Clinical trials: Airway Extubation
Weaning Failure, Mechanical Ventilation Complication
Comparison of Two Extubation Techniques in Critically Ill Adult Patients
Orotracheal extubation consists in the removal of the endotracheal tube (ETT) when it is no longer required. This procedure may carry a considerable risk of complications and extubation failure.
- Trial name
- ExtubAR (NCT03918811)
- Testing
- Positive Pressure Extubation Technique, Traditional Extubation Technique
- Where
- Argentina
- Volunteers
- 725 people
- Sponsor
- Hospital Donación Francisco Santojanni
Respiratory Distress Syndrome, Newborn, Respiratory Tract Diseases
Nasal HFOV Versus Nasal CPAP to Reduce Post-extubation pCO2
To investigate whether nasal high frequency oscillation ventilation (nHFOV) immediately after extubation reduces the arterial partial pressure of carbon dioxide (paCO2) at 72 hours after extubation in comparison with nasal…
- Trial name
- NCT02340299
- Testing
- nHFOV, nCPAP
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Charite University, Berlin, Germany
Airway Extubation
Maximum Expiratory Pressure in Induced Cough as a Predictor of Extubation Failure
Clinical trial for the evaluation of diagnostic tests. The sample was composed of adults under mechanical ventilation who passed the spontaneous breathing trial and was ready to be extubated.
- Trial name
- NCT04356625
- Testing
- MEPic
- Where
- Argentina
- Volunteers
- 80 people
- Sponsor
- Hospital Nacional Profesor Alejandro Posadas
Apnea, Infant, Premature
Randomized Trial of Nasal Continuous Positive Airway Pressure or Synchronized Nasal Ventilation in Premature Infants.
Very premature infants uniformly do not have mature functioning lungs to breathe well nor mature regulation mechanisms to breathe regularly. Assistance with a mechanical respirator is common.
- Conditions
- Apnea, Infant, Premature, Bronchopulmonary Dysplasia
- Trial name
- NCT00188968
- Testing
- Nasal Continuous Positive Airway Pressure, Synchronized Nasal Positive Pressure Ventilation
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- University of Manitoba
Acute Brain Injury, Post-neurosurgical Status
High-Flow Nasal Cannula After Extubation in Acute Brain Injury
Patients with acute brain injury after neurosurgery are at increased risk of extubation failure after removal of the endotracheal tube.
- Conditions
- Acute Brain Injury, Post-neurosurgical Status, Extubation Failure, Postoperative Respiratory Complications
- Trial name
- NCT07664085
- Where
- Vietnam
- Volunteers
- 285 people
- Sponsor
- Bach Mai Hospital
Hypertension
The Effects of Dexmedetomidine to Postoperative Awakening and Extubation-related Changes in Blood Pressure
The postoperative removal of intubation tube induces a noticeable sympathic response and increase of blood pressure. The risk of complications is especially elevated with the patients having cardiac surgery.
- Trial name
- NCT01871129
- Testing
- Dexmedetomidine
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Tampere University Hospital
Acute Respiratory Failure, Airway Extubation
The Maximizing Extubation Outcomes Through Educational and Organizational Research (METEOR) Trial
The METEOR Trial will compare four implementation strategies-traditional online education, protocol-directed care, interprofessional education, and a combination of protocol-directed care and interprofessional education-to test…
- Trial name
- METEOR (NCT05523479)
- Testing
- Traditional online education, Interprofessional education, Clinical protocol
- Where
- 17 sites in United States
- Volunteers
- 13,018 people
- Sponsor
- University of Pittsburgh
Intensive Care, Airway Extubation
High-flow Nasal Oxygen Therapy to Prevent Extubation Failure in Adult Trauma Intensive Care Patients
A significant proportion of patients who are intubated for trauma-related injuries, will fail the extubation process. This means that, when the decision has been made to remove the endotracheal tube, a certain proportion of these…
- Conditions
- Intensive Care, Airway Extubation, Critical Care, Oxygen Therapy
- Trial name
- NCT06110390
- Testing
- High flow nasal oxygen
- Where
- Qatar
- Volunteers
- 450 people
- Sponsor
- Hamad Medical Corporation
Extubation Failure, Prematurity
Comparing HHHFNC and nCPAP Ventilation Methods for the Prevention of Extubation Failure in Preterm Infants
Purpose is to show that HHHFNC method is as effective and safe as nCPAPand even more comfortable than it as non-invasive respiratory support for the prevention of extubation failure in preterm with gestational age of 26-32 weeks.
- Trial name
- NCT02887846
- Testing
- Heated Humidified High-Flow Nasal Cannula
- Volunteers
- 200 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Airway Management, Tracheal Extubation
Interest of Tracheal Extubation in Positive Pressure on Postoperative Oxygenation in Adult Digestive Surgery
Evaluation of a postoperative tracheal extubation protocol under positive pressure in accordance with international recommendations.
- Conditions
- Airway Management, Tracheal Extubation, Postoperative Respiratory Complications, Postoperative Hypoxemia
- Trial name
- ExPress (NCT04381949)
- Testing
- positive pressure extubation
- Where
- France
- Volunteers
- 208 people
- Sponsor
- University Hospital, Rouen
Complication
Is Positive Pressure Extubation a Safe Procedure?
Laboratory studies suggest extubation with positive pressure because it reduces the volume of secretions filtered into the distal airway.
- Trial name
- NCT03174509
- Testing
- Positive pressure extubation, Traditional during extubation
- Where
- Argentina
- Volunteers
- 198 people
- Sponsor
- Hospital Donación Francisco Santojanni
Invasive Mechanical Ventilation, Extubation Time
Measurement of Efferent Neural Drive From Respiratory Centers to Upper Airways Using Electromyography (EMG) of Genioglossus (GG) in Patients Dependent on Invasive Mechanical Ventilation
Muscle activity in the upper airway is influenced by specific states such as anesthesia, sleep, wakefulness, and the phases of respiration.
- Trial name
- NCT07842484
- Testing
- electromyography (EMG) of genioglossus (GG)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Airway Extubation
The Effect of Dexmedetomidine on the Emergence Agitation in Nasal Surgery
The investigators examined the effect of dexmedetomidine on the emergence agitation and postoperative quality of recovery in nasal surgery
- Trial name
- NCT01513772
- Testing
- Dexmedetomidine, Normal saline 0.9%
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Severance Hospital
Premature Birth, Respiratory Insufficiency
Comparison of Two Methods of Continuous Positive Airway Pressure (CPAP) to Support Successful Extubation of Infants of Birth Weights ≤ 1500 Grams (C2CPAP)
Continuous positive airway pressure (CPAP) has been used successfully to promote extubation in the premature infant population. The two methods of CPAP to be examined are currently used by many institutions, yet no study has…
- Trial name
- NCT00187434
- Testing
- Infant Flow System, Bubble CPAP
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Sunnybrook Health Sciences Centre
Mechanical Ventilation Complication, Diaphragm Issues
Effect of Lung Volume Recruitment Technique After Extubation
This study was conducted to investigate the effect of the LVR technique on cough ineffectiveness, to determine its benefit as a simple, safe, and inexpensive cough augmentation technique, and to determine how much the LVR method…
- Conditions
- Mechanical Ventilation Complication, Diaphragm Issues, Cough, Ineffective Airway Clearance
- Trial name
- NCT05128552
- Testing
- Lung volume recruitment technique, Traditional chest physiotherapy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Airway Extubation, Oxygen Inhalation Therapy
High Flow Nasal Cannula in Immediately Post Extubation
The aim of the study is to determine the incidence of failure of extubation in high-risk patients using High Flow Nasal Cannula (HFNC) to prevent such failure in the Intensive Care Unit. A prospective cohort study was performed.
- Trial name
- HFNC (NCT03495947)
- Testing
- high flow nasal cannula
- Where
- Argentina
- Volunteers
- 165 people
- Sponsor
- Hospital Italiano de Buenos Aires
Anesthesia, Intravenous, Laparotomy
TCI vs Manually Controlled Infusion of Propofol
Anesthesia records for patients anesthetized with target controlled infusion of propofol and remifentanil will be matched with patients anesthezied with manyally controlled infusion.
- Conditions
- Anesthesia, Intravenous, Laparotomy, Airway Extubation
- Trial name
- NCT04266535
- Testing
- Target controlled infusion
- Volunteers
- 40 people
- Sponsor
- Regional Hospital West Jutland
Extubation Failure
Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes
This study aims to prospectively validate the diagnostic accuracy of an effort-stratified Cough Peak Flow (CPF) decision algorithm for predicting extubation failure, maintaining strict blinding of the clinical team.
- Trial name
- NCT07737483
- Testing
- Observational measurement of Cough Peak Flow and Tidal Volume
- Volunteers
- 150 people
- Sponsor
- Hospital H+ Queretaro
Airway Extubation
Exploring the Use of Pulse Tissue Doppler in Predicting Extubation Success in Mechanically Ventilated Patients
Determining the appropriate extubation timing for mechanically ventilated patients is a critical issue in the Intensive Care Unit (ICU).
- Trial name
- NCT06154811
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Affiliated Hospital of Jiangnan University
Adenotonsillar Hypertrophy, Obstructive Sleep Apnea
The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation
The investigators aim to investigate the effect of dexmedetomidine on the perioperative respiratory complications in this patient population undergoing both awake and deep tracheal extubation.
- Conditions
- Adenotonsillar Hypertrophy, Obstructive Sleep Apnea, Tonsillitis, Adenoiditis
- Trial name
- NCT02162433
- Testing
- Normal Saline, Dexmedetomidine
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Massachusetts Eye and Ear Infirmary