Clinical trials: Airway Control
Chronic Cough, Eosinophilic Bronchitis
Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases
Cough is the most common presenting symptom to family physician. Chronic Cough affects approximately 10-12% of the general population and is one of the commonest reasons for referral to secondary care.
- Conditions
- Chronic Cough, Eosinophilic Bronchitis, Asthma
- Trial name
- MUCOSA (NCT04765722)
- Testing
- Mepolizumab, Normal Saline
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- McMaster University
Acute Pain, Multiple Trauma
Ketamine Patient-Controlled Analgesia for Acute Pain
This study will compare ketamine and hydromorphone as alternative patient-controlled interventions for trauma-related pain. Patients receiving ketamine PCA are expected to require less total and breakthrough opioid and to have…
- Conditions
- Acute Pain, Multiple Trauma, Fractures
- Trial name
- NCT02062879
- Testing
- Ketamine, Hydromorphone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Airway Management
King Vision® and GlideScope® in Difficult Airways
There are several advantages of video laryngoscopy; especially their ability to provide superior glottis visualization, as compared to traditional laryngoscopy.1-3 The purpose of this three arm study was to compare the safety and…
- Trial name
- NCT03685968
- Testing
- Video laryngoscopes
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Asthma
Early Airway Response to Allergen in Asthmatics (MK-0000-176)
This study will assess the Early Airway Response (EAR) associated change in forced expiratory volume in one second (FEV1) and plasma 9α-11ß-PGF2 ('9P') after single dose pretreatment of nedocromil, montelukast, and mometasone.
- Trial name
- NCT01061333
- Testing
- Nedocromil, Comparator: Montelukast, Comparator: Mometasone
- Volunteers
- 16 people
- Sponsor
- Merck Sharp & Dohme LLC
Acute Respiratory Distress Syndrome
Open Lung Ventilation in ARDS: The PHARLAP Trial
Some people develop the condition called acute respiratory distress syndrome (ARDS). This is a condition where the lungs have become injured from one of a number of various causes, and do not work as they normally do to provide…
- Trial name
- PHARLAP (NCT01667146)
- Testing
- PHARLAP mechanical ventilation strategy, Control group mechanical ventilation strategy
- Where
- 27 sites in Australia, Ireland and 3 more
- Volunteers
- 115 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Bronchiectasis
Evaluation of Cipro Inhale in Patients With Non-cystic Fibrosis Bronchiectasis
The purpose of this study is to find out if bacterial load in the airways can be reduced after inhalation of ciprofloxacin for 28 days.
- Trial name
- NCT00930982
- Testing
- Ciprofloxacin (Cipro, BAYQ3939)
- Where
- 47 sites in United States, Australia and 4 more
- Volunteers
- 124 people
- Sponsor
- Bayer
Tonsillitis, Airway Obstruction
Acetaminophen's Efficacy For Post-operative Pain
The purpose of this study is to compare IV acetaminophen to oral acetaminophen for pain control in children undergoing tonsillectomy with or without adenoidectomy.
- Conditions
- Tonsillitis, Airway Obstruction, Difficulty Swallowing
- Trial name
- NCT01721486
- Testing
- IV acetaminophen, PO acetaminophen
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Kaveh Aslani, MD
Nasal Valve Collapse, Nasal Breathing
Latera RCT - Latera vs. Sham Control for Lateral Nasal Valve Collapse
The primary objective of the LATERA RCT is to demonstrate the superiority of the Latera Implant to improve nasal breathing, compared with a Sham Control procedure.
- Trial name
- NCT03400787
- Testing
- Latera Implant
- Where
- 11 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Spirox, Inc.
Intubation; Difficult
Sedation Effect of Dexmedetomidine Versus Remifentanil to Fibreoptic Intubation
The purpose of this study is to compare the sedation effect of dexmedetomidine and target controlled remifentanil for awake nasotracheal fibreoptic intubation in patients undergoing oral maxillofacial surgery.
- Trial name
- NCT01474213
- Testing
- dexmedetomidine group, remifentanil group
- Where
- 2 sites in China
- Volunteers
- 42 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Acute Respiratory Failure
DirEct Versus VIdeo LaryngosCopE Trial
Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States.
- Trial name
- DEVICE (NCT05239195)
- Testing
- Video Laryngoscope, Direct Laryngoscope
- Where
- 12 sites in United States
- Volunteers
- 1,420 people
- Sponsor
- Vanderbilt University Medical Center
Asthma
An Imaging Study Using PET/CT to Characterize the Effect of Intravenous Reslizumab on Airway Inflammation
This is an exploratory study with the following primary objectives: 1) to establish that PET/CT of the lung can reliably distinguish healthy, non-asthmatic participants from participants with severe asthma and an eosinophilic…
- Trial name
- DEAR (NCT02937168)
- Testing
- Reslizumab, Fludeoxyglucose F 18 (FDG)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Pneumonia, Respiratory Insufficiency
Helmet Continuous Positive Airway Pressure (CPAP) Versus Oxygen Venturi in Severe Acute Respiratory Failure in Pneumonia
The purpose of this study is to compare the efficacy of CPAP application by a helmet and O2 administration by a Venturi mask in terms of achievement of criteria for endotracheal intubation during severe acute respiratory failure…
- Trial name
- NCT01383213
- Testing
- Oxygen therapy, Helmet CPAP
- Where
- Italy
- Volunteers
- 81 people
- Sponsor
- University of Milan
Airway Control
Observational Study of Rapid Sequence Intubation Drug Delivery Using Intraosseous and Intravenous Access.
This study will evaluate using intraosseous vascular access and intravenous vascular access to give patients the necessary medications to perform rapid sequence intubation, for patients with airway difficulties.
- Trial name
- NCT01486407
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Vidacare Corporation
Asthma
Effect of Inhaled TD-8236 on Allergen-induced Asthmatic Response
This will be a randomized, double-blind, placebo-controlled study. The study will use a three-period, six-sequence, complete-block, cross-over study design to characterize two doses of inhaled TD-8236 compared to placebo in…
- Trial name
- NCT04150341
- Testing
- TD-8236
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- Theravance Biopharma
Laryngismus
Laryngeal Mask Airway (LMA) Insertion With Sevoflurane and Remifentanil
The purpose of this study was to determine the most suitable effect-site concentration of remifentanil for the LMA insertion during inhaled induction with 8% sevoflurane in adults.
- Trial name
- NCT01456299
- Testing
- Remifentanil 1, Control, Remifentanil 2
- Where
- South Korea
- Volunteers
- 102 people
- Sponsor
- Gachon University Gil Medical Center
Chronic Obstructive Pulmonary Disease - COPD
Formoterol Dose Ranging Study (ACHIEVE Duaklir USA Phase IIb)
To assess the bronchodilation of three doses of formoterol fumarate (6 μg, 12 μg and 24 μg) twice daily (BID) administered via Pressair® compared to placebo and to open-label nebulized formoterol fumarate (20 μg and 40 μg).
- Trial name
- NCT02796651
- Testing
- Formoterol fumarate (6 μg), Formoterol furmarate (20 μg), Formoterol fumarate (12 μg)
- Where
- 20 sites in United States
- Volunteers
- 132 people
- Sponsor
- AstraZeneca
Obstructive Sleep Apnea
Targeted CPAP Therapy for Obstructive Sleep Apnea in Pregnancy
Prospective, randomized controlled trial. Pregnant women in early pregnancy will be randomized to either the Sleep Study + CPAP (Continuous Positive Airway Pressure Therapy) group or to a Standard Prenatal Care group.
- Trial name
- NCT02755831
- Testing
- CPAP, Pre-natal care
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Airway Morbidity
Endotracheal Tube Versus Laryngeal Mask Airway for Esophagogastroduodenoscopy
Esophagogastroduodenoscopy (EGD) is a relatively common procedure in pediatric patients undergoing evaluation for various gastrointestinal ailments.
- Trial name
- NCT01936662
- Testing
- LMA, ETT
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Indiana University
Airway Management, Intubation, Intratracheal
Soiled Airway Tracheal Intubation and the Effectiveness of Decontamination by Paramedics
In more than one-in-five cases of out-of-hospital cardiac arrest, airways are blocked by vomit and blood. Sometimes, paramedics cannot clear the airway using methods they have been taught.
- Conditions
- Airway Management, Intubation, Intratracheal, Laryngoscopy, Vomiting
- Trial name
- SATIATED (NCT03599687)
- Testing
- Training in SALAD technique
- Where
- United Kingdom
- Volunteers
- 164 people
- Sponsor
- Yorkshire Ambulance Service NHS Trust
Airway Management During Operative Procedure
Evaluation of Micropore"s SpiraLith Absorbents
This is an observational study investigating the duration of use and cost of the new CO2 absorbent Micropore's Spiralith®, compared to Drägersorb® 800+, Drägersorb® Free.
- Trial name
- NCT02550470
- Testing
- Carbon Dioxide Absorbents, Micropore SpiraLith, Sevoflurane
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Rutgers, The State University of New Jersey