positive Expiratory Pressure (OPEP)
- Where
- 3 sites in United States
- Volunteers
- 43 people
- Sponsor
- Hill-Rom
Cystic Fibrosis, Mucociliary Clearance
A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of GS-9411 in Healthy Male Volunteers
The purpose of this study is to evaluate the safety and tolerability of escalating doses of GS-9411 in healthy male volunteers. GS-9411 is a sodium channel inhibitor, that may restore airway hydration and mucociliary clearance in…
- Conditions
- Cystic Fibrosis, Mucociliary Clearance, Airway Hydration
- Trial name
- NCT00951522
- Testing
- GS-9411
- Where
- Australia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Bronchiectasis Adult
Real Life Evaluation of the LibAirty Airway Clearance System in Adults With Bronchiectasis (RELACS)
The purpose of this study is to collect data to assess the use of the LibAirty™ System for improving bronchiectasis symptoms and healthcare resource utilization when it is used at home.
- Trial name
- NCT07135284
- Testing
- Airway clearance system
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Synchrony-Medical, Ltd
Airway Secretion Clearance
Evaluation of High-Frequency Chest Wall Oscillation
To compare the outcomes of patients treated with the Vest and conventional chest physiotherapy to determine if the Vest provides equivalent therapy
- Trial name
- NCT00717873
- Testing
- Airway clearance Device
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Hill-Rom
Broncho-degenerative Disease, Chronic Obstructive Airway Disease
Evaluation of the Safety of the Medical Device Simeox®
The purpose of this study is to determine whether the medical device "simeox" is safe in the treatment of respiratory diseases, in comparison with traditional physiotherapy.
- Conditions
- Broncho-degenerative Disease, Chronic Obstructive Airway Disease, Cystic Fibrosis, Idiopathic Bronchiectasis
- Trial name
- SIMETOL (NCT02061852)
- Testing
- Simeox, Physiotherapy
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Physio-Assist
Obstructive Airway Diseases
Nasal Muco-ciliary Clearance Study With and Without Salt Inhalation
Investigating nasal muco-ciliary clearance by scintigraphy
- Trial name
- NCT04189016
- Testing
- Inhalation from a salt particle inhaler with or without content
- Where
- Denmark
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Liita Care ApS
Chronic Obstructive Pulmonary Disease
Airway Clearance Study
The purpose of the study is to evaluate how the airways in COPD patients, compared to healthy volunteers, absorb steroid drugs from Symbicort Turbuhaler and Seretide Diskus.
- Trial name
- NCT00379028
- Testing
- Budesonide/Formoterol Turbuhaler, Salmeterol/Fluticasone Diskus
- Where
- 2 sites in Sweden, United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Cystic Fibrosis
Trial to Assess the Safety, Tolerability and Pharmacokinetics of GS-9411 in Healthy Male Volunteers
The purpose of this study is to evaluate the safety and tolerability of escalating doses of GS-9411 in healthy male volunteers. GS-9411 is a sodium channel inhibitor, that may restore airway hydration and mucociliary clearance in…
- Trial name
- NCT00800579
- Testing
- GS-9411
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Cystic Fibrosis
Evaluation of an Airway Clearance System
The aim of this study is to assess the effectiveness of an Airway Clearance System.
- Trial name
- NCT03091062
- Testing
- Vest® Airway Clearance System, Monarch™ System
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- Hill-Rom
Bronchiectasis, Mucus; Plug
Simeox 200 US Study
The purpose of this single arm post-market observational study is to evaluate the short-term effectiveness of the Simeox 200 airway clearance device in improving airway clearance in adult patients aged 18 to 85 with…
- Trial name
- IMPACT (NCT07443124)
- Testing
- Intermittent intrapulmonary deflation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Inogen Inc.
Cystic Fibrosis
Evaluation of Device Settings for Airway Clearance Using The Monarch Airway Clearance System
The study will be an open label laboratory study with all subjects receiving HFCWO with The Monarch® System Objective: Assess device settings and to identify frequency/pressure (intensity) combinations that produce high airflow…
- Trial name
- HFCWO (NCT03645473)
- Testing
- Monarch Airway Clearance System
- Volunteers
- 10 people
- Sponsor
- Hill-Rom
Bronchiectasis Adult
Home Airway Clearance in Patients With Bronchiectasis (Home-Care Bronchiectasis)
Bronchiectasis is a chronic multiple etiologies pulmonary disease characterized by permanent dilatation of the caliber of the bronchial tree territory with an alteration of mucociliary clearance.
- Trial name
- NCT04742270
- Testing
- SIMEOX+ respiratory physiotherapy telecare
- Where
- 3 sites in France
- Volunteers
- 22 people
- Sponsor
- Physio-Assist
Non-cystic Fibrosis Bronchiectasis, Chronic Mucus Hypersecretion
Simeox Therapy at Home Versus Standard of Care in NCFB Patients With CMH
This pilot RCT will assess benefits of Simeox technology on lung function, respiratory symptoms, health-related quality of life, subjective efficiency, device adherence at home, Patient satisfaction, tolerance, safety, and…
- Trial name
- NCT06237348
- Testing
- Simeox, Control
- Where
- 2 sites in Poland
- Volunteers
- 50 people
- Sponsor
- Physio-Assist
Pulmonary Cystic Fibrosis
Home Airway Clearance in CF Patients
Regular bronchial clearance is essential in patients with cystic fibrosis for their bronchial health. SIMEOX® (Physio-Assist, Aix en Provence, France) is an innovative medical device for the drainage of the bronchial tree.
- Trial name
- HomeCareSIMEOX (NCT04096664)
- Testing
- SIMEOX
- Where
- 20 sites in France
- Volunteers
- 143 people
- Sponsor
- Physio-Assist
Pulmonary Cystic Fibrosis
Ancillary Home Airway Clearance in CF Patients ( HomeCareSIMEOX )
Regular bronchial clearance is essential in patients with cystic fibrosis for their bronchial health. SIMEOX® (Physio-Assist, Aix en Provence, France) is an innovative medical device for the drainage of the bronchial tree.
- Trial name
- NCT04095078
- Testing
- SIMEOX
- Where
- 5 sites in France
- Volunteers
- 56 people
- Sponsor
- Physio-Assist
Cystic Fibrosis, Mucociliary Clearance
A Randomized, Double-Blind, Placebo-Controlled Multiple Dose Trial of GS-9411 in Healthy Volunteers
The purpose of this study is to evaluate the safety and tolerability of repeated doses of GS-9411 in healthy volunteers. GS-9411 is a sodium channel inhibitor, that may restore airway hydration and mucociliary clearance in the…
- Conditions
- Cystic Fibrosis, Mucociliary Clearance, Airway Hydration
- Trial name
- NCT00999531
- Testing
- GS-9411
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences