Clinical trials: Airway Disease
Pulmonary Edema, Dyspnea
Continuous Positive Airway Pressure for Acute Pulmonary Edema
The investigators hypothesise that CPAP + pharmaceutical treatment, compared to pharmaceutical treatment alone, improves the respiratory and hemodynamic status of the patients before H2 after the inclusion time and decreases the…
- Conditions
- Pulmonary Edema, Dyspnea, Paroxysmal, Congestive Heart Failure
- Trial name
- CPAP (NCT00554580)
- Testing
- Continuous Positive Airway Pressure (CPAP), usual care of acute pulmonary oedema
- Where
- France
- Volunteers
- 208 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstructive Sleep Apnea of Newborn
Nasal and Oronasal Mask in Severe OSA Patients With Nasal Free Airflow of Obstruction
The obstructive sleep apnea (OSA) affects between 10% to 25% of the adults. Continuous positive airway pressure (CPAP) is the first choice of treatment in severe OSA.
- Trial name
- NCT02274194
- Testing
- Nasal CPAP, Oronasal CPAP
- Where
- 2 sites in Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pneumonia, Bronchiolitis
Diagnosing Respiratory Disease in Children Using Cough Sounds
The purpose of this prospective study is to evaluate the efficacy of the ResAppDx software application in diagnosis of pneumonia and other respiratory conditions (bronchiolitis, asthma/reactive airway disease, croup, upper or…
- Conditions
- Pneumonia, Bronchiolitis, Asthma, Croup
- Trial name
- SMARTCOUGH-C (NCT02973282)
- Testing
- Recording of Infants and Children's Cough Sounds
- Where
- 3 sites in United States
- Volunteers
- 1,245 people
- Sponsor
- ResApp Health Limited
Cholecystitis, Endometriosis
Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery
This is a two period cross-over study randomizing patients undergoing laparoscopic surgery into 2 different groups: group 1 in which patients receive "deep neuromuscular blockade" in the beginning portion of their laparoscopic…
- Conditions
- Cholecystitis, Endometriosis, Bowel Obstruction, Fibroids
- Trial name
- NCT02812186
- Testing
- Deep to Moderate NMB, Moderate to Deep NMB, Rocuronium
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Stony Brook University
Surgery, Anesthesia
A Comparison of Desflurane vs. Sevoflurane and the Time to Awakening and the Incidence and Severity of Cough
Goals for ambulatory surgery include providing optimal surgical conditions while ensuring a rapid early recovery without side effect.
- Trial name
- NCT01202162
- Testing
- Desflurane, Administration of Sevoflurane
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Northwestern University
Obstruction; Airway, With Asthma
Impedance Pneumography Measurement During Acute Airway Obstruction and Recovery Phase in Young Children
The purpose of this study is to evaluate the association of signals recorded and analysed with Ventica® LFTS in infants and preschoolers during acute airway obstruction/asthma exacerbation and recovery thereof for changes in the…
- Trial name
- NCT03488303
- Where
- Croatia
- Volunteers
- 30 people
- Sponsor
- Revenio Research
Cystic Fibrosis
High Frequency Chest Wall Oscillation and Cystic Fibrosis
High frequency chest wall oscillation (HFCWO) has been shown to increase tracheal mucus clearance compared with a control group.
- Trial name
- NCT01057524
- Testing
- High Frequency Chest Wall Oscillation (HFCWO), Usual airway clearance
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Imperial College London
Sleep Disturbance
Sleep Disturbance in Chronic Rhinitis
The aim of this study is to evaluate the characteristic of sleep disturbance in allergic and non-allergic rhinitis in Dr. Cipto Mangunkusumo Hospital, Jakarta.
- Trial name
- NCT05312723
- Where
- Indonesia
- Volunteers
- 22 people
- Sponsor
- Universitas Indonesia
Obstructive Sleep Apnea
Investigative Headgear With Nasal Pillows Continuous Positive Airway Pressure (CPAP) Mask
This investigation is designed to evaluate the at-home usability, performance, user acceptance and reliability of the headgear with a CPAP mask for a duration of 6 months.
- Trial name
- NCT02942446
- Testing
- Investigative Headgear with CPAP mask
- Where
- New Zealand
- Volunteers
- 20 people
- Sponsor
- Fisher and Paykel Healthcare
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Obstructive Airways Diseases in Emergency Department (OADED) Study
This is an observational study which aims to evaluate the possibility of using data from a capnography device to assess obstructive airway severity in both Chronic Obstructive Pulmonary Disease (COPD) and Asthma patients.
- Trial name
- NCT02805127
- Volunteers
- 12 people
- Sponsor
- Oridion
Post Operative Sore Throat, Hoarseness
Efficacy of Flurbiprofen Spray for Postoperative Sore Throat Following Double-Lumen Endobronchial Intubation
The goal of this study is to evaluate whether topical flurbiprofen reduces the incidence and severity of postoperative sore throat (POST) and hoarseness in patients undergoing double-lumen tube (DLT) intubation for elective…
- Trial name
- FLURBI-POST (NCT07163429)
- Testing
- Flurbiprofen 8.75 MG, Saline spray
- Where
- Thailand
- Volunteers
- 58 people
- Sponsor
- Kittitorn Supphapipat, MD
Neonatal Respiratory Distress
DIaphragmatic Swing According to Cpap Flow Output in NEOnates (DISCONEO)
The hypothesis behind the study is that the performance of constant flow CPAP (Continuous Positive Airway Pressure) devices (CF-CPAP) is not inferior to that of variable flow CPAP devices (VF-CPAP) in terms of respiratory efforts…
- Trial name
- NCT07513051
- Testing
- CF-CPAP; CF-CPAP; VF-CPAP; VF-CPAP, VF-CPAP; VF-CPAP; CF-CPAP; CF-CPAP, CF-CPAP; VF-CPAP; VF-CPAP; CF-CPAP
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Asthma
Study Evaluating the Effects of AIR645 on Allergen-Induced Airway Responses in Subjects With Mild Atopic Asthma
To assess the efficacy of inhaled AIR645 in the suppression of the Asthmatic Responses in subjects with mild asthma inhaling an allergen.
- Trial name
- NCT00941577
- Testing
- AIR645, Physiologic saline solution
- Where
- 3 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Altair Therapeutics, Inc.
Obstructive Sleep Apnea
Lifestyle Intervention for OSA in Adults
Obstructive sleep apnoea (OSA) is characterized by the presence in the polysomnogram test of more than five apnoea-hypopnoea episodes per hour of sleep (apnoea-hypopnoea index, AHI > 5), each episode lasting more than 10 seconds…
- Trial name
- NCT03851653
- Testing
- Lifestyle Intervention
- Where
- Spain
- Volunteers
- 89 people
- Sponsor
- Universidad de Granada
Laryngeal Masks, Pharyngitis
Postoperative Sore Throat in Children: Comparison Between Two Supraglottic Devices, Ambu® AuraOnce™ Laryngeal Mask Airway (LMA) and I-Gel®.
Sore throat is minor but well recognized complaint after receiving general anaesthesia. It is rated as 8th most undesirable outcome in postoperative period.It not only affects the patient's satisfaction but also can affect…
- Conditions
- Laryngeal Masks, Pharyngitis, Minors, Anesthesia
- Trial name
- NCT03140228
- Testing
- I-Gel, LMA
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Mechanical Ventilation
Mechanical Ventilation in Multiple Fracture Ribs
Chest trauma is the most common injury in the emergency trauma and rib fractures is the most common trauma in chest trauma. Severe rib fractures can cause paradoxical respiration and mediastinal swing, which has large effects on…
- Trial name
- NCT03314701
- Testing
- Biphasic Intermittent Positive Airway Pressure (BIPAP), Airway Pressure Release Ventilation (APRV)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Cystic Fibrosis, Motor Neuron Disease
MN4000 for Treatment of CF and MND Patients in the Home Setting
The study was a non-randomized open label pilot study. It was an observational design conducted at one (1) site in the US. All enrolled subjects received treatment with the MN4000.
- Conditions
- Cystic Fibrosis, Motor Neuron Disease, Airway Clearance Impairment
- Trial name
- NCT03797677
- Testing
- MN 4000
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Hill-Rom
Chronic Obstructive Pulmonary Disease
Functional Respiratory Imaging Study (DARWiIN)
The objective of this clinical study was to evaluate the tolerability, safety, and efficacy of stepping up from fluticasone propionate (FP)/salmeterol (SLM) dry-powder inhaler (DPI) (SERETIDE™ DISKUS™) to extrafine beclometasone…
- Trial name
- DARWiIN (NCT04876677)
- Testing
- Beclomethasone dipropionate/Formoterol Fumarate/Glycopyrronium (BDP/FF/GB)
- Where
- 8 sites in Belgium, Hungary
- Volunteers
- 25 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Obstructive Airways Disease Exacerbated, Chronic Obstructive Airway Disease
Digital Inhaler Use in Obstructive Lung Disease Care
This is a pilot study to evaluate the role digital inhaler technology on patients with obstructive lung disease in preventing admissions and exacerbation, as well as improving symptom control.
- Trial name
- NCT07214337
- Testing
- Digital Inhaler Attachment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Tracheoesophageal Fistula, Esophageal Atresia
Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients
The investigators propose a preliminary study performing exome sequencing on samples from patients and their biologically related family members with tracheal and esophageal birth defects (TED).
- Conditions
- Tracheoesophageal Fistula, Esophageal Atresia, Laryngeal Cleft, Tracheal Stenosis
- Trial name
- TED (NCT03455881)
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
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