Clinical trials: Airway Disease
Apnea of Prematurity
Detection of CardioRespiratory Events Using Acoustic Monitoring in Preterm Infants on CPAP
This is an observational, proof-of-concept, feasibility study where 50 preterm infants with gestational age < 32+0 weeks will be recruited from the neonatal intensive care unit (NICU) at the Montreal Children's Hospital.
- Trial name
- DREAM (NCT05196646)
- Testing
- Respiratory Acoustic Sensors, Nasal thermistor, Respiratory Inductive Plethysmography
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Post Nasal Drip
Capsaicin Cough Threshold in Chronic Cough Due to Postnasal Drip
This study is being done to find out why some people with mucus dripping down the back of their throat have a nagging cough while others do not cough.
- Trial name
- NCT00588627
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Upper Airway Obstruction
Identification of Airway Structures Necessary for Airway Access Via the Skin
Literature shows that anaesthetists have a low success-rate when trying to access the airway percutaneously in case of failed ventilation and intubation.
- Trial name
- NCT02613429
- Testing
- identification of the airway by from the cranial end, identification of the airway from the distal end
- Where
- 2 sites in Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Maternal Hypertension
The Effect of CPAP on Maternal and Infant Outcomes in Pregnant Women With OSAS
The goal of this clinical trial is to learn about the impact of CPAP on the maternal and infant outcomes of women with obstructive sleep apnea syndrome.
- Trial name
- NCT06344702
- Testing
- CPAP
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Obstructive Sleep Apnea
Impact of Telemonitoring to Improve Adherence in Continuous Positive Airway Pressure (CPAP)-Treated Patients
Improvement in CPAP adherence can be obtained by usingTelemonitoring. T4P® is a telemonitoring unit added on CPAP device allowing to obtain a daily report of usage duration, mask leaks, pressure and apnea-hypopnea index.
- Trial name
- NCT02773953
- Testing
- T4PTelemonitoring, CPAP
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Asthma
Airway Smooth Muscle and Asthma Severity
Our hypothesis is that the severity of asthma is determined by the way in which airway smooth muscle cells grow and release inflammatory mediators.
- Trial name
- NCT00779870
- Testing
- bronchoscopy
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cystic Fibrosis
Evaluation of Device Settings for Airway Clearance Using The Monarch Airway Clearance System
The study will be an open label laboratory study with all subjects receiving HFCWO with The Monarch® System Objective: Assess device settings and to identify frequency/pressure (intensity) combinations that produce high airflow…
- Trial name
- HFCWO (NCT03645473)
- Testing
- Monarch Airway Clearance System
- Volunteers
- 10 people
- Sponsor
- Hill-Rom
Hypertension Secondary
Characteristics of Obstructive Sleep Apnea Syndrome Related Hypertension and the Effect of Continuous Positive Airway Pressure Treatment on Blood Pressure
Obstructive sleep apnea syndrome (OSAS) causes nocturnal chronic intermittent hypoxia (CIH) that contributes to the development of hypertension.
- Trial name
- NCT03246022
- Testing
- continuous positive airway pressure
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Huai'an No.1 People's Hospital
Asthma
Influence Of Different Airflow Resistances On Drug Effect Of 50μg Salmeterol And 6 μg Formoterol
Effect of inhaled drugs administered as dry powder is not only dependent on drug efficacy but also on technical properties of the inhalers.
- Trial name
- NCT00327353
- Testing
- formoterol (TURBOHALER), Salmeterol (DISKUS)
- Where
- 2 sites in Germany
- Volunteers
- 77 people
- Sponsor
- GlaxoSmithKline
Sleep Apnea Syndromes
Study of Anatomo-functional Correlation of the Upper Airways
Sleep apnea-hypopnea syndrome (SAHS) is a disorder of nocturnal ventilation due to the occurrence abnormally frequent pauses in breathing.
- Trial name
- P3E (NCT05774522)
- Testing
- Measurement of pharyngeal critical airway closing pressure, Acoustic pharyngometry, Upper airway ultrasound
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
Effects of Gallopamil in Severe Asthma
Severe asthma is a difficult to treat disease, characterized by bronchial remodelling, which is an abnormal repair process that contributes to the development of poorly reversible airway narrowing.
- Trial name
- REMODEL'ASTHME (NCT00896428)
- Testing
- Methoxyverapamil (gallopamil)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Bordeaux
Lung Disease,Obstructive
Airway Responsiveness in Patients With AECOPD Mechanical Ventilation by Inspiratory and Bronchial Dilation Testchronic Obstructive Pulmonary Disease
In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the…
- Trial name
- NCT02592122
- Testing
- Salbutamol Aerosol, No drugs
- Where
- China
- Volunteers
- 120 people
- Sponsor
- snow
Mechanical Ventilation Pressure High, Ventilator-Associated Pneumonia (VAP)
Dynamic Airway Resistance & ML: Guide Sputum Suction in Ventilated Patients
Research has shown that timely suctioning not only improves survival rates but also enhances the quality of life in ventilator-dependent patients.
- Conditions
- Mechanical Ventilation Pressure High, Ventilator-Associated Pneumonia (VAP), Respiratory Depression Neonatal
- Trial name
- NCT07375667
- Testing
- The dynamics of airway resistance, conventional suctioning
- Where
- 3 sites in China
- Volunteers
- 258 people
- Sponsor
- Affiliated Hospital of Nantong University
Nasal Obstruction, Nasal Septum; Deviation
Changes in Nasal Airflow Parameters After Septoplasty and Turbinoplasty
Pathological-anatomical changes in the nasal cavity (nasal septum/perforation, mucosal hypertrophy) negatively affect nasal airflow, increase resistance - cause nasal obstruction and are often an indication for surgery.
- Conditions
- Nasal Obstruction, Nasal Septum; Deviation, Nasal Mucosa Hypertrophy
- Trial name
- NCT04220853
- Testing
- Rhinomanometry in patients after septoplasty and/or turbinoplasty, Acoustic rhinometry in patients after septoplasty and/or turbinoplasty
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Ostrava
Airway Morbidity, Cognitive and Attention Disorders and Disturbances
Short-term Health Benefits of Using Fresh Air Filtration System in Classroom
A randomized crossover trial will be conducted in 90 primary school children in 3 classrooms in Shanghai, China. The effects of fresh air ventilation/filtration system, fresh air ventilation system with no filtration and natual…
- Conditions
- Airway Morbidity, Cognitive and Attention Disorders and Disturbances, Oxidative Stress
- Trial name
- NCT03788330
- Testing
- Fresh air system with filtration
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Fudan University
Upper Respiratory Tract Infection, Nasal Congestion
Evaluation of Efficacy and Safety of Tablets of Paracetamol, Dimethindene Maleate and Phenylephrine Hydrochloride in Reducing Symptoms of Common Cold and Flu
The study is a clinical evaluation of an over the counter (OTC) combination product containing paracetamol (500 mg), dimethindene maleate (1 mg), phenylephrine hydrochloride (10 mg) compared to paracetamol (500 mg) alone in the…
- Conditions
- Upper Respiratory Tract Infection, Nasal Congestion, Rhinorrhea, Sneezing
- Trial name
- NCT01448057
- Testing
- Paracetamol (500 mg)/dimethindene maleate (1 mg)/ phenylephrine hydrochloride (10 mg) tablets, Paracetamol (500 mg) tablets
- Where
- 6 sites in Brazil
- Volunteers
- 341 people
- Sponsor
- Novartis
Sleep Apnea, Obstructive, Insomnia
The IPAD Cohort Study: Insomnia and Positive Airway Pressure Adherence in Children and Adolescents
Positive Airway Pressure (PAP) is a treatment used to help people with sleep-disordered breathing, particularly those with obstructive sleep apnea (OSA).
- Trial name
- IPAD (NCT07176767)
- Testing
- Positive airway pressure therapy
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Lena Xiao
Parkinson's Disease, Sleep Disordered Breathing
Sleep Disordered Breathing and Its Impact on Neuro-cognitive Performance and Quality of Life in Parkinson Disease
The purpose of this study is to determine the impact of sleep and breathing problems during sleep on memory, attention, and general well being (quality of life) in people with Parkinson Disease.
- Conditions
- Parkinson's Disease, Sleep Disordered Breathing, Sleep Obstructive Apnea
- Trial name
- NCT02034357
- Testing
- Neurocognitive function, Sleep evaluations
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- University of Miami
Asthma, Acute Asthma
Budesonide Inhalation Suspension for Acute Asthma in Children
The purpose of this study is to determine whether the addition of budesonide inhalation suspension (BIS) to the standard therapy of albuterol, ipratropium bromide, and systemic corticosteroids (SCS) for moderate to severe asthma…
- Conditions
- Asthma, Acute Asthma, Reactive Airway Exacerbation
- Trial name
- NCT00393367
- Testing
- Budesonide inhalation suspension (0.5 mg/2mL) 2mg, albuterol (5mg/mL) 7.5 or 10mg, Prednisolone, prednisone, or methylprednisolone, Albuterol, ipratropium bromide
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Children's Hospital of Philadelphia
COPD
Cervical Nags Effect on Accessory Muscles
The aim of this work is to record changes on accessory muscles especially sternocleidomastoid and scalene after applying cervical NAGs in COPD patients.
- Trial name
- NCT06736145
- Testing
- Traditional Physical Therapy, Mulligan Glides
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
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