Clinical trials: Airway Disease
Nasal Obstruction
Nasal Obstruction and Olfactory Losses
About 13% of US adults, some 30 million people, suffer from nasal sinus disease. Although nasal obstruction and smell loss are two of the major symptoms of the disease that are crucial to disease management, currently there is a…
- Trial name
- NCT05920330
- Testing
- Nasal Plug
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Apnea, Sleep
Effects of CPAP on Cognitive Function, Neurocognitive Architecture and Function in Patients With OSA: The SMOSAT Trial
Multiple clinical studies have indicated that obstructive sleep apnea (OSA), the most common chronic sleep disorder, may affect neurocognitive function, and that treatment for continuous positive airway pressure (CPAP) has some…
- Trial name
- NCT02886156
- Testing
- CPAP, BSC
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Nasal Obstruction
Pain Relief for Submucosal Resection of Nasal Septum in Adults Does Ketamine Have a Pre-Emptive Effect?
Pain is an unpleasant sensory experience associated with actual or potential tissue damage. Acute pain management is an important aspect of perioperative anesthetic care.
- Trial name
- NCT02294162
- Testing
- Ketamine i.v
- Where
- Israel
- Sponsor
- Western Galilee Hospital-Nahariya
Esophageal Neoplasm, Head and Neck Neoplasm
The Effects of Upper Airway and Digestive Tract Tumors on the Immune System
The goal of this study is to learn how tumors of the upper airway and digestive passages (tongue, throat, mouth, and voicebox) affect the body's immune defenses and energy storage.
- Conditions
- Esophageal Neoplasm, Head and Neck Neoplasm, Laryngeal Neoplasm, Papilloma
- Trial name
- NCT00001603
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Acute Respiratory Distress Syndrome (ARDS)
Assessment of the Reproducibility of the Recruitment-to-inflation Ratio (R/I Ratio) Measurement in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a severe lung condition that often requires invasive mechanical ventilation in the intensive care unit.
- Trial name
- RIRR (NCT07666503)
- Where
- 4 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Schizoaffective Disorder, Schizophrenia
Obstructive Sleep Apnea Treatment in Serious Mental Illness
Serious mental illnesses (SMI) like schizophrenia and bipolar disorder are two of the most disabling and costly chronic illnesses worldwide.
- Conditions
- Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Obstructive Sleep Apnea of Adult
- Trial name
- NCT05457127
- Testing
- Automatic Positive Airway Pressure (APAP)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Morbid Obesity, Cesarean Delivery Affecting Fetus
Effect of CPAP on Fetal pH at Scheduled C-section in Morbidly Obese Women
The objective of our study is to evaluate the effect of CPAP on umbilical cord acid base status in morbidly obese women at the time of scheduled cesarean delivery.
- Trial name
- NCT04993651
- Testing
- CPAP
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Eastern Virginia Medical School
Lung Disease, Undergoing Thoracosocpic Surgery
Nondependent Lung Ventilation and Fluid Responsiveness
The stroke volume variation (SVV), measured using the Vigileo-FloTrac system (Edwards Lifescience, Irvine, CA), has been shown to able to predict fluid responsiveness during one-lung ventilation (OLV) in patients undergoing…
- Trial name
- NCT02191410
- Testing
- High Frequency Positive Pressure Ventilation, Continuous Positive Airway Pressure
- Where
- Saudi Arabia
- Volunteers
- 62 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Asthma
Inflammatory Processes in the Airway of Asthmatics With Persistent Bronchial Hyperreactivity
The purpose of this study is to examine inflammatory processes in the airway of moderate to severe persistent asthmatics who have persistent bronchial hyperreactivity despite chronic administration of inhaled glucocorticoids.
- Trial name
- NCT00217854
- Testing
- Bronchoscopic
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Washington University School of Medicine
Perennial Allergic Rhinitis
Efficacy Study for the Symptomatic Treatment of Perennial Allergic Rhinitis With a 1 Year Safety Extension
Double-blind phase: The objective of the study was to evaluate the efficacy and safety of Bilastine 20 mg, compared to Cetirizine and placebo for the treatment of perennial allergic rhinitis.
- Trial name
- NCT01127620
- Testing
- Bilastine, Cetirizine
- Volunteers
- 650 people
- Sponsor
- Faes Farma, S.A.
Chronic Cough (CC), Upper Airway Cough Syndrome
Inhaled vs Intranasal Corticosteroids for Chronic Cough in Upper Airway Cough Syndrome
Chronic cough - a cough lasting eight weeks or longer - is one of the most common reasons people see a lung specialist. It can disturb sleep, make conversation difficult, and reduce quality of life.
- Conditions
- Chronic Cough (CC), Upper Airway Cough Syndrome, Chronic Rhinitis
- Trial name
- NCT07777796
- Testing
- Budesonide (400μg/d), Mometasone Furoate 50mcg Nasal Spray
- Where
- Poland
- Volunteers
- 56 people
- Sponsor
- Silesian University of Medicine
Asthma
Efficacy and Safety Study of Reslizumab to Treat Poorly Controlled Asthma
The purpose of this study is to determine the effectiveness and safety of reslizumab in the treatment of subjects with poorly controlled asthma.
- Trial name
- NCT00587288
- Testing
- Reslizumab, Saline
- Where
- 30 sites in United States, Canada
- Volunteers
- 106 people
- Sponsor
- Ception Therapeutics
Cystic Fibrosis
Effect of Simvastatin on CF Airway Inflammation
Individuals with cystic fibrosis (CF) have persistent infection in the airways, which the body attempts to fight by recruiting immune cells (neutrophils) to the lung.
- Trial name
- NCT00255242
- Testing
- Simvastatin treatment for 28 days
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Akron Children's Hospital
Asthma, Airway Hyperresponsiveness
Small Airways Disease in Asymptomatic and Symptomatic Subjects With Airway Hyperresponsiveness (AHR)
The purpose of this study is to study differences in small airways (<2mm) parameters in asthma patients, subjects with asymptomatic airway hyperresponsiveness and healthy controls.
- Trial name
- ABHR (NCT01549483)
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Subclinical Cardiovascular Impairments, Obstructive Sleep Apnea Syndrome
Cardiovascular Impairments and Obstructive Sleep Apnea Syndrome
Which are the anthropometric parameters and/or of severity of the syndrome of apnea of sleep (SAS) which make it possible to anticipate occurred of vascular anomalies, anatomical and/or functional precociously found among…
- Trial name
- INFRASAS (NCT01089257)
- Where
- 3 sites in France
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea
Effect of CPAP on Abnormal Gastroesophageal Reflux and Lung Inflammation in IPF
This study will evaluate the effect of CPAP therapy on esophageal pH and lung inflammation in patients with idiopathic pulmonary fibrosis (IPF) and sleep apnea.
- Conditions
- Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea, Gastro Esophageal Reflux
- Trial name
- NCT05359965
- Testing
- Positive Airway Pressure
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Arizona
Nasal Obstruction
Hypnosis to Perform Awake Intubation
Awake intubation is a recommended safety procedure in specific cases where the intubation or ventilation before general anesthesia is at risk.
- Trial name
- Hypnotube (NCT02513511)
- Testing
- laryngoscopy under hypnosis
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Airway Stress Response
Dexmedetomidine vs Labetalol for Airway Stress in Hypertensive Craniotomy Patients
This randomized trial compares dexmedetomidine and labetalol in controlling airway and hemodynamic stress during extubation in hypertensive patients undergoing craniotomy.
- Trial name
- NCT07034898
- Testing
- Dexmedetomidine, Labetalol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Nasal Stuffiness, Sneezing
Cyanobacteria Allergy in Lake Kineret
People swimming or surfing in lake Kineret , sometimes complain of nasal stuffiness , sneezing and itching .Typically, it happens during or immediately after contact with the lake's water .
- Conditions
- Nasal Stuffiness, Sneezing, Itching
- Trial name
- NCT01693198
- Testing
- Skin test with sterile extracts of different cyanobacteria
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
Obstructive Sleep Apnea, Obesity
Sibutramine Versus Continuous Positive Airway Pressure (CPAP)in Obstructive Sleep Apnea (OSA) Patients
The primary objective of this study is to observe if Sibutramine is effective in improving the symptoms and signs of sleep apnea in obese patients.
- Conditions
- Obstructive Sleep Apnea, Obesity, Hypertension
- Trial name
- NCT00729963
- Testing
- Sibutramine, CPAP
- Volunteers
- 45 people
- Sponsor
- Laval University
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