Clinical trials: Airway Disease
Asthma, COPD
The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)
The goal of this clinical trial is to determine if positive pressure during inspiration will improve penetration of aerosolized N-Acetylcysteine (NAC) into airway mucus plugs in the lungs of patients with asthma or Chronic…
- Trial name
- TEAM (NCT06152653)
- Testing
- n-acetylcystine (NAC)+ albuterol, AeroEclipse-VersaPAP System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Hypoxia, Obesity
Nasopharyngeal Airway Combined With Nasal High-flow Oxygen Therapy During Painless Gastroscopy in Obesity Patients
Gastroscopy is a commonly used, direct, and reliable method for screening and diagnosing digestive tract diseases. However, as an invasive examination, it can cause adverse reactions such as pain, nausea, vomiting, and choking…
- Conditions
- Hypoxia, Obesity, Gastrostomy
- Trial name
- NCT06966934
- Testing
- NPA
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Asthma, Obesity
Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics
The objective of this pilot study is to determine whether obesity and metabolic syndrome are in fact synergistic in relation to airway nitric oxide (NO) biology.
- Conditions
- Asthma, Obesity, Metabolic Syndrome
- Trial name
- NCT03215836
- Testing
- Bronchoscopy and Nasal Epithelium Brush Sampling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Sleep Apnea
Intensive Versus Standard Follow up to Improve Continuous Positive Airway Pressure (CPAP) Compliance
The purpose of this study was to compare the effects on sleepiness, quality of life, depression, hospitalization and deaths rate, of intensive vs standard interventions, on CPAP adherence, 2 years after CPAP initiation.
- Trial name
- NCT02016339
- Testing
- Standard care, Intensive care
- Volunteers
- 2,836 people
- Sponsor
- University of Crete
Obstructive Sleep Apnea
Inspire® Upper Airway Stimulation (UAS) System German Post-Market Study
The purpose of this study is to obtain additional safety and efficacy data on the use of Inspire® therapy for the treatment of subjects with moderate to severe Obstructive Sleep Apnea.
- Trial name
- NCT02293746
- Testing
- Inspire® Upper Airway Stimulation (UAS) System
- Where
- 3 sites in Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Inspire Medical Systems, Inc.
Nasal Airway Obstruction
Thermal Imaging as a Potential Diagnostic Tool of Nasal Airflow
Currently, there are no tools that can measure nasal airflow in an objective manner that is non-invasive to the patient. This clinical study aims to address this by evaluating the use of thermal imaging as a diagnostic tool for…
- Trial name
- NCT03233373
- Testing
- Seek CompactPro thermal imager
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
COPD, Healthy Controls
Supramaximal High-Intensity Interval Training in People With and Without Chronic Obstructive Pulmonary Disease
Beyond pulmonary complications, COPD presents with extrapulmonary manifestations including reduced cognitive, cardiovascular, and muscle function.
- Trial name
- COPD-HIIT (NCT06068322)
- Testing
- Exercise training on a stationary bicycle
- Where
- 2 sites in Belgium, Sweden
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Umeå University
Sleep Apnea, Obstructive
NPA-OSA Device Tolerability, Usability and Acclimation Clinical Study in Adult Obstructive Sleep Apnea (OSA) Patients
This pilot study is being done to determine if the nasopharyngeal airway obstructive sleep apnea (NPA-OSA) device can be used in the treatment of OSA in adults.
- Trial name
- NCT06677151
- Testing
- nasopharyngeal airway obstructive sleep apnea (NPA-OSA) device
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Cystic Fibrosis, Airway Clearance Impairment
IPV vs CPT for Airway Clearance During CF Exacerbation
Intrapulmonary Percussive Ventilation (IPV) will show greater improvements in Forced Expiatory Volume in 1 second (FEV1) shorter duration of stay, and greater time to next pulmonary exacerbation in pediatric Cystic Fibrosis…
- Trial name
- NCT03261219
- Testing
- Intrapulmonary Percussive ventilation, Chest Physiotherapy Vest (Incourage)
- Sponsor
- University of Florida
COPD
Predictive Questionnaires for Risk of Acute COPD (Chronic Obstructive Pulmonary Disease) Exacerbations
COPD patients frequently suffer intermittent exacerbations of their disease characterised by acute deterioration of symptoms. Acute exacerbations of COPD (AECOPD) are associated with significant impairment of health status, use…
- Trial name
- NCT01248507
- Where
- Spain
- Volunteers
- 634 people
- Sponsor
- AstraZeneca
Asthma
Comparison of Combination Therapy: Montelukast and Inhaled Steroid on Exercise Induced Bronchoconstriction
The purpose of this study is to compare the effects of 2 weeks therapy of montelukast, budesonide, their combination on exercise induced bronchoconstriction (EIB) and airway inflammation in children and young adults, not on…
- Trial name
- NCT00462592
- Testing
- budesonide, montelukast
- Where
- 2 sites in Canada
- Volunteers
- 18 people
- Sponsor
- Hamilton Health Sciences Corporation
Cystic Fibrosis
High Frequency Chest Wall Oscillation and Cystic Fibrosis
High frequency chest wall oscillation (HFCWO) has been shown to increase tracheal mucus clearance compared with a control group.
- Trial name
- NCT01057524
- Testing
- High Frequency Chest Wall Oscillation (HFCWO), Usual airway clearance
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Imperial College London
Asthma
Poly-unsaturated Fats for Improving Nasal Polyps and Asthma
Asthma is a syndrome compromising many phenotypes including N-ERD (caused by increased 4-series leukotriene (LT) production). n-3 PUFA supplementation modulates 4-series LT and has anti-inflammatory effects.
- Trial name
- PUFFIN (NCT05613803)
- Testing
- Fish oil
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Pulmonary Disease, Chronic Obstructive
Analyzing Lung Tissue in People With and Without Chronic Obstructive Pulmonary Disease Who Are Undergoing Lung Transplantation
Chronic obstructive pulmonary disease (COPD) is a long-term lung disease. People with COPD have difficulty breathing because of lung damage.
- Trial name
- NCT00756522
- Testing
- There is no intervention. Study is observational.
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Washington University School of Medicine
Chronic Obstructive Airway Disease
Czech Multicentre Research Database of Chronic Obstructive Pulmonary Disease (COPD)
The chronic obstructive pulmonary disease (COPD) is the occurrence of chronic bronchitis or emphysema, a pair of commonly co-existing diseases of the lungs in which the airways narrow over time.
- Trial name
- NCT01923051
- Where
- 14 sites in Czechia
- Volunteers
- 813 people
- Sponsor
- Zuzana Zbožínková, M.Sc.
Esophageal Neoplasm, Head and Neck Neoplasm
The Effects of Upper Airway and Digestive Tract Tumors on the Immune System
The goal of this study is to learn how tumors of the upper airway and digestive passages (tongue, throat, mouth, and voicebox) affect the body's immune defenses and energy storage.
- Conditions
- Esophageal Neoplasm, Head and Neck Neoplasm, Laryngeal Neoplasm, Papilloma
- Trial name
- NCT00001603
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Sleep Apnea, Hypertension
Spanish Cohort for the Study of the Effect of CPAP in Hypertension (CEPECTA)
AIMS:To know the effects of the treatment with nasal positive continuous airway pressure (CPAP) on systemic blood pressure and the expression of biological mediators, in systemic hypertension of recent diagnostic, whose have an…
- Trial name
- NCT00202527
- Testing
- Nasal continuos positive airway pressure
- Where
- Spain
- Volunteers
- 340 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Staphylococcus Aureus Pneumonia, Lung Diseases
Mucoid Staphylococcus Aureus in Cystic Fibrosis Airways
Recently, the investigators described a new mucoid phenotype of Staphylococcus aureus cultured from the airways of cystic fibrosis (CF) patients.In this observational study, the investigators plan to determine the prevalence of…
- Conditions
- Staphylococcus Aureus Pneumonia, Lung Diseases, Cystic Fibrosis, Lung Function Decreased
- Trial name
- mucostaph (NCT04171583)
- Where
- 13 sites in Austria, Germany
- Volunteers
- 628 people
- Sponsor
- University Hospital Muenster
VAP - Ventilator Associated Pneumonia
Oral Care With 3% Hydrogen Peroxide (Oroxid®) in ICU - Effects on the Lower Airway Microbial Colonisation
HyPerMICROBE is a single-centre, controlled, randomised, prospective, superiority clinical trial to compare the efficacy of daily oral care with 3% hydrogen peroxide (Oroxid®) versus standard of care (0.2% chlorhexidine…
- Trial name
- HyperMICROBE (NCT06045429)
- Testing
- Oroxid®, Chlorhexidine mouthwash
- Where
- Czechia
- Volunteers
- 160 people
- Sponsor
- Charles University, Czech Republic
Acute Respiratory Failure With Hypoxia
Positive Pressure During Bronchoscopy
It has been demonstrated the application of noninvasive positive pressure ventilation (NPPV) to assist spontaneous breathing through a face mask during fiberoptic bronchoscopy (FOB) with bronchoalveolar lavage (BAL) in severely…
- Trial name
- NCT02167542
- Testing
- Noninvasive Positive Pressure Ventilation, CPAP valve (Boussignac)
- Where
- Portugal
- Volunteers
- 24 people
- Sponsor
- Hospital Sao Joao
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