Clinical trials: Airway Disease
Hypoxia, Esophageal Cancer
Combination COMBO Endoscopy Oropharyngeal Airway With High-Flow Nasal Cannula Oxygenation in Sedated Gastrointestinal Endoscopy for Obese Patients
Hypoxia is the most common adverse event during propofol sedation for gastrointestinal endoscopy, particularly in obese patients.
- Conditions
- Hypoxia, Esophageal Cancer, Gastric Cancer, Polyp of Colon
- Trial name
- NCT06812403
- Testing
- the COMBO Endoscopy Oropharyngeal Airway with High-Flow Nasal Cannula Oxygenation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhejiang University
COVID-19 Pneumonia
High Velocity Nasal Insufflation Versus Continuous Positive Airway Pressure in COVID 19 Pneumonic Patients
compare the efficacy of High-Velocity Nasal Insufflation (HVNI) versus Continuous Positive Airway Pressure (CPAP) in managing COVID 19 pneumonic patients with acute type 1 respiratory failure
- Trial name
- NCT07213518
- Testing
- High Velocity Nasal Insufflation, Continuous Positive Airway Pressure
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Airway Management, Lung Diseases
Comparison of Supraglottic Airway Devices in EBUS
Supraglottic airway devices (SAD) provide ventilation of patients requiring respiratory support without tracheal intubation. Therefore, SAD is used to maintain airway during anesthesia in surgeries that do not require intubation.
- Trial name
- SAD-EBUS (NCT06177769)
- Testing
- LMA classic, LMA Proseal, I-gel
- Where
- Turkey (Türkiye)
- Volunteers
- 183 people
- Sponsor
- Ankara Etlik City Hospital
Obesity, Overweight
AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with excess body weight and obstructive sleep apnoea not treated with positive airway pressure lose weight and improve sleep apnoea.
- Conditions
- Obesity, Overweight, Obstructive Sleep Apnoea
- Trial name
- AMAZE 3 (NCT07571005)
- Testing
- NNC0487-0111
- Where
- 80 sites in United States, Australia and 8 more
- Volunteers
- 300 people
- Sponsor
- Novo Nordisk A/S
Obstructive Sleep Apnea
Efficacy and Stability of Dexmedetomidine Sedation Compared to Propofol Sedation in the Drug Induced Sleep Endoscopy
Obstructive Sleep Apnea Syndrome affect up 12% in adult population. It is associated with an increase rate of hypertension, metabolic syndrome, depression and adverse cardiovascular events.
- Trial name
- DISERT (NCT03892122)
- Testing
- Propofol Fresenius, Dexmedetomidine
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Ospedale Monsignor R. Dimiccoli, Barletta
Pneumonia in Children
Bubble CPAP Team-Based Care Strategy Feasibility Trial
The goal of this pre/post, effectiveness-implementation feasibility trial is to learn if a larger, multisite trial of a bubble continuous positive airway pressure (bCPAP) team-based care strategy is feasible in children with…
- Trial name
- NCT07620054
- Testing
- bCPAP team-based care strategy
- Where
- 2 sites in Pakistan
- Volunteers
- 95 people
- Sponsor
- Yale University
Chronic Obstructive Pulmonary Disease
Efficacy, Safety, and Tolerability of Aclidinium Bromide in the Treatment of Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD) (LAS-MD-38)
The purpose of this study is to evaluate the efficacy, safety and tolerability of aclidinium bromide doses compared with placebo in the treatment of moderate to severe, stable chronic obstructive pulmonary disease.
- Trial name
- LAS-MD-38 (NCT01045161)
- Testing
- Aclidinium bromide
- Where
- 112 sites in United States, Canada
- Volunteers
- 544 people
- Sponsor
- AstraZeneca
Obstructive Sleep Apnea, Refractory Arterial Hypertension
Effect of CPAP on Blood Pressure in Patients With Sleep Apnea and Refractory Hypertension
The purpose of this study is to determine the effects of CPAP treatment on blood pressure in patients with sleep apnea syndrome (SAS) and refractory arterial hypertension (RAH).
- Trial name
- NCT00863135
- Testing
- CPAP, Control
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Corporacion Parc Tauli
COPD
Effect of an Inhaled Glucocorticoid-long-acting Beta Adrenergic Agonist on Endothelial Function in COPD
In the present study, the investigators wish to address the effect of a glucocorticoid/long-acting beta-agonist preparation on endothelial function in COPD patients who do not currently smoke (ex-smokers) by measuring…
- Trial name
- NCT01209715
- Testing
- Fluticasone /salmeterol
- Where
- United States
- Sponsor
- University of Miami
Chronic Obstructive Pulmonary Disease
Cohort Study of Airway Microecology and the Pathogenesis and Evolution of Chronic Obstructive Pulmonary Disease
This study will last for 5 years (2021.2.25-2025.12.31). 210 patients (70 cases in each group) will be enrolled in this study. Eight centers in China will participate in the study.
- Trial name
- NCT04849104
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Obstructive Sleep Apnea
Improving 24-hour Blood Pressure in Obstructive Sleep Apnea
This study examines the combined effects of an angiotensin receptor blocker (ARB), antioxidant supplementation, and continuous positive airway pressure (CPAP) therapy on the lowering of 24-hour blood pressure in persons with…
- Trial name
- NCT04021550
- Testing
- Continuous Positive Airway Pressure CPAP, Telmisartan 80mg, Alpha-Lipoic Acid 600mg
- Sponsor
- University of British Columbia
Biomarkers, Airway Inflammation
The Value of FeNO in Predicting Airway Eosinophilic Inflammation
To investigate and compare the value of FeNO, blood Eos, serum TIgE in predicting the airway eosinophilic inflammationin chronic cough, asthma and COPD.
- Trial name
- FeNO-Eos (NCT04885738)
- Testing
- no intervention
- Where
- China
- Volunteers
- 2,052 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Cancer
Study on Systemic and Airway Cytokines and Oxidative Stress in Lung Cancer Patients Undergoing Surgery
Lung cancer has remained as the top cancer killer in Hong Kong. Even for early resectable stage of lung cancer, only around 60-70% of patients can survive for 5 years after operation, mostly related to disease recurrence.
- Trial name
- NCT00956852
- Where
- Hong Kong
- Volunteers
- 45 people
- Sponsor
- The University of Hong Kong
Snoring, Apnea, Obstructive
Dental Appliance to Treat SDB in Children
The clinical hypothesis of this study is that a currently marketed mouthguard may also be able to reduce the symptoms of sleep-disordered breathing in children.
- Conditions
- Snoring, Apnea, Obstructive, Upper Airway Resistance Syndrome, Sleep-Disordered Breathing
- Trial name
- NCT05661747
- Testing
- Vivos Grow/Vivos Way Device
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Vivos BioTechnologies, Inc.
Mechanical Ventilator Weaning, Acute Brain Injury
Brain-injured Patients Extubation Readiness Study
The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.
- Conditions
- Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation
- Trial name
- Biper (NCT04080440)
- Testing
- Extubation readiness clinical score, Usual Care
- Where
- 21 sites in France
- Volunteers
- 660 people
- Sponsor
- University Hospital, Clermont-Ferrand
COPD, Healthy
Study of Airflow in the Lungs Using Helium MRI
Computer simulations are being developed to predict air flow abnormalities in the airways of patients with lung disease. The purpose of this study is to obtain actual gas flow measurements in the lungs of healthy patients and…
- Conditions
- COPD, Healthy, Constrictive Bronchitis
- Trial name
- NCT02154568
- Testing
- hyperpolarized helium-3 gas with MRI of the chest
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Esophageal Foreign Body, Esophageal Obstruction
Point of Care Ultrasound for the Detection of Esophageal Food Bolus
This will be a prospective, observational, case-control study of adult patients presenting to the WellSpan York Hospital Emergency Department (YHED) with signs and symptoms of esophageal food or foreign body impaction.
- Trial name
- NCT06507670
- Testing
- Point of care ultrasound
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- WellSpan Health
Respiratory Insufficiency, Ventilator-Induced Lung Injury
APRV/BIPAP With Spontaneous Breathing on Lung Protection
Mechanical ventilation (MV) is a cornerstone of management of acute respiratory failure, but MV per se can provoke ventilator-induced lung injury (VILI), especially in acute respiratory distress syndrome (ARDS).
- Trial name
- APRV/BIPAP (NCT02071277)
- Testing
- Pressure targeted modes
- Where
- 2 sites in Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
Obstructive Sleep Apnea, Refractory Hypertension
Effects of Continuous Positive Airway Pressure (CPAP) in Patients With Resistant Hypertension and Obstructive Sleep Apnea (OSA)
Obstructive sleep apnea (OSA) is an important cause of refractory hypertension but the impact of treatment with continuous positive airway pressure (CPAP) is not completely understood.
- Trial name
- NCT00812695
- Testing
- CPAP
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Obstructive Sleep Apnea Syndrome, Brain Infarction
Consequences of Obstructive Sleep Apnea Syndrome (OSAS) After Ischemic Subtentorial Stroke.
Obstructive Sleep Apnea Syndrome (OSAS) is associated with stroke as a risk factor but little is known about the consequences of OSAS on the outcome and the survival after stroke.
- Trial name
- NCT01561677
- Testing
- Continuous Positive Airway pressure-RESPIRONICS
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
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