Clinical trials: Airway Disease
Pulmonary Disease，Chronic Obstructive;
Small Airways Evaluation and Treatment
Chronic obstructive pulmonary disease (COPD) is a common disease , and characterized by progressive development of airflow limitation.
- Trial name
- NCT02526758
- Testing
- beclomethasone, formoterol, budesonide
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zhujiang Hospital
Asthma, COPD
Acute Exacerbations Treated With BenRAlizumab (The ABRA Study)
Exacerbations of asthma and COPD are an important cause of hospital admission and the main cause of annual winter bed shortages.
- Trial name
- ABRA (NCT04098718)
- Testing
- Benralizumab, Prednisolone
- Where
- United Kingdom
- Volunteers
- 158 people
- Sponsor
- University of Oxford
Asthma, Allergy
Effect of Ozone on Airway Inflammation in Allergic Asthmatics Treated With Omalizumab
Ozone can cause acute airway inflammation in both asthmatics and normal volunteers. However, in asthmatics ozone can cause episodes of worsening of asthma.
- Trial name
- NCT00287378
- Testing
- omalizumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Obstructive Pulmonary Disease
Assessment of Ventilation-perfusion Abnormalities in Patients With Stable Smoking-related Airways Disease
Subjects undergo history, examination, lung function assessment after informed consent has been obtained. All subjects will undergo ventilation-perfusion scans.
- Trial name
- NCT00180843
- Testing
- salbutamol + ipratropium bromide nebules, nebulized saline
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- Imperial College London
Mask Ventilation, Airway Obstruction Upper
The Articulated Oral Airway as an Aid to Mask Ventilation
The Articulating Oral Airway (AOA) is a novel oral airway which actively displaces the tongue, allowing for a greater cross-sectional area for mask ventilation.
- Conditions
- Mask Ventilation, Airway Obstruction Upper, Airway Management
- Trial name
- NCT03144089
- Testing
- Articulated Oral Airway, Guedel oral airway (active comparator)
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ron Abrons
Cystic Fibrosis
Microbiome Acquisition and Progression of Inflammation and Airway Disease in Infants and Children With Cystic Fibrosis
Cystic Fibrosis (CF) is a fatal, recessive genetic disorder characterized by progressive inflammation and lung damage. It is unclear whether current treatment strategies, which focus on detection and eradication of pathogenic…
- Trial name
- NCT01661491
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Neoplasms, Airway Obstruction Upper
Difficult Airway Management in Oncology: An International Delphi Consensus Study (DAMO)
Airway management in patients with cancer carries risks that general difficult-airway guidelines do not address. Tumour in the head, neck, or mediastinum can distort or narrow the airway; previous radiotherapy causes fibrosis and…
- Conditions
- Neoplasms, Airway Obstruction Upper, Intubation, Intratracheal, Head and Neck Neoplasms
- Trial name
- DAMO (NCT07822815)
- Testing
- Questionnaire Administration
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Onco Critical Care Society
Obstructive Sleep Apnea Syndrome
Air Leakage Under Continuous Positive Airway Pressure
The software embedded in recent continuous positive pressure devices enables the analysis of the level of leakage that occurs during treatment around the mask or from the mouth.
- Trial name
- SAS-leak-1 (NCT03381508)
- Testing
- Brizzy continuous positive pressure device
- Where
- 3 sites in France
- Volunteers
- 79 people
- Sponsor
- University Hospital, Montpellier
Breathing Disorder During Sleeping, Sleep Habits
Impact of Palatal Expansion and Up-Locker Activator on Sleep and Pharyngeal Dimensions in Children
Objective: The study will aim to compare the effect of palatal expansion with Hyrax and Hyrax combined with Up-Locker on sleep behavior, sleep architecture, quality of life and nasal and pharyngeal airway dimensions, as well as…
- Trial name
- NCT06986343
- Testing
- Hyrax, Hyrax and Uplocker Vacuum Device
- Where
- Colombia
- Volunteers
- 34 people
- Sponsor
- CES University
Obstructive Sleep Apnea of Adult, Preeclampsia
Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy
A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate of hypertensive disorders of…
- Conditions
- Obstructive Sleep Apnea of Adult, Preeclampsia, Obstetrical Complications
- Trial name
- SLEEP (NCT03487185)
- Testing
- Continuous Positive Airway Pressure, Sleep Advice Control
- Where
- 14 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- The George Washington University Biostatistics Center
Ventilation
BASKA Laryngeal Mask Airway in Either Volume or Pressure Controlled Ventilation in Laparoscopic Cholecystectomy
this study will be undertaken to compare the efficacy of BASKA mask in volume controlled and pressure controlled ventilation in laparoscopic cholecystectomy.
- Trial name
- NCT03610126
- Testing
- volume controlled ventilation, pressure controlled ventilation
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Assiut University
Asthma in Children
Exhaled Nitric Oxide and Airway Caliber in Children With Asthma
The purpose of this study is to assess if in steroid naïve asthmatic children with elevated baseline exhaled nitric oxide, treatment with inhaled steroid and normalization of exhaled nitric oxide level results in restoration of…
- Trial name
- NCT01645397
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Atlantic Health System
Asthma, Copd
Effects of Smoking on Bronchial Epithelium
Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases affecting millions of people worldwide.
- Trial name
- NCT00849433
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
COVID-19 Acute Respiratory Distress Syndrome
Positive End Espiratory Pressure Trial in Coronavirus Disease 19 Treated With Continuous Positive Airway Pressure
Consecutive patients with hypoxemic respiratory failure, CT evidence of bilateral pneumonia and diagnosis of Coronavirus Disease 19 (COVID-19) with molecular nasopharyngeal swab consecutively admitted to the COVID Care Unit of…
- Trial name
- NCT05178160
- Testing
- PEEP Standard Protocol
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Santa Maria delle Grazie Hospital
Airway Inflammation, Asthma
An Exploratory Study to Characterise Changes in Airway Inflammation, Symptoms, Lung Function and Reliever Use in Adult Asthma Patients
This is a randomised, active-comparator, open-label, parallel-group, multicentre phase IV exploratory study to characterise changes in airway inflammation, symptoms, lung function, and reliever use in asthma patients using SABA…
- Trial name
- NCT03924635
- Testing
- SYMBICORT and salbutamol
- Where
- 6 sites in United Kingdom
- Volunteers
- 42 people
- Sponsor
- AstraZeneca
Asthma
Airway Inflammation in Swimmers
Studies have shown that the prevalence of respiratory symptoms, airway hyperresponsiveness (AHR) and asthma is high and increasing in elite athletes.
- Trial name
- NCT00207038
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Common Cold
Efficacy and Safety of Resveratrol and Carbossimetyl Beta Glucan in Treatment of Upper Airways Disease in Infancy
outpatient infants (0-6 months of life), affected by symptoms of upper airways disease will be randomly assigned to two type of intervention: A: treatment group, receiving resveratrol and carbossimetyl beta glucan; B: control…
- Trial name
- VIRNEO (NCT03683108)
- Testing
- Resveratrol and Carbossimetyl Beta Glucan, Saline Solution
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Nasal Obstruction, Rhinoplasty
Inferior Turbinate Surgery in Rhinoseptoplasty: a Randomized Clinical Trial With Quality of Life Outcomes
The purpose of this study is to determine whether inferior turbinate surgery during rhinoseptoplasty is effective in improving quality of life and acoustic rhinometry outcomes.
- Conditions
- Nasal Obstruction, Rhinoplasty, Rhinoseptoplasty, Turbinate Surgery
- Trial name
- NCT01457638
- Testing
- Inferior turbinate surgery, No iInferior turbinate surgery
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Noninvasive Ventilation, Respiratory Insufficiency
Can High-flow Nasal Oxygenation Improve Oxygen Saturation During Analgo-sedation in Obese Adults?
Obesity is omnipresent problem in everyday anesthesiology practice associated with low level of blood oxygen (hypoxemia) during analgo-sedation.
- Conditions
- Noninvasive Ventilation, Respiratory Insufficiency, Obesity, Deep Sedation
- Trial name
- NCT03687424
- Testing
- high-flow nasal oxygenation (HFNO), low-flow nasal oxygenation (LFNO)
- Volunteers
- 126 people
- Sponsor
- University of Split, School of Medicine
Respiratory Failure
Prevention of Pressure Ulcers in Patients Under Non-Invasive Mechanical Ventilation
This study aims to test direct application of the Non-Invasive Mechanical Ventilation -NIVM- mask or interface as the most efficient intervention to prevent Pressure Ulcers (PU), compared with other three usual preventive…
- Trial name
- PUPPVMNI (NCT02526862)
- Testing
- Allevyn Thin®, Askina Transorbent Border®, Linovera®
- Where
- Spain
- Volunteers
- 152 people
- Sponsor
- B. Braun Medical SA