Clinical trials: Airway Disease
Obstructive Sleep Apnea
Continuous Positive Airway Pressure (CPAP) Promotion And Prognosis - the Army Sleep Apnea Program (ASAP)
The purpose of this study is to assess the efficacy of Eszopiclone in improving short and intermediate-term compliance with continuous positive airway pressure (CPAP) in patients newly diagnosed with obstructive sleep apnea (OSA).
- Trial name
- CPAPASAP (NCT00612157)
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Walter Reed Army Medical Center
Amyotrophic Lateral Sclerosis ALS7
The Importance of Positive Expiratory Pressure Associated With the In-exsufflator in ALS Patients
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder that impairs motor neurons, with a life expectancy of 2 to 7 years after diagnosis.
- Trial name
- PEPINEX (NCT06249412)
- Testing
- MI-E with PEP function activated during the pause, MI-E without PEP function activated during the pause
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Groupe Hospitalier du Havre
Nasal Congestion
Functional Magnetic Resonance Imaging (fMRI) Study of Nasal Strips in Nasal Congestion
The aim of the study is to evaluate the effect of the nasal strip (relative to the placebo strip) on the nasal passages using anatomical MRI scans and to demonstrate the effect of the strip on breathing correlated cortical…
- Trial name
- NCT02275364
- Testing
- Test strip, Nasal spray
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pneumonia, Airway Clearance
The Effectiveness of Different Nebulized Solutions on Airway Clearance Function in Patients With Pneumonia
Pneumonia is a significant global and national health issue, particularly posing a notable threat to elderly population. Accumulation of sputum in pneumonia patients often results in impaired airway clearance, negatively…
- Trial name
- NCT07586345
- Testing
- Nebulization therapy
- Volunteers
- 80 people
- Sponsor
- Chen, Yao-Hsiang
Emergence Delirium, Post-Operative Cognitive Dysfunction
Post Operative Cognitive Dysfunction After Oncologic Surgery
Aim of this trial is to define if Post-Operative Cognitive Dysfunction, detected analyzing changes between pre-operative and post-operative Neurocognitive Test, and Postoperative Delirium, relate to concentration of effector's…
- Trial name
- NCT03774420
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Padova
Small Airways Diseases, Vaping
The Canadian Lung Outcomes in Users of Vaping Devices Study
Vaping is increasingly popular with both adolescent and adult Canadians, but the long-term health impacts remain unknown. We believe that the tools we currently have to detect lung disease in people who vape may be insufficient…
- Conditions
- Small Airways Diseases, Vaping, Vaping Related Disorder, Vaping Teens
- Trial name
- CLOUD (NCT06819969)
- Where
- 8 sites in Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Obstructive Airway Disease
In Patients With Obstructive Airway Disease, Investigate the Effects of Different Breathing Strategies and Pedaling Rates on the Physiological Response to Bicycle Exercise
The definition of obstructive airway disease is a ratio of the forced expiratory volume in one second (FEV1) to the forced vital capacity (FVC) of less than 0.7, which includes conditions such as chronic obstructive pulmonary…
- Trial name
- NCT06332820
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Sleep Apnea, Obstructive
KPAP vs AirSense 11 With EPR
The KPAP vs AirSense 11 with EPR study is a randomized, crossover study in which treatment efficacy will be compared between SleepRes APAP + KPAP and ResMed APAP + EPR.
- Trial name
- NCT07751562
- Testing
- APAP + KPAP, APAP + EPR
- Volunteers
- 30 people
- Sponsor
- SleepRes Inc.
Respiratory Failure, Hypoxemia
High-flow Nasal Cannula vs. Helmet PSV vs. Helmet CPAP During Respiratory Failure
The investigators designed a cross-over, randomized trial to assess the physiological effects of helmet pressure support ventilation (PSV) and continuous positive airway pressure (CPAP) as compared to high-flow nasal cannula…
- Trial name
- HIGHFLOWHELMET (NCT04241861)
- Testing
- Respiratory support (High-flow oxygen therapy), Respiratory support (Helmet PSV), Respiratory support (Helmet CPAP)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Nasal Valve Collapse, Nasal Breathing
Latera RCT - Latera vs. Sham Control for Lateral Nasal Valve Collapse
The primary objective of the LATERA RCT is to demonstrate the superiority of the Latera Implant to improve nasal breathing, compared with a Sham Control procedure.
- Trial name
- NCT03400787
- Testing
- Latera Implant
- Where
- 11 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Spirox, Inc.
Asthma
Beta Blocker Therapy in Mild to Moderate Asthmatics
Current asthma medicines include inhalers. A common type of inhaler is called a 'beta-agonist' (e.g. salbutamol). They improve asthma symptoms by stimulating areas in the airway causing it to widen.
- Trial name
- ANDA1 (NCT01544634)
- Testing
- Propranolol, Qvar 50, Qvar 100
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Dundee
Premature Birth
Changes in Respiratory Effort in Preterm Infants
Continuous Positive Airway Pressure (CPAP) is used to treat preterm infants with an immature respiratory center and having respiratory distress. CPAP requires intensive care monitoring and special qualified staff.
- Trial name
- NCT02014493
- Testing
- High Flow Nasal Cannulae (HFNC), Continuous Positive Airway Pressure (CPAP)
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- St. Olavs Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Assessment of Risk in Chronic Airways Disease Evaluation
Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of cardiovascular disease,osteoporosis, muscle wasting and diabetes mellitus.
- Trial name
- ARCADE (NCT01656421)
- Where
- United Kingdom
- Volunteers
- 767 people, healthy volunteers welcome
- Sponsor
- Cardiff University
Obstructive Sleep Apnea, Insomnia
Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISA
The comorbidity between obstructive sleep apnea (OSA) and insomnia (COMISA) is common, and associated with poorer sleep quality. CPAP adherence among COMISA patients is worst than among those with OSA only.
- Trial name
- NCT06017921
- Testing
- Eszopiclone 3 mg
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Gastro-esophageal Reflux
Safety Study of Airway Clearance Techniques in Infants.
The purpose of this study is to determine whether three airway clearance techniques ( Bouncing, Assisted Autogenic Drainage ( AAD) and bouncing and AAD) provoke or aggravate gastro-esophageal reflux in infants under the age of 1…
- Trial name
- NCT02128867
- Testing
- Assisted Autogenic Drainage (AAD), bouncing and AAD, bouncing
- Where
- Belgium
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Airway Inflammation
Airborne Ultrafine and Fine Particulate Matter: A Cause for Endothelial Dysfunction in Man?
The purpose of this study is to examine biological pathways of altered blood vessel function resulting from breathing airborne particulate.
- Trial name
- NCT00814281
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Marywood University
Asthma
Eicosanoid Lipids by Airway Cells During Infection With Human Rhinoviruses
The long-range goal of this protocol is to more completely understand the risks and the pathophysiology of asthma exacerbations, in order to develop prevention strategies and/or expedite a return to complete control of baseline…
- Trial name
- NCT01898767
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Wisconsin, Madison
Sleep Apnea, Obstructive, Hypertension
Mechanisms for Individual Differences in Hypertension in Obstructive Sleep
Hypertension is a common consequence of obstructive sleep apnea (OSA). However, not all individuals with OSA have hypertension and there are major individual differences in blood pressure response to positive airway pressure…
- Trial name
- PISA-BP (NCT03176732)
- Testing
- Positive Airway Pressure
- Where
- 2 sites in United States, Iceland
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Asthma, Allergic, Rhinitis,Allergic
Effects of Intranasal Fluticasone Plus Azelastine on Airway Inflammation in Patients With Asthma & Allergic Rhinitis
Single centre, double-blind, placebo controlled, adaptive design, cross-over trial. The primary objective is to assess the additive effects of using combined intranasal fluticasone propionate plus azelastine nasal spray on airway…
- Conditions
- Asthma, Allergic, Rhinitis,Allergic, Allergy
- Trial name
- MAN06 (NCT02953106)
- Testing
- Azelastine-Fluticasone Nasal
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- University of Dundee
Anesthesia
Assessment of Airways Mechanical Properties by FOT and LIR During Anesthesia
The aims of the present study are: 1. To evaluate the effect of the induction of anaesthesia and paralysis in terms of changes in oscillatory mechanics parameters 2.
- Trial name
- NCT01506284
- Testing
- Forced oscillatory technique (FOT) and laser interferometry (LIR).
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Uppsala University Hospital
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