Clinical trials: Airway Remodeling
Anesthesia, Airway Remodeling
GMA-Tulip, I-gel and the LMA-Supreme (LMA-S) Devices in Airway Management (GLAM-I)
Patients were randomly assigned to three supraglottic airway devices (SADs) groups for airway management after anesthesia induced.
- Trial name
- GLAM-I (NCT06383494)
- Testing
- LMA supreme group, I-gel group, GMA-Tulip
- Where
- China
- Volunteers
- 498 people
- Sponsor
- Zhejiang Cancer Hospital
Asthma
Human Rhinovirus Infection and Airway Remodeling Mediators
In this study, the following subjects will be exposed to human rhinovirus (HRV): those with classification of mild-moderate asthma healthy control subjects.
- Trial name
- NCT01847768
- Testing
- GMP-grade HRV-39, Bronchoalveolar Lavage, Methacholine Inhalation Challenge
- Where
- Canada
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Obstructive Sleep Apnea
Effects of Continuous Positive Airway Pressure (CPAP) in Heart Remodeling by Magnetic Resonance Imaging (MRI)
Obstructive sleep apnea (OSA) is independently associated with important heart remodeling that further contributes to overt heart failure.
- Trial name
- OSA-MRI (NCT00727454)
- Testing
- CPAP, No treatment
- Where
- 2 sites in Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Wheezing
Genes, Soy Isoflavones, and Virus
In this study, we will assess whether children without established asthma who have a variation in the switch for the PAI-1 gene will have higher PAI-1 levels and remodeling / allergic inflammatory pathways in their airways than…
- Trial name
- GSV (NCT07828405)
- Testing
- Soy Isoflavone Nutritional Supplements
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Asthma, Obesity
Oxidative Stress in Asthma
40% of all asthma patients in the US are obese. Obese asthmatics have more severe disease than lean asthmatics and do not respond as well to conventional anti-inflammatory therapies.
- Trial name
- NCT04512547
- Testing
- Hyperpolarized 129XeMRI
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bastiaan Driehuys
Asthma
Markers of Airway Inflammation in BAL Fluid From Children With Asthma
The study compares the biochemical markers in bronchoalveolar lavage samples from asthmatic children to those markers found in non-asthmatic children with other respiratory diseases.
- Trial name
- NCT00838552
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- National Jewish Health
Airway Remodeling
Observational Study With Investigation of Two Second Generation Laryngeal Masks
In a observational study the second-generation laryngeal masks LMA Supreme and Ambu AuraGain are investigated.
- Trial name
- OSSGA (NCT02566291)
- Testing
- Success
- Where
- Germany
- Volunteers
- 364 people
- Sponsor
- Johannes Gutenberg University Mainz
Asthma, COPD
Airway Inflammation and Remodeling in Asthma and COPD.
Asthma and chronic obstructive pulmonary disease (COPD) are inflammatory airway diseases. Although the clinical features of asthma and COPD may be similar, the pathogenesis of these diseases differs in many aspects.
- Trial name
- NCT02069054
- Where
- Poland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Airway Remodeling, Chronic Obstructive Pulmonary Disease
Effect of Tiotropium on Airway Remodeling in Patients With Early Stage COPD Accessed by Optical Coherence Tomography
This randomized, open-label, three-arm clinical trial evaluated the effects of tiotropium on airway remodeling in patients with GOLD stage 1 COPD using endobronchial optical coherence tomography (EB-OCT).
- Trial name
- NCT03842839
- Testing
- Tiotropium Inhalation Powder [Spiriva] 0.018mg, Salbutamol sulphate aerosol (Ventolin) 0.1mg
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Nasal Obstruction, Bilateral
Evaluate the Effectiveness of the Vivaer ARC Stylus for Nasal Breathing
A Prospective, Multicenter, Non-Randomized Study of the Aerin Medical Vivaer ARC Stylus for Nasal Airway Obstruction
- Trial name
- NCT04717791
- Testing
- Vivaer® ARC Stylus
- Where
- 3 sites in Germany
- Volunteers
- 118 people
- Sponsor
- HNO-Praxis Alte Post
Asthma, Copd
Effects of Smoking on Bronchial Epithelium
Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases affecting millions of people worldwide.
- Trial name
- NCT00849433
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Asthma; Eosinophilic, Airway Remodeling
BenRalizumab Effect on Airway Remodeling in Severe asTHma
Response to biologic therapies in severe asthma is variable, with patients being either non-responders, responders or super-responders. There is currently no explanation for this broad variation in response.
- Trial name
- BREATH (NCT06288516)
- Testing
- Benralizumab 30 mg/ml
- Where
- Greece
- Volunteers
- 36 people
- Sponsor
- Aristotle University Of Thessaloniki
Asthma, COPD
The Effect of FP-025, on Allergen-induced Airway Responses in Mild Eosinophilic House Dust Mite (HDM)-Allergic Asthma.
This study is a Phase IIa, randomized, placebo-controlled, double-blind, 2-way crossover, 2-center (conducted in EU; The Netherlands) study in male and female subjects with stable, mild HDM-allergic asthma.
- Trial name
- NCT03858686
- Testing
- FP-025 capsules
- Where
- 2 sites in Netherlands
- Volunteers
- 27 people
- Sponsor
- Foresee Pharmaceuticals Co., Ltd.
Chronic Obstructive Pulmonary Disease, Asthma
A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine
Chronic inflammatory pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and interstitial lung diseases (ILD) are…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Bronchiectasis, Cystic Fibrosis
- Trial name
- PALMIRE (NCT07274631)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- CHU de Reims