Clinical trials: Airway Inflammation
Exercised Induced Asthma, Asthma
The Effects of Prebiotics on Gut Bacterial Parameters, Immune Function & Exercise-Induced Airway Inflammation.
The current study aims to explore the role of prebiotic supplementation in adults with and without Asthma/Exercise-Induced Bronchoconstriction (A/EIB).
- Trial name
- NCT02872675
- Testing
- HOST-DM059, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
COPD, COPD Exacerbation
Effects of Blocking TSLP on Airway Inflammation and the Epithelial Immune-response to Exacerbation Triggers in Patients With COPD
A phase 2, multicentre, randomized, double-blind, placebo-controlled, parallel group study to evaluate the effect of tezepelumab on airway inflammation in patients with COPD.
- Conditions
- COPD, COPD Exacerbation, COPD Bronchitis, Airway Disease
- Trial name
- UPSTREAM-COPD (NCT05507242)
- Testing
- Tezepelumab
- Where
- 2 sites in Denmark, United Kingdom
- Volunteers
- 80 people
- Sponsor
- Asger Sverrild
Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea
Effect of CPAP on Abnormal Gastroesophageal Reflux and Lung Inflammation in IPF
This study will evaluate the effect of CPAP therapy on esophageal pH and lung inflammation in patients with idiopathic pulmonary fibrosis (IPF) and sleep apnea.
- Conditions
- Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea, Gastro Esophageal Reflux
- Trial name
- NCT05359965
- Testing
- Positive Airway Pressure
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Arizona
Cystic Fibrosis
Utility of Induced Sputum Using Hypertonic Saline to Evaluate Infection and Inflammation in Cystic Fibrosis
The objective of the study is to evaluate the clinical utility and the feasibility, in an outpatient setting, of sputum induction using hypertonic saline.
- Trial name
- NCT00721071
- Testing
- Hypertonic Saline
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- The Hospital for Sick Children
Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
Endothelial Dysfunction, Monocyte Activation, and Vasculopathy in Patients With Obstructive Sleep Apnea (OSA) and Effect of 6-month CPAP Treatment
This purpose of this study is to 1. Determine the change in endothelial dependent vascular reactivity and vascular properties 2. Determine the changes in monocytes activation 3. Determine the change in pro-inflammatory status 4.
- Conditions
- Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, Endothelium, Inflammation
- Trial name
- NCT01312168
- Testing
- Therapeutic CPAP, Subtherapeutic CPAP
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Anxiety, Depression
Effect of Aerobic Training on Asthmatic Patients
The investigators hypothesize that aerobic training can reduce anxiety, depression and airway inflammation and those benefits may be related to changes in autonomic system.
- Conditions
- Anxiety, Depression, Airway Inflammation
- Trial name
- NCT00989365
- Testing
- Aerobic training
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo General Hospital
COPD
Inflammation in COPD and the Effect of Nicotinamide Riboside
The aim of this study is to investigate if nicotinamide riboside can reduce the airways inflammation associated with chronic obstructive pulmonary disease (COPD) in patients aged 60 or older.
- Trial name
- ICON (NCT04990869)
- Testing
- Nicotinamide Riboside
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD)
Immune Status and Disease Control of Inflammatory Airway Diseases
The goal of this study is to learn how the body's immune system affects disease control in people with different airway inflammatory diseases.We want to understand: 1.Whether specific immune cell patterns in the blood are linked…
- Conditions
- Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis), Bronchiectasis
- Trial name
- ISDC-IAD (NCT07493629)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Ningbo University
Patients Requiring Endotracheal Intubation
Intubated ICU Patients
The purpose of this research study is to determine how cell changes during endotracheal intubation and artificial lung ventilation affect lung inflammation.
- Trial name
- NCT02171091
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Washington University School of Medicine