Clinical trials: Airway Disease
Chronic Rhinosinusitis Without Nasal Polyps, Asthma
Adherence in Global Airways - Steroid Intake and Effects on Chronic Rhinosinosinutis
The purpose of this study is to investigate the relationship between long-term use of systemic steroids in patients with upper and lower respiratory tract diseases and their own production of cortisol (cross-sectional), as well…
- Conditions
- Chronic Rhinosinusitis Without Nasal Polyps, Asthma, Chronic Rhinosinusitis With Nasal Polyps, Steroid-Induced Osteopenia (Diagnosis)
- Trial name
- AGAS 2023 (NCT05843019)
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Christiane Haase
Sleep Apnea Syndrome, Coronary Artery Disease
Evolution of Oxidative Stress in Coronary Patients With Moderate Sleep Apnea Syndrome After Treatment With Continuous Positive Airway Pressure
Published data indicate that obstructive sleep apnea syndrome (OSAS) worse the prognosis of coronary artery disease (CAD) and that oxidative stress can link this 2 diseases.
- Trial name
- CardioX SAS (NCT02893865)
- Testing
- Continuous positive airway pressure
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Montpellier
Emphysema, Pulmonary Disease, Chronic Obstructive
Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a lung disease that is primarily caused by cigarette smoking. The breakdown of elastin, a protein found in the lungs, can cause lung damage and may contribute to the development of…
- Trial name
- NCT00725309
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- Washington University School of Medicine
Asthma
The Prednisone-sparing Effect of Anti-IL-5 Antibody (SB-240563)
The purpose of this study is to determine if treatment with anti-IL-5 antibody has a prednisone-sparing effect in patients with symptomatic eosinophilic bronchitis (with or without asthma).
- Trial name
- NCT00292877
- Testing
- SB-240563 (Mepolizumab)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Sleep Apnea, Obstructive
Evaluation of Self-efficacy as a Predictor for CPAP-compliance in a OSAS-patients French Cohort
Continuous positive airway pressure (CPAP) is the reference treatment for obstructive sleep apnea syndrome (OSAS) and is effective in improving symptoms of OSAS, reducing risk of accidents and improving quality of life.
- Trial name
- SAFES (NCT05053581)
- Testing
- Survey
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Asthma
The Effect of Anti-IL17 on Airway Hyperresponsiveness and Resistance
This observational longitudinal cohort study aims to assess the effect of monoclonal antibodies targeting interleukin 17 (anti-IL-17) on airway hyperreactivity and airway resistance.
- Trial name
- NCT06224634
- Where
- Denmark
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Obstructive Sleep Apnea, Acute Kidney Failure
Effect of Obstructive Sleep Apnea on Central Blood Pressure and Kidney and Endothelial Function
Obstructive sleep apnea (OSA) is a frequently underdiagnosed condition that has emerged as an increasing medical problem with important social and financial implications worldwide.
- Conditions
- Obstructive Sleep Apnea, Acute Kidney Failure, Chronic Kidney Disease
- Trial name
- OSA-AKI (NCT00947479)
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Lodz
Pneumonia
Reduced Ventilator-Free Days and Bacterial Colonization of Sub-Glottic Secretions
Ventilator associated pneumonia (VAP) is common problem among ICU patients and major source of infection among patients receiving mechanical ventilation.
- Trial name
- NCT02311296
- Where
- United States
- Sponsor
- University of Tennessee, Chattanooga
Obstructive Sleep Apnea, Muscle Disorder
Effects of Newly-created Individualized Upper Airway Muscle Functional Training on Patients With OSA
Objectives: To observe the effect of newly-created individualized upper airway muscle functional training on the condition and intraday symptoms of OSA patients; to study the effect of this training method on the excitability of…
- Trial name
- NCT05346705
- Testing
- New individualized upper airway muscle functional training
- Where
- China
- Volunteers
- 300 people
- Sponsor
- First Hospital of China Medical University
Cystic Fibrosis
Correction of Nonsense Mutations in Cystic Fibrosis
The presence of a nonsense mutation leads to the rapid degradation of the carrier mRNA mutation by a mechanism called NMD (nonsense-mediated mRNA decay) [6, 13].
- Trial name
- NCT03670472
- Testing
- smear of nasal fossae
- Where
- 8 sites in France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Lille
Pulmonary Disease, Chronic Obstructive
The Nasal Airway in Chronic Obstructive Pulmonary Disease
The study is based on the theory of a "unified airway" that considers the nose and paranasal sinuses together with lower airways as one integrated unit.
- Trial name
- COPD (NCT02826954)
- Testing
- Upper airway assessment, including nasal biopsy
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Tracheal Disease
Tracheobronchial Bioengineering Using Aortic Matrices for Airway Reconstruction
A technic of tracheal, carinal or bronchial transplantation using a stented cryopreserved aortic has been implemented by Pr E. Martinod in his thoracic surgery dept.
- Trial name
- TRITON (NCT04263129)
- Testing
- Tracheal, carinal or bronchial transplantation using a stented cryopreserved aortic
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stenoses, Dyspnea
Endoscopic Treatment
The placement of an endoprosthesis in the airways leads to rapid and dramatic clinical improvement in the majority of cases of central airway obstruction.
- Trial name
- ETNA (NCT07727824)
- Testing
- Informed consent, Eligibility criteria check, Randomisation
- Where
- 6 sites in France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Toulouse
Intracranial Pressure Increase, Supraglottic Airway Device
Effect of Different Supralottic Airway Devicess on Optic Nerve Sheath Diameter
Direct laryngoscopy and tracheal intubation are associated with increases in intraocular pressure (IOP), intracranial pressure (ICP), heart rate (HR), and blood pressure.
- Conditions
- Intracranial Pressure Increase, Supraglottic Airway Device, Optic Nerve Sheath Diameter
- Trial name
- NCT05499754
- Testing
- pLMA: PROSEAL LARYNGEAL MASK, sLMA : SUPREMA LARYNGEAL MASK, I-jel =I-GEL
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Obstructive Sleep Apnea
Validation and Reproducibility of the Six-minute Step Test in Individuals With Obstructive Sleep Apnea Treated With CPAP
Introduction: The Obstructive Sleep Apnea (OSA) is characterized by obstructed superior airway during sleeping period promoting intermittent hypoxia-reoxygenation events.
- Trial name
- NCT03334331
- Testing
- Six-minute step test, Six-minute walk test
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- Universidade Federal de Pernambuco
Obstructive Sleep Apnea
Change in C-reactive Protein (CRP) in Men and Women With Sleep Apnea After Continuous Positive Airway Pressure (CPAP)
C-reactive protein (CRP) is directly implicated in atherogenesis and associated cardiovascular morbidity in patients with obstructive sleep apnea (OSA).
- Trial name
- NCT01365832
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Greece
- Volunteers
- 436 people
- Sponsor
- University of Crete
Asthma, COPD
SADT in COPD and Oscillometry in Obstructive Airway Disease in Primary Care. The SCOOP-study
Rationale: The Small Airways are a major site of obstruction in many respiratory diseases, including COPD. More insight into a diagnosis of Small Airways Dysfunction (SAD) in patients with COPD is clinically valuable as it might…
- Conditions
- Asthma, COPD, Small Airway Disease
- Trial name
- SCOOP (NCT07374172)
- Testing
- Oscillometer ALDS
- Where
- Netherlands
- Volunteers
- 108 people
- Sponsor
- General Practitioners Research Institute
Asthma
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma.
- Trial name
- NCT06977581
- Testing
- PF-07275315
- Where
- 137 sites in United States, Argentina and 13 more
- Volunteers
- 252 people
- Sponsor
- Pfizer
Obstructive Sleep Apnea
Effect of Upper Airway Stimulation in Patients With Obstructive Sleep Apnea
Upper Airway Stimulation is a new therapy, which is available for patients with obstructive sleep apnea, who are non-compliant to the standard treatment continuous positive airway pressure (CPAP) therapy.
- Trial name
- EFFECT (NCT03760328)
- Testing
- Upper Airway Stimulation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Copd
Searching Clinical Chronic Obstructive Pulmonary Disease Onset
The aim of this study is to determine if presence of dyspnea identifies differences in the 6-min walk test performance among smokers with normal or mild spirometric obstruction, accounting for the confounding effect of heart…
- Trial name
- SOON (NCT03026439)
- Where
- Chile
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.