Clinical trials: Airway Disease
Chronic Cough, Eosinophilic Bronchitis
Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases
Cough is the most common presenting symptom to family physician. Chronic Cough affects approximately 10-12% of the general population and is one of the commonest reasons for referral to secondary care.
- Conditions
- Chronic Cough, Eosinophilic Bronchitis, Asthma
- Trial name
- MUCOSA (NCT04765722)
- Testing
- Mepolizumab, Normal Saline
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- McMaster University
Asthma
A Study To Assess The Effect Of PF-03526299 On Lung Function Following An Allergen Challenge In Asthmatic Subjects
PF-03526299, a novel anti-inflammatory agent should attenuate the effect of a bronchial allergen challenge on lung function and hence provide proof of mechanism for this agent.
- Trial name
- NCT00877539
- Testing
- PF-03526299, Fluticasone propionate
- Where
- 2 sites in United Kingdom
- Volunteers
- 29 people
- Sponsor
- Pfizer
Chronic Obstructive Pulmonary Disease (COPD)
To Determine the Relationship Between Baseline Reversibility and the Efficacy of Indacaterol
In this 5-months study, the response of patients to salbutamol at baseline will be compared with their response to treatment with indacaterol.
- Trial name
- REVERBREZ (NCT01272362)
- Testing
- Indacaterol
- Where
- 137 sites in France
- Volunteers
- 625 people
- Sponsor
- Novartis Pharmaceuticals
Postoperative Period, Physical Therapy Modalities
Positive Pressure Therapy to Optimize LUNG Function After Heart Surgery
The most common cardiac surgeries are myocardial revascularization and valve replacement or plastic surgery. In the postoperative period of cardiac surgeries, the incidence of pulmonary complications ranges from 30% to 50% and is…
- Conditions
- Postoperative Period, Physical Therapy Modalities, Continuous Positive Airway Pressure, Respiratory Function Tests
- Trial name
- PRO-LUNGHS (NCT06611527)
- Testing
- PS+PEEP group, CPAP group
- Where
- Brazil
- Volunteers
- 156 people
- Sponsor
- Federal University of São Paulo
Apnea
A Novel Method of Non-invasive Ventilation in Children
The purpose of this study is to quantify the tidal volume generated by the pressure release immediately following the application of pressure to the chest.
- Trial name
- NCT01394172
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Asthma
Asthma Intervention Research (AIR) Trial
The purpose of this study is to demonstrate the effectiveness and safety of the Alair System for the treatment of asthma. This will be a multicenter, randomized controlled study comparing the effects of treatment with the Alair…
- Trial name
- NCT00214526
- Testing
- Bronchial thermoplasty with the Alair System, Conventional therapy with ICS+LABA
- Volunteers
- 112 people
- Sponsor
- Asthmatx, Inc.
Influenza
Study to Investigate the Efficacy and Safety of Apomivir®
Apomivir® is extracted from a proprietary spirulina strain, FEM-101, a kind of blue cyanobacterium with patented freeze-thaw lysis and extraction method.
- Trial name
- NCT01677689
- Testing
- Apomivir®
- Where
- Taiwan
- Volunteers
- 196 people
- Sponsor
- Far East Bio-Tec Co., Ltd
Deglutition Disorders, Respiratory Distress Syndrome In Premature Infants
Effect of Nasal Continuous Positive Airway Pressure on The Pharyngeal Swallow in Neonates
Oral feeding of neonates while on nasal continuous positive airway pressure (NCPAP) is a common practice in many neonatal intensive care units (NICU) all over the country.
- Conditions
- Deglutition Disorders, Respiratory Distress Syndrome In Premature Infants, Respiratory Aspiration, Newborn, Premature
- Trial name
- NCT02661256
- Testing
- NCPAP, Varibar® Thin Liquid Barium Sulfate for Suspension
- Volunteers
- 7 people
- Sponsor
- NYU Langone Health
Patients Requiring Non-invasive Ventilation
An Oral Intake Screening Tool for Patients Receiving Non-Invasive Ventilation
This study aims to explore how the introduction of an oral intake screening tool can benefit patients requiring noninvasive ventilation.
- Trial name
- NCT02090868
- Testing
- Oral Intake Screening Tool
- Where
- 2 sites in United Kingdom
- Sponsor
- Imperial College London
Obstructive Sleep Apnea Syndrome
Continuous Positive Airway Pressure and Acetazolamide to Treat Sleep Apnea Syndrome Patients at Altitude
The purpose of the study is to investigate the effect of nasal continuous positive airway pressure in combination with acetazolamide as a treatment for sleep related breathing disturbances in patients with the obstructive sleep…
- Trial name
- NCT00928655
- Testing
- acetazolamide, nocturnal continuous positive airway pressure
- Where
- Switzerland
- Volunteers
- 51 people
- Sponsor
- University of Zurich
Difficult Intubation, Morbid Obesity
A Comparison of McGrath MAC Versus C-MAC Videolaryngoscopes in Morbidly Obese Patients
Along with the technological advances in medicine, videolaryngoscope is the most commonly preferred technique for intubation of expected difficult airway management such as morbidly obese patients.
- Conditions
- Difficult Intubation, Morbid Obesity, Videolaryngoscopy
- Trial name
- mcgrath&cmac (NCT03657927)
- Testing
- C-MAC videolaryngoscope, McGrath MAC videolaryngoscope
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Inonu University
Nasal Airway Obstruction
An Ambispective Registry Study Comparing Clinical Outcomes of Surgical Interventions for the Treatment of Nasal Airway Obstruction.
The purpose of this study is to assess and compare the clinical outcomes associated with common surgical interventions for the treatment of nasal airway obstruction (NAO).
- Trial name
- DUO (NCT06992037)
- Where
- United States
- Volunteers
- 1,110 people
- Sponsor
- Aerin Medical
Obstructive Sleep Apnea Syndrome
Multimodal Remote Monitoring and Integrated Educational Program in OSA Patients Initiating Continuous Positive Airway Pressure (CPAP): (SLEEPCONNECT)
Continuous positive airway pressure (CPAP) is the first line therapy for Obstructive Sleep Apnea Syndrome (OSAS) but has limited impact for reducing cardio-metabolic risk.
- Trial name
- SLEEPCONNECT (NCT04054180)
- Testing
- CPAP associated with connected devices: blood pressure monitor , scales and activity monitor
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Grenoble
Chronic Obstructive Pulmonary Disease
SCOPE-Study: Salzburg Chronic Obstructive Pulmonary Disease- Exercise and Oxygen Study
Chronic obstructive pulmonary disease (COPD) is number four of the leading causes of death in the USA and Europe. Moreover, among the top five causes of death, this disease is the only one with increasing mortality rates.
- Trial name
- SCOPE (NCT01150383)
- Testing
- Physical exercise training with supplemental oxygen, Physical exercise training with "room air supplementation"
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Paracelsus Medical University
Lung Fibrosis
Impact of Airway Mucus Plugs on Secondary Pulmonary Fibrosis in COPD Patients: A Single-Center Case-Control Study
Chronic obstructive pulmonary disease (COPD) is frequently accompanied by airway mucus plugs, which are closely associated with airflow obstruction, acute exacerbations, and increased mortality.
- Trial name
- NCT07236541
- Testing
- No intervention; observational biospecimen collection only
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ming Zhong
Obstructive Sleep Apnea
Comparative Assessment of Sleep Positive Airway Pressure Modalities (CASPAM)
Obstructive sleep apnea (OSA) has been one of the topmost global health problems. It is an underdiagnosed disease which have a huge burden on healthcare if left untreated.
- Trial name
- CASPAM (NCT06564896)
- Testing
- CPAP Airsense 10 vs Air-Mini
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- National University of Malaysia
Asthma
Study to Assess the Effect of the NEXThaler® Device (DPI - Dry Powder Inhaler) on the Central and Peripheral Airway Dimensions in Asthmatic Patients
The objective of this study is to evaluate the effect of the combination of formoterol and beclometasone dipropionate in a dry powder inhaler (NEXThaler®) on central and peripheral airway dimensions in asthmatic patients.
- Trial name
- NCT01650441
- Testing
- Beclomethasone dipropionate 100 µg + formoterol fumarate 6 µg, CT thorax
- Where
- Belgium
- Volunteers
- 31 people
- Sponsor
- University Hospital, Antwerp
Airway Disease
Study for the Validation of the Circuit of Examinations and Analyzes for Better Classification of Airway Diseases
ADs (airway diseases) are a group of progressive diseases that lead to a decline of lung function, accelerated by recurrent exacerbations, which can lead to death.
- Trial name
- BABY-ROAD (NCT05826522)
- Testing
- observationnal
- Volunteers
- 50 people
- Sponsor
- Hopital Foch
Tracheomalacia
Dynamic Airway CT is Diagnostic for Tracheomalacia in Children
The purpose of this pilot interventional study is to evaluate the use of Dynamic Airway Computed Tomography (DA-CT) for diagnosis of tracheomalacia in children 0-18 years for whom flexible bronchoscopy has been performed.
- Trial name
- NCT06028646
- Testing
- Dynamic Airway CT scan (DA-CT)
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- NYU Langone Health
Sleep Apnea Syndromes
CPAP Observance During the COVID-19 (SARS-CoV-2) Pandemic
The hypothesis of this work is that the COVID 19 pandemic and the associated lockdowns are likely to modify the adherence to positive airway pressure (PAP) treatments among patients with sleep apnea.
- Trial name
- COVADENE (NCT04775966)
- Where
- France
- Volunteers
- 8,477 people
- Sponsor
- University Hospital, Montpellier
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