Clinical trials: Airway Disease
Asthma
Efficacy of Ciclesonide on Small Airways in Patients With Stable Asthma (18 to 60 y) (BY9010/M1-131)
The aim of this study is to evaluate the involvement of small airways in asthma, as determined by bronchial challenges, CT-scanning, and cellular markers of inflammation. Ciclesonide will be inhaled at one dose level once daily.
- Trial name
- NCT00163345
- Testing
- Ciclesonide
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Diseases, Chronic Airways Limitation
Mepolizumab in Chronic Obstructive Pulmonary Diseases (COPD) With Eosinophilic Bronchitis
Some patients with chronic obstructive pulmonary diseases (COPD) have large number of specific white blood cells called eosinophils in their airways.
- Conditions
- Chronic Obstructive Pulmonary Diseases, Chronic Airways Limitation, Bronchitis
- Trial name
- NCT01463644
- Testing
- Mepolizumab
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- McMaster University
COPD
Portable Positive Pressure Therapy Device
This study will assess the impact the BREATHE device provides on post-exertion recovery time in COPD patients when used during and/or after performing an Activity of Daily Living simulation.
- Trial name
- NCT04452851
- Testing
- BREATHE, BiPAP, COPD Inhaler
- Volunteers
- 20 people
- Sponsor
- Koronis Biomedical Technologies
Intubation; Difficult or Failed, Airway Obstruction
Comparing iView Video Laryngoscope in the Emergency Department
The US Military is rapidly transitioning into preparing for multi-domain operations. Previous data demonstrates that the most common airway replaced in the prehospital combat setting is endotracheal intubation.
- Trial name
- NCT04907695
- Testing
- I View Video Laryngoscope https://www.intersurgical.com/content/files/108253/-1977057700
- Where
- 2 sites in United States
- Volunteers
- 168 people
- Sponsor
- Brooke Army Medical Center
Pulmonary Aspiration of Gastric Contents, Emergency Surgery
Gastric Ultrasound for Airway Management in Emergency Patients
This prospective observational cohort study evaluates the association between gastric residual content and volume, assessed by point-of-care gastric ultrasound (PoCUS), and the choice of airway management technique (Rapid…
- Conditions
- Pulmonary Aspiration of Gastric Contents, Emergency Surgery, Gastric Residual Volume, Airway Management
- Trial name
- NCT07640165
- Testing
- Preoperative Gastric Point-of-Care Ultrasound (PoCUS)
- Where
- Indonesia
- Volunteers
- 43 people
- Sponsor
- Universitas Indonesia
Obstructive Sleep Apnea
Spironolactone to Improve Apnea and Cardiovascular Markers in Obstructive Sleep Apnea Patients
The purpose of this study is to test whether Spironolactone can improve the severity of obstructive sleep apnea and improve cardiovascular biomarkers in people who are not regularly using their Positive Airway Pressure (PAP)…
- Trial name
- NCT04205136
- Testing
- Spironolactone
- Where
- United States
- Sponsor
- University of Michigan
Trauma, Cardiac Arrest
Airway Management Study in Physician Manned Helicopter Emergency Medical Services
An international airway management expert group has recently developed an Utstein-style template for uniform reporting of data from prehospital advanced airway management.
- Conditions
- Trauma, Cardiac Arrest, Emergencies
- Trial name
- AIRPORT (NCT01502111)
- Where
- Norway
- Volunteers
- 2,333 people
- Sponsor
- Norwegian Air Ambulance Foundation
Obstructive Sleep Apnea
The Treatment of Obstructive Sleep Apnea With Continuous Positive Airway Pressure on Appearance and Age
The investigators hypothesized that the treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) will positively affect the appearance of the patient.
- Trial name
- NCT02117271
- Testing
- continuous positive airway pressure, Breathe Right ®
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Nucleo Interdisciplinar da Ciencia do Sono
Infant, Premature, Diseases, Respiratory Distress Syndrome
Functional Residual Capacity During Different Levels of High-flow in Preterm Infants
Although there is a widespread use of HighFlow therapy around the world, there is still uncertainty about the most appropriate initial HighFlow level after nasal continuous positive airway pressure therapy.
- Trial name
- FunkFlow (NCT05237622)
- Testing
- High Flow
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Sleep Apnea
Effects of Upper Airway Muscle Training on Obstructive Sleep Apnea Severity
The purpose of this study is to evaluate the effect of Asate Silent Sleep Training on obstructive sleep apnea (OSA) severity in patients with mild to moderate OSA.
- Trial name
- NCT04053153
- Testing
- Exercise equipment (a musical instrument that is based on the Medical Didgeridoo)
- Sponsor
- Stanford University
Asthma
Additive Effects of QVAR to (Seretide) on Surrogate Markers of Airway Inflammation in Refractory Asthma
The purpose of this study is to establish whether addition of extra-fine particle steroid inhalers achieve additional suppression of small airways inflammation when added to 'standard' Fluticasone/Salmeterol combination therapy…
- Trial name
- PAW01 (NCT00829257)
- Testing
- HFA-BDP, Fluticasone, Seretide
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Dundee
Sleep Apnea, Dyslipidemias
CPAP Effect on Lipid Profile and Hyperuricemia in Patients With Dyslipidemia and Moderate-severe Obstructive Sleep Apnea
Clinical Trial Phase IV Indication: Moderate-severe obstructive sleep apnea and dyslipidemia. Objectives: Main objective: To test whether 12 months of CPAP treatment associated with conventional pharmacological treatment improves…
- Conditions
- Sleep Apnea, Dyslipidemias, Hyperuricemia
- Trial name
- CPAPLIP (NCT06463561)
- Testing
- Continuous positive airway pressure, Hygienic-dietary recommendations and daily physical activity promotion
- Where
- Spain
- Volunteers
- 220 people
- Sponsor
- Hospital Universitario La Paz
Obstructive Sleep Apnea, Hypertension
Antihypertensive and PAP Treatment in Obstructive Sleep Apnea Patients With Hypertension (AHPAP)
The investigators will perform a long term registry based prospective analysis on incidence of major cardiovascular events or death in hypertensive patients with obstructive sleep apnea .
- Conditions
- Obstructive Sleep Apnea, Hypertension, Death, Cardiac, Treatment Compliance
- Trial name
- AHPAP (NCT05115994)
- Testing
- Continous positive airway pressure
- Where
- Sweden
- Volunteers
- 10,000 people
- Sponsor
- Vastra Gotaland Region
Asthma
Sphingosine-1-phosphate in Asthma
This study is being undertaken in order to enhance our understanding how human airways are being constricted in healthy people and in individuals with asthma.
- Trial name
- NCT04134351
- Testing
- Bronchial challenge test
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cardiac Arrest
Effectiveness of Pediatric Intubation
We hypothesized that the Venner videolaryngoscope (A.P. Advance™) is beneficial for intubation of pediatric manikins while performing CPR. In the current study, we compared effectiveness of the Venner videolaryngoscope (A.P.
- Trial name
- PETI (NCT02289651)
- Testing
- Venner, Miller
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- International Institute of Rescue Research and Education
Sleep Apnea Syndromes
Detection of Airway Obstruction by Manometry in Different Sleep Stages and Comparing it to DISE
Patients with OSA receive manometry measurements with Apneagraph (AG) during one night of sleep. All patients are simultaneously evaluated with polysomnography.
- Trial name
- NCT02969551
- Testing
- Manometry and possibly DISE
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Obstructive Sleep Apnea Syndrome
Upper Airway Physical Therapy for the Treatment of Obstructive Sleep Apnea
The purpose of this study is to determine the effectiveness and feasibility of upper airway muscle physical therapy utilizing negative airway pressure (NAP) breathing training in patients with Obstructive Sleep Apnea Syndrome…
- Trial name
- NCT02109731
- Testing
- Negative airway pressure delivery
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Rochester
COPD Exacerbation Acute
The Effect of Airway and Chest Wall Oscillation on Respiratory Functions in COPD Patients in Acute Exacerbation
Chronic obstructive pulmonary disease (COPD); It is a common, treatable and preventable disease characterized by progressive and irreversible airflow limitation and has systemic effects with respiratory system involvement.
- Trial name
- NCT06274957
- Testing
- CONTROL, PEP DEVICE, HFCWO DEVICE
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Saglik Bilimleri Universitesi
Respiratory Distress Syndrome, Newborn
Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway
With the development of the Intubation Surfactant Extubation technic, in which surfactant is administered during a brief intubation followed by immediate extubation, surfactant therapy can be given during nasal continuous…
- Trial name
- NCT01173237
- Testing
- Use tracheal intubation for surfactant therapy, Use of Proseal laryngeal mask airway for surfactant therapy
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Minas Gerais
Nontuberculous Mycobacterial Lung Disease, Bronchiectasis
Hypertonic Saline Inhalation for Nontuberculous Mycobacterial Lung Disease
This multicenter randomized controlled trial evaluates the clinical and microbiological effects of inhaled 3% hypertonic saline in treatment-naïve patients with nontuberculous mycobacterial lung disease (NTM-LD).
- Trial name
- HiNTM (NCT07647575)
- Testing
- Nebulized 3% Hypertonic Saline, Nebulized Normal Saline
- Where
- Taiwan
- Volunteers
- 262 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
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